Mihir Gupta, MD
Assistant ProfessorCards
About
Research
Publications
2026
Diagnostic Pathways and Procedural Risk in Primary Central Nervous System Lymphoma: A Nationwide Analysis.
Qureshi K, Arakali S, Anzueto J, Huddleston D, Hobbs J, Saenz S, Thakkar R, Jayaram R, Goulart C, Alok K, Gupta M. Diagnostic Pathways and Procedural Risk in Primary Central Nervous System Lymphoma: A Nationwide Analysis. Acta Haematologica 2026, 1-11. PMID: 42081433, DOI: 10.1159/000552333.Peer-Reviewed Original ResearchIt’s Not “Personal”: Health Information Disclosure and the Physical- Mental Distinction
Covo Y, Klug T, Olgun M, Ahmed Ramy M, Darji R, Gupta M. It’s Not “Personal”: Health Information Disclosure and the Physical- Mental Distinction. The Columbia Journal Of Law & The Arts 2026, 49: 495-548. DOI: 10.52214/jla.v49i3.14724.Peer-Reviewed Original Research
2025
Multi-Institutional Assessment of Circulating Cell-Free DNA in Cerebrospinal Fluid Facilitates Central Nervous System Lymphoma Diagnosis and Treatment Initiation
Prager B, Gupta M, West T, Ramundo C, Bagin J, de Macedo Filho L, Georgantas N, Pilacky R, Forst D, Jordan J, Mansouri A, Carter B, Cahill D, Nahed B, Dietrich J, Wang C, Shankar G. Multi-Institutional Assessment of Circulating Cell-Free DNA in Cerebrospinal Fluid Facilitates Central Nervous System Lymphoma Diagnosis and Treatment Initiation. Neurosurgery 2025, 99: 40-49. PMID: 41190874, DOI: 10.1227/neu.0000000000003835.Peer-Reviewed Original ResearchUnderstanding the Comorbidities Among Psychiatric Disorders, Chronic Low Back Pain, and Spinal Degenerative Disease Using Observational and Genetically Informed Analyses
Qiu D, Friligkou E, He J, Cabrera-Mendoza B, Aslan M, Gupta M, Polimanti R. Understanding the Comorbidities Among Psychiatric Disorders, Chronic Low Back Pain, and Spinal Degenerative Disease Using Observational and Genetically Informed Analyses. Biological Psychiatry Global Open Science 2025, 5: 100588. PMID: 41036474, PMCID: PMC12483661, DOI: 10.1016/j.bpsgos.2025.100588.Peer-Reviewed Original ResearchSurgical Outcomes in Patients with Primary or Metastatic Spinal Leiomyosarcoma: A Systematic Review and Meta-Analysis
Serrato P, Gupta M, Hawkins D, Sathyamangalam Samiappan S, Saha P, Lubelski D, Lee S. Surgical Outcomes in Patients with Primary or Metastatic Spinal Leiomyosarcoma: A Systematic Review and Meta-Analysis. World Neurosurgery 2025, 199: 124067. PMID: 40368091, DOI: 10.1016/j.wneu.2025.124067.Peer-Reviewed Original ResearchTargeting sickle cell pathobiology and pain with novel transdermal curcumin
Goel Y, Arellano M, Fouda R, Garcia N, Lomeli R, Kerr D, Argueta D, Gupta M, Velasco G, Prince R, Banerjee P, Jana S, Alayash A, Friedman J, Gupta K. Targeting sickle cell pathobiology and pain with novel transdermal curcumin. PNAS Nexus 2025, 4: pgaf053. PMID: 40007577, PMCID: PMC11854080, DOI: 10.1093/pnasnexus/pgaf053.Peer-Reviewed Original ResearchSomatic SMARCB1 mutation in spinal meningioma represents branched evolution in a patient with multiple sporadic meningiomas
Gupta M, Samiappan S, Alanya H, Yalcin K, Gultekin B, Sharaf R, Elsamadicy A, Figuera D, Samuel N, Mishra-Gorur K, Kolb L, McGuone D, Gunel M, Erson-Omay E, Moliterno J, Mendel E. Somatic SMARCB1 mutation in spinal meningioma represents branched evolution in a patient with multiple sporadic meningiomas. Neuro-Oncology Advances 2025, 7: vdaf067. PMID: 40386121, PMCID: PMC12081948, DOI: 10.1093/noajnl/vdaf067.Peer-Reviewed Original Research
2024
Rapid Tumor DNA Analysis of Cerebrospinal Fluid Accelerates Treatment of Central Nervous System Lymphoma.
Gupta M, Bradley J, Massaad E, Burns E, Georgantas NZ, Maron G, Batten J, Gallagher A, Thierauf J, Nayyar N, Gordon A, Jones S, Pisapia M, Sun Y, Jones PS, Barker FG 2nd, Curry W, Gupta R, Romero J, Wang N, Brastianos P, Martinez-Lage M, Tateishi K, Forst DA, Nahed BV, Batchelor TT, Ritterhouse LL, Iser F, Kessler T, Jordan JT, Dietrich J, Meyerson ML, Cahill DP, Lennerz JK, Carter B, Shankar GM. Rapid Tumor DNA Analysis of Cerebrospinal Fluid Accelerates Treatment of Central Nervous System Lymphoma. Blood 2024 PMID: 38776489, DOI: 10.1182/blood.2024023832.Peer-Reviewed Original ResearchSickle cell disease in India: current status and progress
Jain D, Gupta M, Madkaikar M, Jena R, Khargekar N, Saraf S, Krishnamurti L, Gupta K. Sickle cell disease in India: current status and progress. The Lancet Haematology 2024, 11: e322-e323. PMID: 38701819, DOI: 10.1016/s2352-3026(24)00109-1.Peer-Reviewed Original ResearchRadical surgical resection with molecular margins is associated with improved survival in IDH wild-type glioblastoma
Massaad E, Smith W, Bradley J, Esposito E, Gupta M, Burns E, Burns R, Velarde J, Berglar I, Gupta R, Martinez-Lage M, Dietrich J, Lennerz J, Dunn G, Jones P, Choi B, Kim A, Frosch M, Barker F, Curry W, Carter B, Nahed B, Cahill D, Shankar G. Radical surgical resection with molecular margins is associated with improved survival in IDH wild-type glioblastoma. Neuro-Oncology 2024, 26: 1660-1669. PMID: 38581292, PMCID: PMC11376447, DOI: 10.1093/neuonc/noae073.Peer-Reviewed Original Research
Clinical Care
Overview
Mihir Gupta, MD, is a fellowship-trained spine surgeon with a background in neurosurgery and orthopaedics. He performs both traditional and minimally invasive procedures to treat an array of complex spinal disorders.
Dr. Gupta says he was drawn to spine surgery because of how quickly the field is evolving. “We finally have a much better understanding of why people have back or neck pain and how to make it better safely,” he says. “And that doesn’t always involve surgery. Our job is to figure out when surgery is appropriate, and more importantly, when it is not the best solution.”
Dr. Gupta treats a variety of spine conditions including those that are degenerative, deformative, or the result of tumors, infections, or trauma. He also performs revision spine surgeries, or surgeries for people who have had surgery in the past but have a persistent or new problem.
Before he walks in the exam room and meets a new patient, Dr. Gupta says he likes to do his homework and look through any imaging studies they brought. “That way, I can focus on listening to them and doing a very thorough physical exam,” he says. “A thoughtful evaluation and really good physical exam are vital for making an accurate diagnosis. Often, I think patients haven’t had their problem explained in a way that makes sense to them, and I prioritize that.”
Spine procedures, Dr. Gupta says, are highly personalized. “There isn’t a one-size-fits-all approach. Our diagnostics have come so far that we have better imaging that allows us to see where pain is coming from and if surgery is needed,” Dr. Gupta says. “We also have better tools now with robotics and navigation and minimally invasive methods. These all allow us to tailor the right solution for them.”
Surgery, he points out, is often the last resort and, in some cases, is not the right solution for a patient’s pain. “We work closely with the pain management team, anesthesiology, physical therapists, and interventional radiologists to come up with nonsurgical options,” he says.
Dr. Gupta’s research interests include understanding how genetics contribute to different spinal disorders and how care can be personalized.
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Minimally Invasive Spinal Surgery
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Learn More on Yale MedicineDegenerative and Rheumatologic Spinal Disorders
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