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Yale Cancer Center-Advanced Training Program for Physician-Scientists (YCC-ATPP)

The YCC-ATPP training program is led by principal investigators Roy S. Herbst, MD, PhD, and Lieping Chen, MD, PhD. This five-year grant provides salary and research funds for four 3rd year Hematology/Medical Oncology fellows who are strongly committed to be independent physician-scientists performing basic, translational, clinical, or outcomes research in a cancer-related field each year.
This program builds on the foundation of excellence established during clinical training in our Heme/MedOnc Fellowship Program. The goal of this training is to develop the skills necessary to function independently, including the ability to design, initiate, and complete research projects, and to effectively write grants and manuscripts. This T32 will firmly position Heme/MedOnc fellows as independent clinical, translational, or basic cancer research leaders of tomorrow.

Curriculum

All YCC-ATPP T32 fellows have access to several courses offered by the Yale Investigative Medicine Program during the award period. These courses provide a basic foundation in biostatistics, translational research, grant writing, and responsible conduct of research. A unique feature specific to the YCC-ATPP T32 program are three required courses, Molecular Pathology (YCC-ATPP-01), Genomic and Precision Medicine (YCC-ATPP-02) and Research in Progress (YCC-ATPP-03). Molecular Pathology (YCC-ATPP-01) is designed to give fellows a strong foundation in cancer genetics, as well as the benefits and limitations of various profiling methods and in interpreting profiling results. Genomic and Precision Medicine (YCC-ATPP-02) is designed to give fellows a strong understanding of how to combine clinical and genomics data across different scales and resolutions to enable new perspectives for essential biomedical questions and the development of novel personalized medicine in cancer. Research in Progress is a required weekly seminar series together with Dr. Kluger’s ITOP K12 Scholars. Molecular Pathology (YCC-ATPP-01), Genomic and Precision Medicine (YCC-ATPP-02) and Research in Progress (YCC-ATPP-03) are required courses for all YCC-ATPP T32 fellows.

Eligibility and Requirements

Yale Cancer Center-Advanced Training Program for Physician-scientists (YCC-ATPP) is a five-year training program that provides salary and research funds for four Hematology/Oncology (Hem/Onc) fellows each year who are strongly committed to be independent physician-scientists performing basic, translational, clinical, or outcomes research in a cancer-related field.

Eligibility:

MD (or equivalent) or MD/PhD degree, completion of second year fellowship training in Heme/MedOnc fellowship program
Hold U.S. citizenship or permanent residency
Strong commitment to a career in cancer research
Required to stay for an additional year (4th year) for the fellowship program

Effort:

YCC-ATPP fellows must commit = 75% effort to research and related training activities in the first year of training and 100% effort to research and related training activities in the second year.

Salary and research support:

YCC-ATPP will cover the full salary and fringe benefits of the fellows at their Yale Post Graduate Year (PGY) levels.
Applicants may request up to $16,000 per year for tuition and fees, and up to $10,226 per year for research support and travel funds.

Yale is an equal opportunity employer. Yale values diversity among its students, staff, and faculty and welcomes applications from candidates with a broad range of backgrounds and perspectives

Mentorship

All YCC-ATPP T32 fellows are provided with a Mentor Team comprised of three mentors: a practicing hematologist/oncologist faculty, a basic/translational research scientist with expertise in cancer biology, and a member of the Executive Committee with expertise aligned with the project. One mentor functions as the primary mentor, interacting most closely with the fellow, and in some cases where necessary (e.g., depending on career goals, etc.), a secondary mentor may be chosen. We have carefully selected a diverse pool of faculty who serves as primary or secondary mentors. Please see below for detailed mentor information.

Program Directors

  • Alfred Gilman Professor of Pharmacology and Professor of Medicine (Medical Oncology); Director, Yale Cancer Center; President and Physician-in-Chief, Smilow Cancer Hospital; Deputy Dean for Cancer Research, Yale School of Medicine

    Dr. Eric Winer is the Director of Yale Cancer Center as well as President and Physician-in-Chief of Smilow Cancer Hospital. He is also the Alfred Gilman Professor of Medicine and Deputy Dean for Cancer Research at Yale. An internationally renowned expert in breast cancer, Dr. Winer has led and collaborated on dozens of clinical trials that have changed the care of individuals with all stages and subtypes of the disease. Dr. Winer was President of the American Society of Clinical Oncology (ASCO) from 2022-2023 and Chair of the Board of Directors from 2023-2024. He is the current Chair of the Scientific Advisory Board of the Breast Cancer Research Foundation. Dr Winer served as Chief Scientific Advisor for Susan G. Komen for the Cure for over 10 years and was co-chair of the CALGB/Alliance Breast Committee for over a decade and then led the National Cancer Institute Breast Cancer Steering Committee from 2016-2022. Dr. Winer, who was formerly a Professor of Medicine at Harvard Medical School and on the faculty of the Dana-Farber Cancer Institute, was the recipient of the William Silen Lifetime Achievement in Mentoring Award from Harvard Medical School in 2020. He has received numerous awards for his breast cancer research, notably the William L. McGuire Memorial Lecture Award in 2016 at the San Antonio Breast Cancer Symposium, the Gianni Bonadonna Breast Cancer Award at ASCO in 2017, and the Susan G. Komen Brinker Award for Clinical Research in 2018. He has published over 500 peer-reviewed research articles. Dr. Winer is an alumnus of both Yale College and Yale School of Medicine. After receiving his medical degree in 1983, he completed training in internal medicine and served as chief resident at Yale New Haven Hospital. He completed a fellowship in hematology/oncology at Duke University School of Medicine and served on the Duke faculty from 1989 to 1997. He then joined Dana-Farber Cancer Institute, Brigham and Women’s Hospital, and Harvard Medical School where he built an internationally prominent breast cancer program. He served as principal investigator of the Specialized Program of Research Excellence in breast cancer at Dana-Farber for over a decade. Prior to his move to Yale, he held the Thompson Chair in Breast Cancer Research and served as senior vice president for medical affairs at Dana-Farber Cancer Institute.

2024-2026 Fellows

  • Assistant Professor of Medicine (Medical Oncology & Hematology)

    Jennifer Afranie-Sakyi, MD, is an assistant professor of medicine (medical oncology and hematology). A graduate of Yale's Medical Oncology-Hematology Fellowship Program, Afranie-Sakyi was the recipient of the prestigious American Society of Hematology Minority Hematology Fellow Award and has published and presented research on sickle cell disease. She cares for patients in both New Haven and Orange.
  • Hospital Resident

    Hometown: Minnetonka, Minnesota Undergraduate: MIT Medical School: Dartmouth Clinical Interests: Surgical Oncology and Thoracic Surgery Research Interests: Cancer Immunology, Peritoneal Surface Malignancies, Mesothelioma, Immunotherapy, Clinical Trial Design and Implementation, Robotic Surgery, AI-application/analysis, and Computational/Prediction Modeling Hobbies: Ice hockey, golf, rock climbing, billiards, coding, pickle-ball, hiking, gardening, and camping
  • Assistant Professor of Internal Medicine (Medical Oncology & Hematology)

    Dr. Xiao Wang is an Assistant Professor of Medicine (Medical Oncology) at Yale School of Medicine and a member of the Center for Gastrointestinal Cancers at Yale Cancer Center. He provides care for patients with gastrointestinal malignancies at Smilow Cancer Hospital in North Haven, with a strong commitment to patient-centered, compassionate, and comprehensive oncology care. Dr. Wang earned his undergraduate degree from the University of Michigan and his medical degree from the Johns Hopkins School of Medicine. He then completed his Internal Medicine residency at the University of Pennsylvania, where he also served as a hospitalist caring for patients with hematologic and lymphatic malignancies. He subsequently completed fellowship training in Medical Oncology at Yale, during which he was funded on the prestigious T32 training grant at the Yale Cancer Center. In addition to his clinical practice, Dr. Wang is a health services researcher focused on precision oncology care delivery and outcomes at both national and local levels. He is a member of Yale’s Cancer Outcomes, Public Policy and Effectiveness Research (COPPER) Center and has led, presented, and published research on molecular testing practices in cancer care.

2025-2027 Fellows

  • Clinical Fellow

    Amin Nassar, M.D., is a hematology/oncology fellow at Yale University. He received his medical degree from the American University of Beirut and completed residency at Brigham and Women’s Hospital. Dr. Nassar also pursued a two-year postdoctoral training at Brigham and Women’s Hospital where he worked under the mentorship of Professors Dr. David Kwiatkowski, Dr. Toni Choueiri, and Dr. Matthew Freedman at Harvard Medical School. His research focuses on the identification of genomic biomarkers across ancestral populations with cancer. Dr. Nassar currently serves on the editorial board of “Molecular biology reports”, “Translational oncology”, and “Frontiers in Oncology”. He is also one of the Associate Guest editors for the journal “Frontiers in Oncology”. He has published >50 original articles, 20 as first or co-first author, which include, as detailed below, first-author papers in Nature Communications, Cancer Cell, Journal of Clinical Oncology, Journal of Thoracic Oncology, JNCI, and The New England Journal of Medicine. He has also been an invited speaker to several conferences including AACR, XXIV SBOC, Korean Society of Medical Oncology, and Prostate Cancer Foundation. Dr. Nassar is interested in a career as a physician-scientist with a clinical focus in thoracic oncology. He is currently pursuing a PhD in tumor immunology at the Flavell lab.