Anna Lynn, MD, PhD
Hospital ResidentAbout
Research
Publications
2025
Investigation of the protein corona and biodistribution profile of polymeric nanoparticles for intra-amniotic delivery
Lynn A, Shin K, Eaton D, Rose M, Zhang X, Ene M, Grundler J, Deschenes E, Rivero R, Bracaglia L, Glazer P, Stitelman D, Saltzman W. Investigation of the protein corona and biodistribution profile of polymeric nanoparticles for intra-amniotic delivery. Biomaterials 2025, 320: 123238. PMID: 40064138, PMCID: PMC11972154, DOI: 10.1016/j.biomaterials.2025.123238.Peer-Reviewed Original ResearchAmniotic fluidProtein corona formationProtein coronaIntra-amniotic deliveryNP delivery systemPEGylated nanoparticlesSurface polyethylene glycolPoly(lactic-co-glycolic acidProtein corona compositionLung cells in vitroCorona formationPLA-PEG nanoparticlesNon-PEGylated nanoparticlesCells in vitroLevels of albuminFetal bowelFetal lungFetal organsNP biodistributionPoly(lactic-acidDense brush conformationCorona compositionPolyvinyl alcoholBiodistribution profileCellular association
2024
Opportunities for Incorporation of Primary Palliative Care in Acute Care Surgery: A Narrative Review.
Lynn A, Miller S, Brackett A, Kodadek L. Opportunities for Incorporation of Primary Palliative Care in Acute Care Surgery: A Narrative Review. American Journal Of Hospice And Palliative Medicine® 2024, 10499091241309087. PMID: 39680802, DOI: 10.1177/10499091241309087.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPrimary palliative careAcute care surgeryPalliative carePalliative care principlesPractice of acute care surgeryAcute care surgical patientsNarrative reviewPrimary surgical teamCaregiver supportSymptom managementCare principlesClinician perspectivesSeverity of illnessPalliative interventionsCareSignificant barriersPractice existPromote educationIdentification of patientsIncreased awarenessBenefit patientsSurgical traineesSurgical settingPatient populationCultural factorsThe Technical and Ethical framework of Fetal Therapy: Past and Current Advances
Lynn, A.Y., Glazer, P.M., Saltzman, W.M. et al. The Technical and Ethical Framework of Fetal Therapy: Past and Current Advances. Curr Stem Cell Rep 10, 30–36 (2024). https://doi.org/10.1007/s40778-024-00235-wPeer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2022
Evaluation of the Association of Endometrial Thickness, Insulin Resistance, and Menstrual Patterns in Adolescent Females with Polycystic Ovarian Syndrome
Lynn A, Solomon N, Zamani M, Rowe E, Seifer D, Vash-Margita A. Evaluation of the Association of Endometrial Thickness, Insulin Resistance, and Menstrual Patterns in Adolescent Females with Polycystic Ovarian Syndrome. Journal Of Pediatric And Adolescent Gynecology 2022, 36: 134-139. PMID: 36403727, DOI: 10.1016/j.jpag.2022.11.005.Peer-Reviewed Original ResearchConceptsPCOS groupInsulin resistanceMenstrual patternAdolescent femalesControl groupRetrospective case-control studyLarge-scale prospective studiesAcute pelvic painEndometrial stripe thicknessTransabdominal pelvic ultrasoundTertiary children's hospitalPolycystic ovarian syndromeBody mass indexCase-control studyInstitutional review boardAdolescent PCOSEndometrial thicknessPelvic painOvarian syndromePCOS diagnosisPelvic ultrasoundUnique pathophysiologyEndocrinology clinicChildren's HospitalMass indexPolyglycerol and Poly(ethylene glycol) exhibit different effects on pharmacokinetics and antibody generation when grafted to nanoparticle surfaces
Shin K, Suh HW, Grundler J, Lynn AY, Pothupitiya JU, Moscato ZM, Reschke M, Bracaglia LG, Piotrowski-Daspit AS, Saltzman WM. Polyglycerol and Poly(ethylene glycol) exhibit different effects on pharmacokinetics and antibody generation when grafted to nanoparticle surfaces. Biomaterials 2022, 287: 121676. PMID: 35849999, DOI: 10.1016/j.biomaterials.2022.121676.Peer-Reviewed Original ResearchUnderstanding Sociodemographic Disparities in Maternal-Fetal Surgery Study Participation
Wilpers A, Lynn AY, Eichhorn B, Powne AB, Lagueux M, Batten J, Bahtiyar MO, Gross CP. Understanding Sociodemographic Disparities in Maternal-Fetal Surgery Study Participation. Fetal Diagnosis And Therapy 2022, 49: 125-137. PMID: 35272297, PMCID: PMC9117502, DOI: 10.1159/000523867.Peer-Reviewed Original ResearchConceptsTwin-twin transfusion syndromeCongenital diaphragmatic herniaGravidity/parityPotential health disparitiesRandomized control trialSurgery StudyDisease groupSociodemographic variablesExclusion criteriaHealth disparitiesCommon disease groupMaternal-fetal surgeryParticipants' sociodemographic characteristicsMedian sample sizeTransfusion syndromeDiaphragmatic herniaThoracic lesionsMaternal agePacific Islander personsPrevalence ratiosSacrococcygeal teratomaSociodemographic disparitiesFetal anomaliesDisease populationFetal surgery
2020
The association between anti-Müllerian hormone and vitamin 25(OH)D serum levels and polycystic ovarian syndrome in adolescent females
Simpson S, Seifer DB, Shabanova V, Lynn AY, Howe C, Rowe E, Caprio S, Vash-Margita A. The association between anti-Müllerian hormone and vitamin 25(OH)D serum levels and polycystic ovarian syndrome in adolescent females. Reproductive Biology And Endocrinology 2020, 18: 118. PMID: 33218348, PMCID: PMC7679991, DOI: 10.1186/s12958-020-00676-y.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeRotterdam diagnostic criteriaNon-PCOS groupMedian AMHOvarian syndromePCOS groupDiagnostic criteriaAnti-Müllerian hormone levelsAdolescent femalesRetrospective chart reviewTraditional clinical markersAnti-Müllerian hormoneCross-sectional studyWilcoxon rank sum testSignificant unadjusted differencesRank sum testD deficiencyChart reviewClinical featuresEndocrinology clinicSerum levelsAdjusted analysisUnadjusted comparisonsInsurance typeSurrogate marker
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