Anand Chellappa Reghuvaran Nair, PhD
Associate Research ScientistAbout
Research
Publications
2025
APOL1 Variants Promote T Cell Excitation by Modulating Calcium (Ca2+) Signaling Downstream of T Cell Receptors (TCRs) in Graft Rejection
Pell J, Tanvir E, Sun Z, Azzi J, Murakami N, Reghuvaran A, Kumar A, Barsotti G, Ishibe S, Heeger P, Menon M. APOL1 Variants Promote T Cell Excitation by Modulating Calcium (Ca2+) Signaling Downstream of T Cell Receptors (TCRs) in Graft Rejection. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.2025kn5bktfx. DOI: 10.1681/asn.2025kn5bktfx.Peer-Reviewed Original ResearchUrine mRNA Assay to Measure Compartment-Specific Kidney Injury
Barsotti G, Kumar A, Yi Z, Pell J, Tanvir E, Moledina D, Luciano R, Reghuvaran A, Meliambro K, Perincheri S, Zhang W, He J, Menon M. Urine mRNA Assay to Measure Compartment-Specific Kidney Injury. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.2025c7mvzqgd. DOI: 10.1681/asn.2025c7mvzqgd.Peer-Reviewed Original ResearchA T Cell Intrinsic Role for APOL1 Risk Alleles in Allograft Rejection
Pell J, Tanvir E, Sun Z, Reghuvaran A, Guerra M, Mizuno H, Kumar A, Zhang W, Azzi J, Murakami N, Ishibe S, Heeger P, Menon M. A T Cell Intrinsic Role for APOL1 Risk Alleles in Allograft Rejection. American Journal Of Transplantation 2025, 25: s91-s92. DOI: 10.1016/j.ajt.2025.07.188.Peer-Reviewed Original ResearchRole of GCC2 in T Cell Mediated Allograft Rejection in Mice
Tanvir E, Pell J, Reghuvaran A, Kumar A, Qin L, Mandel-Brahm C, Tellides G, Menon M. Role of GCC2 in T Cell Mediated Allograft Rejection in Mice. American Journal Of Transplantation 2025, 25: s875-s876. DOI: 10.1016/j.ajt.2025.07.2079.Peer-Reviewed Original ResearchFocus on a CKD-Associated Locus: SHROOM3 and Other Suspects
Qian L, Reghuvaran A, Menon M. Focus on a CKD-Associated Locus: SHROOM3 and Other Suspects. Kidney International Reports 2025, 10: 1329-1331. PMID: 40485672, PMCID: PMC12142795, DOI: 10.1016/j.ekir.2025.03.037.Peer-Reviewed Original Research
2024
Shroom3-Rock Interaction and Profibrotic Function: Resolving the Mechanism of a CKD Genome-Wide Association Study Risk Allele
Reghuvaran A, Kumar A, Barsotti G, Pell J, Tanvir E, He J, Menon M. Shroom3-Rock Interaction and Profibrotic Function: Resolving the Mechanism of a CKD Genome-Wide Association Study Risk Allele. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024qmq3drgr. DOI: 10.1681/asn.2024qmq3drgr.Peer-Reviewed Original ResearchRationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis
Barsotti G, Luciano R, Kumar A, Meliambro K, Kakade V, Tokita J, Naik A, Fu J, Peck E, Pell J, Reghuvaran A, Tanvir E, Patel P, Zhang W, Li F, Moeckel G, Perincheri S, Cantley L, Moledina D, Wilson F, He J, Menon M. Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis. Kidney International Reports 2024, 9: 1354-1368. PMID: 38707807, PMCID: PMC11068976, DOI: 10.1016/j.ekir.2024.02.006.Peer-Reviewed Original ResearchMinimal change diseaseRandomized Controlled TrialsSafety of metforminDouble-blindPodocyte injuryAdjunctive therapyPlacebo-controlled randomized controlled trialsPhase III studyPhase II trialPrimary glomerular diseaseFocal segmental glomerulosclerosisEffect of metforminPhase IIPlacebo-ControlledPreclinical dataNovel urineChange diseaseTissue markersRandomized trialsSegmental glomerulosclerosisGlomerular diseaseMechanistic biomarkersObservational studyFSGSInexpensive agent
2023
Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 mismatches associated with kidney transplant survival
Sun Z, Zhang Z, Banu K, Gibson I, Colvin R, Yi Z, Zhang W, De Kumar B, Reghuvaran A, Pell J, Manes T, Djamali A, Gallon L, O'Connell P, He J, Pober J, Heeger P, Menon M. Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 mismatches associated with kidney transplant survival. Journal Of Clinical Investigation 2023, 133: e170420. PMID: 37676733, PMCID: PMC10617779, DOI: 10.1172/jci170420.Peer-Reviewed Original ResearchConceptsDeath-censored graft lossHuman leukocyte antigenExpression quantitative trait lociT cellsTGF-β1TGF-β1/Smad pathwayDonor-recipient differencesKidney allograft lossChronic allograft rejectionKidney transplant survivalDonor-recipient mismatchActive TGF-β1Allograft lossGraft lossAllograft rejectionTransplant cohortPeripheral bloodLeukocyte antigenClinical trialsImmune cellsHaplotype mismatchGenome-wide scaleTransplant survivalQuantitative trait lociSingle nucleotide polymorphism dataComparative evaluation of glomerular morphometric techniques reveals differential technical artifacts between focal segmental glomerulosclerosis and normal glomeruli
Reghuvaran A, Lin Q, Basgen J, Banu K, Shi H, Vashist A, Pell J, Perinchery S, He J, Moledina D, Wilson F, Menon M. Comparative evaluation of glomerular morphometric techniques reveals differential technical artifacts between focal segmental glomerulosclerosis and normal glomeruli. Physiological Reports 2023, 11: e15688. PMID: 37423891, PMCID: PMC10329935, DOI: 10.14814/phy2.15688.Peer-Reviewed Original ResearchWCN23-0470 BAC-transgenic mice show a novel T-cell intrinsic role for FSGS-associated APOL1 risk-variants in T-cell activation
Pell J, Reghuvaran A, Nagata S, Banu K, He J, Craft J, Shi H, Chernova I, Ishibe S, Menon M. WCN23-0470 BAC-transgenic mice show a novel T-cell intrinsic role for FSGS-associated APOL1 risk-variants in T-cell activation. Kidney International Reports 2023, 8: s392-s393. DOI: 10.1016/j.ekir.2023.02.882.Peer-Reviewed Original Research
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