2024
Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia
Berbrier D, Adler T, Leone C, Paidas M, Stachenfeld N, Usselman C. Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia. AJP Heart And Circulatory Physiology 2024, 327: h140-h154. PMID: 38700469, PMCID: PMC11932533, DOI: 10.1152/ajpheart.00020.2024.Peer-Reviewed Original ResearchMuscle sympathetic nerve activitySystolic blood pressureResponse to acute stimuliIsometric handgrip exercise protocolMental stressHandgrip exercise protocolCardiovascular diseaseExercise-induced increaseEffective prevention strategiesAcute stimuliExercise protocolHistory of preeclampsiaBlood pressureIntegrated muscle sympathetic nerve activityElevated long-term riskElevated cardiovascular riskLong-term riskEnd-expiratory apneaSympathetic nerve activityPrevention strategiesHandgrip exerciseBlood pressure responseRisk factorsExaggerated pressorHealthy pregnancyPrior Exposure to Experimental Preeclampsia Increases Atherosclerotic Plaque Inflammation in Atherogenic Mice—Brief Report
Biwer L, Man J, Camarda N, Carvajal B, Karumanchi S, Jaffe I. Prior Exposure to Experimental Preeclampsia Increases Atherosclerotic Plaque Inflammation in Atherogenic Mice—Brief Report. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: 946-953. PMID: 38450510, PMCID: PMC10978246, DOI: 10.1161/atvbaha.123.320474.Peer-Reviewed Original ResearchConceptsAtherosclerotic plaque inflammationLDLr-KO micePlaque inflammationAortic root plaque sizeEvidence of premature atherosclerosisFlow cytometryRisk factorsHistory of preeclampsiaIncreased risk of myocardial infarctionPreexisting risk factorsRisk of myocardial infarctionFed high-fat dietExpression of IGFBP6Mouse atherosclerosis modelHigh-density lipoproteinAortic cytokinesNecrotic core areaPreeclampsia exposureSerum sFlt1Normotensive pregnanciesHigh-fat dietPreeclampsia pregnanciesCD3+T cellsHigh-fat feedingLow-density lipoprotein
2023
Women with Preexisting CKD and a History of Preeclampsia Have a High Rate of Subsequent Pregnancy Complications but Are Seldom Linked to Adequate Care
Gupta S, Jim B, Golestaneh L. Women with Preexisting CKD and a History of Preeclampsia Have a High Rate of Subsequent Pregnancy Complications but Are Seldom Linked to Adequate Care. Journal Of The American Society Of Nephrology 2023, 34: 644-644. DOI: 10.1681/asn.20233411s1644d.Peer-Reviewed Original Research
2021
Association of Preeclampsia With Incident Stroke in Later Life Among Women in the Framingham Heart Study
de Havenon A, Delic A, Stulberg E, Sheibani N, Stoddard G, Hanson H, Theilen L. Association of Preeclampsia With Incident Stroke in Later Life Among Women in the Framingham Heart Study. JAMA Network Open 2021, 4: e215077. PMID: 33900402, PMCID: PMC8076961, DOI: 10.1001/jamanetworkopen.2021.5077.Peer-Reviewed Original ResearchConceptsHistory of preeclampsiaVascular risk factorsIncident strokeRisk factorsFramingham Heart StudyMarginal structural modelsCohort studyStroke incidenceRelative riskHeart StudyLater lifeTime-varying covariatesMidlife vascular risk factorsPopulation-based cohort studyHigher diastolic blood pressureAbsence of preeclampsiaCholesterol-lowering medicationsDiastolic blood pressureAge 45 yearsAssociation of preeclampsiaBlood pressureMore pregnanciesStudy visitPreeclampsiaMAIN OUTCOME
2020
Lower Urinary Pathogens: Do More Pathogenic Bacteria Increase the Risk of Pyelonephritis?
Rosett HA, Krischak MK, Sachdeva S, Weaver KE, Heine RP, Denoble AE, Dotters-Katz SK. Lower Urinary Pathogens: Do More Pathogenic Bacteria Increase the Risk of Pyelonephritis? American Journal Of Perinatology 2020, 39: 473-478. PMID: 32971563, DOI: 10.1055/s-0040-1717093.Peer-Reviewed Original ResearchConceptsLower urinary tract infectionsHistory of preeclampsiaPreterm birthPregnant womenLow birthweightPathogenic infectionsOutside of pregnancyRisk of pyelonephritisOdds of progressionSingle tertiary centerPreterm birth rateRisk of progressionUrinary tract infectionBody mass indexRate of progressionHistory of pyelonephritisAsymptomatic bacteriuriaChronic hypertensionMedian LOSObstetric outcomesUrinary culturePostpartum dataRetrospective cohortSecondary outcomesTract infectionsCardiovascular Considerations in Caring for Pregnant Patients: A Scientific Statement From the American Heart Association
Mehta LS, Warnes CA, Bradley E, Burton T, Economy K, Mehran R, Safdar B, Sharma G, Wood M, Valente AM, Volgman A, Council O. Cardiovascular Considerations in Caring for Pregnant Patients: A Scientific Statement From the American Heart Association. Circulation 2020, 141: e884-e903. PMID: 32362133, DOI: 10.1161/cir.0000000000000772.Peer-Reviewed Original ResearchConceptsCardio-obstetrics teamCardiovascular diseaseCardiac conditionsMultidisciplinary cardio-obstetrics teamHistory of preeclampsiaPregnancy-related mortalityPrimary care cliniciansAmerican Heart AssociationScientific statementHypertensive disordersMaternal morbidityPregnant patientsPreconception counselingValvular diseaseCare cliniciansComorbid conditionsThromboembolic diseaseAortic diseaseCardiovascular ConsiderationsCerebrovascular diseaseYear postpartumHeart AssociationMaternal mortalityMaternal ageMyocardial infarctionA recent history of preeclampsia is associated with elevated central pulse wave velocity and muscle sympathetic outflow
Usselman CW, Adler TE, Coovadia Y, Leone C, Paidas MJ, Stachenfeld NS. A recent history of preeclampsia is associated with elevated central pulse wave velocity and muscle sympathetic outflow. AJP Heart And Circulatory Physiology 2020, 318: h581-h589. PMID: 32004082, DOI: 10.1152/ajpheart.00578.2019.Peer-Reviewed Original ResearchConceptsMuscle sympathetic nerve activitySympathetic nerve activityArterial stiffnessBaroreflex sensitivityPreeclamptic womenUncomplicated pregnanciesNerve activityBlood pressureCardiovascular diseaseCentral pulse wave velocityCardiovagal baroreflex sensitivityElevated arterial stiffnessMuscle sympathetic outflowElevated cardiovascular riskHistory of preeclampsiaNormal blood pressurePeripheral arterial stiffnessSympathetic baroreflex sensitivitySympathetic nervous systemPulse wave velocityHigher MSNACardiovascular dysregulationSympathetic outflowCardiovascular riskNormal pregnancy
2018
Sympathetic Nervous System Reactivity in Women following Preeclamptic Pregnancies
Usselman C, Adler T, Leone C, Paidas M, Stachenfeld N. Sympathetic Nervous System Reactivity in Women following Preeclamptic Pregnancies. The FASEB Journal 2018, 32: 714.7-714.7. DOI: 10.1096/fasebj.2018.32.1_supplement.714.7.Peer-Reviewed Original ResearchMuscle sympathetic nerve activityPreeclamptic pregnanciesWomen 6Cardiovascular diseaseBaseline muscle sympathetic nerve activitySympathetic nervous system dysregulationBaseline mean arterial pressureSympathetic nervous system responsesSympathetic nerve activityHistory of preeclampsiaMean arterial pressureTotal peripheral resistanceSympathetic nervous system reactivityChronic sympathetic activationDepartment of ObstetricsSympathetic nervous systemLife-long riskNervous system dysregulationNervous system responsesGreater sympathetic reactivityFull-text articlesChemoreflex stressMSNA responsesPreeclamptic womenArterial pressure
2017
Contribution of Increased Angiotensin II Sensitivity to Microvascular Dysfunction in Women With a History of Preeclampsia
Usselman CW, Stachenfeld NS. Contribution of Increased Angiotensin II Sensitivity to Microvascular Dysfunction in Women With a History of Preeclampsia. Hypertension 2017, 70: 245-246. PMID: 28652470, DOI: 10.1161/hypertensionaha.117.09527.Peer-Reviewed Original ResearchConceptsAngiotensin II sensitivityHistory of preeclampsiaMicrovascular dysfunctionII sensitivityPreeclampsia
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