2025
Comparison of High-Flow Nasal Cannula and Conventional Oxygen Therapy for High Risk Patients During Bronchoscopy Examination: A Multicenter Randomized Controlled Trial.
Qin H, Li J, Wang J, Yang Y, Jing G, Chen R, Tan W, Zhang Y, Li T, Yang J, Dai B, Wang Q, Jiao Y, Xia Y, Huang H, Li Q, Dong Y, Bai C, Zhang W. Comparison of High-Flow Nasal Cannula and Conventional Oxygen Therapy for High Risk Patients During Bronchoscopy Examination: A Multicenter Randomized Controlled Trial. Annals Of The American Thoracic Society 2025, 22: 1018-1026. PMID: 40106752, DOI: 10.1513/annalsats.202410-1109oc.Peer-Reviewed Original ResearchConceptsHigh-flow nasal cannulaConventional oxygen therapyHigh-risk patientsMulticenter randomized controlled trialTreatment escalationTranscutaneous carbon dioxideOxygen therapyBronchoscopy examinationRandomized Controlled TrialsRisk patientsAirway stenosisNasal cannulaCompare high-flow nasal cannulaConventional oxygen therapy groupControlled TrialsDuration of desaturationOccurrence of desaturationHigh-risk factorsHigh-risk populationNo significant differenceEndoscopy examinationAdverse eventsBronchoscopyClinical trialsPatients
2024
Protective mechanical ventilation in critically ill patients after surgery
Zorrilla-Vaca A, Arevalo J, Grant M. Protective mechanical ventilation in critically ill patients after surgery. Current Opinion In Critical Care 2024, 30: 679-683. PMID: 39503212, DOI: 10.1097/mcc.0000000000001215.Peer-Reviewed Original ResearchIntensive care unitVentilator-induced lung injuryLung protective strategyCritically ill patientsMechanical ventilationCare unitLung injurySurgical patientsFast-track extubation protocolOpen-lung ventilation strategyIll patientsRisk of ventilator-induced lung injuryHigh-flow nasal cannulaHigh-risk surgical patientsOpen lung ventilationOperating roomNoninvasive ventilation supportProtective mechanical ventilationPositive-end expiratory pressureAcute lung injuryMechanically Ventilated PatientsStandard of careThoracic surgeryNasal cannulaRetrospective studyComparison between high-flow nasal cannula and conventional oxygen therapy in COVID-19 patients: a systematic review and meta-analysis
Wang J, Peng Y, Dai B, Hou H, Zhao H, Wang W, Tan W. Comparison between high-flow nasal cannula and conventional oxygen therapy in COVID-19 patients: a systematic review and meta-analysis. Therapeutic Advances In Respiratory Disease 2024, 18: 17534666231225323. PMID: 38230522, PMCID: PMC10798115, DOI: 10.1177/17534666231225323.Peer-Reviewed Original ResearchConceptsAcute hypoxemic respiratory failureHigh-flow nasal cannulaConventional oxygen therapyCOVID-19-related acute hypoxemic respiratory failureIntensive care unitHospital length of stayInvasive mechanical ventilationLength of stayIntensive care unit settingCOVID-19 patientsIntubation rateNasal cannulaMechanical ventilationOxygen therapyRatio of arterial oxygen partial pressure to fractional inspired oxygenHospital lengthArterial oxygen partial pressure to fractional inspired oxygenEfficacy of high-flow nasal cannulaIntensive care unit length of stayControlled TrialsSystematic reviewRespiratory support strategiesIntensive care unit lengthHypoxemic respiratory failureMortality rateRatio of oxygen saturation index for predicting high-flow nasal cannula outcomes in emergency department for COVID-19 patients with severe hypoxemia: A retrospective study
Karam C, Oseili A, Shebbo F, Fakih M, El-Khatib M. Ratio of oxygen saturation index for predicting high-flow nasal cannula outcomes in emergency department for COVID-19 patients with severe hypoxemia: A retrospective study. Turkish Journal Of Emergency Medicine 2024, 24: 41-47. PMID: 38343517, PMCID: PMC10852130, DOI: 10.4103/tjem.tjem_159_23.Peer-Reviewed Original ResearchAcute hypoxemic respiratory failureHigh-flow nasal cannulaSevere acute hypoxemic respiratory failureHigh-flow nasal cannula therapyCOVID-19 patientsROX indexVentilatory supportHFNC therapyOutcomes of high-flow nasal cannulaHFNC outcomesEffect of high-flow nasal cannulaRetrospective study objectsHigh-flow nasal cannula initiationEmergency departmentHypoxemic respiratory failureIntensive care unit patientsTertiary care academic medical centerInvasive ventilatory supportReceiver operating characteristic curveOxygen saturation indexRespiratory failureSevere hypoxemiaNasal cannulaRetrospective studyOxygen therapy
2023
Effect Modifiers of the Association of High-Flow Nasal Cannula and Bronchiolitis Length of Stay.
Winer J, Richardson T, Berg K, Berry J, Chang P, Etinger V, Hall M, Kim G, Meneses Paz J, Treasure J, Aronson P. Effect Modifiers of the Association of High-Flow Nasal Cannula and Bronchiolitis Length of Stay. Hospital Pediatrics 2023, 13: 1018-1027. PMID: 37795554, PMCID: PMC10593863, DOI: 10.1542/hpeds.2023-007295.Peer-Reviewed Original ResearchConceptsEffect of HFNCICU servicesEffect modifiersHigh-flow nasal cannula therapyMulticenter retrospective cohort studyPediatric Health Information SystemAge groupsHigh-flow nasal cannulaNon-ICU patientsRetrospective cohort studyComplex chronic conditionsMultivariable Poisson regressionFuture prospective studiesPotential effect modifiersInitial desaturationInitial tachypneaCohort studyClinical factorsNasal cannulaHospital recordsProspective studyHospitalized childrenChronic conditionsHFNCPatientsThe effects of flow settings during high-flow nasal cannula support for adult subjects: a systematic review
Li J, Albuainain F, Tan W, Scott J, Roca O, Mauri T. The effects of flow settings during high-flow nasal cannula support for adult subjects: a systematic review. Critical Care 2023, 27: 78. PMID: 36855198, PMCID: PMC9974062, DOI: 10.1186/s13054-023-04361-5.Peer-Reviewed Original ResearchConceptsHigh-flow nasal cannulaHigh-flow nasal cannula treatmentIn vivo studiesPatient's peak inspiratory flowHigh-flow nasal cannula supportFraction of inspired oxygenPositive end-expiratory pressurePeak inspiratory flowSystematic reviewEnd-expiratory pressureDead space washoutNon-dependent lung regionsIn vitro studiesRisk of biasROX indexNasal cannulaClinical findingsImprove oxygenationPediatric populationPatient discomfortAlveolar overdistentionInspiratory flowWeb of SciencePatient comfortPatientsComparison of high-flow nasal cannula and conventional oxygen therapy for high-risk patients during bronchoscopy examination: protocol for a randomized controlled trial
Qin H, Jing G, Tan W, Wang J, Yin Y, Chen R, Zhang W, Li J. Comparison of high-flow nasal cannula and conventional oxygen therapy for high-risk patients during bronchoscopy examination: protocol for a randomized controlled trial. Trials 2023, 24: 12. PMID: 36604711, PMCID: PMC9815677, DOI: 10.1186/s13063-022-07001-5.Peer-Reviewed Original ResearchConceptsConventional oxygen therapyHigh-risk patientsBronchoscopy examinationHigh-risk factorsNasal cannulaRandomized Controlled TrialsNasal routeOxygen therapyConventional oxygen therapy groupHigh-flow nasal cannulaFraction of inspired oxygenComplications of bronchoscopyConventional nasal cannulaEffect of HFNCIncidence of hypoxiaIncidence of hypoxemiaHFNC groupHypoxemic patientsSpO2 <Treatment escalationMorbid obesityImprove oxygenationEndoscopy examinationAdverse eventsHFNC
2022
Electrical Impedance Tomography in Acute Respiratory Distress Syndrome Management
Jimenez J, Weirauch A, Culter C, Choi P, Hyzy R. Electrical Impedance Tomography in Acute Respiratory Distress Syndrome Management. Critical Care Medicine 2022, 50: 1210-1223. PMID: 35607967, DOI: 10.1097/ccm.0000000000005582.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndrome managementAcute respiratory distress syndromeManagement of acute respiratory distress syndromeRespiratory distress syndrome managementHigh-flow nasal cannulaRespiratory distress syndromeInvasive mechanical ventilationPositive-end expiratory pressureControlled Trials databasesPatient-ventilator interactionCochrane Central RegisterClinically Meaningful OutcomesRandomized Controlled TrialsIndividualized managementDistress syndromePhysiological principlesCase seriesNasal cannulaSyndromic managementClinical outcomesMechanical ventilationProne positionLung recruitmentExpiratory pressureObservational cohortComparison between high-flow nasal cannula and noninvasive ventilation in COVID-19 patients: a systematic review and meta-analysis
Peng Y, Dai B, Zhao H, Wang W, Kang J, Hou H, Tan W. Comparison between high-flow nasal cannula and noninvasive ventilation in COVID-19 patients: a systematic review and meta-analysis. Therapeutic Advances In Respiratory Disease 2022, 16: 17534666221113663. PMID: 35861299, PMCID: PMC9340323, DOI: 10.1177/17534666221113663.Peer-Reviewed Original ResearchConceptsHigh-flow nasal cannulaAcute hypoxemic respiratory failureHigh-flow nasal cannula groupIntensive care unitClinical outcomes of COVID-19Noninvasive ventilation groupNoninvasive ventilationInvasive mechanical ventilationRandomized Controlled TrialsOutcomes of COVID-19Intubation rateNasal cannulaClinical outcomesCOVID-19-related acute hypoxemic respiratory failureMechanical ventilationHospital LOSPositive airway pressureHypoxemic respiratory failureMortality rateIntensive care unit LOSMeta-analysisSystematic reviewCPAP groupCOVID-19 patientsAirway pressureEffectiveness of the use of a high-flow nasal cannula to treat COVID-19 patients and risk factors for failure: a meta-analysis
Xu D, Dai B, Tan W, Zhao H, Wang W, Kang J. Effectiveness of the use of a high-flow nasal cannula to treat COVID-19 patients and risk factors for failure: a meta-analysis. Therapeutic Advances In Respiratory Disease 2022, 16: 17534666221091931. PMID: 35467449, PMCID: PMC9047804, DOI: 10.1177/17534666221091931.Peer-Reviewed Original ResearchConceptsHigh-flow nasal cannulaInitiation of high-flow nasal cannulaHigh-flow nasal cannula failureSequential Organ Failure AssessmentRegister of Randomized Controlled TrialsCOVID-19 patientsBody mass indexFailure groupROX indexRisk factorsHigher heart rateWhite blood cellsNasal cannulaChronic Health Evaluation (APACHE) II scoreEfficacy of high-flow nasal cannulaHeart rateDuration of HFNCOdds ratioCochrane Central Register of Randomized Controlled TrialsRisk of HFNC failureHigher white blood cellWhite blood cell countLower ROX indexOrgan Failure AssessmentPooled odds ratio
2021
Dexamethasone in hospitalised COVID-19 patients not on intensive respiratory support
Crothers K, DeFaccio R, Tate J, Alba PR, Goetz MB, Jones B, King JT, Marconi V, Ohl ME, Rentsch CT, Rodriguez-Barradas MC, Shahrir S, Justice AC, Akgün KM, Group F. Dexamethasone in hospitalised COVID-19 patients not on intensive respiratory support. European Respiratory Journal 2021, 60: 2102532. PMID: 34824060, PMCID: PMC8841623, DOI: 10.1183/13993003.02532-2021.Peer-Reviewed Original ResearchConceptsIntensive respiratory supportHospitalised COVID-19 patientsCOVID-19 patientsNasal cannulaEarly dexamethasoneRespiratory supportSevere acute respiratory syndrome coronavirus 2Low-flow nasal cannulaAcute respiratory syndrome coronavirus 2Coronavirus disease 2019 (COVID-19) patientsRespiratory syndrome coronavirus 2Cox proportional hazards modelUS Veterans Affairs hospitalsSyndrome coronavirus 2Veterans Affairs hospitalProportional hazards modelCOVID-19Prior corticosteroidsCause mortalityMortality benefitTotal patientsCoronavirus 2Unexposed groupReal-world findingsEarly initiationNeutropenia in adult acute myeloid leukemia patients represents a powerful risk factor for COVID-19 related mortality
Stahl M, Narendra V, Jee J, Derkach A, Maloy M, Geyer M, Mato A, Roeker L, Tallman M, Shah G, Daniyan A, Goldberg A. Neutropenia in adult acute myeloid leukemia patients represents a powerful risk factor for COVID-19 related mortality. Leukemia & Lymphoma 2021, 62: 1940-1948. PMID: 34180767, PMCID: PMC10080398, DOI: 10.1080/10428194.2021.1885664.Peer-Reviewed Original ResearchConceptsAdult acute myeloid leukemia patientsAcute myeloid leukemia patientsMemorial Sloan Kettering Cancer CenterCourse of COVID-19 infectionAssociated with increased odds of deathDiagnosis of AMLClinical course of COVID-19 infectionMyeloid leukemia patientsFlow nasal cannulaAssociated with increased oddsOdds of deathClinical courseHematologic malignanciesChronic leukemiaNasal cannulaLeukemia patientsCOVID-19 infectionMechanical ventilationPoor outcomeCancer CenterActive treatmentLeukemia subtypesRelated mortalityPatientsRisk factors
2020
Advanced Respiratory Support in the Contemporary Cardiac ICU
Metkus TS, Miller PE, Alviar CL, Baird-Zars VM, Bohula EA, Cremer PC, Gerber DA, Jentzer JC, Keeley EC, Kontos MC, Menon V, Park JG, Roswell RO, Schulman SP, Solomon MA, van Diepen S, Katz JN, Morrow DA. Advanced Respiratory Support in the Contemporary Cardiac ICU. Critical Care Explorations 2020, 2: e0182. PMID: 33235999, PMCID: PMC7678799, DOI: 10.1097/cce.0000000000000182.Peer-Reviewed Original ResearchHigh-flow nasal cannulaAdvanced respiratory supportCardiac ICU admissionInvasive mechanical ventilationCardiac ICURespiratory supportICU admissionNoninvasive ventilationNasal cannulaMechanical ventilationHospital mortalityCritical Care Cardiology Trials NetworkChronic obstructive pulmonary diseaseAdvanced respiratory therapiesCardiac ICU patientsPrimary cardiac problemsProspective cohort studyPulmonary vascular diseaseObstructive pulmonary diseaseCritical care needsGeneral medical problemsCritical care trainingNoncardiac diagnosesReintubation rateAdmission diagnosis
2019
Factors affecting FiO2 and PEEP during high‐flow nasal cannula oxygen therapy: A bench study
Sun Y, Dai B, Peng Y, Tan W, Zhao H. Factors affecting FiO2 and PEEP during high‐flow nasal cannula oxygen therapy: A bench study. The Clinical Respiratory Journal 2019, 13: 758-764. PMID: 31465634, DOI: 10.1111/crj.13087.Peer-Reviewed Original ResearchConceptsHigh-flow nasal cannulaPositive end-expiratory pressurePeak inspiratory flowHigh-flow nasal cannula oxygen therapyOxygen therapyTidal volumeInspiratory flowFraction of inspired O<sub>2</sub> (FiO<sub>2</sub>Nasal cannula oxygen therapyTherapy in vitroEnd-expiratory pressureNasal cannulaMultivariate linear regressionConsecutive breathsTherapyBench studySet-flow
2018
Environmental or Nasal Cannula Supplemental Oxygen for Preterm Infants: A Randomized Cross-Over Trial
Travers C, Carlo W, Nakhmani A, Bhatia S, Gentle S, Amperayani V, Indic P, Aban I, Ambalavanan N. Environmental or Nasal Cannula Supplemental Oxygen for Preterm Infants: A Randomized Cross-Over Trial. The Journal Of Pediatrics 2018, 200: 98-103. PMID: 29705116, PMCID: PMC6109600, DOI: 10.1016/j.jpeds.2018.03.010.Peer-Reviewed Original ResearchConceptsEpisodes of intermittent hypoxemiaPreterm infantsNasal cannulaIntermittent hypoxemiaSupplemental oxygenRandomized cross-over trialCross-over trialGestational agePostnatal dayBirth weightPretermHypoxemiaDecreased episodesInfantsOxygen saturationCannulaHoursPatient monitoringPatientsBirthWeeksTrials
2016
A regional cohort study of the treatment of critically ill children with bronchiolitis
Carroll CL, Faustino EV, Pinto MG, Sala KA, Canarie MF, Li S, Giuliano JS, Consortium T. A regional cohort study of the treatment of critically ill children with bronchiolitis. Journal Of Asthma 2016, 53: 1006-1011. PMID: 27177013, DOI: 10.1080/02770903.2016.1180697.Peer-Reviewed Original ResearchConceptsRSV bronchiolitisChildren's HospitalMechanical ventilationIll childrenChest physiotherapyICU lengthCohort studyMedical CenterConnecticut Children's Medical CenterHigh-flow nasal cannulaYale-New Haven Children's HospitalRegional cohort studyInvasive mechanical ventilationLonger ICU lengthRetrospective cohort studyRisk of intubationMortality risk scoreIntrapulmonary percussive ventilationChildren's Medical CenterUse of therapiesIntensive care courseClinical characteristicsNasal cannulaHypertonic salineMore frequent use
2015
Oral Alimentation in Neonatal and Adult Populations Requiring High-Flow Oxygen via Nasal Cannula
Leder SB, Siner JM, Bizzarro MJ, McGinley BM, Lefton-Greif MA. Oral Alimentation in Neonatal and Adult Populations Requiring High-Flow Oxygen via Nasal Cannula. Dysphagia 2015, 31: 154-159. PMID: 26590570, DOI: 10.1007/s00455-015-9669-3.Peer-Reviewed Original ResearchConceptsOral alimentationOral feedingNasal cannulaMedical conditionsIntensive care unit settingPatient-specific determinantsAdult ICU patientsHigh-flow oxygenUnderlying medical conditionsFunctional swallowSwallow testingAdult patientsCohort studyRespiratory supportICU patientsICU inpatientsFlow oxygenUnit settingRespiratory issuesPatientsAdult populationHigh acuityParticipant characteristicsSuccessful resumptionAlimentation
2014
Systematic use of the RAM nasal cannula in the Yale–New Haven Children’s Hospital Neonatal Intensive Care Unit: a quality improvement project
Nzegwu NI, Mack T, DellaVentura R, Dunphy L, Koval N, Levit O, Bhandari V. Systematic use of the RAM nasal cannula in the Yale–New Haven Children’s Hospital Neonatal Intensive Care Unit: a quality improvement project. The Journal Of Maternal-Fetal & Neonatal Medicine 2014, 28: 718-721. PMID: 24874561, DOI: 10.3109/14767058.2014.929659.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitNon-invasive ventilationNasal continuous positive airway pressure ventilationNasal intermittent positive pressure ventilationHospital Neonatal Intensive Care UnitNasal cannulaIntensive care unitCare unitPressure ventilationChildren's Hospital neonatal intensive care unitContinuous positive airway pressure ventilationPositive airway pressure ventilationIntermittent positive pressure ventilationPositive pressure ventilationQuality improvement projectOverall success rateNIPPV groupRespiratory supportNeonatal populationSingle centerClinical efficacySmall trialsObservational studyStatement recommendationsInfants
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