2025
Hippocampal encoding of memories in human infants
Yates T, Fel J, Choi D, Trach J, Behm L, Ellis C, Turk-Browne N. Hippocampal encoding of memories in human infants. Science 2025, 387: 1316-1320. PMID: 40112047, DOI: 10.1126/science.adt7570.Peer-Reviewed Original ResearchConceptsInfantile amnesiaFunctional magnetic resonance imagingEncoding of memoriesMemory taskEpisodic memoryHippocampal encodingHuman infantsAwake infantsMemoryEncoding mechanismMagnetic resonance imagingAmnesiaMemory-basedIndividual memoryAutobiographical recordResonance imagingPostencodingHippocampusPeriod of human lifeYears of ageInfancyBrainTaskRetrievalPattern integration and differentiation: Dual process model of episodic memory
Evensmoen H, Rimol L, Rise H, Hansen T, Nili H, Winkler A, Håberg A. Pattern integration and differentiation: Dual process model of episodic memory. Imaging Neuroscience 2025, 3: imag_a_00433. DOI: 10.1162/imag_a_00433.Peer-Reviewed Original ResearchEpisodic memoryBrain regionsAssociated with successful memoryModels of episodic memoryHuman episodic memoryDual-process modelActivity patternsSubsequent memoryAnterior hippocampusPosterior hippocampusSuccessful memoryEpisodic orderParticipation episodesObject presentationMemoryHippocampusTemporal compressionBrainEpisodesParticipantsPattern integrityFMRIItems
2024
Inducing representational change in the hippocampus through real-time neurofeedback
Peng K, Wammes J, Nguyen A, Iordan C, Norman K, Turk-Browne N. Inducing representational change in the hippocampus through real-time neurofeedback. Philosophical Transactions Of The Royal Society B Biological Sciences 2024, 379: 20230091. PMID: 39428880, PMCID: PMC11491844, DOI: 10.1098/rstb.2023.0091.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingReal-time functional magnetic resonance imagingPatterns of fMRI activityCategorical perception taskReal-time neurofeedbackNeurocognitive mechanismsFMRI sessionStimulus similarityFMRI activationTask demandsBehavioral consequencesUntrained objectsNeural representationPerception taskMemory integrationRepresentational changeEndogenous neuromodulatorNeurofeedbackHippocampusCortical representationIncreased coactivationMagnetic resonance imagingVisual cortexMemoryMultiple theoriesVentral hippocampal parvalbumin interneurons gate the acute anxiolytic action of the serotonergic psychedelic DOI
Tiwari P, Davoudian P, Kapri D, Vuruputuri R, Karaba L, Sharma M, Zanni G, Balakrishnan A, Chaudhari P, Pradhan A, Suryavanshi S, Bath K, Ansorge M, Fernandez-Ruiz A, Kwan A, Vaidya V. Ventral hippocampal parvalbumin interneurons gate the acute anxiolytic action of the serotonergic psychedelic DOI. Neuron 2024, 112: 3697-3714.e6. PMID: 39321791, PMCID: PMC11581910, DOI: 10.1016/j.neuron.2024.08.016.Peer-Reviewed Original ResearchAnxiolytic actionVentral hippocampusParvalbumin (PV)-positive interneuronsAnxiety-like behaviorAction of DOIPV-positive interneuronsPsychedelic DOIAnxiolytic responseAnxiolytic effectsSerotonergic psychedelicsFast-spiking cellsParvalbumin interneuronsGABAergic interneuronsVHPCFiring rateDOIHippocampusInterneuronsTherapeutic potentialReceptorsPsychedelicsCellular triggersGenetic approachesElectrophysiologyTransient impairment in microglial function causes sex-specific deficits in synaptic maturity and hippocampal function in mice exposed to early adversity
Ahmed S, Polis B, Jamwal S, Sanganahalli B, MacDowell Kaswan Z, Islam R, Kim D, Bowers C, Giuliano L, Biederer T, Hyder F, Kaffman A. Transient impairment in microglial function causes sex-specific deficits in synaptic maturity and hippocampal function in mice exposed to early adversity. Brain Behavior And Immunity 2024, 122: 95-109. PMID: 39134183, PMCID: PMC11402597, DOI: 10.1016/j.bbi.2024.08.010.Peer-Reviewed Original ResearchEarly-life adversityModel of early-life adversityContextual fear conditioningLimited beddingFear conditioningSynaptic engulfmentLB miceSynaptic pruningSex-specific deficitsHippocampus of maleSex-specific effectsHippocampal deficitsAdolescent miceHippocampal functionEarly adversityChemogenetic activationSynaptic connectionsBehavioral aberrationsPotential compensatory mechanismsSynaptic abnormalitiesHippocampusAblation of microgliaRodent hippocampusDeficitsWeeks of lifeNested compressed co-representations of multiple sequential experiences during sleep
Liu K, Sibille J, Dragoi G. Nested compressed co-representations of multiple sequential experiences during sleep. Nature Neuroscience 2024, 27: 1816-1828. PMID: 39030341, PMCID: PMC11912804, DOI: 10.1038/s41593-024-01703-6.Peer-Reviewed Original ResearchNeurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm
Jiang Y, Luo C, Wang J, Palaniyappan L, Chang X, Xiang S, Zhang J, Duan M, Huang H, Gaser C, Nemoto K, Miura K, Hashimoto R, Westlye L, Richard G, Fernandez-Cabello S, Parker N, Andreassen O, Kircher T, Nenadić I, Stein F, Thomas-Odenthal F, Teutenberg L, Usemann P, Dannlowski U, Hahn T, Grotegerd D, Meinert S, Lencer R, Tang Y, Zhang T, Li C, Yue W, Zhang Y, Yu X, Zhou E, Lin C, Tsai S, Rodrigue A, Glahn D, Pearlson G, Blangero J, Karuk A, Pomarol-Clotet E, Salvador R, Fuentes-Claramonte P, Garcia-León M, Spalletta G, Piras F, Vecchio D, Banaj N, Cheng J, Liu Z, Yang J, Gonul A, Uslu O, Burhanoglu B, Uyar Demir A, Rootes-Murdy K, Calhoun V, Sim K, Green M, Quidé Y, Chung Y, Kim W, Sponheim S, Demro C, Ramsay I, Iasevoli F, de Bartolomeis A, Barone A, Ciccarelli M, Brunetti A, Cocozza S, Pontillo G, Tranfa M, Park M, Kirschner M, Georgiadis F, Kaiser S, Van Rheenen T, Rossell S, Hughes M, Woods W, Carruthers S, Sumner P, Ringin E, Spaniel F, Skoch A, Tomecek D, Homan P, Homan S, Omlor W, Cecere G, Nguyen D, Preda A, Thomopoulos S, Jahanshad N, Cui L, Yao D, Thompson P, Turner J, van Erp T, Cheng W, Feng J. Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm. Nature Communications 2024, 15: 5996. PMID: 39013848, PMCID: PMC11252381, DOI: 10.1038/s41467-024-50267-3.Peer-Reviewed Original ResearchConceptsGray matter changesDisorder constructsEnlarged striatumPsychiatric conditionsMental disordersSubcortical regionsSchizophreniaBiological foundationsMatter changesBrain imagingStriatumDisordersBiological factorsIndividualsSubtypesHealthy subjectsCross-sectional brain imagingHippocampusTemporal trajectoriesInternational cohortSubgroup 2Subgroup 1SubgroupsHippocampal Engrams and Contextual Memory
Vasudevan K, Hassell J, Maren S. Hippocampal Engrams and Contextual Memory. Advances In Neurobiology 2024, 38: 45-66. PMID: 39008010, PMCID: PMC12006847, DOI: 10.1007/978-3-031-62983-9_4.Peer-Reviewed Original ResearchConceptsContextual fear conditioningFear conditioningFear memoryRetrieval of contextual fear memoryRetrieval of aversive memoriesNeural substrates of memoryPost-traumatic stress disorderContextual fear memorySubstrate of memoryActivity-dependent taggingRetrieval of eventsAversive memoryEncoding contextStress disorderContextual stimuliNeural substratesMemory ensemblesHippocampal ensemblesNeuronal mechanismsContextual learningHippocampusMemoryFearRetrievalEncodingAcute Stress Effects on Statistical Learning and Episodic Memory
Sherman B, Huang I, Wijaya E, Turk-Browne N, Goldfarb E. Acute Stress Effects on Statistical Learning and Episodic Memory. Journal Of Cognitive Neuroscience 2024, 36: 1741-1759. PMID: 38713878, PMCID: PMC11223726, DOI: 10.1162/jocn_a_02178.Peer-Reviewed Original ResearchEpisodic memoryAcute stressStatistical learningEffects of acute stressStress-induced cortisol levelsImpaired episodic memoryModulate learning processesAcute stress effectsImpact hippocampal functionEpisodic encodingRodent workEvidence of learningHippocampal functionStress effectsHippocampal pathwaysLearning tasksBehavioral experimentsPreliminary evidenceCortisol levelsNo stressMemoryMultiple measuresHippocampusScene categoriesParticipantsModelling adult neurogenesis in the aging rodent hippocampus: a midlife crisis
Arellano J, Rakic P. Modelling adult neurogenesis in the aging rodent hippocampus: a midlife crisis. Frontiers In Neuroscience 2024, 18: 1416460. PMID: 38887368, PMCID: PMC11181911, DOI: 10.3389/fnins.2024.1416460.Peer-Reviewed Original ResearchAdult neurogenesisHippocampal functionAdult hippocampal neurogenesisAged animalsMiddle aged animalsHippocampal neurogenesisGranule cellsDentate gyrusMature granule cellsRodent hippocampusMidlife crisisNeurogenesisFunctional relevanceRodentsDramatically with ageNeuronsYoung animalsOlder animalsGyrusHippocampusRatsRobust neurogenesisHippocampalMeta-analysisDentateEarly adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice
Islam R, White J, Arefin T, Mehta S, Liu X, Polis B, Giuliano L, Ahmed S, Bowers C, Zhang J, Kaffman A. Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice. Biology Of Sex Differences 2024, 15: 39. PMID: 38715106, PMCID: PMC11075329, DOI: 10.1186/s13293-024-00616-0.Peer-Reviewed Original ResearchConceptsLateral entorhinal cortexContextual fear conditioningDorsal hippocampusHippocampal developmentSex differencesFear conditioningEarly adversityLimited beddingSevere deficitsModel of early adversitySex-specific deficitsReelin-positive neuronsPerforant pathwayReelin-positive cellsDiffusion magnetic resonance imagingEx vivo diffusion magnetic resonance imagingContextual freezingContextual memoryAdolescent miceHippocampal functionLife adversityEntorhinal cortexHippocampusDeficitsAdolescent malesImpact of Abl2/Arg deficiency on anxiety and depressive behaviors in mice
Yao X, Chen R, Chen H, Koleske A, Xiao X. Impact of Abl2/Arg deficiency on anxiety and depressive behaviors in mice. Behavioural Brain Research 2024, 468: 115022. PMID: 38697301, DOI: 10.1016/j.bbr.2024.115022.Peer-Reviewed Original ResearchDepressive-like behaviorBehavioral testsMarble-burying behavior testAnxiety/depression-related behaviorsAnxiety-like behaviorElevated plus mazeTail suspension testEmotion-related behaviorsOpen field testWT micePlus mazeDepressive behaviorSuspension testAgonist gaboxadolMemory deficitsY-mazeAnxietyInhibitory neurotransmissionCompared to WT miceSensory/motor functionTissue injury responsesWild-typeHippocampusGABAergic synapseIntraperitoneal treatmentSelective disrupted gray matter volume covariance of amygdala subregions in schizophrenia
Chang Z, Liu L, Lin L, Wang G, Zhang C, Tian H, Liu W, Wang L, Zhang B, Ren J, Zhang Y, Xie Y, Du X, Wei X, Wei L, Luo Y, Dong H, Li X, Zhao Z, Liang M, Zhang C, Wang X, Yu C, Qin W, Liu H. Selective disrupted gray matter volume covariance of amygdala subregions in schizophrenia. Frontiers In Psychiatry 2024, 15: 1349989. PMID: 38742128, PMCID: PMC11090100, DOI: 10.3389/fpsyt.2024.1349989.Peer-Reviewed Original ResearchGray matter volume covarianceGray matter volumeAnterior amygdaloid areaAmygdala subregionsSchizophrenia patientsNegative Symptom ScaleVoxel-wise general linear modelHealthy controlsDuration of illnessOrbitofrontal cortexMatter volumeRight BASchizophreniaAmygdalaSymptom ScaleConnectivity patternsSubregionsSample size of patientsSize of patientsFunctional abnormalitiesCorrelation analysisStriatumGeneralized linear modelPatientsHippocampusDominant, Mesial Temporal Lobe Epilepsy Due to Hippocampal Sclerosis
Herlopian A. Dominant, Mesial Temporal Lobe Epilepsy Due to Hippocampal Sclerosis. 2024, 735-745. DOI: 10.1007/978-3-031-23828-4_29.Peer-Reviewed Original ResearchHippocampal sclerosisOlfactory hallucinationsNeuropsychological outcomesTemporal lobe epilepsyMesial temporal lobe epilepsyDeep brain stimulationHippocampalVisual field defectsBrain stimulationLobe epilepsyThermoablative therapyField defectsSeizure outcomePost-ablationFebrile seizuresPharmacoresistant epilepsyPotential complicationsTherapyPatientsPalilaliaSclerosisHallucinationsHippocampusEpilepsySniffingRelating depressive and manic symptomatology to 1H-MRS spectra
Choquette A, Dager A, Marjańska M, Zatony M, Pearlson G, Glahn D, Knowles E. Relating depressive and manic symptomatology to 1H-MRS spectra. Journal Of Affective Disorders Reports 2024, 16: 100774. DOI: 10.1016/j.jadr.2024.100774.Peer-Reviewed Original ResearchAnterior cingulate cortexN-acetylaspartateRight anterior cingulate cortexAssociated with maniaDepressive symptom scalesSymptom Rating ScaleProfiles of associationDisorder symptomatologyManic symptomsReduced N-acetylaspartateCingulate cortexAffective disordersNeurochemical levelsSymptom ScaleManiaCholine-containing compoundsDichotomous diagnosisMagnetic resonance spectroscopyRating ScalePotential in vivo biomarkersHippocampusIllness etiologyMagnetic resonance spectroscopy dataTotal cholineFollow-upStriatal and Extrastriatal Monoaminergic Disruption in Progressive Supranuclear Palsy
Ma J, Dong C, Qiao H, Barret O, Tamagnan G, Mao W, Xu E, Zhang C, Lu J, Chan P, Liu S. Striatal and Extrastriatal Monoaminergic Disruption in Progressive Supranuclear Palsy. Movement Disorders 2024, 39: 847-854. PMID: 38477228, DOI: 10.1002/mds.29769.Peer-Reviewed Original ResearchVesicular monoamine transporter 2Vesicular monoamine transporter 2 bindingProgressive supranuclear palsy groupPositron emission tomographyProgressive supranuclear palsyHealthy controlsParkinson's diseaseStriatal VMAT2 bindingMonoamine transporter 2Mini-Mental State ExaminationNucleus accumbensMontreal Cognitive AssessmentVMAT2 bindingRating ScaleCognitive AssessmentSubstantia nigraMini-MentalSupranuclear palsyState ExaminationProgressive Supranuclear Palsy Rating ScaleHippocampusPET/Computed TomographyPD groupClinical characteristicsStriatumNeurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches
Yang B, Xiang B, Wang T, Ma S, Li C. Neurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches. Psychiatry Research 2024, 334: 115815. PMID: 38422867, PMCID: PMC11017751, DOI: 10.1016/j.psychres.2024.115815.Peer-Reviewed Original ResearchConceptsMediodorsal nucleus of the thalamusMedial prefrontal cortexPrefrontal cortexNeurogenetic underpinningsDorsolateral prefrontal cortexBrain transcriptomeDrug memoryOrbitofrontal cortexInhibitory controlSmoking severityAssociated with CPDHuman brain transcriptomeMediodorsal nucleusWhole-brainNeurogenetic mechanismsPrimary motor cortexMechanisms of individual variationCortexHub proteinsGenetic riskAmygdalaStriatumMotor cortexOPFCHippocampusDifferential Alterations of Expression of the Serotoninergic System Genes and Mood-Related Behavior by Consumption of Aspartame or Potassium Acesulfame in Rats
Martínez-Magaña J, Genis-Mendoza A, Gallegos-Silva I, López-Narváez M, Juárez-Rojop I, Diaz-Zagoya J, Tovilla-Zárate C, González-Castro T, Nicolini H, Solis-Medina A. Differential Alterations of Expression of the Serotoninergic System Genes and Mood-Related Behavior by Consumption of Aspartame or Potassium Acesulfame in Rats. Nutrients 2024, 16: 490. PMID: 38398814, PMCID: PMC10892058, DOI: 10.3390/nu16040490.Peer-Reviewed Original ResearchConceptsMood-related behaviorsConsumption of aspartameHippocampus of ratsAnxiety-like behaviorDepressive-like behaviorChronic consumptionSerotoninergic genesDefensive buryingNeurobiological alterationsSerotonin genesBrain areasNeurodevelopmental stagesBrain expressionMale Wistar ratsReduced weight gainDifferential effectsHippocampusDifferential alterationsWistar ratsBrainSystem genesRatsBody mass index controlWeight gainAlteration of expressionAbsence in CX3CR1 receptor signaling promotes post‐ischemic stroke cognitive function recovery through suppressed microglial pyroptosis in mice
Ge Y, Yang J, Chen J, Dai M, Dou X, Yao S, Yao C, Lin Y. Absence in CX3CR1 receptor signaling promotes post‐ischemic stroke cognitive function recovery through suppressed microglial pyroptosis in mice. CNS Neuroscience & Therapeutics 2024, 30: e14551. PMID: 38421089, PMCID: PMC10850801, DOI: 10.1111/cns.14551.Peer-Reviewed Original ResearchConceptsMorris water mazeNovel object recognition testObject recognition testCX3CR1<sup>-/-</sup> micePost-stroke cognitive impairmentRecognition testCX3CR1 receptorCognitive behavioral performanceWater mazeBehavioral performanceCognitive dysfunctionDouble-positive cellsCognitive functionSource of morbidityCognitive impairmentPositron emission tomographyEnhanced neurogenesisCognitive function recoveryCX3CR1 knockoutExpression of GSDMDMicroglial pyroptosisChronic phaseInfarct volumeCX3CR1HippocampusThe associations between synaptic density and “A/T/N” biomarkers in Alzheimer’s disease: An 18F-SynVesT-1 PET/MR study
Li J, Huang Q, Qi N, He K, Li S, Huang L, Pan F, Ren S, Hua F, Huang Y, Guan Y, Guo Q, Zhao J, Xie F. The associations between synaptic density and “A/T/N” biomarkers in Alzheimer’s disease: An 18F-SynVesT-1 PET/MR study. Cerebrovascular And Brain Metabolism Reviews 2024, 44: 1199-1207. PMID: 38295871, PMCID: PMC11179616, DOI: 10.1177/0271678x241230733.Peer-Reviewed Original ResearchSynaptic densityF-FDG PET/CTInvestigate synaptic densityFDG uptakeF-FDGCognitive impairmentClinical syndromeCI groupPlasma testingPET/MR studiesPathological changesSubgroups of individualsSynaptic density lossDensity lossBiomarkersAlzheimer's clinical syndromePatientsPET/MRHippocampusAlzheimer's diseaseHippocampal volumeParahippocampal gyrusCI+ groupDiseaseSynapse loss
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply