Perinatal Hypoxia and Immune System Activation in Schizophrenia Pathogenesis: Critical Considerations During COVID-19 Pandemic.
Kawikova I, Hakenova K, Lebedeva M, Kleteckova L, Jakob L, Spicka V, Wen L, Spaniel F, Vales K. Perinatal Hypoxia and Immune System Activation in Schizophrenia Pathogenesis: Critical Considerations During COVID-19 Pandemic. Physiological Research 2024, 73: s615-s639. PMID: 39589306, PMCID: PMC11627263, DOI: 10.33549/physiolres.935501.Peer-Reviewed Original ResearchConceptsPerinatal hypoxiaPerinatal factorsMaternal immune activationImmune system activationDevelopment of experimental modelsInteraction of genetic backgroundAssociated with hypoxiaNeurodevelopmental disordersMaternal infectionObstetric complicationsSchizophrenia pathogenesisImmune activationMetabolic disturbancesTherapeutic strategiesPerinatal periodSchizophrenia etiologyDisorganized thoughtsExperimental modelSchizophreniaSystem activityEmotional bluntingHypoxiaChronic stressGenetic backgroundCognitive impairment
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