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Slide 16

Stimulation of afferents can both Start and Stop Persistent Activity

Persistent activity in the prefrontal cortex in vivo can be initiated by a cue and stopped by the performance of the task. Here we show that activation of the cortical network with a local electrical stimulus can both start and stop the UP state (A), depending upon the amplitude of the electrical stimulus as well as the time from the beginning of the UP state (B).

From : Shu, Y-S., Hasenstaub, A., and McCormick, D.A. (2003) Turning on and off recurrent, balance cortical activity. Nature 423: 288-293.