2025
Structural Brain Changes Associated With Risky Drinking in Late-Life Depression
Steffens D, Wang L, Manning K, Pearlson G. Structural Brain Changes Associated With Risky Drinking in Late-Life Depression. The American Journal Of Geriatric Psychiatry Open Science Education And Practice 2025, 6: 1-14. PMID: 40535612, PMCID: PMC12176382, DOI: 10.1016/j.osep.2025.01.003.Peer-Reviewed Original ResearchStructural brain changesBrain changesAlcohol useAlcohol consumptionCortical thicknessFronto-striatal circuitsInferior parietal sulcusVolumetric brain changesFrontal cortical regionsLate-life depressionDecreased depression severityModerate drinkersDecreased alcohol consumptionOlder adultsRisky drinkersRisky alcohol useImpact of alcohol useCognitive batteryDepression severityDepressive episodeDSM criteriaStudy psychiatristClinical InterviewOlder depressivesPosterior cingulate
2024
The Role of 3’ Regulatory Region Flanking Kinectin 1 Gene in Schizophrenia
Guo X, Luo X, Huang X, Zhang Y, Ji J, Wang X, Wang K, Wang J, Pan X, Chen B, Tan Y, Luo X. The Role of 3’ Regulatory Region Flanking Kinectin 1 Gene in Schizophrenia. ALPHA PSYCHIATRY 2024, 25: 413-420. PMID: 39148597, PMCID: PMC11322729, DOI: 10.5152/alphapsychiatry.2024.241616.Peer-Reviewed Original ResearchGray matter volumeAssociated with volumetric reductionsBasal gangliaSuperior frontal cortexDevelopment of schizophreniaSingle-nucleotide polymorphismsRisk of schizophreniaNucleus accumbensFrontal cortexPosterior cingulateMatter volumeInsular cortexBrain areasSchizophreniaSubcortical nucleiVolumetric reductionCortexPutamenCortical areasIndependent samplesRisk allelesSignificance of variantsRegulatory regionsMRNA expressionGenome-wide association studiesIntrinsic connectivity demonstrates a shared role of the posterior cingulate for cue reactivity in both gambling and cocaine use disorders
Vaccaro A, Lacadie C, Potenza M. Intrinsic connectivity demonstrates a shared role of the posterior cingulate for cue reactivity in both gambling and cocaine use disorders. Addictive Behaviors 2024, 155: 108027. PMID: 38581751, PMCID: PMC11273263, DOI: 10.1016/j.addbeh.2024.108027.Peer-Reviewed Original ResearchConceptsCocaine use disorderPosterior cingulate cortexCue reactivityBehavioral addictionsUse disorderGambling disorderPosterior cingulatePosterior cingulate cortex connectivityHealthy comparison subjectsIntrinsic connectivity distributionIntervention developmentCocaine cuesFMRI taskAddictive disordersCingulate cortexComparison subjectsNeurobiological foundationsSad videosDecreased connectivityFunctional connectivityCocainePost Hoc AnalysisAddictionRelevant to maintenanceGambling
2023
Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers
Boen R, Kaufmann T, van der Meer D, Frei O, Agartz I, Ames D, Andersson M, Armstrong N, Artiges E, Atkins J, Bauer J, Benedetti F, Boomsma D, Brodaty H, Brosch K, Buckner R, Cairns M, Calhoun V, Caspers S, Cichon S, Corvin A, Crespo-Facorro B, Dannlowski U, David F, de Geus E, de Zubicaray G, Desrivières S, Doherty J, Donohoe G, Ehrlich S, Eising E, Espeseth T, Fisher S, Forstner A, Fortaner-Uyà L, Frouin V, Fukunaga M, Ge T, Glahn D, Goltermann J, Grabe H, Green M, Groenewold N, Grotegerd D, Grøntvedt G, Hahn T, Hashimoto R, Hehir-Kwa J, Henskens F, Holmes A, Håberg A, Haavik J, Jacquemont S, Jansen A, Jockwitz C, Jönsson E, Kikuchi M, Kircher T, Kumar K, Le Hellard S, Leu C, Linden D, Liu J, Loughnan R, Mather K, McMahon K, McRae A, Medland S, Meinert S, Moreau C, Morris D, Mowry B, Mühleisen T, Nenadić I, Nöthen M, Nyberg L, Ophoff R, Owen M, Pantelis C, Paolini M, Paus T, Pausova Z, Persson K, Quidé Y, Marques T, Sachdev P, Sando S, Schall U, Scott R, Selbæk G, Shumskaya E, Silva A, Sisodiya S, Stein F, Stein D, Straube B, Streit F, Strike L, Teumer A, Teutenberg L, Thalamuthu A, Tooney P, Tordesillas-Gutierrez D, Trollor J, van ’t Ent D, van den Bree M, van Haren N, Vázquez-Bourgon J, Völzke H, Wen W, Wittfeld K, Ching C, Westlye L, Thompson P, Bearden C, Selmer K, Alnæs D, Andreassen O, Sønderby I, Group E. Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers. Biological Psychiatry 2023, 95: 147-160. PMID: 37661008, PMCID: PMC7615370, DOI: 10.1016/j.biopsych.2023.08.018.Peer-Reviewed Original ResearchConceptsMedial visual cortexCortical surface areaBrain differencesCortical thicknessTemporal poleVisual cortexDeletion carriersGlobal brain measuresRegional brain differencesCopy number variantsSuperior temporal cortexSomatosensory cortexBrain valuesAltered neurodevelopmentAuditory cortexGlobal differencesRegional differencesTemporal cortexNumber variantsPosterior cingulateCortexBrain structuresBrain measuresStandardized differenceNoncarriers
2022
Sex differences in default mode network connectivity in healthy aging adults
Ficek-Tani B, Horien C, Ju S, Xu W, Li N, Lacadie C, Shen X, Scheinost D, Constable T, Fredericks C. Sex differences in default mode network connectivity in healthy aging adults. Cerebral Cortex 2022, 33: 6139-6151. PMID: 36563018, PMCID: PMC10183749, DOI: 10.1093/cercor/bhac491.Peer-Reviewed Original ResearchConceptsDefault mode networkPreclinical Alzheimer's diseaseAlzheimer's diseaseSex differencesBrain connectivity changesDefault mode network connectivityIntrinsic connectivity distributionSeed-based analysisMode network connectivityMedial prefrontal cortexPosterior DMN nodesHealthy aging adultsImpact of sexLifetime riskDMN connectivityWhole brainPosterior cingulateDMN nodesSignificant sex differencesPrefrontal cortexConnectivity changesAging AdultsHealthy participantsDMN functionMode networkAge, gender and body-mass-index relationships with in vivo CB1 receptor availability in healthy humans measured with [11C]OMAR PET
Radhakrishnan R, Worhunsky PD, Zheng MQ, Najafzadeh S, Gallezot JD, Planeta B, Henry S, Nabulsi N, Ranganathan M, Skosnik PD, Pittman B, Cyril D'Souza D, Carson RE, Huang Y, Potenza MN, Matuskey D. Age, gender and body-mass-index relationships with in vivo CB1 receptor availability in healthy humans measured with [11C]OMAR PET. NeuroImage 2022, 264: 119674. PMID: 36243269, DOI: 10.1016/j.neuroimage.2022.119674.Peer-Reviewed Original Research
2019
Grey Matter Volume Differences Associated with Extremely Low Levels of Cannabis Use in Adolescence
Orr C, Spechler P, Cao Z, Albaugh M, Chaarani B, Mackey S, D'Souza D, Allgaier N, Banaschewski T, Bokde ALW, Bromberg U, Büchel C, Quinlan E, Conrod P, Desrivières S, Flor H, Frouin V, Gowland P, Heinz A, Ittermann B, Martinot JL, Martinot MP, Nees F, Orfanos D, Paus T, Poustka L, Millenet S, Fröhner JH, Radhakrishnan R, Smolka MN, Walter H, Whelan R, Schumann G, Potter A, Garavan H. Grey Matter Volume Differences Associated with Extremely Low Levels of Cannabis Use in Adolescence. Journal Of Neuroscience 2019, 39: 1817-1827. PMID: 30643026, PMCID: PMC6407302, DOI: 10.1523/jneurosci.3375-17.2018.Peer-Reviewed Original ResearchConceptsGray matter volumeCannabis useCannabis usersPerceptual Reasoning IndexGreater gray matter volumeMedial temporal lobeBilateral posterior cingulateGeneralized anxiety symptomsBilateral medial temporal lobesInitiation of cannabisRates of cannabisLong-term neurocognitive effectsGray matter volume differencesCognitive effectsHuman adolescentsNeurocognitive effectsAnxiety symptomsVoxel-based morphometryLingual gyrusPosterior cingulateRecreational cannabis useAdolescent periodTemporal regionsHeavy patternNeural maturation
2017
92. Peripheral Oxytocin and Vasopressin Modulates Regional Brain Activity Differently in Men and Women With Schizophrenia
Rubin L, Li S, Yao L, Keedy S, Reilly J, Hill S, Bishop J, Carter S, Pournajafi-Nazarloo H, Drogos L, Gershon E, Pearlson G, Tamminga C, Clementz B, Keshavan M, Lui S, Sweeney J. 92. Peripheral Oxytocin and Vasopressin Modulates Regional Brain Activity Differently in Men and Women With Schizophrenia. Schizophrenia Bulletin 2017, 43: s50-s50. PMCID: PMC5475587, DOI: 10.1093/schbul/sbx021.131.Peer-Reviewed Original ResearchHigher AVP levelsHigher ALFFMale patientsCerebellar cortexFrontal cortexArginine vasopressinHigher OT levelsPosterior cingulateOT levelsFemale patientsLower ALFFAVP levelsPoor verbal fluencyHealthy individualsRegional cerebral functionSpontaneous neuronal activitySex-dependent mannerAVP serum concentrationsBrain activityRegional brain activityVerbal fluencyEmotion processingSuperior temporal gyrusClinical associationsSerum concentrationsAssociation between abnormal brain functional connectivity in children and psychopathology: A study based on graph theory and machine learning
Sato J, Biazoli C, Salum G, Gadelha A, Crossley N, Vieira G, Zugman A, Picon F, Pan P, Hoexter M, Amaro E, Anés M, Moura L, Del’Aquilla M, Mcguire P, Rohde L, Miguel E, Jackowski A, Bressan R. Association between abnormal brain functional connectivity in children and psychopathology: A study based on graph theory and machine learning. The World Journal Of Biological Psychiatry 2017, 19: 119-129. PMID: 28635541, DOI: 10.1080/15622975.2016.1274050.Peer-Reviewed Original ResearchConceptsBilateral posterior temporal corticesAbnormal brain functional connectivityMental health disordersBilateral posterior cingulateBrain networksBrain functional connectivityResting-state fMRI dataPosterior temporal cortexBrain network organizationLevels of psychopathologyTemporal cortexHealth disordersTemporal polePosterior cingulateMental disordersBrain developmentFunctional connectivityBrain connectivitySignificant decreaseDisordersGraph theory measuresIndividual brain networksBiological measuresPsychopathologySubjects
2016
Pivotal response treatment prompts a functional rewiring of the brain among individuals with autism spectrum disorder
Venkataraman A, Yang D, Dvornek N, Staib LH, Duncan JS, Pelphrey KA, Ventola P. Pivotal response treatment prompts a functional rewiring of the brain among individuals with autism spectrum disorder. Neuroreport 2016, 27: 1081-1085. PMID: 27532879, PMCID: PMC5007196, DOI: 10.1097/wnr.0000000000000662.Peer-Reviewed Original ResearchConceptsPivotal Response TreatmentAutism spectrum disorderOccipital-temporal cortexAttentional systemResponse treatmentSpectrum disorderOrbitofrontal cortexPosterior cingulateHigh-level objectsBehavioral interventionsLearning mechanismPerception shiftProcessing areasNeural circuitsFunctional rewiringCortexTreatment regimenAutismInterventionNovel Bayesian frameworkCingulateFunctional changesIndividualsDisordersObjectsNeural Correlates of Success and Failure Signals During Neurofeedback Learning
Radua J, Stoica T, Scheinost D, Pittenger C, Hampson M. Neural Correlates of Success and Failure Signals During Neurofeedback Learning. Neuroscience 2016, 378: 11-21. PMID: 27063101, PMCID: PMC5537049, DOI: 10.1016/j.neuroscience.2016.04.003.Peer-Reviewed Original ResearchConceptsNeurofeedback signalFeedback learningMedial prefrontal/anterior cingulate cortexFeedback-driven learningPrecuneus/posterior cingulateClear adaptive valueDefault mode networkLevel-dependent responsesAnterior cingulate cortexOperant conditioning paradigmReduction of anxietyNeurofeedback learningNeural correlatesSignals of failureNeural processesNeurofeedback interventionConditioning paradigmNeurofeedback experimentsMode networkOrbitofrontal cortexCingulate cortexPosterior cingulateFunctional runsAbstract representationLearning
2015
Language comprehension and brain function in individuals with an optimal outcome from autism
Eigsti IM, Stevens MC, Schultz RT, Barton M, Kelley E, Naigles L, Orinstein A, Troyb E, Fein DA. Language comprehension and brain function in individuals with an optimal outcome from autism. NeuroImage Clinical 2015, 10: 182-191. PMID: 26862477, PMCID: PMC4707189, DOI: 10.1016/j.nicl.2015.11.014.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderTypical developmentTD groupBrain networksSentence comprehension taskIndividuals ages 8Functional MRI scansLanguage comprehensionASD groupComprehension taskLanguage abilityLateralized regionsLanguage performanceRight homologueOO individualsSpectrum disorderBrain functioningPosterior cingulateLanguage processingAge 8Temporal regionsBrain regionsBrain functionMinority of individualsIntensive learning
2014
Age effects on the default mode and control networks in typically developing children
Sato J, Salum G, Gadelha A, Picon F, Pan P, Vieira G, Zugman A, Hoexter M, Anés M, Moura L, Del'Aquilla M, Amaro E, McGuire P, Crossley N, Lacerda A, Rohde L, Miguel E, Bressan R, Jackowski A. Age effects on the default mode and control networks in typically developing children. Journal Of Psychiatric Research 2014, 58: 89-95. PMID: 25085608, DOI: 10.1016/j.jpsychires.2014.07.004.Peer-Reviewed Original ResearchConceptsDefault mode networkMode networkYears of ageCross-sectional community sampleRight anterior insulaDefault modePosterior temporal cortexDorsal anteriorAge effectsNeurodevelopment studiesHealthy subjectsTemporal cortexPosterior cingulateState fMRI dataAnterior insulaBrain developmentSame acquisition parametersLeft posterior temporal cortexNeuronal modulesState fMRILate childhoodDevelopmental formationBrain networksCommunity sampleField of neuroimaging
2013
The posterior cingulate cortex as a plausible mechanistic target of meditation: findings from neuroimaging
Brewer JA, Garrison KA. The posterior cingulate cortex as a plausible mechanistic target of meditation: findings from neuroimaging. Annals Of The New York Academy Of Sciences 2013, 1307: 19-27. PMID: 24033438, DOI: 10.1111/nyas.12246.Peer-Reviewed Original ResearchConceptsReal-time functional magnetic resonanceFunctional magnetic resonanceKey brain regionsStudies of meditationPsychological modelsMeditation trainingNeurophenomenological studiesMindfulness trainingNeurobiological mechanismsPosterior cingulateBrain regionsMindfulnessMeditationTrainingNeurofeedbackCingulateFindingsPlausible targetMagnetic resonanceTask-related concurrent but opposite modulations of overlapping functional networks as revealed by spatial ICA
Xu J, Zhang S, Calhoun VD, Monterosso J, Li CS, Worhunsky PD, Stevens M, Pearlson GD, Potenza MN. Task-related concurrent but opposite modulations of overlapping functional networks as revealed by spatial ICA. NeuroImage 2013, 79: 62-71. PMID: 23611864, PMCID: PMC3677796, DOI: 10.1016/j.neuroimage.2013.04.038.Peer-Reviewed Original ResearchConceptsCommon brain regionsSpatial independent component analysisDifferent functional networksMedial frontoparietal corticesFunctional networksCognitive tasksBrain regionsFrontoparietal cortexMultiple cognitive processesFunctional magnetic resonance imaging (fMRI) dataHigher-order association corticesTask-related modulationSame brain regionsCognitive processesVisual tasksMagnetic resonance imaging dataVentral tegmental areaPosterior cingulateAssociation cortexHealthy participantsHuman brainTimecoursesSubcortical structuresSpatial ICATask
2012
Neural mechanisms of cognitive behavioral therapy response in Hoarding Disorder: A pilot study
Tolin D, Stevens M, Nave A, Villavicencio A, Morrison S. Neural mechanisms of cognitive behavioral therapy response in Hoarding Disorder: A pilot study. Journal Of Obsessive-Compulsive And Related Disorders 2012, 1: 180-188. DOI: 10.1016/j.jocrd.2012.04.001.Peer-Reviewed Original ResearchCognitive behavioral therapyMedial frontal gyrusFrontal gyrusHemodynamic activityManualized group cognitive behavioral therapyCognitive behavioral therapy responsePosterior cingulateFunctional magnetic resonance imaging (fMRI) taskGroup cognitive behavioral therapyRight superior temporal gyrusDecision-making taskInsula/putamenRight posterior hippocampusSuperior temporal gyrusHealthy control participantsParietal lobe regionsHippocampus/parahippocampusNeural functionHoarding DisorderNeural mechanismsBehavioral therapyTemporal gyrusPosterior hippocampusHC participantsLobe regions
2011
Meditation experience is associated with differences in default mode network activity and connectivity
Brewer JA, Worhunsky PD, Gray JR, Tang YY, Weber J, Kober H. Meditation experience is associated with differences in default mode network activity and connectivity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 20254-20259. PMID: 22114193, PMCID: PMC3250176, DOI: 10.1073/pnas.1112029108.Peer-Reviewed Original ResearchConceptsDefault mode networkExperienced meditatorsDefault mode network activitySelf-referential processingDorsal anterior cingulateDorsolateral prefrontal cortexPossible neural mechanismsFunctional connectivity analysisMeditation typesNeural mechanismsMeditation experienceBrain activityDefault modePrefrontal cortexAnterior cingulatePosterior cingulateContemplative traditionsConnectivity analysisDifferent meditationsNeural response to eye contact and paroxetine treatment in generalized social anxiety disorder
Schneier FR, Pomplun M, Sy M, Hirsch J. Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder. Psychiatry Research 2011, 194: 271-278. PMID: 22047726, PMCID: PMC3230304, DOI: 10.1016/j.pscychresns.2011.08.006.Peer-Reviewed Original ResearchConceptsParoxetine treatmentInferior parietal lobuleGeneralized social anxiety disorderNeural responsesPosterior cingulateParietal lobuleAnxiety disordersGSAD patientsEye contactMiddle occipital cortexMiddle frontal gyrusFunctional magnetic resonanceSymptomatic improvementHealthy comparison participantsOccipital cortexSocial anxiety disorderSymptom reductionAnterior cingulatePatientsUnmedicated adultsParahippocampal cortexNeural circuitrySupramarginal gyrusFrontal gyrusCingulateThe Default Mode Network and Altered Consciousness in Epilepsy
Danielson N, Guo J, Blumenfeld H. The Default Mode Network and Altered Consciousness in Epilepsy. Behavioural Neurology 2011, 24: 55-65. DOI: 10.1155/2011/912720.Peer-Reviewed Original ResearchLoss of consciousnessDefault mode networkDefault mode network activitySeizure typesMode networkArousal systemNetwork inhibition hypothesisTypes of seizuresSubcortical arousal systemsCertain cortical regionsPrecuneus/posterior cingulateLateral parietal cortexNetwork activityActive inhibitionAltered consciousnessAbsence seizuresCortical deactivationCortical areasEpileptic seizuresAwake statePosterior cingulateParietal cortexSeizuresCortical regionsElectrophysiological modalities
2009
Brain Regions for Perceiving and Reasoning About Other People in School‐Aged Children
Saxe RR, Whitfield‐Gabrieli S, Scholz J, Pelphrey KA. Brain Regions for Perceiving and Reasoning About Other People in School‐Aged Children. Child Development 2009, 80: 1197-1209. PMID: 19630902, DOI: 10.1111/j.1467-8624.2009.01325.x.Peer-Reviewed Original ResearchConceptsTemporo-parietal junctionPosterior superior temporal sulcusRight temporo-parietal junctionSuperior temporal sulcusMedial prefrontal cortexSchool-aged childrenBiological motionTemporal sulcusCharacters' thoughtsPrefrontal cortexPeople's thoughtsMental factsPosterior cingulateBrain regionsCortical regionsYoung childrenOlder childrenSame storyThoughtPhysical contextResponse selectivityChildrenPeoplePerceivingCingulate
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