2025
Intermediate Signaling Mechanisms Regulating Human Fetal Membrane Responses to Gram‐Positive Bacterial Peptidoglycan
Georges H, Fischer A, Abrahams V. Intermediate Signaling Mechanisms Regulating Human Fetal Membrane Responses to Gram‐Positive Bacterial Peptidoglycan. American Journal Of Reproductive Immunology 2025, 93: e70090. PMID: 40435036, PMCID: PMC12124414, DOI: 10.1111/aji.70090.Peer-Reviewed Original ResearchConceptsToll-like receptorsPro-inflammatory cytokines IL-1bFetal membrane explantsHuman FM explantsPathogenesis of chorioamnionitisP65-NFkBResponse to Gram-positive bacteriaP38 MAPKElevated levelsTLR2 agonist peptidoglycanCytokines IL-1bChemokine IL-8FM explantsNeonatal morbidityPreterm birthStimulation of TLR4Fetal membranesMembrane weakeningIL-1BIL-8TLR7/8 activationMembrane explantsSecreted factorsERK signalingLipopolysaccharide stimulationBuprenorphine induces human fetal membrane sterile inflammation
Lynn T, Kelleher M, Georges H, McCauley E, Logan R, Yonkers K, Abrahams V. Buprenorphine induces human fetal membrane sterile inflammation. Journal Of Reproductive Immunology 2025, 168: 104445. PMID: 39914058, PMCID: PMC11890952, DOI: 10.1016/j.jri.2025.104445.Peer-Reviewed Original ResearchConceptsOpioid-use disorderPreterm birthToll-like receptor 4Prostaglandin E2Sterile inflammationRate of preterm birthAssociated with pregnancy complicationsInnate immune toll-like receptor 4Maternal-fetal interfaceNeutrophil chemokine IL-8Induce sterile inflammationM-opioid receptorCytokines IL-1bInflammatory cytokines IL-6Chemokine IL-8Cytokines IL-6Maternal morbidityPregnancy complicationsOpioid useOpioid-usersHuman FMInflammatory profileMembrane weakeningIL-1BPreterm
2019
Acute alcohol consumption alters the peripheral cytokines IL-8 and TNF-α
Hillmer AT, Nadim H, Devine L, Jatlow P, O'Malley SS. Acute alcohol consumption alters the peripheral cytokines IL-8 and TNF-α. Alcohol 2019, 85: 95-99. PMID: 31759072, PMCID: PMC7739954, DOI: 10.1016/j.alcohol.2019.11.005.Peer-Reviewed Original ResearchConceptsCytokine levelsIL-8Cytokine responsesAlcohol challengePro-inflammatory cytokines TNFPro-inflammatory chemokine IL-8Acute alcohol challengePeripheral cytokine responseSerum cytokine levelsCytokine IL-8Moderate alcohol drinkersChemokine IL-8Peripheral cytokine levelsAlcohol consumption altersCytokines of interestAlcohol drinkersCytokines TNFBlood concentrationsImmune functionImmune communicationCytokinesTNFLinear mixed modelsTrigger releaseDrinking-related behaviors
2014
Reduced bioenergetics and toll-like receptor 1 function in human polymorphonuclear leukocytes in aging
Qian F, Guo X, Wang X, Yuan X, Chen S, Malawista SE, Bockenstedt LK, Allore HG, Montgomery RR. Reduced bioenergetics and toll-like receptor 1 function in human polymorphonuclear leukocytes in aging. Aging 2014, 6: 131-139. PMID: 24595889, PMCID: PMC3969281, DOI: 10.18632/aging.100642.Peer-Reviewed Original ResearchConceptsToll-like receptor 1Polymorphonuclear leukocytesOlder adultsChemokine IL-8Loss of CD62LAge-dependent deficienciesPotential therapeutic opportunitiesHuman polymorphonuclear leukocytesTLR1 expressionIL-8PMN functionPMN activationMultiple pathwaysImmune functionYoung donorsP38 MAP kinaseReceptor 1Bacterial infectionsTherapeutic opportunitiesProgressive declineGlucose uptakeReduced expressionAdultsStimulationLeukocytes
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