Research Cores

The Administrative Core will provide scientific, financial, and administrative oversight for all Yale SPORE in Lung Cancer activities. The Core will be responsible for all project and core resources of the Lung SPORE and will ensure compliance with all general, governmental, and specific National Institutes of Health grant regulations and requirements, including timely communications and consultations with the National Cancer Institute.

The Biostatistics and Bioinformatics Core collaborates and supports the Yale SPORE in Lung Cancer projects on the statistical design and bioinformatics analysis of the individual projects and addresses the analytic questions arising from these projects. The Core plays an important role across the Yale Lung SPORE program because they have the responsibility to monitor the conduct of projects from a statistical perspective, including: the conduct of regular interim analyses, dynamic updates of power calculations, development of new biostatistical and bioinformatics methodology as needed. The Core will oversee data management services and ensure that data collected is of high quality and evaluated with statistical rigor. The Core is also responsible for bioinformatics including next generation sequencing data analysis, analyzing publically available genomic data, and the employment of appropriate methods to address the very high dimensional data generated from this SPORE.

The Biospecimen, Pathology, and Genomics Core for the Yale SPORE in Lung Cancer (YSILC) is the central repository of specimens necessary for the execution of the SPORE program. This Core focuses on tissue acquisition, processing, analysis and distribution to the internal projects of the YSILC as well as external investigators when there is adequate material to accommodate those requests. The collection of tissue from lung cancer specimens, including primary tumor biopsies and resections, biopsies of metastases and recurrences will all be facilitated by this Core. The Core will also coordinate blood and/or serum collection from these patients, as well as patients from whom no tissue is available, but whose blood is critical for studies related to treatment. In collaboration with the Biostatistics and Bioinformatics Core, this Core collects correlative clinical and biologic information to include with specimen distribution. Finally, the Core will provide tissue analysis services including quantitative measurements of protein, miRNA and mRNA as well as DNA genotyping and sequencing.

For investigators interested in requesting tissue specimens, please complete this request form and submit to: Kurt.Schalper@yale.edu