2025
Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7‐year period despite high levels of physical activity
Gogniat M, Khan O, Li J, Park C, Robb W, Zhang P, Sun Y, Moore E, Houston M, Pechman K, Shashikumar N, Davis L, Liu D, Landman B, Cole K, Bolton C, Gifford K, Hohman T, Full K, Jefferson A. Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7‐year period despite high levels of physical activity. Alzheimer's & Dementia 2025, 21: e70157. PMID: 40357887, PMCID: PMC12070248, DOI: 10.1002/alz.70157.Peer-Reviewed Original ResearchConceptsSedentary behaviorSedentary timeOlder adultsLevels of physical activityAPOE-e4 carrier statusReduce sedentary timeBrain structuresIncreased sedentary behaviorAPOE-e4 statusRisk factorsModifiable risk factorsLongitudinal linear regressionAlzheimer's diseaseHippocampal volume reductionPhysical activityEffect modificationAPOE-e4E4 statusEpisodic memoryNeuropsychological assessmentApolipoprotein EWorse cognitionAging AdultsGenetic riskCognitive changesVisualizing functional network connectivity differences using an explainable machine-learning method
Sendi M, Itkyal V, Edwards-Swart S, Chun J, Mathalon D, Ford J, Preda A, van Erp T, Pearlson G, Turner J, Calhoun V. Visualizing functional network connectivity differences using an explainable machine-learning method. Physiological Measurement 2025, 46: 045009. PMID: 40245920, DOI: 10.1088/1361-6579/adce52.Peer-Reviewed Original ResearchConceptsCognitive control networkFunctional network connectivitySubcortical networksSHapley Additive exPlanationsExplainable machine learningMachine learning modelsStatistical learning approachResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingClassification accuracyLack interpretabilityMachine-learning methodsMachine learningSynthetic dataLearning approachLearning modelsNetwork connectivityAging AdultsRandom forestOlder aged adultsNetworkSomatomotor networkConnectivity differencesNeural mechanismsCatBoost modelP-1430. Use of Patient-Informed Resources Tailored to Diverse Populations Living with HIV to Improve Shared Decision-Making (SDM)
Nall R, Collins-Ogle M, Short W, Springer S, Molloy L, Simone L, Napolitan C, Carter J, Jimenez J, Pillinger K. P-1430. Use of Patient-Informed Resources Tailored to Diverse Populations Living with HIV to Improve Shared Decision-Making (SDM). Open Forum Infectious Diseases 2025, 12: ofae631.1605. PMCID: PMC11778905, DOI: 10.1093/ofid/ofae631.1605.Peer-Reviewed Original ResearchShared decision-making toolsShared decision-makingPopulation of PWHDiverse populationsConcept of shared decision-makingLack of patient interestLow health literacyCare team rolesHIV care teamSpecific health needsLack of professional trainingHealth literacyCare teamHIV careSDM toolConversation guideHealth needsHealth careHIV clinicPatient interestImprove engagementExpert providersAging AdultsFormal trainingPatient information
2024
Identifying diagnosed major chronic diseases associated with recent housing instability among aging adults: data from the ‘All of Us’ research program
Beydoun H, Vieytes C, Beydoun M, Lampros A, Tsai J. Identifying diagnosed major chronic diseases associated with recent housing instability among aging adults: data from the ‘All of Us’ research program. Journal Of Public Health 2024, 47: 15-23. PMID: 39586798, PMCID: PMC12034092, DOI: 10.1093/pubmed/fdae300.Peer-Reviewed Original ResearchUs Research ProgramHousing instabilityAging AdultsChronic diseasesOdds ratioChronic disease preventionAssociated with lower oddsPsychiatric diagnosisConfidence intervalsElectronic health recordsAssociated with psychiatric diagnosesEstimate odds ratiosCardiovascular diseaseMultivariate logistic regression modelDiverse group of adultsLogistic regression modelsTreatment of chronic diseasesCross-sectional dataHealth recordsHealthcare utilizationLower oddsGroup of adultsYears of ageDiagnosed diabetesCancer diagnosisApplying Concepts of Successful Aging in Measuring and Promoting Whole Person Health
Tsai J, Jones A. Applying Concepts of Successful Aging in Measuring and Promoting Whole Person Health. Medical Care 2024, 62: s21-s23. PMID: 39514489, PMCID: PMC11548807, DOI: 10.1097/mlr.0000000000002040.Peer-Reviewed Original ResearchConceptsWhole-person healthPersonal healthLife course perspectiveTransform healthcare systemsAdult populationWell-beingAging adult populationUS veteran populationAge-friendly practicesPopulation at-riskPublic health concernPoor healthAbsence of diseaseHealthcare systemVeteran populationSuccessful agingAging AdultsAge-FriendlyHealthCourse perspectiveHealth concernReview studiesAgePopulationMultiple indicators
2022
Sex differences in default mode network connectivity in healthy aging adults
Ficek-Tani B, Horien C, Ju S, Xu W, Li N, Lacadie C, Shen X, Scheinost D, Constable T, Fredericks C. Sex differences in default mode network connectivity in healthy aging adults. Cerebral Cortex 2022, 33: 6139-6151. PMID: 36563018, PMCID: PMC10183749, DOI: 10.1093/cercor/bhac491.Peer-Reviewed Original ResearchConceptsDefault mode networkPreclinical Alzheimer's diseaseAlzheimer's diseaseSex differencesBrain connectivity changesDefault mode network connectivityIntrinsic connectivity distributionSeed-based analysisMode network connectivityMedial prefrontal cortexPosterior DMN nodesHealthy aging adultsImpact of sexLifetime riskDMN connectivityWhole brainPosterior cingulateDMN nodesSignificant sex differencesPrefrontal cortexConnectivity changesAging AdultsHealthy participantsDMN functionMode networkInactivity is associated with worse cognition and neurodegeneration in aging adults
Gogniat M, Khan O, Li J, Park C, Robb W, Moore E, Houston M, Pechman K, Liu D, Hohman T, Gifford K, Jefferson A. Inactivity is associated with worse cognition and neurodegeneration in aging adults. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.067713.Peer-Reviewed Original ResearchCommunity-dwelling older adultsAPOE e4 statusEpisodic memory performanceGray matter volumeE4 statusPhysical activityOlder adultsMemory performanceMatter volumeAging AdultsGenetic riskGreater physical activityAverage daily minutesIncreased physical activityFramingham Stroke Risk Profile scoreAPOE-e4 statusStratified modelsAssociated with worse cognitionCortical thicknessModifiable risk factorsTotal gray matter volumeBrain aging outcomesDays of wrist actigraphyE4 carriersParietal lobe volumeReduced grip strength potentially indicates depression: Investigating multicontinental databases
Oh J, Kim S, Lee D, Yon D, Lee S, Smith L, Kostev K, Koyanagi A, Solmi M, Carvalho A, Shin J, Son N, Lee S. Reduced grip strength potentially indicates depression: Investigating multicontinental databases. Journal Of Affective Disorders 2022, 323: 426-434. PMID: 36481227, DOI: 10.1016/j.jad.2022.12.006.Peer-Reviewed Original ResearchConceptsHandgrip strengthOlder aged adultsCross-sectional studyIncreased aORAging AdultsAssessment of handgrip strengthIncreased likelihood of depressionParticipants aged >Handgrip strength scoreLikelihood of depressionLow handgrip strengthUnited KingdomReduced grip strengthUnited StatesPopulation at-riskGrip strengthMulti-national studyStrength scoresDepression measuresHigher OROdds ratioAORHandgripAt-riskIncreased likelihood
2021
Sex differences in connectivity in the default mode network in healthy aging adults
Ficek B, Horien C, Lacadie C, Shen X, Scheinost D, Constable T, Fredericks C. Sex differences in connectivity in the default mode network in healthy aging adults. Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.056050.Peer-Reviewed Original ResearchIntrinsic connectivity distributionDefault mode networkAlzheimer's diseaseHealthy aging adultsElevated riskAging AdultsLarge cross-sectional studyPosterior default mode networkSex differencesMode networkCross-sectional cohortCross-sectional studyPreclinical Alzheimer's diseaseSymptomatic Alzheimer's diseaseResting-state scansSex-based differencesAnterior nodeAD showDMN connectivityHealthy adultsFunctional MRI dataNormal individualsResults FemalesZ-scoreFunctional connectivity
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