2025
Steamed panax notoginseng mitigates CA-MRSA USA300-induced necroptosis in human neutrophils
Zhang L, Feng X, An H, Yang W, Xia Y, Wen B, Zheng H, Chen Y, Cheng Y, Jiang C, Lu C, Tan Y. Steamed panax notoginseng mitigates CA-MRSA USA300-induced necroptosis in human neutrophils. Frontiers In Pharmacology 2025, 16: 1546652. PMID: 40520183, PMCID: PMC12163054, DOI: 10.3389/fphar.2025.1546652.Peer-Reviewed Original ResearchCA-MRSAVirulence factorsCommunity-associated methicillin-resistant <i>Staphylococcus aureus</i> (CAQuorum-sensing signaling pathwayPolymorphonuclear neutrophil countMethicillin-resistant <i>Staphylococcus aureus</i> (MRPhagocytic function of polymorphonuclear neutrophilsGenes of MRSAPolymorphonuclear neutrophilsSignaling pathwayCA-MRSA infectionsHost innate immune responseBacterial virulence factorsDrug-resistant bacterial infectionsMCP-1IL-1BIL-8Pro-inflammatory cytokines IL-1bDisrupt innate immunityInnate immune responseRNA-seqFunctions of polymorphonuclear neutrophilsPathogenic microbial infectionsPanax notoginsengCytokines IL-1bIntermediate Signaling Mechanisms Regulating Human Fetal Membrane Responses to Gram‐Positive Bacterial Peptidoglycan
Georges H, Fischer A, Abrahams V. Intermediate Signaling Mechanisms Regulating Human Fetal Membrane Responses to Gram‐Positive Bacterial Peptidoglycan. American Journal Of Reproductive Immunology 2025, 93: e70090. PMID: 40435036, PMCID: PMC12124414, DOI: 10.1111/aji.70090.Peer-Reviewed Original ResearchConceptsToll-like receptorsPro-inflammatory cytokines IL-1bFetal membrane explantsHuman FM explantsPathogenesis of chorioamnionitisP65-NFkBResponse to Gram-positive bacteriaP38 MAPKElevated levelsTLR2 agonist peptidoglycanCytokines IL-1bChemokine IL-8FM explantsNeonatal morbidityPreterm birthStimulation of TLR4Fetal membranesMembrane weakeningIL-1BIL-8TLR7/8 activationMembrane explantsSecreted factorsERK signalingLipopolysaccharide stimulationBroxyquinoline targets NLRP3 to inhibit inflammasome activation and alleviate NLRP3-associated inflammatory diseases
Tang H, Zou X, Chen P, Wang Y, Gao S, Wang T, Xu Y, Ji S. Broxyquinoline targets NLRP3 to inhibit inflammasome activation and alleviate NLRP3-associated inflammatory diseases. International Immunopharmacology 2025, 156: 114687. PMID: 40253767, DOI: 10.1016/j.intimp.2025.114687.Peer-Reviewed Original ResearchConceptsExperimental autoimmune encephalomyelitisNLR family pyrin domain-containing 3Inflammasome activationInflammatory diseasesASC speck formationInflammasome-associated diseasesNEK7-NLRP3 interactionDamage signalingNF-kB pathwayHost defensePyrin domain-containing 3Speck formationAIM2 inflammasome activationActivation of NLRP3 inflammasomeFamily pyrin domain-containing 3Autoimmune encephalomyelitisMurine modelInterleukin-1bIL-1BInhibiting inflammasome activationNLRP3 inflammasome inhibitorAntimicrobial drugsNF-kBProteinTherapeutic agentsBuprenorphine induces human fetal membrane sterile inflammation
Lynn T, Kelleher M, Georges H, McCauley E, Logan R, Yonkers K, Abrahams V. Buprenorphine induces human fetal membrane sterile inflammation. Journal Of Reproductive Immunology 2025, 168: 104445. PMID: 39914058, PMCID: PMC11890952, DOI: 10.1016/j.jri.2025.104445.Peer-Reviewed Original ResearchConceptsOpioid-use disorderPreterm birthToll-like receptor 4Prostaglandin E2Sterile inflammationRate of preterm birthAssociated with pregnancy complicationsInnate immune toll-like receptor 4Maternal-fetal interfaceNeutrophil chemokine IL-8Induce sterile inflammationM-opioid receptorCytokines IL-1bInflammatory cytokines IL-6Chemokine IL-8Cytokines IL-6Maternal morbidityPregnancy complicationsOpioid useOpioid-usersHuman FMInflammatory profileMembrane weakeningIL-1BPreterm
2024
IL-1β Induces Human Endothelial Surface Expression of IL-15 by Relieving let-7c-3p Suppression of Protein Translation.
Mullan C, Summer L, Lopez-Giraldez F, Tobiasova Z, Manes T, Yasothan S, Song G, Jane-Wit D, Saltzman W, Pober J. IL-1β Induces Human Endothelial Surface Expression of IL-15 by Relieving let-7c-3p Suppression of Protein Translation. The Journal Of Immunology 2024, 213: 1338-1348. PMID: 39302113, PMCID: PMC11493510, DOI: 10.4049/jimmunol.2400331.Peer-Reviewed Original ResearchIL-15Surface expressionIL-1BIL-15 transcriptsEndothelial cellsCD8 T cell activationExpression of IL-15EC surface expressionIL-15 transpresentationComplement activationGraft endothelial cellsActivity of CTLT cell activationIL-15 mRNAEndothelial surface expressionAbsence of complement activationCultured human endothelial cellsIL-1-mediated activationIL-15RAProtein translationAllograft rejectionRNA polymerase II-mediated transcriptionHuman endothelial cellsSuppression of protein translationIL-1β mediates Candida tropicalis-induced immunosuppressive function of MDSCs to foster colorectal cancer
Zhang Z, Chen Y, Pan X, Li P, Ren Z, Wang X, Chen Y, Shen S, Wang T, Lin A. IL-1β mediates Candida tropicalis-induced immunosuppressive function of MDSCs to foster colorectal cancer. Cell Communication And Signaling 2024, 22: 408. PMID: 39164774, PMCID: PMC11337875, DOI: 10.1186/s12964-024-01771-y.Peer-Reviewed Original ResearchConceptsImmunosuppressive function of MDSCsFunction of MDSCsExpression of IL-1bImmunosuppressive functionC. tropicalisColorectal cancerIL-1BProgression of colorectal cancerAntitumor immunityNLRP3 inflammasome activationColon cancer xenograft modelTumor-infiltrating MDSCsInhibit antitumor immunityPotential immunotherapeutic strategyRegulating tumor immunityTreatment of colorectal cancerSeverity of colorectal cancerCancer xenograft modelColon cancer cell linesInflammasome activationHuman colorectal cancerNLRP3 inflammasomeIn vitro supplementationImmunotherapeutic strategiesPromote CRC progressionNew applications of clioquinol in the treatment of inflammation disease by directly targeting arginine 335 of NLRP3
Chen P, Wang Y, Tang H, Zhou C, Liu Z, Gao S, Wang T, Xu Y, Ji S. New applications of clioquinol in the treatment of inflammation disease by directly targeting arginine 335 of NLRP3. Journal Of Pharmaceutical Analysis 2024, 15: 101069. PMID: 39902456, PMCID: PMC11788862, DOI: 10.1016/j.jpha.2024.101069.Peer-Reviewed Original ResearchNOD-like receptor protein 3Innate immune-mediated inflammationExperimental acute peritonitisInhibition of nod-like receptor protein 3Treatment of inflammation diseasesTumor necrosis factor-aImmune-mediated inflammationLowered serum levelsNOD-like receptor protein 3 inflammasomeReduced cytokine secretionNLRP3 inflammasome assemblyTarget arginineNACHT domainComponent proteinsReceptor protein 3Inflammasome assemblyAcute peritonitisSerum levelsCytokine secretionTreatment strategiesInterleukin-1bTNF-aInhibitory concentrationIL-1BInhibiting NLRP3 activationCaspase-4/11 promotes hyperlipidemia and chronic kidney disease-accelerated vascular inflammation by enhancing trained immunity
Sun Y, Lu Y, Liu L, Saaoud F, Shao Y, Xu K, Drummer C, Cueto R, Shan H, Jiang X, Zhao H, Wang H, Yang X. Caspase-4/11 promotes hyperlipidemia and chronic kidney disease-accelerated vascular inflammation by enhancing trained immunity. JCI Insight 2024, 9: e177229. PMID: 39024553, PMCID: PMC11343595, DOI: 10.1172/jci.insight.177229.Peer-Reviewed Original ResearchChronic kidney diseaseTrained immunityAortic endothelial cellsVascular inflammationEndothelial cellsRecruitment of macrophagesIL-1b levelsHuman aortic endothelial cellsHigh-fat dietMembrane expressionN-terminal gasdermin DCytokine secretionPathological analysisIL-1BKidney diseaseNeointima hyperplasiaCaspase-4/11HyperlipidemiaInflammationCytosolic lipopolysaccharideCaspase-11RNA sequencingGasdermin DImmunityLipopolysaccharideHigh burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children
Watkins T, Green A, Amat J, Cheemarla N, Hänsel K, Lozano R, Dudgeon S, Germain G, Landry M, Schulz W, Foxman E. High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children. Journal Of Experimental Medicine 2024, 221: e20230911. PMID: 38949638, PMCID: PMC11215523, DOI: 10.1084/jem.20230911.Peer-Reviewed Original ResearchConceptsBacterial pathobiontsRespiratory virusesBurden of virusesSARS-CoV-2Innate immune activationSARS-CoV-2 viral loadDynamic host-pathogen interactionsInnate immune responseViral coinfectionCytokine profileViral loadNasal virusImmune activationProinflammatory responseIL-1BNasopharyngeal samplesHost-pathogen interactionsImmune responseInterferon responsePathobiontsInnate immunityPaired samplesCXCL10Healthy 1-year-oldVirusDecidual Cells Block Inflammation-Mediated Inhibition of 15-Hydroxyprostaglandin Dehydrogenase in Trophoblasts
de Assis V, Kayisli U, Ozmen A, Semerci N, Totary-Jain H, Pakasticali N, Halade G, Lockwood C, Guzeloglu-Kayisli O. Decidual Cells Block Inflammation-Mediated Inhibition of 15-Hydroxyprostaglandin Dehydrogenase in Trophoblasts. American Journal Of Pathology 2024, 194: 1724-1736. PMID: 38879084, DOI: 10.1016/j.ajpath.2024.05.005.Peer-Reviewed Original ResearchConditioned medium supernatantTerm decidual cellsDecidual cellsExtravillous trophoblastHPGD expressionGestational age-matched controlsHuman trophoblast stem cellsFetal membrane ruptureMaternal-fetal interfaceTrophoblast stem cellsAge-matched controlsDecidua parietalisCervical ripeningUterine quiescencePreterm birthUterine contractionsAnchoring villiPrimary trophoblastsParacrine mechanismsParacrine inhibitionPregnancy maintenanceIL-1BInactivate prostaglandinsStem cellsProstaglandinAbstract 3015: Matrix Metalloproteinase Inhibition In Rat Abdominal Aortic Aneurysm
Zaghloul M, Elizondo-Benedetto S, Arif B, Heo G, Luehmann H, Liu Y, Gropler R, Sadeghi M, Zayed M. Abstract 3015: Matrix Metalloproteinase Inhibition In Rat Abdominal Aortic Aneurysm. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: a3015-a3015. DOI: 10.1161/atvb.44.suppl_1.3015.Peer-Reviewed Original ResearchAbdominal aortic aneurysmPostoperative day 3Rupture of abdominal aortic aneurysmsTreated ratsInhibition of matrix metalloproteinasesMatrix metalloproteinase inhibitionMatrix metalloproteinase inhibitorsMatrix metalloproteinasesAortic aneurysmRat modelAbdominal aortic aneurysm diameterUntreated groupMale Sprague-Dawley ratsAbdominal aortic aneurysm rupture rateSprague-Dawley ratsAortic diameter measurementsActive MMP-9Rate of ruptureDegradation of extracellular matrix proteinsAbdominal aortic aneurysm researchIL-17ARadiotracer uptakeUntreated ratsTNF-aIL-1B
2023
A discrete ‘early-responder’ stromal-cell subtype orchestrates immunocyte recruitment to injured tissue
Yaghi O, Hanna B, Langston P, Michelson D, Jayewickreme T, Marin-Rodero M, Benoist C, Mathis D. A discrete ‘early-responder’ stromal-cell subtype orchestrates immunocyte recruitment to injured tissue. Nature Immunology 2023, 24: 2053-2067. PMID: 37932455, PMCID: PMC10792729, DOI: 10.1038/s41590-023-01669-w.Peer-Reviewed Original ResearchConceptsMesenchymal stromal cellsStromal cellsMouse modelMouse model of muscular dystrophyModels of muscular dystrophyAcute injuryUnique surface markersRecruitment of neutrophilsResponse to injuryStromal cell subtypesImmunomodulatory programsImmunocyte recruitmentCell collaborationTissue regenerationStroma-specificTNF-aSurface markersDay 1IL-1BCell subtypesInflammatory programMuscular dystrophyInduce inflammationSubtypesOncostatin MIncreased Interleukins: Effect of Risperidone in Individuals with Schizophrenia—a Systematic Review
Ramos-Méndez M, Tovilla-Zárate C, Juárez-Rojop I, López-Narváez M, Genis-Mendoza A, González-Castro T, Martínez-Magaña J, Villar-Juárez G, Bellizzia-Rodríguez M, Castillo-Avila R, Hernández-Díaz Y, Ojeda R. Increased Interleukins: Effect of Risperidone in Individuals with Schizophrenia—a Systematic Review. SN Comprehensive Clinical Medicine 2023, 5: 142. DOI: 10.1007/s42399-023-01479-z.Peer-Reviewed Original ResearchInterleukin levelsIL-10IL-6IL-8IL-4IL-2IL-1BSystematic reviewPro-inflammatory cytokine levelsRole of risperidoneFirst-line treatmentPro-inflammatory interleukinsEffects of risperidoneCase-control studyCytokine levelsIL-17AIL-12Regular treatmentRisperidoneSerum increasesControl groupInterleukinSchizophreniaSystematic searchMore studiesModulating IL-1β and its receptors shapes spike-specific CD4+ T cell responses to mRNA vaccination
Park H, Shin M, Shin J, Kim H, Kang B, Par-Young J, Unlu S, Afinogenova Y, Catanzaro J, Young J, Kim M, Lee S, You S, Racke M, Bucala R, Kang I. Modulating IL-1β and its receptors shapes spike-specific CD4+ T cell responses to mRNA vaccination. The Journal Of Immunology 2023, 210: 159.20-159.20. DOI: 10.4049/jimmunol.210.supp.159.20.Peer-Reviewed Original ResearchCOVID-19 mRNA vaccinesT cellsIL-1βIL-1R2MRNA vaccinesIL-1 receptor 1IL-1R1 expressionIL-1R2 expressionSpike-specific CD4Vaccine-induced CD4T cell immunityT cell responsesSpecific antibody productionMRNA vaccinationCell immunityDurable immunityIL-1R1IL-1BCD4Healthy individualsQuest DiagnosticsAntibody productionCell responsesReceptor 1Receptor system
2021
Suicide associated with COVID-19 infection: an immunological point of view.
Choi M, Yang J, Lee S, Kim J, Oh J, Lee J, Stubbs B, Lee K, Koyanagi A, Hong S, Ghayda R, Hwang J, Dragioti E, Jacob L, Carvalho A, Radua J, Thompson T, Smith L, Fornaro M, Stickley A, Bettac E, Han Y, Kronbichler A, Yon D, Lee S, Shin J, Lee E, Solmi M. Suicide associated with COVID-19 infection: an immunological point of view. European Review For Medical And Pharmacological Sciences 2021, 25: 6397-6407. PMID: 34730221, DOI: 10.26355/eurrev_202110_27013.Peer-Reviewed Original ResearchConceptsCOVID-19 patientsTh2 cytokinesCause of deathIFN-gCOVID-19 infectionInflammatory featuresCytokine pathwaysIL-1BCytokine stormInflammatory responseObservational studyPubMed databaseInflammationImmunological pointPatientsCoronavirus disease 2019CytokinesInfectionMeta-analysesNeurological conditionsCOVID-19Risk of suicideIncreased suicide riskDeathPeripheral levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and interleukin-1β across the mood spectrum in bipolar disorder: A meta-analysis of mean differences and variability
Solmi M, Suresh Sharma M, Osimo E, Fornaro M, Bortolato B, Croatto G, Miola A, Vieta E, Pariante C, Smith L, Fusar-Poli P, Shin J, Berk M, Carvalho A. Peripheral levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and interleukin-1β across the mood spectrum in bipolar disorder: A meta-analysis of mean differences and variability. Brain Behavior And Immunity 2021, 97: 193-203. PMID: 34332041, DOI: 10.1016/j.bbi.2021.07.014.Peer-Reviewed Original ResearchConceptsC-reactive proteinInflammatory mediator levelsTNF-aIL-6Meta-analysisSystematic review of observational studiesIL-1BSystematic reviewManic episodesReview of observational studiesBipolar disorderLow-quality studiesFull-text reviewMediator levelsDepressive episodeHealthy controlsBody mass indexCase-control studyCo-primary outcomesPhase of bipolar disorderMood spectrumTumor necrosis factor-aDisease activity stateDuration of illnessData extraction
2020
Macrophage inhibitory factor (MIF) gene polymorphisms are associated with disease susceptibility and with circulating MIF levels in active non‐segmental vitiligo in patients from western Mexico
Garcia‐Orozco A, Martinez‐Magaña I, Riera‐Leal A, Muñoz‐Valle J, Martinez‐Guzman M, Quiñones‐Venegas R, Sánchez‐Zuno G, Fafutis‐Morris M. Macrophage inhibitory factor (MIF) gene polymorphisms are associated with disease susceptibility and with circulating MIF levels in active non‐segmental vitiligo in patients from western Mexico. Molecular Genetics & Genomic Medicine 2020, 8: e1416. PMID: 32705792, PMCID: PMC7549602, DOI: 10.1002/mgg3.1416.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibition factorNon-segmental vitiligoActive non-segmental vitiligoSerum concentrationsActivation of immune cellsExpression of MIFCirculating MIF levelsMacrophage inhibitory factorWestern Mexican populationPathogenesis of vitiligoAssociated with disease susceptibilityMigration inhibition factorIn situ expressionMIF levelsActive vitiligoAutomated immunohistochemistryDisease activityIFN-gReal-time PCRGene polymorphismsImmune cellsControl subjectsProinflammatory cytokinesTNF-aIL-1B
2019
Manganese is associated with increased plasma interleukin-1β during pregnancy, within a mixtures analysis framework of urinary trace metals
Aung M, Meeker J, Boss J, Bakulski K, Mukherjee B, Cantonwine D, McElrath T, Ferguson K. Manganese is associated with increased plasma interleukin-1β during pregnancy, within a mixtures analysis framework of urinary trace metals. Reproductive Toxicology 2019, 93: 43-53. PMID: 31881266, PMCID: PMC7138746, DOI: 10.1016/j.reprotox.2019.12.004.Peer-Reviewed Original ResearchConceptsIL-1BBayesian kernel machine regressionKernel machine regressionInterleukin-1bInterquartile range differenceCross-sectional studyAssociated with biomarkersReproductive health outcomesImmune signaling moleculesHealth outcomesLIFECODES birth cohortPregnant womenImmune perturbationsImmune biomarkersBirth cohortUrinary manganeseMachine regressionLinear regressionExposure analytesAssociationSignaling moleculesRegressionPair-wise associationsTrimesterPregnancy
2016
Inflammasome activation by cell volume regulation and inflammation-associated hyponatremia: A vicious cycle
Kim J, Park J, Eisenhut M, Yu J, Shin J. Inflammasome activation by cell volume regulation and inflammation-associated hyponatremia: A vicious cycle. Medical Hypotheses 2016, 93: 117-121. PMID: 27372869, DOI: 10.1016/j.mehy.2016.05.018.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell SizeCells, CulturedCentral Nervous SystemHumansHyponatremiaInappropriate ADH SyndromeInflammasomesInflammationInterleukin-1betaInterleukin-6LysosomesMiceModels, TheoreticalNeuronsNLR Family, Pyrin Domain-Containing 3 ProteinOsmolar ConcentrationOsmosisRatsRats, WistarStress, MechanicalConceptsCNS diseaseCentral nervous systemRelease of IL-1bAntidiuretic hormoneMulti-protein complexesIL-1BCell swellingSecretion of antidiuretic hormoneIL-6Nucleotide-bindingEffect of cell swellingTransient receptor potential channelsAntidiuretic hormone secretionPrevention of permanent brain damageFunction of inflammasomesProduction of antidiuretic hormoneRelease of IL-6Activate transient receptor potential channelsPosterior pituitary glandInterleukin (IL)-1bIntracellular environmentIL-1 injectionAction of prostaglandinsCell volume regulationInflammatory mediator production
2015
Gut commensal dependence of autoreactivity and Th17 cells in systemic autoimmunity (MUC9P.740)
Manfredo Vieira S, Ruff W, Hiltensperger M, Yu A, Goodman A, Kriegel M. Gut commensal dependence of autoreactivity and Th17 cells in systemic autoimmunity (MUC9P.740). The Journal Of Immunology 2015, 194: 205.4-205.4. DOI: 10.4049/jimmunol.194.supp.205.4.Peer-Reviewed Original ResearchAntiphospholipid syndromeSegmented filamentous bacteriaSystemic autoimmunityGut microbiotaAntiphospholipid antibody productionRegulatory IL-10Gut microbiota compositionAntigen-specific effectsBroad-spectrum antibioticsAnaerobic gut microbiotaTh17 cellsIL-17Infectious triggerPathogenic autoantibodiesPulmonary emboliIL-10IL-21Myocardial infarctionIL-1BSplenocyte proliferationAntibody productionMicrobiota compositionImmune systemAutoimmunityMicrobiota
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