2024
Proteogenomic characterization of pancreatic neuroendocrine tumors uncovers hypoxia and immune signatures in clinically aggressive subtypes
Tanaka A, Ogawa M, Zhou Y, Otani Y, Hendrickson R, Miele M, Li Z, Klimstra D, Wang J, Roehrl M. Proteogenomic characterization of pancreatic neuroendocrine tumors uncovers hypoxia and immune signatures in clinically aggressive subtypes. IScience 2024, 27: 110544. PMID: 39206147, PMCID: PMC11350455, DOI: 10.1016/j.isci.2024.110544.Peer-Reviewed Original ResearchClinically aggressive subtypePancreatic neuroendocrine tumorsProteomic subtypesNeuroendocrine tumorsAggressive subtypeImmune hot tumorsSystemic treatment optionsVariable clinical outcomesTumor grading systemPredicting patient outcomesHot tumorsCytotoxic chemotherapyImmune signaturesImmunosuppressive moleculesImmunotherapy targetClinical aggressivenessSomatostatin analogsRecurrence rateClinical outcomesTreatment optionsEndocrine neoplasmsGlycolysis upregulationPanNETsProteogenomic characterizationInflammatory pathwaysProteogenomic characterization of primary colorectal cancer and metastatic progression identifies proteome-based subtypes and signatures
Tanaka A, Ogawa M, Zhou Y, Namba K, Hendrickson R, Miele M, Li Z, Klimstra D, Buckley P, Gulcher J, Wang J, Roehrl M. Proteogenomic characterization of primary colorectal cancer and metastatic progression identifies proteome-based subtypes and signatures. Cell Reports 2024, 43: 113810. PMID: 38377004, PMCID: PMC11288375, DOI: 10.1016/j.celrep.2024.113810.Peer-Reviewed Original ResearchConceptsMetastatic colorectal adenocarcinomaModulation of major histocompatibility complexColorectal adenocarcinomaMetastatic progressionEpithelial-to-mesenchymal transition featuresPrimary colorectal adenocarcinomaTumor microenvironment analysisPrimary colorectal cancerCopy number alterationsProgression of colorectal adenocarcinomaAlternative telomere lengtheningTumor suppressor geneOncogenic pathway activationAntigen processing pathwayMajor histocompatibility complexProteomic subtypesLiver metastasesMetastatic lesionsImmune signaturesGenomic alterationsImmune evasionColorectal cancerMicroenvironment analysisSuppressor geneProteogenomic characterization
2019
Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma
Gao Q, Zhu H, Dong L, Shi W, Chen R, Song Z, Huang C, Li J, Dong X, Zhou Y, Liu Q, Ma L, Wang X, Zhou J, Liu Y, Boja E, Robles A, Ma W, Wang P, Li Y, Ding L, Wen B, Zhang B, Rodriguez H, Gao D, Zhou H, Fan J. Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma. Cell 2019, 179: 561-577.e22. PMID: 31585088, DOI: 10.1016/j.cell.2019.08.052.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsbeta CateninCarcinoma, HepatocellularCell ProliferationCohort StudiesFemaleFructose-Bisphosphate AldolaseGene Expression ProfilingGene Expression Regulation, NeoplasticHep G2 CellsHepatitis B virusHepatitis B, ChronicHumansLiver NeoplasmsMaleMiceMice, Inbred BALB CMiddle AgedProteogenomicsTumor MicroenvironmentConceptsHepatitis B virus (HBV)-related hepatocellular carcinomaHBV-related HCCMetabolic reprogrammingHepatocellular carcinomaProteogenomic characterizationHBV-related hepatocellular carcinomaCell proliferationAdjacent liver tissuesIntegrative proteogenomic analysisMicroenvironment dysregulationBenefit clinical practiceTumor thrombusPatient survivalPaired tumorPrognostic biomarkerMetabolic profileActivation statusClinical practiceGenetic profileCarcinomaLiver tissueTumorSignaling pathwayPromote glycolysisPatients
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