2025
Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette disorder
Wang Y, Fasching L, Wu F, Suvakov M, Huttner A, Berretta S, Roberts R, Leckman J, Fernandez T, Abyzov A, Vaccarino F. Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette disorder. Biological Psychiatry 2025 PMID: 39892689, DOI: 10.1016/j.biopsych.2024.12.022.Peer-Reviewed Original ResearchActivity of cis-regulatory elementsCis-regulatory elementsMedium spiny neuronsDifferential gene expression analysisChromatin accessibility analysesCell typesDifferential gene expressionGene expression changesMitochondrial oxidative metabolismGene expression analysisSnATAC-seqOpen chromatin datasetsPutative enhancersSynaptic adhesionChromatin datasetsOxidative metabolismEpigenomic regulationTranscriptome analysisActivation of immune responsesIdentified cell typesExpression analysisSynaptic dysfunctionGene expressionExpression changesTranscriptome
2024
mTOR inhibition enhances synaptic and mitochondrial function in Alzheimer’s disease in an APOE genotype-dependent manner
Sanganahalli B, Mihailovic J, Vekaria H, Coman D, Yackzan A, Flemister A, Aware C, Wenger K, Hubbard W, Sullivan P, Hyder F, Lin A. mTOR inhibition enhances synaptic and mitochondrial function in Alzheimer’s disease in an APOE genotype-dependent manner. Cerebrovascular And Brain Metabolism Reviews 2024, 44: 1745-1758. PMID: 38879800, PMCID: PMC11494852, DOI: 10.1177/0271678x241261942.Peer-Reviewed Original ResearchResponse to rapamycinE3FAD miceMitochondrial functionAlzheimer's diseaseMammalian target of rapamycinAD genetic risk factorsApolipoprotein E4Neuronal mitochondrial functionMitochondrial oxidative metabolismE4FAD miceHuman APOE4 geneTCA cycle rateGenetic risk factorsGenotype-dependent mannerE3FADTarget of rapamycinAPOE4 geneAPOE3 alleleGlutamate-glutamine cycleAPOE4 carriersBioenergetic measurementsE4FADMetabolic functionsAPOE genotypeMammalian target of rapamycin inhibition
2023
Mitochondrial leak metabolism induces the Spemann-Mangold Organizer via Hif-1α in Xenopus
MacColl Garfinkel A, Mnatsakanyan N, Patel J, Wills A, Shteyman A, Smith P, Alavian K, Jonas E, Khokha M. Mitochondrial leak metabolism induces the Spemann-Mangold Organizer via Hif-1α in Xenopus. Developmental Cell 2023, 58: 2597-2613.e4. PMID: 37673063, PMCID: PMC10840693, DOI: 10.1016/j.devcel.2023.08.015.Peer-Reviewed Original ResearchConceptsSpemann-Mangold organizerATP productionMitochondrial respirationC subunit ringHIF-1αMitochondrial oxidative metabolismEmbryonic patterningCell fateATP synthaseC subunitVentral mesodermHIF-1α activationInstructive roleHypoxia-inducible factor-1αΒ-cateninGeneral mechanismXenopusFactor-1αRespirationMembrane leakOxidative metabolismMetabolismMesodermActivationOxygen consumption
2022
Overexpression of UCP3 decreases mitochondrial efficiency in mouse skeletal muscle in vivo
Codella R, Alves TC, Befroy DE, Choi CS, Luzi L, Rothman DL, Kibbey RG, Shulman GI. Overexpression of UCP3 decreases mitochondrial efficiency in mouse skeletal muscle in vivo. FEBS Letters 2022, 597: 309-319. PMID: 36114012, DOI: 10.1002/1873-3468.14494.Peer-Reviewed Original ResearchConceptsOverexpression of UCP3ATP synthesisMitochondrial oxidationMitochondrial transmembrane proteinInner mitochondrial membraneSkeletal muscleMitochondrial oxidative phosphorylationMitochondrial oxidative metabolismMuscle-specific overexpressionMouse skeletal muscleTransmembrane proteinMitochondrial membraneProton leakPrecise functionOxidative phosphorylationMitochondrial efficiencyUCP3 expressionMitochondrial inefficiencyOverexpressionProtein 3UCP3Oxidative metabolismVivoMagnetic resonance spectroscopyPhosphorylation
2009
AAV3-mediated transfer and expression of the pyruvate dehydrogenase E1 alpha subunit gene causes metabolic remodeling and apoptosis of human liver cancer cells
Glushakova L, Lisankie M, Eruslanov E, Ojano-Dirain C, Zolotukhin I, Liu C, Srivastava A, Stacpoole P. AAV3-mediated transfer and expression of the pyruvate dehydrogenase E1 alpha subunit gene causes metabolic remodeling and apoptosis of human liver cancer cells. Molecular Genetics And Metabolism 2009, 98: 289-299. PMID: 19586787, PMCID: PMC2779054, DOI: 10.1016/j.ymgme.2009.05.010.Peer-Reviewed Original ResearchConceptsPyruvate dehydrogenase complexSubunit geneReporter geneWarburg effectCell deathCancer cellsGreen fluorescent reporter geneLiver cancer cellsAlpha-subunit geneFluorescent reporter geneHuman hepatoblastomaE1alpha subunit geneHuH-6 cellsApoptotic cell deathProtein expressionMitochondrial oxidative metabolismHuman alpha-fetoprotein promoterMitochondrial respiratory chain activityBeta-actin promoterRespiratory chain activityChicken beta-actin promoterReactive oxygen speciesExpression systemDehydrogenase complexMetabolic remodeling
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