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Slide 6

Example of Persistent Activity Interspersed with Periods of Quiescence in the Slow Oscillation in Prefrontal Cortical Slices in vitro.

Examples of the spontaneous generation of the UP and DOWN states in the prefrontal cortical slice in vitro. A. Normal membrane potential - note the low frequency action potential generation in this layer 5 pyramidal cell. Top trace is a nearby multiple unit recording in layer 5 illustrating that the UP state is synchronized in the local population. B. Hyperpolarization of the neuron to prevent the generation of action potentials in the intracellularly recorded neuron illustrates the barrages of synaptic activity occurring during the UP state.