Goals
- Elucidate pathways of cancer biology that impact radiation therapy.
- Conduct innovative clinical and translational research to improve radiation therapy
DNA Damage and Genome Integrity
The DNA Damage and Genome Integrity (DGI) Research Program at Yale Cancer Center comprises a broadly based, multifaceted research effort in radiation therapy, radiation biology, radiological physics, and related areas of tumor biology, including a major effort in DNA damage and repair. It is led by co-leaders Ranjit S. Bindra, MD, PhD; Georges El Fakhri, PhD, DAHR; and Megan C. King, PhD. Its long-term goal is to improve the treatment of cancer in general and the effectiveness of radiation therapy in particular. Some of the key themes include studies of carcinogenesis, genetic instability and cell growth control; elucidation of DNA repair pathways; investigation of tumor hypoxia and the impact of hypoxia on cancer therapy; preclinical development of radiation sensitizers and DNA repair inhibitors; including combination of DNA repair inhibitors with immune therapy; molecular correlations with outcomes in radiation therapy; health services and disparities research in radiation oncology; design and conduct of clinical trials relevant to radiation oncology; and improvements in radiation dosimetry, imaging, and delivery.
Program Members
Co-Leaders
Harvey and Kate Cushing Professor of Therapeutic Radiology and Professor of Pathology; Vice Chair for Translational Research and Faculty Development, Therapeutic Radiology; Co-Director, Chênevert Family Brain Tumor Center; YCC Co-Leader Radiology/Radiotherapy Program, Therapeutic Radiology; Chief, Pediatrics Central Nervous System Radiotherapy Program, Therapeutic Radiology; Chief, Central Nervous System Radiotherapy Program, Therapeutic Radiology
Elizabeth Mears and House Jameson Professor of Radiology and Biomedical Imaging, Therapeutic Radiology and of Biomedical Informatics & Data Science; Director, PET Center; Vice Chair Scientific Research, Radiology & Biomedical Imaging; Director, Yale Biomedical Imaging Institute
Professor of Cell Biology and of Molecular, Cellular and Development Biology; Co-Leader, DNA Damage and Genome Integrity, Yale Cancer Center; Associate Cancer Center Director, Basic Science
Program Members
Assistant Professor of Therapeutic Radiology; Director of Clinical Informatics, Therapeutic Radiology; Director Medical School Clerkship, Therapeutic Radiology; Director of Theranostics at Griffin Hospital, Therapeutic Radiology; Medical School Thesis Oversight, Therapeutic Radiology; Radiation Safety, Therapeutic Radiology; Assistant Cancer Center Director, Bioinformatics
Harvey and Kate Cushing Professor of Therapeutic Radiology and Professor of Pathology; Vice Chair for Translational Research and Faculty Development, Therapeutic Radiology; Co-Director, Chênevert Family Brain Tumor Center; YCC Co-Leader Radiology/Radiotherapy Program, Therapeutic Radiology; Chief, Pediatrics Central Nervous System Radiotherapy Program, Therapeutic Radiology; Chief, Central Nervous System Radiotherapy Program, Therapeutic Radiology
Associate Professor of Surgery (Thoracic); Director of Robotic Thoracic Surgery
Senior Research Scientist in Therapeutic Radiology and in Dermatology and Clinical Professor of Therapeutic Radiology
Associate Professor of Radiology & Biomedical Imaging and of Pharmacology
Professor of Therapeutic Radiology; Vice Chair for Physics, Therapeutic Radiology; Vice Chair for Faculty Development, Therapeutic Radiology; Director of Medical Physics, Therapeutic Radiology
Professor of Radiology and Biomedical Imaging and of Biomedical Engineering; Director of Graduate Studies, Biomedical Engineering
Professor of Laboratory Medicine, of Pathology and of Molecular Biophysics and Biochemistry; Associate Director, Molecular Diagnostics Laboratory
Professor of Therapeutic Radiology; Vice Chair for Physics Research and Education, Therapeutic Radiology; Director, Cesium Irradiation Shared Resource for Yale Cancer Center, Therapeutic Radiology; Smilow Chief Physicist; Director of Medical Physics Residency Program
Professor of Neurosurgery; Assistant Dean for Admissions, Medical Education; Associate Vice Chair of Academic Affairs; Director, Stereotactic Radiosurgery; Director, Gamma Knife Center, YNHH; Director, Stereotactic Radiosurgery Fellowship
Associate Professor of Radiology and Biomedical Imaging and of Biomedical Engineering
Professor of Therapeutic Radiology; Vice Chair for Brachytherapy , Therapeutic Radiology; Chief, Gynecologic Radiotherapy Program, Therapeutic Radiology
Professor of Therapeutic Radiology and Biomedical Informatics and Data Science; Director of Physics Research, Therapeutic Radiology
Waldemar Von Zedtwitz Professor of Genetics and Professor of Molecular Biophysics and Biochemistry and of Therapeutic Radiology