2025
Cochlear Implantation With Sporadic Inner Ear Schwannomas: Outcomes in 106 Patients From an International Multi-Institutional Study
Marinelli J, Rahne T, Dornhoffer J, Lohse C, Cottrell J, Roland J, Thompson N, Brown K, Lucas J, Babu S, Lindquist N, Perkins E, Tan D, Lane J, Hunter J, Harvey E, Deep N, Cerasiello S, Kircher M, Espahbodi M, Tooker E, West N, Caye-Thomasen P, Carlson M, Plontke S. Cochlear Implantation With Sporadic Inner Ear Schwannomas: Outcomes in 106 Patients From an International Multi-Institutional Study. Otology & Neurotology 2025, 46: 10-18. PMID: 39666742, DOI: 10.1097/mao.0000000000004362.Peer-Reviewed Original ResearchConceptsIpsilateral cochlear implantationOpen-set speech perceptionCochlear implantationSpeech perceptionSpeech perception test scoresGross total resectionSpeech perception scoresSpeech perception testsSpeech perception outcomesCochlear implant performanceAudiometric follow-upAcademic medical centerTotal resectionTertiary academic medical centerPerception outcomesInternational multi-institutional studyPerception scoresHigh-complexity tumorsLow complexity tumorsMedian scoreIncomplete tumor resectionPerception testsMulti-institutional studyMedical CenterStatistically significant difference
2024
Hearing Preservation and Functional Outcomes After Resection of Epidermoid Lesions of the Cerebellopontine Angle With High Hearing Risk
Papazian M, Cottrell J, Yang J, Kay-Rivest E, Friedmann D, Jethanamest D, Kondziolka D, Pacione D, Sen C, Golfinos J, Roland J, McMenomey S. Hearing Preservation and Functional Outcomes After Resection of Epidermoid Lesions of the Cerebellopontine Angle With High Hearing Risk. Otology & Neurotology 2024, 46: 308-313. PMID: 39951666, DOI: 10.1097/mao.0000000000004408.Peer-Reviewed Original ResearchConceptsInternal auditory canalCerebellopontine anglePostoperative audiogramsPreoperative hearingHearing preservationAssociated with hearing outcomesEpidermoid lesionsInternal auditory canal involvementExperience of treating patientsHearing preservation rateGross total resectionAverage tumor volumeHEAR scoreHearing riskHearing lossCerebellopontine angle epidermoidsHearingOutcome measuresEvidence of lesionsMicrosurgical resectionTotal resectionPreoperative extentStatistically significant changesTumor volumeAuditory canalIdentifying G6PC3 as a Potential Key Molecule in Hypoxic Glucose Metabolism of Glioblastoma Derived from the Depiction of 18F‐Fluoromisonidazole and 18F‐Fluorodeoxyglucose Positron Emission Tomography
Okamoto M, Yamaguchi S, Sawaya R, Echizenya S, Ishi Y, Kaneko S, Motegi H, Toyonaga T, Hirata K, Fujimura M. Identifying G6PC3 as a Potential Key Molecule in Hypoxic Glucose Metabolism of Glioblastoma Derived from the Depiction of 18F‐Fluoromisonidazole and 18F‐Fluorodeoxyglucose Positron Emission Tomography. BioMed Research International 2024, 2024: 2973407. PMID: 38449509, PMCID: PMC10917478, DOI: 10.1155/2024/2973407.Peer-Reviewed Original ResearchConceptsPositron emission tomographyF-FDGMRNA expressionOverall survivalGlucose metabolismF-FDG positron emission tomographyAssociated with poor overall survivalProtein expressionEmission tomographyGross total resectionPotential key moleculesFluorine-18 fluorodeoxyglucoseHypoxic conditionsDegree of glucose metabolismMolecular mechanisms of glucose metabolismAggressive primary brain tumorPoor overall survivalPrimary brain tumorKey moleculesTotal resectionPreoperative examinationIntratumoral hypoxiaPrognostic valuePoor prognosisBiomarkers of glioblastomaTreatment-wise glioblastoma survival Inference with multi-parametric preoperative MRI
Liu X, Shusharina N, Shih H, Kuo C, El Fakhri G, Woo J. Treatment-wise glioblastoma survival Inference with multi-parametric preoperative MRI. Proceedings Of SPIE--the International Society For Optical Engineering 2024, 12927: 129272h-129272h-5. PMID: 39444513, PMCID: PMC11497473, DOI: 10.1117/12.3006897.Peer-Reviewed Original Research
2023
Risk Factors Related to Transient Diabetes Insipidus Development Following Transsphenoidal Pituitary Adenoma Resection: A Multicentric Study
Yasuda M, Renedo D, Sosa S, Danilowicz K, Recalde R, Zaninovich R, Abbati S, Cervio A, Giovannini S, Villalonga J, Ulloque-Caamaño L, Reddy K, Socolovsky M, Campero A. Risk Factors Related to Transient Diabetes Insipidus Development Following Transsphenoidal Pituitary Adenoma Resection: A Multicentric Study. World Neurosurgery 2023, 175: e636-e643. PMID: 37030477, DOI: 10.1016/j.wneu.2023.03.150.Peer-Reviewed Original ResearchConceptsGross total resectionTrans-sphenoidal surgeryPituitary adenoma resectionRisk factorsPostoperative DITotal resectionAdenoma resectionMultivariable modelFemale genderTranssphenoidal pituitary adenoma resectionMultivariate logistic regression modelDifferent neurosurgical centersMulticenter case seriesIndependent risk factorMean tumor sizeSignificant predictorsLogistic regression analysisLogistic regression modelsTransient DITransient diabetesYounger patientsCase seriesMean ageTumor sizeMulticentric studyEpstein-Barr virus–associated primary intracranial leiomyosarcoma in an immunocompetent patient: illustrative case
Tabor J, Lei H, Morales-Valero S, O’Brien J, Gopal P, Erson-Omay E, Fulbright R, Moliterno J. Epstein-Barr virus–associated primary intracranial leiomyosarcoma in an immunocompetent patient: illustrative case. Journal Of Neurosurgery Case Lessons 2023, 5: case22532. PMID: 36692065, PMCID: PMC10550697, DOI: 10.3171/case22532.Peer-Reviewed Original ResearchEpstein-Barr virusPrimary intracranial leiomyosarcomaHuman immunodeficiency virusImmunocompetent statusImmunocompetent patientsIntracranial leiomyosarcomaMainstay of treatmentGross total resectionLeft-sided headacheSmooth muscle tumorsLeft middle cranial fossaMagnetic resonance imagingMiddle cranial fossaDura-based massUncomplicated resectionPrompt diagnosisTotal resectionAssociated edemaImmunodeficiency virusPoor prognosisMuscle tumorsRare diagnosisRare tumorImmunocompromised individualsPatients
2022
SURG-23. EFFICACY OF LASER INTERSTITIAL THERMAL THERAPY (LITT) FOR NEWLY DIAGNOSED AND RECURRENT IDH WILD-TYPE GLIOBLASTOMA
de Groot J, Kim A, Prabhu S, Rao G, Laxton A, Fecci P, O'Brien B, Sloan A, Chiang V, Tatter S, Mohammadi A, Placantonakis D, Strowd R, Chen C, Hadjipanayis C, Khasraw M, Sun D, Piccioni D, Sinicrope K, Campian J, Kurz S, Williams B, Smith K, Tovar-Spinoza Z, Leuthardt E. SURG-23. EFFICACY OF LASER INTERSTITIAL THERMAL THERAPY (LITT) FOR NEWLY DIAGNOSED AND RECURRENT IDH WILD-TYPE GLIOBLASTOMA. Neuro-Oncology 2022, 24: vii256-vii257. PMCID: PMC9660753, DOI: 10.1093/neuonc/noac209.989.Peer-Reviewed Original ResearchLaser interstitial thermal therapyIDH wild-type glioblastomaConventional surgical resectionWild-type glioblastomaInterstitial thermal therapySurgical resectionProspective multicenter registryMaximal safe resectionTime of diagnosisGross total resectionPrimary brain tumorsCytoreductive approachMedian OSAdjuvant temozolomideHospital stayMulticenter registryAdverse eventsOverall survivalRecurrent patientsClinical outcomesRecurrent GBMTraditional resectionMedian lengthSurgical approachTreatment options
2021
NCMP-08. CHALLENGING DIAGNOSIS AND MANAGEMENT OF PCNSL IN AN IMMUNOSUPPRESSED PATIENT ON MYCOPHENOLATE MOFETIL FOR MYASTHENIA GRAVIS
Bricoune O, Mokhtari S, Etame A, Robinson T, Pina Y, Macaulay R. NCMP-08. CHALLENGING DIAGNOSIS AND MANAGEMENT OF PCNSL IN AN IMMUNOSUPPRESSED PATIENT ON MYCOPHENOLATE MOFETIL FOR MYASTHENIA GRAVIS. Neuro-Oncology 2021, 23: vi148-vi149. DOI: 10.1093/neuonc/noab196.581.Peer-Reviewed Original ResearchPrimary CNS lymphomaDiffuse large B-cell lymphomaMycophenolate mofetilMyasthenia gravisEnhancing lesionsBrain MRIAcetylcholine receptor antibody-positive myasthenia gravisDiagnosis of PCNSLManagement of PCNSLAntibody-positive myasthenia gravisLarge B-cell lymphomaLeft eye visionRepeat brain MRIFocal neurological deficitsCerebrospinal fluid analysisPositive myasthenia gravisGross total resectionPeriventricular white matterLeft frontal lesionNew enhancing lesionsAdditional diagnostic testsB-cell lymphomaLeft medullaOral prednisoneRituximab IVRadiation Necrosis with Proton Therapy in a Patient with Aarskog-Scott Syndrome and Medulloblastoma
Puthenpura V, DeNunzio NJ, Zeng X, Giantsoudi D, Aboian M, Ebb D, Kahle KT, Yock TI, Marks AM. Radiation Necrosis with Proton Therapy in a Patient with Aarskog-Scott Syndrome and Medulloblastoma. International Journal Of Particle Therapy 2021, 8: 58-65. PMID: 35127977, PMCID: PMC8768897, DOI: 10.14338/ijpt-21-00013.1.Peer-Reviewed Original ResearchRadiation necrosisAarskog-Scott syndromeProton beam radiation therapyHigh-dose dexamethasoneGross total resectionHyperbaric oxygen therapyPosterior fossa tumorsBeam radiation therapyGroup 3 medulloblastomaCancer predisposition syndromeRare genetic syndromeConcurrent vincristineTruncal weaknessRadiographic improvementClinical stabilizationOxygen therapyTotal resectionPathologic correlatesGait instabilityFossa tumorsRadiation therapyPossible associationSyndromeDevelopment of medulloblastomaPotential association
2020
Clinical and genomic factors associated with seizures in meningiomas.
Gupte TP, Li C, Jin L, Yalcin K, Youngblood MW, Miyagishima DF, Mishra-Gorur K, Zhao AY, Antonios J, Huttner A, McGuone D, Blondin NA, Contessa JN, Zhang Y, Fulbright RK, Gunel M, Erson-Omay Z, Moliterno J. Clinical and genomic factors associated with seizures in meningiomas. Journal Of Neurosurgery 2020, 135: 835-844. PMID: 33276341, DOI: 10.3171/2020.7.jns201042.Peer-Reviewed Original ResearchPreoperative seizuresPostoperative seizuresAtypical histologyMultivariate analysisWorse progression-free survivalGenomic subgroupsYale-New Haven HospitalAssociation of seizuresAntiepileptic drug useProgression-free survivalSeizure-free patientsGross total resectionExtent of resectionMultiple risk factorsNF2 mutationsNew Haven HospitalLogistic regression modelsPostoperative radiationSeizure freedomClinical courseSeizure presentationSomatic NF2 mutationsBrain invasionRecurrent tumorsRisk factorsThalamic tumors in children: case series from our institution and literature review
Renedo D, Ferraro F, Johnson A, Argañaraz R, Giovannini S, Zabala J, Zemma E, Mantese B. Thalamic tumors in children: case series from our institution and literature review. Child's Nervous System 2020, 37: 457-463. PMID: 32712861, DOI: 10.1007/s00381-020-04830-0.Peer-Reviewed Original ResearchConceptsThalamic tumorsCase seriesSurgical approachStereotactic-guided biopsyGross total resectionEndoscopic third ventriculostomyGrade IV tumorsHigh-grade tumorsInvasive surgical proceduresTime of treatmentSubtotal resectionMedian ageVentriculoperitoneal shuntMotor deficitsGrade IIIThird ventriculostomyGrade IGrade IIObservational studySurgical proceduresPatientsResultsFrom 2013TumorsCommon formResectionPersistent STAG2 mutation despite multimodal therapy in recurrent pediatric glioblastoma
Hong CS, Vasquez JC, Kundishora AJ, Elsamadicy AA, Beckta JM, Sule A, Marks AM, Leelatian N, Huttner A, Bindra RS, DiLuna ML, Kahle KT, Erson-Omay EZ. Persistent STAG2 mutation despite multimodal therapy in recurrent pediatric glioblastoma. Npj Genomic Medicine 2020, 5: 23. PMID: 32528726, PMCID: PMC7264170, DOI: 10.1038/s41525-020-0130-7.Peer-Reviewed Original ResearchPediatric patientsStandard chemoradiationSTAG2 mutationsTumor clonesPediatric glioblastomaGross total resectionMultiple surgical resectionsTime of recurrenceHigh-grade gliomasDNA damage repair defectsWhole-exome sequencingVariety of treatmentsSurgical resectionNovel deleterious mutationsStandard therapyTotal resectionVaccine therapyClinical evidencePreclinical dataTreatment optionsMultimodal therapyPreclinical studiesClinical settingTherapyAdult counterpartsAbstract A65: Longitudinal detection of TERT-mutant plasma cell-free circulating tumor DNA in newly diagnosed glioblastoma patients
Cordova C, Syeda M, Corless B, Wiggins J, Patel A, Kurz S, Delara M, Sawaged Z, Utate M, Placantonakis D, Golfinos J, Schafrick J, Silverman J, Jain R, Snuderl M, Zagzag D, Karlin-Neumann G, Polsky D, Chi A. Abstract A65: Longitudinal detection of TERT-mutant plasma cell-free circulating tumor DNA in newly diagnosed glioblastoma patients. Clinical Cancer Research 2020, 26: a65-a65. DOI: 10.1158/1557-3265.liqbiop20-a65.Peer-Reviewed Original ResearchCell-free circulating tumor DNAPlasma cell-free circulating tumor DNADroplet digital PCRTumor DNAClinical outcomesDroplet digital PCR assayGBM patientsC228TC250TTERT mutationsIDHwt glioblastomasPlasma samplesLiquid biopsyPost-RT follow-upPromoter mutations C228TTERT promoter hotspot mutationsNewly diagnosed GBM patientsAssociated with clinical outcomesMonitoring of glioblastomaMonths post radiationDiagnosed glioblastoma patientsGross total resectionPromoter hotspot mutationsIDH wild-typeFFPE tumor samples
2019
Extent of resection of epidermoid tumors and risk of recurrence: case report and meta-analysis.
Shear BM, Jin L, Zhang Y, David WB, Fomchenko EI, Erson-Omay EZ, Huttner A, Fulbright RK, Moliterno J. Extent of resection of epidermoid tumors and risk of recurrence: case report and meta-analysis. Journal Of Neurosurgery 2019, 133: 291-301. PMID: 31277071, DOI: 10.3171/2019.4.jns19598.Peer-Reviewed Original ResearchGross total resectionSubtotal resectionRecurrence rateAverage recurrence rateEpidermoid tumorsSafe gross total resectionTransient cranial nerve palsyUnderwent subtotal resectionCranial nerve palsyCommon surgical complicationExtent of resectionRisk of recurrenceTreatment of choiceCritical neurovascular structuresLong-term riskUse of adjunctsIntracranial epidermoid tumorsCubic spline modelsWeb of ScienceNerve palsyRepeat resectionInitial surgeryNatural cubic spline modelSurgical complicationsPooled proportionDefining an Intermediate-risk Group for Low-grade Glioma: A National Cancer Database Analysis
JAIRAM V, KANN BH, PARK HS, MICCIO JA, BECKTA JM, YU JB, PRABHU RS, GAO SJ, MEHTA MP, CURRAN WJ, BINDRA RS, CONTESSA JN, PATEL KR. Defining an Intermediate-risk Group for Low-grade Glioma: A National Cancer Database Analysis. Anticancer Research 2019, 39: 2911-2918. PMID: 31177129, DOI: 10.21873/anticanres.13420.Peer-Reviewed Original ResearchConceptsIntermediate-risk groupInferior overall survivalOverall survivalAdjuvant therapyLow-grade gliomasTumor sizePrognostic featuresMultivariate analysisPre-operative tumor sizeNational Cancer Database AnalysisNational Cancer DatabaseLow-risk patientsCohort of patientsKaplan-Meier methodPoor prognostic featuresGross total resectionHigh-risk groupPatterns of careAdditional prognostic featuresRTOG 9802Clinical factorsTotal resectionCancer DatabaseRisk groupsClinical classification
2017
Is the chiasm-pituitary corridor size important for achieving gross-total resection during endonasal endoscopic resection of craniopharyngiomas?
Omay SB, Almeida JP, Chen YN, Shetty SR, Liang B, Ni S, Anand VK, Schwartz TH. Is the chiasm-pituitary corridor size important for achieving gross-total resection during endonasal endoscopic resection of craniopharyngiomas? Journal Of Neurosurgery 2017, 129: 642-647. PMID: 29171802, DOI: 10.3171/2017.6.jns163188.Peer-Reviewed Original ResearchConceptsGross total resectionExtended endonasal approachSubtotal resectionLarge tumorsPituitary glandFirst-line surgical approachEndonasal endoscopic resectionAvailable preoperative imagingMidline craniopharyngiomasOBJECTIVE CraniopharyngiomasPrefixed chiasmEndocrine outcomesRelative contraindicationVisual outcomeEndoscopic resectionAuthors' centerPreoperative imagingOptic chiasmSurgical approachVisual deteriorationResults ThirtyPituitary stalkThird ventricleHigh riskResectionOverall survival in patients with glioblastoma before and after bevacizumab approval
Johnson DR, Omuro AMP, Ravelo A, Sommer N, Guerin A, Ionescu-Ittu R, Shi S, Macalalad A, Uhm JH. Overall survival in patients with glioblastoma before and after bevacizumab approval. Current Medical Research And Opinion 2017, 34: 813-820. PMID: 29025274, DOI: 10.1080/03007995.2017.1392294.Peer-Reviewed Original ResearchConceptsOverall survivalTreatment of patientsBevacizumab approvalProgressive glioblastomaGBM diagnosisUS population-based cancer registry dataPopulation-based cancer registry dataCox proportional hazards regressionLarge population-based studyOS of patientsApproval of bevacizumabGross total resectionKaplan-Meier analysisPopulation-based studyProportional hazards regressionLimited therapeutic optionsCancer registry dataAdjusted hazardAdult patientsMedian ageTotal resectionStudy cohortAggressive diseaseHazards regressionTherapeutic optionsTransorbital endoscopic eyelid approach for resection of sphenoorbital meningiomas with predominant hyperostosis: report of 2 cases.
Almeida JP, Omay SB, Shetty SR, Chen YN, Ruiz-Treviño AS, Liang B, Anand VK, Levine B, Schwartz TH. Transorbital endoscopic eyelid approach for resection of sphenoorbital meningiomas with predominant hyperostosis: report of 2 cases. Journal Of Neurosurgery 2017, 128: 1885-1895. PMID: 28862553, DOI: 10.3171/2017.3.jns163110.Peer-Reviewed Original ResearchConceptsSphenoorbital meningiomasEyelid approachIntraconal tumorsEndoscopic approachIntracranial componentOcular movement disordersOptic nerve compressionGross total resectionStandard of careTransorbital endoscopic approachAdjacent hyperostosisEndonasal decompressionPrior craniotomyRadiographic outcomesNerve compressionHigh morbiditySphenoidal wingPostoperative measurementsVisual deteriorationOrbital apexPlaque diseaseIntracranial portionInvasive alternativeMovement disordersSurgical technique
2016
Primary spinal myxopapillary ependymoma in the pediatric population: a study from the Surveillance, Epidemiology, and End Results (SEER) database
Lucchesi KM, Grant R, Kahle KT, Marks AM, DiLuna ML. Primary spinal myxopapillary ependymoma in the pediatric population: a study from the Surveillance, Epidemiology, and End Results (SEER) database. Journal Of Neuro-Oncology 2016, 130: 133-140. PMID: 27423644, DOI: 10.1007/s11060-016-2218-6.Peer-Reviewed Original ResearchConceptsGross total resectionOverall survivalSpinal myxopapillary ependymomaMyxopapillary ependymomaSubtotal resectionPatient demographicsPediatric patientsEnd Results (SEER) databaseNational Cancer DatabaseKaplan-Meier methodGoal of treatmentYears of ageLargest survival analysisAdjuvant radiationMean followPatients 21SEER databaseSurgical resectionMedian agePediatric populationResults databaseTumor recurrenceCauda equinaTreatment modalitiesCancer Database
2015
Adjuvant hypofractionated partial-brain radiation therapy for pediatric Ewing sarcoma brain metastases: case report.
van Dams R, Park HS, Alomari AK, Ricciardi AS, Rao H, McNamara J, DiLuna ML, Bindra RS. Adjuvant hypofractionated partial-brain radiation therapy for pediatric Ewing sarcoma brain metastases: case report. Journal Of Neurosurgery Pediatrics 2015, 17: 434-8. PMID: 26636250, DOI: 10.3171/2015.8.peds15313.Peer-Reviewed Original ResearchConceptsPartial brain radiation therapyRadiation therapyCase reportSarcoma brain metastasesEvidence of diseaseGross tumor resectionGross total resectionBrain metastasesInflammatory changesIntracranial metastasesSarcoma metastasisTumor resectionMetastasisTherapyResectionPatientsLimited marginReasonable approachReportDexamethasoneDiseaseGyBrainMonths
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