Ania Jastreboff, MD, PhD
Cards
Professional Highlights
About
Research
Clinical Care
Professional Highlights
About
Research
Clinical Care
Professional Highlights
Honors
- 7 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Honors
- 7 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Honors
- 7 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Titles
Professor of Medicine (Endocrinology)
Director, Yale Obesity Research Center (Y-Weight)
Co-Director, Yale Center for Weight Management
Medical Director, Yale Stress Center
Education
Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)
University of Maryland at Baltimore (2002)
Bucknell University, Art History/Major, Music/Minor. Magna cum laude (1998)
Appointments
Titles
Professor of Medicine (Endocrinology)
Director, Yale Obesity Research Center (Y-Weight)
Co-Director, Yale Center for Weight Management
Medical Director, Yale Stress Center
Education
Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)
University of Maryland at Baltimore (2002)
Bucknell University, Art History/Major, Music/Minor. Magna cum laude (1998)
Appointments
Titles
Professor of Medicine (Endocrinology)
Director, Yale Obesity Research Center (Y-Weight)
Co-Director, Yale Center for Weight Management
Medical Director, Yale Stress Center
Education
Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)
University of Maryland at Baltimore (2002)
Bucknell University, Art History/Major, Music/Minor. Magna cum laude (1998)
Appointments
Publications Overview
- 108 Publications
- 7,623 Citations
- 55 Yale Co-Authors
Y-Weight: Yale Obesity Research Center
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileBoard Certification
2016
Clinical Specialties
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileBoard Certification
2016
Clinical Specialties
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileBoard Certification
2016
Clinical Specialties
Honors
- 7 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Honors
- 7 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Honors
- 7 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Titles
Professor of Medicine (Endocrinology)
Director, Yale Obesity Research Center (Y-Weight)
Co-Director, Yale Center for Weight Management
Medical Director, Yale Stress Center
Education
Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)
University of Maryland at Baltimore (2002)
Bucknell University, Art History/Major, Music/Minor. Magna cum laude (1998)
Appointments
Titles
Professor of Medicine (Endocrinology)
Director, Yale Obesity Research Center (Y-Weight)
Co-Director, Yale Center for Weight Management
Medical Director, Yale Stress Center
Education
Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)
University of Maryland at Baltimore (2002)
Bucknell University, Art History/Major, Music/Minor. Magna cum laude (1998)
Appointments
Titles
Professor of Medicine (Endocrinology)
Director, Yale Obesity Research Center (Y-Weight)
Co-Director, Yale Center for Weight Management
Medical Director, Yale Stress Center
Education
Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)
University of Maryland at Baltimore (2002)
Bucknell University, Art History/Major, Music/Minor. Magna cum laude (1998)
Appointments
Publications Overview
- 108 Publications
- 7,623 Citations
- 55 Yale Co-Authors
Y-Weight: Yale Obesity Research Center
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileBoard Certification
2016
Clinical Specialties
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileBoard Certification
2016
Clinical Specialties
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileBoard Certification
2016
Clinical Specialties
Honors
- 7 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Honors
- 7 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Honors
- 7 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
About
Titles
Professor of Medicine (Endocrinology)
Director, Yale Obesity Research Center (Y-Weight); Co-Director, Yale Center for Weight Management; Medical Director, Yale Stress Center
Biography
Ania M. Jastreboff, MD, PhD is a Professor in Medicine and Pediatrics at Yale School of Medicine. Dr. Jastreboff is a clinically active physician-scientist and international thought leader in the scientific development and clinical application of novel anti-obesity pharmacotherapeutics revolutionizing obesity treatment. As founding director of the Yale Obesity Research Center (Y-Weight), she is leading and shaping pivotal landmark studies of dual- and triple-receptor hormone agonists and NIH-funded studies investigating the physiology of obesity. She has served as lead investigator and author for trials investigating novel nutrient-stimulated hormone (NuSH)-based therapies for obesity including dual hormone receptor agonist, tirzepatide, a GIP/GLP-1 receptor agonist (Jastreboff, et al., NEJM, 2022 & NEJM, 2024), triple hormone receptor agonist, retatrutide, a GIP/GLP-1/Glucagon receptor agonist (Jastreboff, et al., NEJM, 2023), and a monthly monoclonal antibody peptide conjugate, maridebart cafraglutide, a GIP receptor antagonist GLP-1 receptor agonist (Jastreboff, et, al., NEJM, 2025). Trained in both adult endocrinology and pediatric endocrinology, she serves on the Board of Governance for The Obesity Society, as a director on the American Board of Obesity Medicine, developing Obesity Clinical Practice Guidelines, and as co-director of the Yale Center for Weight Management, where she sees patients and teach trainees. She is a highly sought after speaker, teaching internationally, nationally, and locally. She is also a compassionate advocate for patients with obesity, from grass-roots patient groups to interviews with Ms. Oprah Winfrey.
Videos of Dr. Jastreboff speaking with Ms. Oprah Winfrey about obesity (YouTube podcast)
- The Truth about Obesity (posted Jan-14-2025)
- How People Treat You After Weight Loss (posted Jan-21-2025)
- What Exactly is Obesity? (posted May-10-2024)
Videos of Dr. Jastreboff and colleagues from the NEJM about:
- What causes obesity: https://www.nejm.org/doi/full/...
- Supporting patients with obesity: https://www.nejm.org/doi/full/...
- Medications and surgery for obesity treatment: https://www.nejm.org/doi/full/...
Video of Dr. Jastreboff speaking at the Lincoln Center about the biology of obesity and anti-obesity medications for the Yale For Humanity Illuminated event (NYC - January 2025)
Yale video with Dr. Jastreboff about anti-obesity medications and the biology of obesity.
Podcast (Yale Talk) with the president of Yale University, Dr. Peter Salovey, speaking with Dr. Jastreboff.
Clinically, Dr. Jastreboff specializes in sophisticated use of anti-obesity medication combinations to help patients reach their weight and health goals.
Appointments
Endocrinology
ProfessorPrimary
Other Departments & Organizations
- Center for Weight Management
- Center for Weight Management - NH & North Haven
- Diabetes Center
- Diabetes Program
- Diabetes Research Center
- Endocrinology
- Internal Medicine
- Obesity Research Working Group
- Pediatric Weight Solutions Program
- Status of Women in Medicine Committee (SWIM)
- Yale Medicine
- Yale Obesity Research Center (Y-Weight)
- Yale Stress Center
Education & Training
- Student - Yale Advanced Emerging Leaders
- Yale University (2023)
- Yale Public Voices Fellowship
- Yale University (2022)
- Clinical Scholar
- Yale University School of Medicine (2013)
- YCCI Clinical Research Scholar
- Yale School of Medicine (2013)
- PhD
- Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)
- Neuromanaging in Psychiatry
- Yale School of Medicine (2011)
- Postdoctoral Fellowship
- Yale School of Medicine (2011)
- Postdoctoral Fellowship
- Yale School of Medicine (2011)
- Food Policy and Science
- Yale University (2010)
- Learning to Mentor the next generation of scientists
- Yale School of Medicine (2009)
- Nutrition and Chronic Disease
- Yale University (2009)
- Chief Resident
- University of Maryland (2006)
- Residency
- University of Maryland School of Medicine (2006)
- Intern
- University of Maryland (2003)
- MD
- University of Maryland at Baltimore (2002)
- BA
- Bucknell University, Art History/Major, Music/Minor. Magna cum laude (1998)
Research
Overview
obesity and cancer; anti-obesity pharmacotherapy; cancer prevention and risk reduction
Medical Research Interests
Public Health Interests
ORCID
0000-0003-1446-0991Y-Weight: Yale Obesity Research Center
Investigating novel pharmacological therapeutics for obesity treatment and probing the mechanisms of obesity in translational physiology studies
View Lab Website
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Rajita Sinha, PhD
Wendy Silverman, PhD, ABPP
Alissa Chen, MD, MPH
Harlan Krumholz, MD, SM
Michelle Van Name, MD
Yuan Lu, ScD
Publications
2025
Uptake of and Disparities in Semaglutide and Tirzepatide Prescribing for Obesity in the US
Kim C, Ross J, Jastreboff A, Meeker D, Freedman H, Krumholz H, Lu Y. Uptake of and Disparities in Semaglutide and Tirzepatide Prescribing for Obesity in the US. JAMA 2025, 333: 2203-2206. PMID: 40299371, PMCID: PMC12042086, DOI: 10.1001/jama.2025.4735.Peer-Reviewed Original ResearchCitationsAltmetricOnce-Monthly Maridebart Cafraglutide for the Treatment of Obesity — A Phase 2 Trial
Jastreboff A, Ryan D, Bays H, Ebeling P, Mackowski M, Philipose N, Ross L, Liu Y, Burns C, Abbasi S, Pannacciulli N. Once-Monthly Maridebart Cafraglutide for the Treatment of Obesity — A Phase 2 Trial. New England Journal Of Medicine 2025 PMID: 40549887, DOI: 10.1056/nejmoa2504214.Peer-Reviewed Original ResearchAltmetricConceptsBaseline to weekDose escalationTreatment of obesityTreatment policy estimandType 2 diabetesObese cohortBody weightDose-ranging trialPhase 2 trialGastrointestinal adverse eventsGlycated hemoglobin levelsPeptide-antibody conjugatesGlucagon-like peptide-1 receptor agonismIntention-to-treat approachOnce-monthlyDouble-blindPlacebo groupPlacebo-controlledReceptor antagonismReceptor agonismHemoglobin levelsAdverse eventsPlaceboSafety signalsObesityTirzepatide for reduction of morbidity and mortality in adults with obesity: rationale and design of the SURMOUNT‐MMO trial
Lam C, Rodriguez A, Aminian A, Ferrannini E, Heerspink H, Jastreboff A, Laffin L, Pandey A, Ray K, Ridker P, Sanyal A, Yki‐Jarvinen H, Mason D, Strzelecki M, Bartee A, Cui C, Hurt K, Linetzky B, Bunck M, Nissen S. Tirzepatide for reduction of morbidity and mortality in adults with obesity: rationale and design of the SURMOUNT‐MMO trial. Obesity 2025 PMID: 40545827, DOI: 10.1002/oby.24332.Peer-Reviewed Original ResearchAltmetricConceptsSecondary cardiovascular disease preventionCardiovascular disease preventionCardiovascular diseaseGlucagon-like peptide-1 receptor agonistsGlucose-dependent insulinotropic polypeptide receptorPeptide-1 receptor agonistsMultiple cardiovascular risk factorsCardiovascular risk factorsHeart failure eventsNonfatal myocardial infarctionType 2 diabetesReduction of morbidityDisease preventionDouble-blindPrimary endpointReceptor agonistsClinical benefitImprove morbidityObesityCoronary revascularizationRisk factorsOutcome trialsTirzepatideMultiple outcomesSubstantial weight reduction1771-P: Influence of Stressful and Traumatic Life Events and Chronic Stress on Ad-lib Sweet Food Intake and Its Relationship to Obesity
DOYLE E, FOGELMAN N, JOSEPH K, HU P, JASTREBOFF A, SINHA R. 1771-P: Influence of Stressful and Traumatic Life Events and Chronic Stress on Ad-lib Sweet Food Intake and Its Relationship to Obesity. Diabetes 2025, 74 DOI: 10.2337/db25-1771-p.Peer-Reviewed Original ResearchConceptsTraumatic life eventsCumulative Adversity InterviewLife eventsChronic stressSweet food intakeCue contextLife traumaAcute stressCumulative stressful life eventsScript-driven imageryFood ad libitumRecent life eventsStressful life eventsTotal life eventsSnack foods ad libitumSweet food consumptionFood intakeEffects of stressChronic stress scoresStress scoresFood cuesCommunity adultsNeutral contextsCue conditionTraumatic events2002-LB: Amycretin, a Novel, Unimolecular GLP-1 and Amylin Receptor Agonist—Results of a Phase 1b/2a Clinical Trial
DAHL K, ADELBORG K, DEY S, DUQUE DO VALE R, KEY C, TOUBRO S, JASTREBOFF A. 2002-LB: Amycretin, a Novel, Unimolecular GLP-1 and Amylin Receptor Agonist—Results of a Phase 1b/2a Clinical Trial. Diabetes 2025, 74 DOI: 10.2337/db25-2002-lb.Peer-Reviewed Original ResearchConceptsMultiple-ascending doseOnce-weeklyConsistent with dose proportionalityGLP-1Double-blind studyBody weightBody weight reductionDose escalationIncreasing dose levelsDose proportionalityMaintenance doseTolerability profileBaseline BMISingle-centerHbA1c <Treatment armsPart BAgonist resultsDose levelsTreatment durationAmylin agonistsB-E.Percentage changePlaceboTEAEsAmycretin, a novel, unimolecular GLP-1 and amylin receptor agonist administered subcutaneously: results from a phase 1b/2a randomised controlled study
Dahl K, Toubro S, Dey S, Duque do Vale R, Flint A, Gasiorek A, Heydorn A, Jastreboff A, Key C, Petersen S, Vegge A, Adelborg K. Amycretin, a novel, unimolecular GLP-1 and amylin receptor agonist administered subcutaneously: results from a phase 1b/2a randomised controlled study. The Lancet 2025 PMID: 40550231, DOI: 10.1016/s0140-6736(25)01185-7.Peer-Reviewed Original ResearchCitationsAltmetricConceptsTreatment-emergent adverse eventsAmylin receptor agonistAdverse eventsGLP-1Receptor agonistsTreatment durationPlasma concentration-time curvePhase 1b/2a studyConcentration-time curveMaximum plasma concentrationEarly-phase studiesClinical Research CentreRandomised controlled studyProportion of discontinuationBaseline bodyweightPart BTolerability profileMaintenance dosePlacebo-controlledGastrointestinal eventsPrimary endpointSecondary endpointsFull analysisWeight loss propertiesPlasma concentrations512 Predicting outcomes of lifestyle and stress reduction interventions for obesity with DNA methylation and psychological measures
Harvanek Z, Li C, Xu K, Jastreboff A, Sinha R. 512 Predicting outcomes of lifestyle and stress reduction interventions for obesity with DNA methylation and psychological measures. Journal Of Clinical And Translational Science 2025, 9: 150-150. PMCID: PMC12050514, DOI: 10.1017/cts.2024.1093.Peer-Reviewed Original ResearchConceptsStress reduction interventionsReduction interventionsLinear mixed modelsActivity counselingLifestyle interventionPsychological measuresObesity-related outcomesIntervention control groupBaseline psychological measuresEffects of lifestyleYears of obesityRisk of comorbiditiesEpigenetic age accelerationNumerous health issuesAssociated with obesityPost-interventionRandomized-controlled trialsReduce obesityHealth issuesYear follow-upDecreased riskHOMA-IRLifestylePsychological factorsInterventionEffects of Tirzepatide in Type 2 Diabetes Individual Variation and Relationship to Cardiometabolic Outcomes
Aminorroaya A, Oikonomou E, Biswas D, Jastreboff A, Khera R. Effects of Tirzepatide in Type 2 Diabetes Individual Variation and Relationship to Cardiometabolic Outcomes. Journal Of The American College Of Cardiology 2025, 85: 1858-1872. PMID: 40368575, PMCID: PMC12186526, DOI: 10.1016/j.jacc.2025.03.516.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsElevated body mass indexCardiometabolic abnormalitiesBody mass indexOdds of elevated body mass indexType 2 diabetesIndividual participant data meta-analysisMass indexParticipant data meta-analysisOdds of MetSCardiometabolic risk factorsComponents of metabolic syndromeData meta-analysisHigh-density lipoprotein cholesterolCardiometabolic healthStudy design differencesMixed-effects modelsBaseline usePhase 3 randomized clinical trialSodium-glucose cotransporter 2 inhibitorsOddsStudy outcomesEffects of tirzepatideMeta-analysisRisk factorsClinical subpopulations
2024
Efficacy of antiobesity medications for weight reduction in older adults: a systematic review
Chen A, Hajduk A, Grimshaw A, Fried T, Jastreboff A, Lipska K. Efficacy of antiobesity medications for weight reduction in older adults: a systematic review. Obesity 2024 PMID: 39725567, PMCID: PMC12198421, DOI: 10.1002/oby.24160.Peer-Reviewed Original ResearchAltmetricConceptsOlder adultsAntiobesity medicationsStudy of older adultsOlder adults ageAdult ageCardiovascular diseaseRisk of biasAdverse events associated with useWeight reductionStatistically significant weight reductionFood and Drug AdministrationClinical careSystematic reviewInclusion criteriaLimited evidenceBaseline weightPlacebo groupObservational studySeven medicationsAdverse eventsAdultsDrug AdministrationEvaluation studiesMedicationSignificant weight reductionEligibility for Anti-Obesity Medications through Medicare for Older Adults with Overweight or Obesity
Chetty A, Khunte M, Chen A, Jastreboff A, Krumholz H, Lu Y. Eligibility for Anti-Obesity Medications through Medicare for Older Adults with Overweight or Obesity. American Heart Journal 2024, 278: 8. DOI: 10.1016/j.ahj.2024.09.022.Peer-Reviewed Original ResearchConceptsAnti-obesity medicationsOlder adultsType 2 diabetesNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyCardiovascular diseaseNutrition Examination SurveyOlder ageMale sexExamination SurveyMinority race/ethnicitySociodemographic statusPopulation of beneficiariesMedicare beneficiariesPost-MarchLow-incomeMedicare Part D.Medicare coverageMedicareStudy sampleWhite racePre-marchEligibility ratesObesityPooled data
Clinical Trials
Current Trials
GLP-1 analogue effects on food cues, stress, motivation for highly palatable foods, and weight
HIC ID2000027868RolePrincipal InvestigatorPrimary Completion Date06/30/2025Recruiting ParticipantsGenderBothAge18 years - 55 years
Academic Achievements & Community Involvement
Activities
activity The Obesity Society
2017 - PresentPeer Review Groups and Grant Study SectionsReviewerDetailsGrant Reviewer (Scientific Review Committee)activity The Endocrine Society
2019 - PresentProfessional OrganizationsCommittee MemberDetailsHormone Health Network (HHN) committeeactivity ADA (American Diabetes Association)
07/01/2019 - PresentMeeting Planning and ParticipationMemberDetailsObesity/Pathogenesis of Obesity Subcommitteeactivity Obesity - National Childhood Obesity Awareness Month Special Issue
06/01/2021 - PresentJournal ServiceAssociate Editoractivity Diabetes Care
2022 - PresentJournal ServiceAssociate Editor
Honors
honor Clinician of the Year Award, The Obesity Society
01/02/2023National AwardThe Obesity SocietyDetailsUnited Stateshonor American Board of Obesity Medicine (ABOM), Board of Directors (2022-2025)
05/01/2022National AwardABOMDetailsUnited Stateshonor Nominated for the Leonard Tow Humanism in Medicine Award Yale Teaching
01/01/2020Yale University AwardYale Universityhonor NIH/NIDDK K23 Mentored Patient-Oriented Research Career Development Award
05/01/2014National AwardDetailsUnited Stateshonor Young Physician-Scientist Award
10/15/2013National AwardAmerican Association for Clinical Investigation (ASCI)DetailsUnited States
Clinical Care
Overview
Ania M. Jastreboff, MD, PhD, is an adult and pediatric endocrinologist with expertise in obesity medicine and weight management. She cares for patients who have prediabetes, insulin resistance, metabolic syndrome, and type 1 and type 2 diabetes.
Dr. Jastrebroff, who is director of the Yale Obesity Research Center (Y-Weight), says she empathizes with patients who struggle to lose weight or maintain weight loss. “Carrying excess weight and having obesity is not a lifestyle choice. Obesity is a chronic disease and should be treated with the same vigor and integrity as other chronic diseases,” she says. “We are in the infancy of our understanding of the mechanisms that underlie obesity. Many novel treatments are under development, including new anti-obesity medications, endoscopic procedures, and the refining of behavioral and surgical interventions.”
An assistant professor of medicine (endocrinology) and of pediatrics (endocrinology) at Yale School of Medicine, Dr. Jastrebroff says one of her goals is to conduct clinic research that will lead to better treatments for obesity and also have a clear public health impact in mitigating the obesity “pandemic.”
Clinical Specialties
Fact Sheets
Diabetes: Symptoms, Causes, and Treatments
Learn More on Yale Medicine
Board Certifications
Obesity Medicine
- Certification Organization
- AB of Obesity Medicine
- Original Certification Date
- 2016
Yale Medicine News
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileNews & Links
News
- July 17, 2025
Once-Monthly Obesity Medication Shows Promise for Those With and Without Type 2 Diabetes
- June 02, 2025
New Professors in the Department of Internal Medicine
- May 05, 2025
Why Aren’t People Who Need Weight Loss Drugs Getting Them?
- February 12, 2025Source: WTNH
Weight Loss Revolution Part 1: The pros and cons of weight loss drugs
Get In Touch
Contacts
Administrative Support
Locations
Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.