2025
The Endothelial Glycocalyx: The First Line of Defense in the Prevention and Treatment of Kidney Diseases
Yuan X, Jia M, Zhou L, Hou G, Zhang B, Ouyang X, Huang Y. The Endothelial Glycocalyx: The First Line of Defense in the Prevention and Treatment of Kidney Diseases. Kidney Medicine 2025, 101122. DOI: 10.1016/j.xkme.2025.101122.Peer-Reviewed Original ResearchAcute kidney injuryChronic kidney diseaseTreatment of kidney diseaseKidney diseaseEndothelial glycocalyxRenal microvasculatureEndothelial cellsFirst lineEndothelial cell barrierImmune system dysregulationRenal tubulointerstitial fibrosisSurface of endothelial cellsEndothelial cell membraneFirst line of defenseKidney injuryTubulointerstitial fibrosisSystem dysregulationEG damageEpithelial cellsCell barrierEarly preventionDiseaseA Review of Relapse in Opioid Use Disorder
Draghmeh K, Gold M, Fuehrlein B. A Review of Relapse in Opioid Use Disorder. Current Addiction Reports 2025, 12: 58. DOI: 10.1007/s40429-025-00672-5.Peer-Reviewed Original ResearchUse disorderEnhance treatment retentionMindfulness-based therapyStress system dysregulationRelapse vulnerabilityOpioid use disorderNeurobiological mechanismsDopamine deficitMedication-Assisted TreatmentContingency managementTreatment retentionPsychosocial interventionsMechanisms of relapseReduce relapseBehavioral componentsReviewOpioid use disorderSignificant public health challengeSystem dysregulationPublic health challengeRelapse rateAt-risk populationsSocietal burdenEmergency therapyAt-riskRelapse
2023
Appraising the Preclinical Evidence of the Role of the Renin-Angiotensin-Aldosterone System in Antenatal Programming of Maternal and Offspring Cardiovascular Health Across the Life Course: Moving the Field Forward: A Scientific Statement From the American Heart Association
Alexander B, South A, August P, Bertagnolli M, Ferranti E, Grobe J, Jones E, Loria A, Safdar B, Sequeira-Lopez M, Health O. Appraising the Preclinical Evidence of the Role of the Renin-Angiotensin-Aldosterone System in Antenatal Programming of Maternal and Offspring Cardiovascular Health Across the Life Course: Moving the Field Forward: A Scientific Statement From the American Heart Association. Hypertension 2023, 80: e75-e89. PMID: 36951054, PMCID: PMC10242542, DOI: 10.1161/hyp.0000000000000227.Peer-Reviewed Original ResearchConceptsAldosterone systemCardiovascular healthCardiovascular diseaseLong-term cardiovascular healthAntenatal risk factorsRisk of hypertensionAdverse cardiovascular healthAmerican Heart AssociationMaternal-fetal healthTranslational research studiesPregnancy complicationsRenin-AngiotensinPreclinical evidenceComplicated pregnanciesPlacental interfaceHeart AssociationRisk factorsSystem dysregulationNovel therapiesClinical careRisk individualsHealth outcomesLife courseDiseaseScientific evidence
2018
7 Stress System Sensitivity and Emotion Regulation in Early Abstinence from Substance Use Disorders—Targets for Medications Development
Fox H, Milivojevic V, Blaine S, Sinha R. 7 Stress System Sensitivity and Emotion Regulation in Early Abstinence from Substance Use Disorders—Targets for Medications Development. 2018, 120-141. DOI: 10.1016/b978-0-12-813693-5.00007-1.Peer-Reviewed Original ResearchMedication developmentDrug useAlpha-2 adrenergic agonistsStress system dysregulationStress-induced cravingPreclinical dataSystem dysregulationAdrenergic agonistsDrug AdministrationEarly abstinenceBiobehavioral mechanismsBiobehavioral adaptationsDysphoric statesNovel targetSubstance useRelapseAbstinenceNew foodsSeries of studiesUrgent needMedicationsGuanfacineAgonistsHuman paradigm
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