2024
Differential Alterations of Expression of the Serotoninergic System Genes and Mood-Related Behavior by Consumption of Aspartame or Potassium Acesulfame in Rats
Martínez-Magaña J, Genis-Mendoza A, Gallegos-Silva I, López-Narváez M, Juárez-Rojop I, Diaz-Zagoya J, Tovilla-Zárate C, González-Castro T, Nicolini H, Solis-Medina A. Differential Alterations of Expression of the Serotoninergic System Genes and Mood-Related Behavior by Consumption of Aspartame or Potassium Acesulfame in Rats. Nutrients 2024, 16: 490. PMID: 38398814, PMCID: PMC10892058, DOI: 10.3390/nu16040490.Peer-Reviewed Original ResearchConceptsMood-related behaviorsConsumption of aspartameHippocampus of ratsAnxiety-like behaviorDepressive-like behaviorChronic consumptionSerotoninergic genesDefensive buryingNeurobiological alterationsSerotonin genesBrain areasNeurodevelopmental stagesBrain expressionMale Wistar ratsReduced weight gainDifferential effectsHippocampusDifferential alterationsWistar ratsBrainSystem genesRatsBody mass index controlWeight gainAlteration of expression
2011
1H-[13C]-Nuclear Magnetic Resonance Spectroscopy Measures of Ketamine's Effect on Amino Acid Neurotransmitter Metabolism
Chowdhury GM, Behar KL, Cho W, Thomas MA, Rothman DL, Sanacora G. 1H-[13C]-Nuclear Magnetic Resonance Spectroscopy Measures of Ketamine's Effect on Amino Acid Neurotransmitter Metabolism. Biological Psychiatry 2011, 71: 1022-1025. PMID: 22169441, PMCID: PMC3660962, DOI: 10.1016/j.biopsych.2011.11.006.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexSubanesthetic dosesAcute effectsNeurotransmitter cyclingMagnetic resonance spectroscopy measuresMPFC of ratsPotential physiological processesAntidepressant-like propertiesSaline-treated animalsAmino acid neurotransmittersHippocampus of ratsDose of ketamineEffects of ketamineGlial energy metabolismMPFC levelsGlutamate releaseKetamine effectsΓ-aminobutyric acidGlial metabolismKetaminePrefrontal cortexEnrichment of glutamateVivo studiesEnergy metabolismRats
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