Slide 10

The slow oscillation can form the basis of epileptic seizures, similar to those underlying the Lennox-Gastaut syndrome

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Figure 10.  Illustrated here is the transition from the slow oscillation, recorded intracellularly in vivo, to a spike-wave cortical seizure.  The transition to the seizure is associated with a marked increase in the discharge of the cortical neurons during the "UP" state.  During the seizure, Spike-Wave activity is intermixed with tonic depolarization and runs of fast activity, similar to that occurring in the children with Lennox-Gastaut syndrome.  B-D illustrate portions of the trace in A at higher resolution.

This figure is from:  Mircea Steriade, Florin Amzica, Dag Neckelmann, and Igor Timofeev 
Spike-Wave Complexes and Fast Components of Cortically Generated Seizures. II. Extra- and Intracellular Patterns 
J Neurophysiol 1998 80: 1456-1479.