2024
Analytical Investigation of the Profile of Human Chorionic Gonadotropin in Highly Purified Human Menopausal Gonadotrophin Preparations
Capolupo A, Petrocchi S, Melchiorre M, Jonas K, D’Hooghe T, Hanyaloglu A, Sunkara S, Palmese A, Ozgumus B, Amoresano A, Angiuoni G, Montenegro S, Simone P, Lispi M. Analytical Investigation of the Profile of Human Chorionic Gonadotropin in Highly Purified Human Menopausal Gonadotrophin Preparations. International Journal Of Molecular Sciences 2024, 25: 9405. PMID: 39273352, PMCID: PMC11395176, DOI: 10.3390/ijms25179405.Peer-Reviewed Original ResearchConceptsBeta subunitFollicle-stimulating hormoneAdvanced molecular analysisSulfated glycansSources of hCGHP-hMGProtein impuritiesLuteinizing hormonePlacental originClinical profileLevels of beta-hCGLC-MS/MSHuman menopausal gonadotrophin preparationsUrine of pregnant womenGlycan distributionHuman menopausal gonadotropinRatio of follicle-stimulating hormoneGlycosylation patternsLiquid chromatography-tandem mass spectrometryAnalysis of impuritiesChromatography-tandem mass spectrometryHuman chorionic gonadotropinBeta-subunit of hCGAlpha subunitBeta-subunit of LH
2022
Circulating miRNAs in the first trimester and pregnancy complications: a systematic review
Subramanian A, Weiss D, Nyhan K, Dewan A, Jukic A. Circulating miRNAs in the first trimester and pregnancy complications: a systematic review. Epigenetics 2022, 18: 2152615. PMID: 36503407, PMCID: PMC9980650, DOI: 10.1080/15592294.2022.2152615.Peer-Reviewed Original ResearchConceptsPregnancy complicationsSystematic reviewFirst trimesterMiR-520hPlacental originMiR-518bFuture pregnancy complicationsMost pregnancy complicationsFirst-trimester serumFirst trimester biomarkersPotential early biomarkersGestational hypertensionPreterm birthPlacental pathologyEarly biomarkersComplicationsEarly placentationPotential biomarkersPlasma miRNAsPreeclampsiaMiR-125bEarly detectionBiomarkersMiR-365aMost evidence
2014
Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth
Ferguson K, McElrath T, Chen Y, Loch-Caruso R, Mukherjee B, Meeker J. Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth. American Journal Of Obstetrics And Gynecology 2014, 212: 208.e1-208.e8. PMID: 25111586, PMCID: PMC4312513, DOI: 10.1016/j.ajog.2014.08.007.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPreterm birthAssociated with increased odds of spontaneous preterm birthCases of spontaneous preterm birthOdds of spontaneous preterm birthPathways to preterm birthMechanisms of preterm birthNested Case-Control StudyLevels of 8-isoprostaneOxidative stressUrinary biomarkers of oxidative stressConcentrations of 8-isoprostaneUrinary oxidative stress biomarkersLevels of 8-OHdGMaternal oxidative stressCase-control studyProspective birth cohortUrinary 8-OHdG concentrationsAssociated with increased oddsInvestigate oxidative stressDelivered pretermBiomarkers of oxidative stressPlacental originUrinary concentrations of 8-isoprostanePreterm
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