Alfred Lee, MD, PhD
Professor of Medicine (Hematology)Cards
About
Research
Publications
2026
Prospective Evaluation of Large Language Model Integration Into a Classical Hematology Case Conference
Kewan T, Lee A, Van Doren L. Prospective Evaluation of Large Language Model Integration Into a Classical Hematology Case Conference. JMIR Formative Research 2026, 10: e89939. PMID: 41849561, PMCID: PMC12998601, DOI: 10.2196/89939.Peer-Reviewed Original ResearchUtilization patterns of hematology consultation in the intensive care unit: an 11-year single-center experience
Allen C, Streiff M, Naik R, Seam N, Kadri S, Lee A, Knauert M, Goshua G. Utilization patterns of hematology consultation in the intensive care unit: an 11-year single-center experience. Blood Advances 2026, 10: 1943-1946. PMID: 41348859, PMCID: PMC12995476, DOI: 10.1182/bloodadvances.2025018327.Peer-Reviewed Original ResearchThrombopoietin-Receptor Agonists in Chemotherapy-Induced Thrombocytopenia
Goshua G, Lee A. Thrombopoietin-Receptor Agonists in Chemotherapy-Induced Thrombocytopenia. The New England Journal Of Medicine 2026, 394: 1125-1126. PMID: 41812200, DOI: 10.1056/nejme2517578.Peer-Reviewed Original ResearchBurnout in Sickle Cell Disease-Focused Hematology-Oncology Trained Physicians: A National Cross-Sectional Study
Restrepo V, Marshall A, Feder K, Afranie-Sakyi J, Carrithers B, Jones-Wonni B, Mensah C, Zhou B, Mistry R, McGann P, Azar S, De Castro L, Calhoun C, Bozang K, Brown T, Lee A, Van Doren L. Burnout in Sickle Cell Disease-Focused Hematology-Oncology Trained Physicians: A National Cross-Sectional Study. Blood Advances 2026 PMID: 41817318, DOI: 10.1182/bloodadvances.2025018338.Peer-Reviewed Original ResearchThis study investigates burnout in U.S. hematology-oncology physicians specializing in sickle cell disease, showing higher burnout rates linked to systemic factors, reduced recreation, and lower job pride.Cost-effectiveness of first-line IV vs oral iron for iron-deficiency anemia in women with heavy menstrual bleeding
Wang D, Sra M, Ito S, Ng D, Glaeser-Khan S, Wang D, Hirniak S, Lee A, Cuker A, Goshua G. Cost-effectiveness of first-line IV vs oral iron for iron-deficiency anemia in women with heavy menstrual bleeding. Blood Advances 2026, 10: 1508-1517. PMID: 41504430, PMCID: PMC12952766, DOI: 10.1182/bloodadvances.2025018315.Peer-Reviewed Original ResearchConceptsHeavy menstrual bleedingIV iron dextranIron deficiency anemiaQuality-adjusted life yearsOral ferrous sulfateFirst-line treatmentIron dextranOral ironMenstrual bleedingCost-effective treatmentIron deficiencyFrequent gastrointestinal side effectsIV iron sucroseOral iron therapyFirst-line therapyQuality-adjusted life-year benefitsFirst-line optionIncremental cost-effectiveness ratioGastrointestinal side effectsCohort of womenCost-effectiveness ratioIron therapyIron sucroseIV ironTreatment delay
2025
When genotype and phenotype disagree: rethinking thrombophilia testing in the genomic era
Ryu J, Lee A. When genotype and phenotype disagree: rethinking thrombophilia testing in the genomic era. Journal Of Thrombosis And Haemostasis 2025, 23: 3806-3808. PMID: 41260738, DOI: 10.1016/j.jtha.2025.07.044.Peer-Reviewed Original ResearchMolecular clues to venous thromboembolism recurrence
Ryu J, Lee A. Molecular clues to venous thromboembolism recurrence. Blood 2025, 146: 2281-2282. PMID: 41196621, DOI: 10.1182/blood.2025030460.Peer-Reviewed Original ResearchBurnout in sickle cell disease-focused hematology-oncology trained providers: A national cross-sectional study
Restrepo V, Afranie-Sakyi J, Carrithers B, Jones-Wonni B, Mistry R, Mensah C, McGann P, Azar S, De Castro L, Calhoun C, Marshall A, Lee A, Van Doren L. Burnout in sickle cell disease-focused hematology-oncology trained providers: A national cross-sectional study. Blood 2025, 146: 831-831. DOI: 10.1182/blood-2025-831.Peer-Reviewed Original ResearchCross-sectional surveyLogistic regression modelsNational cross-sectional studySickle cell disease providerHematology-OncologySense of prideRecreation timeSickle cell diseasePrevalence of burnoutComplex clinical careBivariate logistic regression modelSingle-item instrumentPredictors of burnoutRegression modelsCross-sectional studyHigh burnout ratesContribution of workPhysician turnoverMedication errorsBetween-group comparisonsPatient acuityBurnout prevalenceHigh-acuity populationSystemic barriersNegative predictors of burnoutAutoimmune hemolytic anemia: An underrecognized contributor to anemia and hemolysis in babesiosis infection
Park A, Restrepo V, Tormey C, Foster G, Lee A, Van Doren L. Autoimmune hemolytic anemia: An underrecognized contributor to anemia and hemolysis in babesiosis infection. Blood 2025, 146: 2693. DOI: 10.1182/blood-2025-2693.Peer-Reviewed Original ResearchAutoimmune hemolytic anemiaDirect antiglobulin testMarkers of hemolysisDegree of anemiaStandard antibiotic regimenRBC exchangeRBC transfusionClinical featuresRetrospective studyDAT testingRetrospective study of patientsCo-InfectionPrimary diagnosisTreated with RBC transfusionBlood product transfusionAnalysis of patientsTertiary care centerYale-New Haven HospitalCorrelates of anemiaStudy of patientsComplication of babesiosisRisk of severe illnessAntibiotic regimenChi-square testImmunomodulatory therapyA proteomic map of thromboinflammatory signatures in antiphospholipid syndrome: results from antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION) registry
Pine A, Butt A, Andreoli L, Knight J, Gerosa M, Cecchi I, Branch D, Lopez-Pedrera R, Belmont H, Kello N, Petri M, Cervera R, Pengo V, Meroni P, Cohen H, Willis R, Bertolccini M, Goshua G, Gu S, Hwa J, Lee A, Erkan D, Sharda A. A proteomic map of thromboinflammatory signatures in antiphospholipid syndrome: results from antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION) registry. Frontiers In Immunology 2025, 16: 1676578. PMID: 41181143, PMCID: PMC12571811, DOI: 10.3389/fimmu.2025.1676578.Peer-Reviewed Original ResearchConceptsAntiphospholipid syndromeInflammatory signatureClinical trialsAdaptive immune response pathwaysPersistently aPL-positive patientsPathogenesis of antiphospholipid syndromeClinical antiphospholipid syndromePathophysiology of antiphospholipid syndromeAPL-positive patientsCirculating antiphospholipid antibodiesPresence of aPLAntiphospholipid syndrome classificationAdaptive immune activationActivation of coagulationStatistical significanceAntiPhospholipid Syndrome AllianceMultiple pathophysiological mechanismsObstetric morbidityAntiphospholipid antibodiesImmune response pathwaysImmune cellsImmune activationAutoimmune diseasesProteomic screenClinical severity
Academic Achievements & Community Involvement
Clinical Care
Overview
Alfred Ian Lee, MD, PhD, is Professor of Medicine (Hematology) and Program Director for the hematology/oncology fellowship program. He received his MD/PhD from the Yale School of Medicine in 2004. Dr. Lee completed residency in internal medicine at Brigham & Women’s Hospital, where he served as Chief Medical Resident, followed by a fellowship in hematology/oncology at Dana-Farber Cancer Institute. His primary academic interests are classical hematology, thrombosis, and medical education.
He has received such honors as the Charles W. Bohmfalk Prize for teaching in the basic sciences, the Leah M. Lowenstein Award for excellence in the promotion of humane and egalitarian medical education, the Yale Cancer Center Award for Mentorship Excellence, and the David J. Lefell Prize for Clinical Excellence.
Clinical Specialties
Hematology; Hematology & Oncology
Fact Sheets
Hereditary Hemorrhagic Telangiectasia (HHT)
Learn More on Yale MedicineBleeding Disorders
Learn More on Yale MedicineHodgkin's Lymphoma
Learn More on Yale MedicineAnemia
Learn More on Yale Medicine
Yale Medicine News
News & Links
News
- March 19, 2026Source: Medscape (with Drs. Alfred Lee and George Goshua)
Can Romiplostim Reduce Chemotherapy Disruptions in GI Cancer?
- December 09, 2025
Yale research advances presented at American Society of Hematology annual meeting
- December 01, 2025
Yale Cancer Center Experts to Present Latest Findings at American Society of Hematology’s Annual Meeting
- February 06, 2025Source: Medscape
Compassion Fatigue: How Oncologists Can Recognize the Signs
Get In Touch
Contacts
Administrative Support
Locations
Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.