2025
Public Water Arsenic and Birth Outcomes in the Environmental Influences on Child Health Outcomes Cohort
Nigra A, Bloomquist T, Rajeev T, Burjak M, Casey J, Goin D, Herbstman J, Ornelas Van Horne Y, Wylie B, Cerna-Turoff I, Braun J, McArthur K, Karagas M, Ames J, Sherris A, Bulka C, Padula A, Howe C, Fry R, Eaves L, Breton C, Cassidy-Bushrow A, Lewis J, MacKenzie D, Beene D, Farzan S, Sathyanarayana S, Hipwell A, Morello-Frosch R, Snyder B, Hartert T, Elliott A, O’Connor T, Kress A, Smith P, Newby L, Adair L, Jacobson L, Catellier D, McGrath M, Douglas C, Duggal P, Knapp E, Kress A, Blackwell C, Mansolf M, Lai J, Ho E, Cella D, Gershon R, Macy M, Das S, Freedman J, Mallal S, McLean J, Shah R, Shilts M, Alshawabkeh A, Cordero J, Meeker J, Trasande L, Camargo C, Hasegawa K, Zhu Z, Sullivan A, Dabelea D, Perng W, Bekelman T, Wilkening G, Magzamen S, Moore B, Starling A, Rinehart D, Koinis Mitchell D, D'Sa V, Deoni S, Mueller H, Duarte C, Monk C, Canino G, Posner J, Murray T, Lugo-Candelas C, Dunlop A, Brennan P, Hockett C, Elliott A, Ferrara A, Croen L, Hedderson M, Ainsworth J, Bacharier L, Bendixsen C, Gern J, Gold D, Hartert T, Jackson D, Johnson C, Joseph C, Kattan M, Khurana Hershey G, Lemanske, Jr. R, Lynch S, Miller R, O’Connor G, Ober C, Ownby D, Rivera-Spoljaric K, Ryan P, Seroogy C, Singh A, Wood R, Zoratti E, Habre R, Farzan S, Gilliland F, Hertz-Picciotto I, Bennett D, Schweitzer J, Schmidt R, LaSalle J, Hipwell A, Karr C, Bush N, LeWinn K, Sathyanarayana S, Zhao Q, Tylavsky F, Carroll K, Loftus C, Leve L, Ganiban J, Neiderhiser J, Weiss S, Litonjua A, McEvoy C, Spindel E, Tepper R, Newschaffer C, Lyall K, Volk H, Landa R, Ozonoff S, Piven J, Hazlett H, Pandey J, Schultz R, Dager S, Botteron K, Messinger D, Stone W, Ames J, O'Connor T, Miller R, Oken E, Hacker M, James-Todd T, O'Shea T, Fry R, Frazier J, Singh R, Rollins C, Montgomery A, Vaidya R, Joseph R, Washburn L, Gogcu S, Bear K, Rollins J, Hooper S, Taylor G, Jackson W, Thompson A, Daniels J, Hernandez M, Lu K, Msall M, Lenski M, Obeid R, Pastyrnak S, Jensen E, Sakai C, Santos H, Kerver J, Paneth N, Barone C, Elliott M, Ruden D, Fussman C, Herbstman J, Margolis A, Schantz S, Geiger S, Aguiar A, Tabb K, Strakovsky R, Woodruff T, Morello-Frosch R, Padula A, Stanford J, Porucznik C, Giardino A, Wright R, Wright R, Collett B, Baumann-Blackmore N, Gangnon R, McKennan C, Wilson J, Altman M, Aschner J, Stroustrup A, Merhar S, Moore P, Pryhuber G, Hudak M, Reynolds Lyndaker A, Lampland A, Rochelson B, Jan S, Blitz M, Katzow M, Brown Z, Chiuzan C, Rafael T, Lewis D, Meirowitz N, Poindexter B, Gebretsadik T, Osmundson S, Straughen J, Eapen A, Cassidy-Bushrow A, Wegienka G, Sitarik A, Woodcroft K, Urquhart A, Levin A, Johnson-Hooper T, Davidson B, Ma T, Barrett E, Blaser M, Dominguez-Bello M, Horton D, Jimenez M, Rosen T, Palomares K, Avalos L, Zhu Y, Hunt K, Newman R, Bloom M, Alkis M, Roberts J, Mumford S, Burris H, DeMauro S, Yee L, Hamvas A, Olidipo A, Haddad A, Eiland L, Spillane N, Suri K, Fisher S, Goldstein J, Mithal L, DeRegnier R, Maitre N, Nguyen R, JaKa M, Sidebottom A, Paidas M, Potter J, Ruby N, Duthely L, Jayakumar A, Young K, Maldonado I, Miller M, Slaughter J, Keim S, Lynch C, Venkatesh K, Whitworth K, Symanski E, Northrup T, Mendez-Figueroa H, Mosquera R, Karagas M, Madan J, MacKenzie D, Lewis J, Rennie B, Leventhal B, Kim Y, Bishop S, Nozadi S, Luo L, Lester B, Marsit C, Everson T, Loncar C, McGowan E, Sheinkopf S, Carter B, Check J, Helderman J, Neal C, Smith L. Public Water Arsenic and Birth Outcomes in the Environmental Influences on Child Health Outcomes Cohort. JAMA Network Open 2025, 8: e2514084. PMID: 40522663, PMCID: PMC12171937, DOI: 10.1001/jamanetworkopen.2025.14084.Peer-Reviewed Original ResearchConceptsBirth weight-for-gestational age z-scoreLow birth weightAge z-scoreAdjusted risk ratiosAdverse birth outcomesBirth outcomesBirth weightMaximum contaminant levelWater arsenicWater arsenic exposureRisk ratioGestational agePreterm birthZ-scoreContamination levelsCohort studyAssociated with adverse birth outcomesHigher risk of low birth weightArsenic exposureParent-infant dyadsRisk of low birth weightUS Environmental Protection Agency maximum contaminant levelChild health outcomesAssociated with birth outcomesEnvironmental Protection Agency maximum contaminant levelEffects of Prenatal Exposure to PM2.5 Chemical Components on Adverse Birth Outcomes and Under-5 Mortality in South Korea
Byun G, Choi Y, Lee J, Bell M. Effects of Prenatal Exposure to PM2.5 Chemical Components on Adverse Birth Outcomes and Under-5 Mortality in South Korea. Epidemiology 2025, 36: 531-540. PMID: 40257114, PMCID: PMC12118620, DOI: 10.1097/ede.0000000000001868.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir PollutantsChild MortalityChild, PreschoolFemaleHumansInfantInfant MortalityInfant, Low Birth WeightInfant, NewbornInfant, Small for Gestational AgeLogistic ModelsMaleMaternal ExposureParticulate MatterPregnancyPregnancy OutcomePremature BirthPrenatal Exposure Delayed EffectsRepublic of KoreaConceptsAdverse birth outcomesAssociated with adverse birth outcomesBirth outcomesRisk of preterm birthExposure to PMPreterm birthLow birth weightAssociated with increased odds of PTBIncreased risk of PTBOdds of preterm birthAssociations of prenatal exposureUnder-5 MortalityExposure to fine particulate matterPopulation of South KoreaAssociated with increased oddsPrenatal exposureAge 5 yearsDeath recordsBirth weightBirth recordsUnder-5Pregnancy exposureEffects of prenatal exposureEffect estimatesLogistic regression
2024
Influenza Activity and Preterm Birth in the Atlanta Metropolitan Area: A Time-Series Analysis from 2010 to 2017
Zheng X, Wang T, Hao H, D’Souza R, Strickland M, Warren J, Darrow L, Chang H. Influenza Activity and Preterm Birth in the Atlanta Metropolitan Area: A Time-Series Analysis from 2010 to 2017. Epidemiology 2024, 36: 141-148. PMID: 39588975, PMCID: PMC11785485, DOI: 10.1097/ede.0000000000001819.Peer-Reviewed Original ResearchInfluenza-like illnessExposure lagTest positivityPreterm birthPregnant peopleRisk of adverse birth outcomesIncreased risk of adverse birth outcomesInfluenza activityAssociated with increased risk of preterm birthInterquartile range increaseAdverse birth outcomesTime-varying confoundersComposite measureRisk of preterm birthShort-term associationsAssociated with increased riskPublic health burdenPoisson log-linear modelSymptoms of influenza-like illnessEstimate associationsBirth outcomesEffect modificationAnnual influenza epidemicsRange increaseMaternal characteristicsBarriers and facilitators for implementing the WHO Safe Childbirth Checklist (SCC) in Mozambique: A qualitative study using the Consolidated Framework for Implementation Research (CFIR)
He A, Kanduma E, Pérez-Escamilla R, Buckshee D, Chaquisse E, Cuco R, Desai M, Munguambe D, Reames S, Manuel I, Spiegelman D, Xu D. Barriers and facilitators for implementing the WHO Safe Childbirth Checklist (SCC) in Mozambique: A qualitative study using the Consolidated Framework for Implementation Research (CFIR). PLOS Global Public Health 2024, 4: e0003174. PMID: 39236014, PMCID: PMC11376584, DOI: 10.1371/journal.pgph.0003174.Peer-Reviewed Original ResearchConsolidated Framework for Implementation ResearchSafe Childbirth ChecklistBirth attendantsImplementation researchFocus group discussionsChildbirth practicesWHO Safe Childbirth ChecklistQualitative studyReduce adverse birth outcomesChildbirth-related complicationsGroup discussionsQuality of careNeonatal deathWeak health systemsAdverse birth outcomesPre-implementation assessmentEvidence-based practiceDeductive thematic analysisLow-resource settingsNeonatal mortality rateHealth systemMaternity carePre-implementationBirth outcomesProvider motivationDisparities in exposure to concentrated animal feeding operations (CAFOs) and risk of adverse birth outcomes in Pennsylvania, USA
Son J, Bell M. Disparities in exposure to concentrated animal feeding operations (CAFOs) and risk of adverse birth outcomes in Pennsylvania, USA. Heliyon 2024, 10: e34985. PMID: 39145018, PMCID: PMC11320432, DOI: 10.1016/j.heliyon.2024.e34985.Peer-Reviewed Original ResearchAdverse birth outcomesRisk of preterm birthBirth outcomesAssociated with higher riskLow birth weightWIC statusHealth outcomesMaternal characteristicsPreterm birthAssociated with higher risk of preterm birthRisk of adverse birth outcomesPennsylvania Department of HealthHigher risk of preterm birthAssociated health outcomesDepartment of HealthCross-sectional studyAssociated health burdenSignificant public health concernPublic health concernPrenatal careEvaluate disparitiesChild healthBirth recordsMarital statusSmoking statusAssociations between Individual- and Structural-Level Racism and Gestational Age at Birth in the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be
Barcelona V, Chen L, Zhao Y, Samari G, Monk C, McNeil R, Baccarelli A, Wapner R. Associations between Individual- and Structural-Level Racism and Gestational Age at Birth in the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be. Journal Of Urban Health 2024, 101: 682-691. PMID: 38992222, PMCID: PMC11329443, DOI: 10.1007/s11524-024-00889-1.Peer-Reviewed Original ResearchConceptsExperiences of discriminationNulliparous womenMeasures of structural racismSecondary analysis of dataStructural racismNulliparous Pregnancy Outcomes StudyMonitoring Mothers-to-BeAdverse birth outcomesMeasuring structural racismMothers-to-bePregnancy Outcomes StudyGestational ageIndex of ConcentrationBirth outcomesModifiable factorsExperiences of racismSecondary analysisNuMoM2b studyAnalysis of dataSubgroup analysisOutcome studiesU.S. measuresWomenIndividual-Structural-levelAssociations of maternal blood metal concentrations with plasma eicosanoids among pregnant women in Puerto Rico
Kim C, Cathey A, Park S, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Associations of maternal blood metal concentrations with plasma eicosanoids among pregnant women in Puerto Rico. The Science Of The Total Environment 2024, 928: 172295. PMID: 38588744, DOI: 10.1016/j.scitotenv.2024.172295.Peer-Reviewed Original ResearchConceptsAdverse birth outcomesSex-specific associationsBirth outcomesBlood metal concentrationsMetal concentrationsPregnant womenInfant sexEicosanoid profileMetal exposurePlasma eicosanoidsWeeks of pregnancyDecreased concentrations of CdConcentrations of CdConcentrations of CuEffect modificationRegulating inflammatory responsesBirth cohortAssessed associationsAssociated with increased concentrationsPregnancy outcomesFemale fetusesEffect sizeInflammatory activitySignificant associationInflammatory responseMaternal exposure to ambient air temperature and adverse birth outcomes: An umbrella review of systematic reviews and meta-analyses
Nyadanu S, Dunne J, Tessema G, Mullins B, Kumi-Boateng B, Bell M, Duko B, Pereira G. Maternal exposure to ambient air temperature and adverse birth outcomes: An umbrella review of systematic reviews and meta-analyses. The Science Of The Total Environment 2024, 917: 170236. PMID: 38272077, DOI: 10.1016/j.scitotenv.2024.170236.Peer-Reviewed Original ResearchConceptsAdverse birth outcomesBirth outcomesRisk of biasSystematic reviewUmbrella reviewMeta-analysesUmbrella review of systematic reviewsReview of systematic reviewsJoanna Briggs Institute critical appraisal toolsAssociated with adverse birth outcomesPrimary studiesSystematic review repositoriesOverlap of primary studiesEpidemiological evidenceMultiple Systematic ReviewsCritical appraisal toolsAssociated with increased risk of preterm birthEnvironmental health researchModerate risk of biasRisk of preterm birthElectronic grey literatureSystematic review guidelinesMaternal exposureAssociated with increased riskAppraisal tool
2023
Associations between maternal urinary rare earth elements during pregnancy and birth weight-for-gestational age: Roles of cord blood vitamin D levels
Fang X, Xie Y, Cao S, Liu J, Shi Y, Yu L, Zheng T, Liu H, Li Y, Xu S, Xia W. Associations between maternal urinary rare earth elements during pregnancy and birth weight-for-gestational age: Roles of cord blood vitamin D levels. The Science Of The Total Environment 2023, 912: 169222. PMID: 38081430, DOI: 10.1016/j.scitotenv.2023.169222.Peer-Reviewed Original ResearchCord blood vitamin D levelsBlood vitamin D levelsCord blood vitamin DVitamin D levelsBlood vitamin DFetal growth restrictionGestational ageD levelsVitamin DPrenatal exposureBirth weightUrinary concentrationsGrowth restrictionLow vitamin D levelsZ-scoreMother-newborn pairsAdverse birth outcomesLower BWAverage urinary concentrationsBirth outcomesFetal growthCord bloodHigher oddsEnvironmental exposuresExposure-mediator interactionEffects of air pollution on adverse birth outcomes and pregnancy complications in the U.S. state of Kansas (2000–2015)
Hao H, Yoo S, Strickland M, Darrow L, D’Souza R, Warren J, Moss S, Wang H, Zhang H, Chang H. Effects of air pollution on adverse birth outcomes and pregnancy complications in the U.S. state of Kansas (2000–2015). Scientific Reports 2023, 13: 21476. PMID: 38052850, PMCID: PMC10697947, DOI: 10.1038/s41598-023-48329-5.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusAdverse birth outcomesLow birth weightGestational hypertensionBirth outcomesBirth weightPregnancy complicationsPreterm birthFirst trimesterRisk of GDMMaternal medical complicationsSingleton live birthsWeeks of pregnancyO3 exposureAdverse pregnancyPregnancy exposurePregnancy outcomesDiabetes mellitusMedical complicationsAdverse birthThird trimesterNeonatal mortalityResidential census tractsSocio-economic status factorsDiscrete-time survivalWildfire smoke exposure during pregnancy and perinatal, obstetric, and early childhood health outcomes: A systematic review and meta-analysis
Foo D, Stewart R, Heo S, Dhamrait G, Choi H, Song Y, Bell M. Wildfire smoke exposure during pregnancy and perinatal, obstetric, and early childhood health outcomes: A systematic review and meta-analysis. Environmental Research 2023, 241: 117527. PMID: 37931734, DOI: 10.1016/j.envres.2023.117527.Peer-Reviewed Original ResearchConceptsEarly childhood health outcomesWildfire smoke exposureAdverse birth outcomesChildhood health outcomesSmoke exposureHealth outcomesMaternal exposureBirth outcomesLow birthweightHomogenous studiesSystematic reviewData extractionEpidemiological observational studiesOvid/EmbaseOvid/MedlineAdverse health outcomesScreening of titlesWeb of ScienceBirthweight reductionPreterm birthBias assessmentDistance of residenceObservational studyIndependent reviewersChild healthAdverse birth outcomes are associated with circulating matrix metalloproteinases among pregnant women in Puerto Rico
Kim C, Cathey A, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Adverse birth outcomes are associated with circulating matrix metalloproteinases among pregnant women in Puerto Rico. Journal Of Reproductive Immunology 2023, 159: 103991. PMID: 37454540, PMCID: PMC10726844, DOI: 10.1016/j.jri.2023.103991.Peer-Reviewed Original ResearchConceptsBirth outcomesMatrix metalloproteinasesFetal sexPregnant womenFemale fetusesNewborn lengthVisit 3Associated with increased odds of preeclampsiaVisit 1Impact of matrix metalloproteinasesCustomized Luminex assayGestational diabetes mellitusOdds of preeclampsiaAdverse birth outcomesAssociated with increased oddsGestational ageHealthy pregnancyMale fetusesUterine remodelingLuminex assayLogistic regression modelsDiabetes mellitusStudy visitsInverse associationExtracellular matrixAssociation between Sexual Activity during Pregnancy, Pre- and Early-Term Birth, and Vaginal Cytokine Inflammation: A Prospective Study of Black Women
Dougherty K, Zhao Y, Dunlop A, Corwin E. Association between Sexual Activity during Pregnancy, Pre- and Early-Term Birth, and Vaginal Cytokine Inflammation: A Prospective Study of Black Women. Healthcare 2023, 11: 1995. PMID: 37510436, PMCID: PMC10379435, DOI: 10.3390/healthcare11141995.Peer-Reviewed Original ResearchSpontaneous preterm birthVaginal sexBirth outcomesLate pregnancySexual activityCytokine inflammationEarly-term birthFull-term birthElevated IL6 levelsAdverse birth outcomesBlack pregnant womenPreterm birthPregnant womenIL6 levelsProspective studyPregnancyInflammationBirthSexOutcomesWomenAssociationBlack womenPositive associationInconsistent mediation modelAssociation Between Estimated Geocoded Residential Maternal Exposure to Lithium in Drinking Water and Risk for Autism Spectrum Disorder in Offspring in Denmark
Liew Z, Meng Q, Yan Q, Schullehner J, Hansen B, Kristiansen S, Voutchkova D, Olsen J, Ersbøll A, Ketzel M, Raaschou-Nielsen O, Ritz B. Association Between Estimated Geocoded Residential Maternal Exposure to Lithium in Drinking Water and Risk for Autism Spectrum Disorder in Offspring in Denmark. JAMA Pediatrics 2023, 177: 617-624. PMID: 37010840, PMCID: PMC10071398, DOI: 10.1001/jamapediatrics.2023.0346.Peer-Reviewed Original ResearchConceptsMaternal exposureOdds ratioStratified analysisNationwide population-based case-control studyPopulation-based case-control studyDanish Medical Birth RegistryDanish Psychiatric Central RegisterAutism spectrum disorderMedical Birth RegistryNovel environmental risk factorTenth Revision codesAdverse birth outcomesControl participantsMaternal prenatal exposureMaternal residential addressBirth yearCase-control studyPsychiatric Central RegisterMood-stabilizing effectsAir pollution exposureEnvironmental risk factorsInternational Statistical ClassificationWnt/β-catenin signalingStudy teamRelated Health ProblemsNeighborhood Incarceration Rates and Adverse Birth Outcomes in New York City, 2010-2014
Holaday L, Tolliver D, Moore T, Thompson K, Wang E. Neighborhood Incarceration Rates and Adverse Birth Outcomes in New York City, 2010-2014. JAMA Network Open 2023, 6: e236173. PMID: 37000451, PMCID: PMC10066462, DOI: 10.1001/jamanetworkopen.2023.6173.Peer-Reviewed Original ResearchConceptsHigher incidence rate ratioIncidence rate ratiosAdverse birth outcomesLow birth weightPreterm birthBirth outcomesBirth weightRacial disparitiesHigh rateVery preterm birthCross-sectional studyPercentage of birthsSubstantial racial disparitiesSecondary outcomesPrimary outcomeBlack raceMultivariable modelNeighborhood disadvantageNew York City DepartmentMAIN OUTCOMECensus tractsMaternal factorsPoisson regressionUS census tractsRate ratio
2022
Maternal blood metal concentrations are associated with C-reactive protein and cell adhesion molecules among pregnant women in Puerto Rico
Kim C, Cathey A, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal blood metal concentrations are associated with C-reactive protein and cell adhesion molecules among pregnant women in Puerto Rico. Environmental Epidemiology 2022, 6: e214. PMID: 35975168, PMCID: PMC9374188, DOI: 10.1097/ee9.0000000000000214.Peer-Reviewed Original ResearchVascular cell adhesion moleculeC-reactive proteinLevels of C-reactive proteinAssociated with C-reactive proteinCell adhesion moleculesAdverse birth outcomesIntercellular adhesion moleculeFetal sexAdhesion moleculesBirth outcomesPregnant womenLinear mixed effects modelsVisit 3Visit 1Maternal C-reactive proteinCustomized Luminex assaySignificant associationBlood samplesPositive associationPrenatal metal exposureWeeks gestationLuminex assayMale fetusesBirth cohortAssessed associationsThe influence of structural racism, pandemic stress, and SARS-CoV-2 infection during pregnancy with adverse birth outcomes
Janevic T, Lieb W, Ibroci E, Lynch J, Lieber M, Molenaar NM, Rommel AS, de Witte L, Ohrn S, Carreño JM, Krammer F, Zapata LB, Snead MC, Brody RI, Jessel RH, Sestito S, Adler A, Afzal O, Gigase F, Missall R, Carrión D, Stone J, Bergink V, Dolan SM, Howell EA, Group K. The influence of structural racism, pandemic stress, and SARS-CoV-2 infection during pregnancy with adverse birth outcomes. American Journal Of Obstetrics & Gynecology MFM 2022, 4: 100649. PMID: 35462058, PMCID: PMC9022447, DOI: 10.1016/j.ajogmf.2022.100649.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionGestational age infantsGestational age newbornsPreterm birthAdverse birth outcomesBirth outcomesZone improvement plan codeRelative riskPandemic-related stressPublic insuranceElectronic medical record databasePregnant personsSerologic enzyme-linked immunosorbentBody mass indexLog-binomial regressionMedical record databaseCOVID-19 mortality ratesEnzyme-linked immunosorbentNeighborhood measuresProspective cohortHighest quartileAdjusted analysisMass indexInsurance statusMaternal ageBiomarkers of Exposure to Phthalate Mixtures and Adverse Birth Outcomes in a Puerto Rico Birth Cohort
Cathey A, Watkins D, Rosario Z, Vélez C, Mukherjee B, Alshawabkeh A, Cordero J, Meeker J. Biomarkers of Exposure to Phthalate Mixtures and Adverse Birth Outcomes in a Puerto Rico Birth Cohort. Environmental Health Perspectives 2022, 130: 037009. PMID: 35333099, PMCID: PMC8953418, DOI: 10.1289/ehp8990.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPreterm birthFetal sexGestational agePregnancy outcomesBirth outcomesBayesian kernel machine regressionPhthalate metabolitesRisk of early deliveryAssociated with increased odds of PTBOdds of preterm birthPhthalate mixtureReduced gestational ageIndividual phthalate metabolitesMeasures of birth weightAssociated with increased riskPhthalate metabolite mixturesAdverse birth outcomesAssociated with increased oddsPuerto Rico TestsiteEnvironmental risk scoreEarly deliveryBirth weightPregnancy cohortLongitudinal pregnancy cohortTrophoblast inclusions and adverse birth outcomes
Firestein MR, Kliman HJ, Sania A, Brink LT, Holzer PH, Hofmann KM, Milano KM, Pini N, Shuffrey LC, Odendaal HJ, Fifer WP. Trophoblast inclusions and adverse birth outcomes. PLOS ONE 2022, 17: e0264733. PMID: 35231069, PMCID: PMC8887719, DOI: 10.1371/journal.pone.0264733.Peer-Reviewed Original ResearchConceptsBirth outcomesGestational ageLiveborn deliveryLive birthsFull-term live birthsChorionic villiPreterm live birthsSpecific placental pathologyFull-term birthInduction of laborAdverse birth outcomesGestational age birthweightSafe Passage StudyTrophoblast inclusionsGreater odds ratioWarrants further investigationPlacental infarctionPlacenta accretaPreterm birthPlacental pathologyVillous edemaPatient populationAlcohol exposureOdds ratioChorionic plateMaternal blood metal concentrations are associated with matrix metalloproteinases (MMPs) among pregnant women in Puerto Rico
Kim C, Cathey A, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal blood metal concentrations are associated with matrix metalloproteinases (MMPs) among pregnant women in Puerto Rico. Environmental Research 2022, 209: 112874. PMID: 35123972, PMCID: PMC10443181, DOI: 10.1016/j.envres.2022.112874.Peer-Reviewed Original ResearchConceptsBlood metal concentrationsAdverse birth outcomesMetal concentrationsAssociated with matrix metalloproteinasesMatrix metalloproteinasesBirth outcomesFetal sexHealthy pregnancyLinear mixed effects modelsUterine remodelingPregnant womenFemale fetusesExposure to heavy metalsHeavy metal exposureCustomized Luminex assayFetal sex effectLevels of inflammatory cytokinesTrimester of pregnancyBlood metal levelsMetal levelsHeavy metalsMetal exposureMeasured blood concentrationsLuminex assayMale fetuses
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