Gregor Gryglewski, MD, PhD
Assistant Professor Adjunct in the Child Study CenterCards
About
Research
Publications
2025
Simplified methods for SERT occupancy estimation measured with [11C]DASB PET bolus plus infusion
Ponce de León M, Murgaš M, Silberbauer L, Hacker M, Gryglewski G, Hahn A, Lanzenberger R. Simplified methods for SERT occupancy estimation measured with [11C]DASB PET bolus plus infusion. NeuroImage 2025, 311: 121208. PMID: 40221064, DOI: 10.1016/j.neuroimage.2025.121208.Peer-Reviewed Original ResearchTHE ANTERIOR CINGULATE CORTEX LINKS SEROTONIN TRANSPORTER GENETICS AND EMOTION PROCESSING
Kloebl *, Murgaš M, Reed M, Silberbauer L, Hartmann A, Godbersen G, Hahn A, Gryglewski G, Rujescu D, Lanzenberger R. THE ANTERIOR CINGULATE CORTEX LINKS SEROTONIN TRANSPORTER GENETICS AND EMOTION PROCESSING. The International Journal Of Neuropsychopharmacology 2025, 28: i18-i19. PMCID: PMC11814669, DOI: 10.1093/ijnp/pyae059.032.Peer-Reviewed Original ResearchAnterior cingulate cortex activationAnterior cingulate cortexEmotional processingSerotonin reuptake inhibitorsSerotonin transporterSerotonin transporter expressionBrain functionHappy facesNeutral facesCingulate cortexReuptake inhibitorsBrain activitySerotonin transporter binding potentialMeasures of emotional processingSingle nucleotide polymorphism rs25531Anterior cingulate cortex connectivityImpact of 5-HTTLPRAssess attributional styleSituational Attributions QuestionnaireAcute tryptophan depletionFacial emotion processingIncreased amygdala activationSerotonin transporter bindingSerotonin transporter polymorphismEffect of citalopramEXTRACELLULAR VESICLES IN MAJOR DEPRESSIVE DISORDER AND THEIR RELATIONSHIP TO TREATMENT OUTCOME
Eggerstorfer *, Zadka Ł, Rusak A, Godbersen G, Opalińska A, Unterholzner J, Haczkiewicz-Leśniak K, Silberbauer L, Hahn A, Murgaš M, Gomułkiewicz A, Rujescu D, Podhorska-Okołów M, Lanzenberger R, Gryglewski G. EXTRACELLULAR VESICLES IN MAJOR DEPRESSIVE DISORDER AND THEIR RELATIONSHIP TO TREATMENT OUTCOME. The International Journal Of Neuropsychopharmacology 2025, 28: i32-i33. PMCID: PMC11815236, DOI: 10.1093/ijnp/pyae059.056.Peer-Reviewed Original ResearchMDD patientsPathophysiology of psychiatric disordersPlasma of MDD patientsOutcome of MDDAntidepressant treatment responseSerotonin transporter occupancyDepression Rating ScaleTreated with escitalopramHealthy controlsExpression of SLC6A4Expression of exosome markersAntidepressant treatmentDepressive disorderSerotonin transporterExosomal markersPsychiatric disordersTransporter occupancyNanoparticle tracking analysisMDDMental disordersMRNA expressionDiverse neurotransmittersRating ScaleCD9 expressionExtracellular vesicles
2024
Extracellular vesicles in major depression and their serotonin transporter cargo
Eggerstorfer B, Zadka Ł, Buzalewicz I, Vraka C, Rusak A, Godbersen G, Opalińska A, Unterholzner J, Ulatowska-Jarża A, Philippe C, Haczkiewicz-Leśniak K, Silberbauer L, Murgaš M, Nics L, Hahn A, Hacker M, Gomułkiewicz A, Rujescu D, Podhorska-Okołów M, Lanzenberger R, Gryglewski G. Extracellular vesicles in major depression and their serotonin transporter cargo. Neuroscience Applied 2024, 3: 104920. DOI: 10.1016/j.nsa.2024.104920.Peer-Reviewed Original ResearchSerotonin transporter connectivity mapping reveals distinct anterior cingulate cortex association profiles in healthy vs. depressed subjects under pharmacological challenge
Klug S, Silberbauer L, Murgaš M, Klöbl M, Nics L, Godbersen G, Gryglewski G, Hacker M, Lanzenberger R, Hahn A. Serotonin transporter connectivity mapping reveals distinct anterior cingulate cortex association profiles in healthy vs. depressed subjects under pharmacological challenge. Neuroscience Applied 2024, 3: 104945. DOI: 10.1016/j.nsa.2024.104945.Peer-Reviewed Original Research
2023
Impact of genetic variants within serotonin turnover enzymes on human cerebral monoamine oxidase A in vivo
Spies M, Murgaš M, Vraka C, Philippe C, Gryglewski G, Nics L, Balber T, Baldinger-Melich P, Hartmann A, Rujescu D, Hacker M, Winkler-Pjrek E, Winkler D, Lanzenberger R. Impact of genetic variants within serotonin turnover enzymes on human cerebral monoamine oxidase A in vivo. Translational Psychiatry 2023, 13: 208. PMID: 37322010, PMCID: PMC10272199, DOI: 10.1038/s41398-023-02506-2.Peer-Reviewed Original ResearchConceptsMAO-A levelsMAO-A VTSerotonin turnoverCerebral serotonin systemPositron emission tomography studyGenetic variantsEmission tomography studiesTryptophan hydroxylase 2 geneCerebral MAODepressed cohortBrain MAOMonoamine oxidase ASerotonin systemRelated clinical phenomenaRs1386494Distribution volumeTPH2 polymorphismsTomography studyClinical phenomenaMonoamine oxidaseSerotonin transporter occupancy with citalopram challenge in single positron emission tomography [11C]DASB scans
De León M, Murgaš M, Silberbauer L, Hacker M, Gryglewski G, Hahn A, Lanzenberger R. Serotonin transporter occupancy with citalopram challenge in single positron emission tomography [11C]DASB scans. Neuroscience Applied 2023, 2: 103358. DOI: 10.1016/j.nsa.2023.103358.Peer-Reviewed Original Research
2022
Meta-analysis of molecular imaging of translocator protein in major depression
Eggerstorfer B, Kim JH, Cumming P, Lanzenberger R, Gryglewski G. Meta-analysis of molecular imaging of translocator protein in major depression. Frontiers In Molecular Neuroscience 2022, 15: 981442. PMID: 36226319, PMCID: PMC9549359, DOI: 10.3389/fnmol.2022.981442.Peer-Reviewed Original ResearchBody mass indexMajor depressive disorderMDD patientsMolecular imaging studiesTranslocator proteinImaging studiesTSPO availabilityPositron emission tomography studyMarkers of neuroinflammationSerotonin transporter availabilityEmission tomography studiesSystematic literature searchTime of scanningEffect sizeMolecular neuroimaging studiesMass indexDepressive disorderHealthy controlsMajor depressionTransporter availabilityHealthy subjectsTreatment statusDepression severityTemporal cortexBrain regionsABCB1 variants and sex affect serotonin transporter occupancy in the brain
Silberbauer LR, Rischka L, Vraka C, Hartmann AM, Godbersen GM, Philippe C, Pacher D, Nics L, Klöbl M, Unterholzner J, Stimpfl T, Wadsak W, Hahn A, Hacker M, Rujescu D, Kasper S, Lanzenberger R, Gryglewski G. ABCB1 variants and sex affect serotonin transporter occupancy in the brain. Molecular Psychiatry 2022, 27: 4502-4509. PMID: 36071112, PMCID: PMC7613909, DOI: 10.1038/s41380-022-01733-1.Peer-Reviewed Original ResearchConceptsMinor allele carriersTransporter occupancyAllele carriersABCB1 single nucleotide polymorphismsBasic clinical variablesCitalopram plasma concentrationsYears of ageMajor allele homozygotesCross-over designPET/MRISERT occupancyClinical variablesTreatment promisesClinical algorithmMajor depressionPlasma concentrationsPrecision pharmacotherapyABCB1 variantsHealthy volunteersABCB1 geneAllele homozygotesSame dosageDrug-target engagementTarget engagementSingle nucleotide polymorphismsBiodistribution and dosimetry of the GluN2B-specific NMDA receptor PET radioligand (R)-[11C]Me-NB1
Rischka L, Murgaš M, Pichler V, Vraka C, Rausch I, Winkler D, Nics L, Rasul S, Silberbauer LR, Reed MB, Godbersen GM, Unterholzner J, Handschuh P, Gryglewski G, Mindt T, Mitterhauser M, Hahn A, Ametamey SM, Wadsak W, Lanzenberger R, Hacker M. Biodistribution and dosimetry of the GluN2B-specific NMDA receptor PET radioligand (R)-[11C]Me-NB1. EJNMMI Research 2022, 12: 53. PMID: 36018389, PMCID: PMC9418393, DOI: 10.1186/s13550-022-00925-8.Peer-Reviewed Original ResearchExtrasynaptic NMDA receptorsStandardized uptake valueNMDA receptorsUrinary bladderEffective dose coefficientsPET radioligandNeuropsychiatric disordersTreatment monitoringSynaptic NMDA receptorsTime-integrated activity coefficientsCentral nervous systemUrinary bladder contentsDrug developmentDose coefficientsAdverse eventsExcitotoxic processTRIAL REGISTRATIONBladder contentsHealthy subjectsSynaptic transmissionSide effectsBone marrowNervous systemUptake valueEffective dose