2025
Associations of Genetically Predicted NPR3 and NPR2 Perturbation and Preeclampsia Risk: A Two‐Sample Mendelian Randomization Analysis
de La Harpe R, Rogne T, Nyberg M, Cronjé H, Burgess S, Karhunen V, Gill D. Associations of Genetically Predicted NPR3 and NPR2 Perturbation and Preeclampsia Risk: A Two‐Sample Mendelian Randomization Analysis. International Journal Of Hypertension 2025, 2025: 9972031. PMID: 40406480, PMCID: PMC12097871, DOI: 10.1155/ijhy/9972031.Peer-Reviewed Original ResearchGenome-wide association studiesMendelian randomizationTwo-sample Mendelian randomization analysisRisk of preeclampsiaTwo-sample MR analysisGenetic association estimatesGenetic instrumental variablesPreeclampsia riskMendelian randomization analysisFemale participantsC-type natriuretic peptideIndividual-level dataEffects of C-type natriuretic peptideGenetic instrumentsMR analysisUK BiobankRandomization analysisAssociation estimatesMR paradigmAssociation studiesGenetic variantsPregnancy complicationsProtective effects of C-type natriuretic peptideTwo-sampleInstrumental variables
2024
Safety of the Seasonal Influenza Vaccine in 2 Successive Pregnancies
Getahun D, Liu I, Sy L, Glanz J, Zerbo O, Vazquez-Benitez G, Nelson J, Williams J, Hambidge S, McLean H, Irving S, Weintraub E, Qian L. Safety of the Seasonal Influenza Vaccine in 2 Successive Pregnancies. JAMA Network Open 2024, 7: e2434857. PMID: 39298167, PMCID: PMC11413712, DOI: 10.1001/jamanetworkopen.2024.34857.Peer-Reviewed Original ResearchConceptsAdverse perinatal outcomesPreterm premature rupture of membranesPremature rupture of membranesPreterm premature ruptureRupture of membranesRisk of preeclampsiaSeasonal influenza vaccineInfluenza vaccineAssociated with increased riskInterpregnancy intervalPerinatal outcomesVaccine typesPlacental abruptionPreterm birthInfluenza seasonAssociated with increased risk of preeclampsiaCohort studyRisk of adverse perinatal outcomesAssociated with increased risk of adverse perinatal outcomesSingleton live birth pregnanciesRelative riskLive-birth pregnanciesGestational age birthsRetrospective cohort studyAdjusted relative risksQuality of Blood Pressure Monitoring During Telehealth Visits for Pregnant Patients at Risk of Preeclampsia
Nadkarni S, Oyama S, May H, Adeyemo O. Quality of Blood Pressure Monitoring During Telehealth Visits for Pregnant Patients at Risk of Preeclampsia. Telemedicine Journal And E-Health 2024, 30: 2165-2172. PMID: 38752870, PMCID: PMC11807852, DOI: 10.1089/tmj.2024.0003.Peer-Reviewed Original ResearchSelf-measured blood pressureRisk of preeclampsiaPregnant patientsBlood pressure monitoringHome blood pressure cuffTelehealth visitsBlood pressure cuffHypertensive disorders of pregnancyRisk factorsFetal medicine clinicsPreeclampsia risk factorsDisorders of pregnancyPressure monitoringUnited States Preventive Services Task ForceRetrospective chart reviewCause of morbidityPreventive Services Task ForceBlood pressure recordingsPressure cuffHypertensive disordersObstetric visitChart reviewPreeclampsiaPatient numbersBlood pressure
2023
Dyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study
Hosier H, Lipkind H, Rasheed H, DeWan A, Rogne T. Dyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study. Hypertension 2023, 80: 1067-1076. PMID: 36883459, DOI: 10.1161/hypertensionaha.122.20426.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaProtective effectCholesteryl Ester Transfer Protein InhibitionLack of effectMendelian randomization studyMendelian randomization analysisMaternal morbidityElevated HDLLeading causeLipid levelsObservational studyPreeclampsiaLipid measurementsReduced riskAncestry groupsPharmacological targetsRandomization studyHDLLDLRandomization analysisSingle nucleotide polymorphismsNew targetsDyslipidemiaRiskProtein inhibition
2018
Excess glucose induce trophoblast inflammation and limit cell migration through HMGB1 activation of Toll‐Like receptor 4
Heim KR, Mulla MJ, Potter JA, Han CS, Guller S, Abrahams VM. Excess glucose induce trophoblast inflammation and limit cell migration through HMGB1 activation of Toll‐Like receptor 4. American Journal Of Reproductive Immunology 2018, 80: e13044. PMID: 30175447, DOI: 10.1111/aji.13044.Peer-Reviewed Original ResearchConceptsToll-like receptor 4High mobility group box 1Damage-associated molecular patternsHMGB1 activationIL-1βIL-8Trophoblast responsesReceptor 4Human first trimester trophoblast cell lineFirst trimester trophoblast cell lineInflammatory IL-8Risk of preeclampsiaGroup box 1Uric acidIL-1β responseExcess glucoseTrophoblast cell lineCell migrationTrophoblast inflammationPregnancy outcomesTLR4 antagonistLPS-RSIL-6SFlt-1HMGB1 inhibitor
2017
Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia
Tong M, Johansson C, Xiao F, Stone PR, James JL, Chen Q, Cree LM, Chamley LW. Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia. Scientific Reports 2017, 7: 16556. PMID: 29185455, PMCID: PMC5707355, DOI: 10.1038/s41598-017-16448-5.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaAntiphospholipid antibodiesTLR-9Placental vesiclesEndothelial cellsFirst trimester human placental explantsMaternal endothelial cell dysfunctionToll-like receptor 9Danger-associated molecular patternsHuman placental explantsPathogenesis of preeclampsiaEndothelial cell dysfunctionEndothelial cell activationPlacental extracellular vesiclesLevels of mtDNAPlacental factorsPlacental explantsReceptor 9Cell dysfunctionNano-vesiclesPreeclampsiaPharmaceutical interventionsCell activationAmount of mtDNAMolecular patternsFirst-trimester screening for early and late preeclampsia using maternal characteristics, biomarkers, and estimated placental volume
Sonek J, Krantz D, Carmichael J, Downing C, Jessup K, Haidar Z, Ho S, Hallahan T, Kliman HJ, McKenna D. First-trimester screening for early and late preeclampsia using maternal characteristics, biomarkers, and estimated placental volume. American Journal Of Obstetrics And Gynecology 2017, 218: 126.e1-126.e13. PMID: 29097177, DOI: 10.1016/j.ajog.2017.10.024.Peer-Reviewed Original ResearchConceptsLate-onset preeclampsiaEarly-onset preeclampsiaFirst-trimester screeningWeeks' gestationMaternal characteristicsPlacental volumeUterine artery pulsatility indexArtery pulsatility indexRisk of preeclampsiaAddition of biomarkersDiagnosis of preeclampsiaDetection rateFalse positive rateMaternal biomarkersCombination of markersLate preeclampsiaPerinatal morbidityCohort studyOnset preeclampsiaArterial pressurePulsatility indexFirst trimesterMedical historySerum biomarkersMedical records
2016
Urinary Concentrations of Bisphenol A and Phthalate Metabolites Measured during Pregnancy and Risk of Preeclampsia
Cantonwine D, Meeker J, Ferguson K, Mukherjee B, Hauser R, McElrath T. Urinary Concentrations of Bisphenol A and Phthalate Metabolites Measured during Pregnancy and Risk of Preeclampsia. Environmental Health Perspectives 2016, 124: 1651-1655. PMID: 27177253, PMCID: PMC5047771, DOI: 10.1289/ehp188.Peer-Reviewed Original ResearchRisk of preeclampsiaUrinary concentrations of BPAUrinary concentrations of bisphenol APhthalate metabolitesUrinary concentrationsAssociated with increased risk of preeclampsiaHazard ratioCases of preeclampsiaNested Case-Control StudyDevelopment of preeclampsiaProspective birth cohort studyAssociated with increased riskPhthalate metabolite concentrationsCox proportional hazards modelsAdjusted Cox proportional hazards modelsCase-control studyAdjusted hazard ratiosCalculate hazard ratiosProportional hazards modelBirth cohort studyWeeks gestationPreterm birthAssociated with onsetPreeclampsiaUrinary BPA
2015
Folic acid supplementation in early pregnancy and the risk of preeclampsia, small for gestational age offspring and preterm delivery
Martinussen MP, Bracken MB, Triche EW, Jacobsen GW, Risnes KR. Folic acid supplementation in early pregnancy and the risk of preeclampsia, small for gestational age offspring and preterm delivery. European Journal Of Obstetrics & Gynecology And Reproductive Biology 2015, 195: 94-99. PMID: 26500184, PMCID: PMC4684439, DOI: 10.1016/j.ejogrb.2015.09.022.Peer-Reviewed Original ResearchMeSH KeywordsAdultCohort StudiesFemaleFolic AcidHumansInfant, Low Birth WeightInfant, NewbornInfant, Small for Gestational AgeObesityOdds RatioPre-EclampsiaPregnancyPregnancy ComplicationsPregnancy Trimester, FirstPremature BirthProspective StudiesProtective FactorsRisk FactorsVitamin B ComplexYoung AdultConceptsFolic acid supplementationLow birth weightFolic acid intakePreterm birthAcid supplementationFirst trimesterLean mothersBirth weightAcid intakeEarly pregnancyOdds ratioGestational age offspringProspective cohort studyFolic acid supplementsFolic acid usePregnancy outcome dataRisk of preeclampsiaPossible protective effectMonths of pregnancyObese mothersPreterm deliveryCohort studyObstetric recordsAge offspringFolate intake
2014
Glucose and Metformin Modulate Human First Trimester Trophoblast Function: a Model and Potential Therapy for Diabetes‐Associated Uteroplacental Insufficiency
Han CS, Herrin MA, Pitruzzello MC, Mulla MJ, Werner EF, Pettker CM, Flannery CA, Abrahams VM. Glucose and Metformin Modulate Human First Trimester Trophoblast Function: a Model and Potential Therapy for Diabetes‐Associated Uteroplacental Insufficiency. American Journal Of Reproductive Immunology 2014, 73: 362-371. PMID: 25394884, PMCID: PMC4356646, DOI: 10.1111/aji.12339.Peer-Reviewed Original ResearchMeSH KeywordsAngiogenesis Inducing AgentsAntigens, CDCarrier ProteinsCell LineCell MovementChemokine CCL5Chemokine CXCL1Diabetes ComplicationsDiabetes MellitusEndoglinFemaleGlucoseGranulocyte Colony-Stimulating FactorHumansInflammationInterleukinsMetforminNLR Family, Pyrin Domain-Containing 3 ProteinPlacentaPre-EclampsiaPregnancyPregnancy Trimester, FirstReceptors, Cell SurfaceTrophoblastsUterusVascular Endothelial Growth Factor Receptor-1ConceptsHuman first trimester trophoblast cell lineAnti-angiogenic factor sFlt-1First trimester trophoblast cell lineNalp3/ASC inflammasomeInflammatory cytokines/chemokinesFirst trimester trophoblast cellsGlucose-induced inflammationRisk of preeclampsiaCytokines/chemokinesAbsence of metforminIL-1β productionIL-1β secretionTrophoblast cell lineUteroplacental insufficiencyIL-1βIL-6SFlt-1Trophoblast functionsIL-8Pathogenic roleInflammatory responseASC inflammasomeSupernatant cytokinesPotential therapyExcess glucose
2012
Screening for Gestational Diabetes Mellitus: Are the Criteria Proposed by the International Association of the Diabetes and Pregnancy Study Groups Cost-Effective?
Werner EF, Pettker CM, Zuckerwise L, Reel M, Funai EF, Henderson J, Thung SF. Screening for Gestational Diabetes Mellitus: Are the Criteria Proposed by the International Association of the Diabetes and Pregnancy Study Groups Cost-Effective? Diabetes Care 2012, 35: 529-535. PMID: 22266735, PMCID: PMC3322683, DOI: 10.2337/dc11-1643.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusIncremental cost-effectiveness ratioPregnancy Study GroupsIADPSG recommendationsPostdelivery careDiabetes mellitusStudy groupRisk of preeclampsiaPrimary outcome measureFuture diabetes riskCurrent screening practicesCost-effectiveness ratioCurrent standardDecision analysis modelGDM womenIADPSG criteriaFuture diabetesBirth injuryGlucose screeningShoulder dystociaDiabetes riskScreening practicesOutcome measuresDiabetesPrenatal monitoring
2000
Prepregnancy body mass index and gestational weight gain as risk factors for preeclampsia and transient hypertension
Saftlas A, Wang W, Risch H, Woolson R, Hsu C, Bracken M. Prepregnancy body mass index and gestational weight gain as risk factors for preeclampsia and transient hypertension. Annals Of Epidemiology 2000, 10: 475. PMID: 11018413, DOI: 10.1016/s1047-2797(00)00167-8.Peer-Reviewed Original ResearchPrepregnancy body mass indexGestational weight gainBody mass indexRisk of preeclampsiaTransient hypertensionRisk factorsWeight gainObese womenMass indexHigh gestational weight gainNormal BMI subjectsProspective cohort studyStrong risk factorImmediate postpartum periodMild risk factorDelivery chartsUnderweight womenCohort studyPrepregnancy obesityBMI categoriesWeeks' gestationHighest quartilePrenatal careObserved weight gainPostpartum periodAbortion and Its Effect on Risk of Preeclampsia and Transient Hypertension
Eras J, Saftlas A, Triche E, Hsu C, Risch H, Bracken M. Abortion and Its Effect on Risk of Preeclampsia and Transient Hypertension. Epidemiology 2000, 11: 36-43. PMID: 10615841, DOI: 10.1097/00001648-200001000-00009.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaTransient hypertensionNulliparous womenDecreased riskMore abortionsPregnancy-related risk factorsHistory of abortionHypertensive disordersWeeks' gestationGestational ageSubsequent pregnancyPrenatal careRisk factorsObstetric practicePrior abortionMonths gestationPreeclampsiaHypertensionInduced abortionReproductive historyReferent groupProtective factorsGestationWomenAbortion
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply