2025
Relationship Between Brain Activity and Impaired Consciousness in Frontal Lobe Seizures
Salardini E, Vaddiparti A, Kumar A, Qu J, Martin R, Gebre R, Arencibia C, Dhakar M, Grover E, Quraishi I, Sternberg E, George I, Sivaraju A, Bonito J, Zaveri H, Gober L, Ahammad S, Ghoshal S, Wu K, Farooque P, Hirsch L, Damisah E, Gerrard J, Spencer D, Yoo J, Young J, Friedman D, Shum J, Blumenfeld H. Relationship Between Brain Activity and Impaired Consciousness in Frontal Lobe Seizures. Neurology 2025, 105: e213965. PMID: 40893057, PMCID: PMC12406365, DOI: 10.1212/wnl.0000000000213965.Peer-Reviewed Original ResearchConceptsFocal to bilateral tonic-clonicCortical regionsCortical slow wavesFrontal lobeImpaired consciousnessFrontal lobe seizuresSlow-wave frequency rangeFocal temporal lobe epilepsyFocal to bilateral tonic-clonic seizuresSlow wavesQuality of lifeNegative consequencesTemporal lobe epilepsyBrain activityConsequences of epilepsyTemporal lobe seizuresBilateral tonic-clonicSubcortical arousalFocal seizure typesLobe epilepsyActivity patternsTonic-clonicFast activitySeizure typesPower increases
2022
Electronic seizure diaries for clinical care and research
Gray TE, Hirsch LJ, Quraishi IH. Electronic seizure diaries for clinical care and research. Epileptic Disorders 2022, 24: 803-811. PMID: 35811431, DOI: 10.1684/epd.2022.1451.Peer-Reviewed Original ResearchElectroencephalographic changes in purified pharmaceutical cannabidiol therapy
Herlopian A, Barnett JR, Nascimento FA, Lee H, Thiele EA. Electroencephalographic changes in purified pharmaceutical cannabidiol therapy. Epilepsy & Behavior 2022, 128: 108558. PMID: 35078115, DOI: 10.1016/j.yebeh.2022.108558.Peer-Reviewed Original ResearchConceptsInterictal epileptiform dischargesElectroencephalographic changesCBD treatmentIctal findingsSleep architectureEEG changesInvestigational New Drug programPredominant seizure typeNew drug programPre-treatment EEGYears of ageSubjective cognitive improvementElectrographic findingsElectrographic improvementRefractory epilepsySeizure typesClinical outcomesElectrographic changesEpileptiform dischargesPatientsCognitive improvementDrug programsSubstantial associationEEG studiesTreatment
2021
Simulated driving in the epilepsy monitoring unit: Effects of seizure type, consciousness, and motor impairment
Kumar A, Martin R, Chen W, Bauerschmidt A, Youngblood MW, Cunningham C, Si Y, Ezeani C, Kratochvil Z, Bronen J, Thomson J, Riordan K, Yoo JY, Shirka R, Manganas L, Krestel H, Hirsch LJ, Blumenfeld H. Simulated driving in the epilepsy monitoring unit: Effects of seizure type, consciousness, and motor impairment. Epilepsia 2021, 63: e30-e34. PMID: 34816425, PMCID: PMC8883409, DOI: 10.1111/epi.17136.Peer-Reviewed Original ResearchConceptsSeizure typesFocal seizuresMotor functionMotor impairmentYale-New Haven HospitalVideo-electroencephalographic monitoringAbnormal motor functionEpilepsy monitoring unitNew Haven HospitalImpaired consciousnessMyoclonic seizuresRetrospective studySeizure characteristicsMotor involvementIctal eventsImpaired drivingLarge cohortSeizuresImpairmentPatientsResponsivenessDriving restrictionsVideo reviewMonitoring unitEpilepsy
2020
Development and validation of a predictive model of drug-resistant genetic generalized epilepsy.
Choi H, Detyniecki K, Bazil C, Thornton S, Crosta P, Tolba H, Muneeb M, Hirsch LJ, Heinzen EL, Sen A, Depondt C, Perucca P, Heiman GA, Adcock J, Andrade D, Cavalleri G, Costello D, Delanty N, Dugan P, Goldstein D, Kwan P, Nascimento F, O’Brien T, Radthke R, Smith P, Thomas R. Development and validation of a predictive model of drug-resistant genetic generalized epilepsy. Neurology 2020, 95: e2150-e2160. PMID: 32759205, PMCID: PMC7713754, DOI: 10.1212/wnl.0000000000010597.Peer-Reviewed Original ResearchConceptsGenetic generalized epilepsyCatamenial epilepsyGeneralized epilepsyPsychiatric conditionsOngoing longitudinal observational studyGeneralized tonic clonicTertiary epilepsy centerNegative prognostic factorCase-control studyLongitudinal observational studyClinical prediction modelAED resistanceTonic clonicPrognostic factorsSeizure typesEpilepsy centersAntiepileptic drugsAbsence seizuresObservational studyOngoing longitudinal studyEpilepsyCase statusAED responsePatientsExternal testing datasetAntiepileptic drug withdrawal and seizure severity in the epilepsy monitoring unit
Duy PQ, Krauss GL, Crone NE, Ma M, Johnson EL. Antiepileptic drug withdrawal and seizure severity in the epilepsy monitoring unit. Epilepsy & Behavior 2020, 109: 107128. PMID: 32417383, DOI: 10.1016/j.yebeh.2020.107128.Peer-Reviewed Original ResearchConceptsEpilepsy monitoring unitBilateral tonic-clonic seizuresSevere seizure typeTonic-clonic seizuresFocal seizuresSeizure typesAED doseLorazepam administrationAntiepileptic drug reductionAntiepileptic drug withdrawalDrug withdrawal ratesReceiver-operating characteristic curveRisk of complicationsAED dosageAED withdrawalEMU stayConsecutive patientsSeizure clustersAED reductionDrug withdrawalSeizure severityPresurgical patientsDrug reductionSeizuresEffective dose
2018
S20. EEG features of nonconvulsive seizures in critically ill patients - Findings from the TRENdS trial
Husain A, Lee J, Kolls B, Hirsch L, Swisher C, Sinha S, Palade A, Dombrowski K, Gallentine W, Hahn C, Gerard E, Bhapkar M, Lokhnygina Y, Westover M. S20. EEG features of nonconvulsive seizures in critically ill patients - Findings from the TRENdS trial. Clinical Neurophysiology 2018, 129: e149-e150. DOI: 10.1016/j.clinph.2018.04.380.Peer-Reviewed Original ResearchSeizure onset frequencyNonconvulsive seizuresRhythmic dischargesMost subjectsDelta frequencyCommon seizure typeCohort of subjectsEEG featuresIll patientsSeizure typesSeizure terminationExtent of spreadSeizuresSeizure studiesWave dischargesSharp dischargeBeta rangeTheta frequencyLittle dataTheta rangeCohortSubjectsTreatmentOnsetCommon morphology
2017
Does age affect response to quinidine in patients with KCNT1 mutations? Report of three new cases and review of the literature
Abdelnour E, Gallentine W, McDonald M, Sachdev M, Jiang YH, Mikati MA. Does age affect response to quinidine in patients with KCNT1 mutations? Report of three new cases and review of the literature. Seizure 2017, 55: 1-3. PMID: 29291456, DOI: 10.1016/j.seizure.2017.11.017.Peer-Reviewed Original ResearchConceptsKCNT1 mutationsEpilepsy of infancyRetrospective chart reviewPotassium channel blockerYears of agePotential therapeutic agentFunction mutationsMigrating Focal SeizuresKCNT1 gainKCNT1 geneQuinidine initiationChart reviewRefractory seizuresSeizure frequencyQuinidine therapySeizure responseSeizure typesFocal seizuresEpilepsy syndromesVideo-EEGChannel blockersNew casesTherapeutic agentsPatientsAdditional childrenNovel clinical manifestations in patients with KCNA2 mutations
Sachdev M, Gaínza-Lein M, Tchapyjnikov D, Jiang YH, Loddenkemper T, Mikati MA. Novel clinical manifestations in patients with KCNA2 mutations. Seizure 2017, 51: 74-76. PMID: 28806589, DOI: 10.1016/j.seizure.2017.07.018.Peer-Reviewed Original ResearchConceptsGeneralized tonic-clonic seizuresTonic-clonic seizuresElectrical status epilepticusNovel clinical manifestationYear old maleStatus epilepticusKCNA2 mutationsClonic seizuresClinical manifestationsMyoclonic-astatic seizuresStatus epilepticus episodesYear old femaleYears of ageAstatic seizuresSeizure typesEpileptic manifestationsFocal seizuresPatient 1Patient 2Patient 3Clinical criteriaSevere manifestationsEpileptic encephalopathyBlood samplesPatients
2016
Chapter 16 Epilepsy and Consciousness
Blumenfeld H. Chapter 16 Epilepsy and Consciousness. 2016, 255-270. DOI: 10.1016/b978-0-12-800948-2.00016-9.Peer-Reviewed Original ResearchSeizure typesImpaired consciousnessNormal consciousnessDiverse seizure typesTemporal lobe seizuresTonic-clonic seizuresParietal association cortexMedial thalamusUpper brainstemAbsence seizuresNeuronal activityPatient injuryBehavioral testingAssociation cortexEpileptic seizuresSeizuresInterhemispheric regionSynchronous dischargesLateral frontalNeuroimaging signalsAbnormal increaseAnatomical regionsEpilepsySpecific anatomical structuresConsciousness system
2015
Cross-sensitivity of patient-perceived adverse cognitive effects with antiepileptic drug use
Chen B, Detyniecki K, Hirsch LJ, Moeller J, Javed A, Kato K, Legge A, Buchsbaum R, Choi H. Cross-sensitivity of patient-perceived adverse cognitive effects with antiepileptic drug use. Epilepsy & Behavior 2015, 46: 151-157. PMID: 25935515, DOI: 10.1016/j.yebeh.2015.03.020.Peer-Reviewed Original ResearchConceptsAdverse cognitive effectsMore antiepileptic drugsAntiepileptic drugsAbsence seizure typesSpecific antiepileptic drugsAntiepileptic drug useMultiple antiepileptic drugsCertain antiepileptic drugsCognitive effectsHigh rateAED selectionClinical characteristicsIndependent predictorsSeizure typesSingle centerAED loadIndividual patientsPatientsDrug usePhenytoinIntolerabilityAED mechanismsLamotrigineVPAZNS
2014
Clinical whole-genome sequencing in severe early-onset epilepsy reveals new genes and improves molecular diagnosis
Martin HC, Kim GE, Pagnamenta AT, Murakami Y, Carvill GL, Meyer E, Copley RR, Rimmer A, Barcia G, Fleming MR, Kronengold J, Brown MR, Hudspith KA, Broxholme J, Kanapin A, Cazier JB, Kinoshita T, Nabbout R, Consortium T, Bentley D, McVean G, Heavin S, Zaiwalla Z, McShane T, Mefford HC, Shears D, Stewart H, Kurian MA, Scheffer IE, Blair E, Donnelly P, Kaczmarek LK, Taylor JC. Clinical whole-genome sequencing in severe early-onset epilepsy reveals new genes and improves molecular diagnosis. Human Molecular Genetics 2014, 23: 3200-3211. PMID: 24463883, PMCID: PMC4030775, DOI: 10.1093/hmg/ddu030.Peer-Reviewed Original ResearchMeSH KeywordsChildChild, PreschoolChromosomes, Human, Pair 9EpilepsyGenetic Predisposition to DiseaseGenome-Wide Association StudyHigh-Throughput Nucleotide SequencingHumansKCNQ2 Potassium ChannelMaleMembrane ProteinsMutationNAV1.2 Voltage-Gated Sodium ChannelNerve Tissue ProteinsPathology, MolecularPotassium ChannelsPotassium Channels, Sodium-ActivatedProto-Oncogene Proteins c-cblUniparental DisomyYoung AdultConceptsSevere early-onset epilepsyEarly-onset epilepsyOhtahara syndromeMolecular diagnosisWhole-genome sequencingClinical whole-genome sequencingPathogenic de novo mutationsHomozygous missense variantPotassium channel currentsSeizure typesO patientsDiagnostic yieldOS casesPatientsPower of WGSMolecular genetic diagnosisEpilepsyClinical phenotypeClinical diagnosisClinical toolHeterogeneous disorderDevelopmental delayDe novo mutationsDiagnosisMissense variants
2012
Impaired consciousness in epilepsy
Blumenfeld H. Impaired consciousness in epilepsy. The Lancet Neurology 2012, 11: 814-826. PMID: 22898735, PMCID: PMC3732214, DOI: 10.1016/s1474-4422(12)70188-6.Peer-Reviewed Original ResearchConceptsConsciousness systemQuality of lifeImpaired consciousnessEmotional healthDiverse seizure typesNormal human lifeComplex partial seizuresImpairment of consciousnessImproved treatment strategiesBehavioral testingBrain dysfunctionPartial seizuresSeizure typesTreatment strategiesEpileptic seizuresConsciousnessEpilepsySeizuresHuge consequencesNeuroimagingAlertnessAnatomical structuresSame setImpairmentLife
2011
Depiction of Seizure First Aid Management in Medical Television Dramas
Moeller AD, Moeller JJ, Rahey SR, Sadler RM. Depiction of Seizure First Aid Management in Medical Television Dramas. Canadian Journal Of Neurological Sciences / Journal Canadien Des Sciences Neurologiques 2011, 38: 723-727. PMID: 21856575, DOI: 10.1017/s0317167100054093.Peer-Reviewed Original ResearchConceptsFirst aid managementHealth care professionalsCare professionalsMedical television dramasPresence of seizuresAid managementSeizure first aidFirst aidAmerica guidelinesSeizure typesInvoluntary movementsSeizuresEpilepsy FoundationPerson's mouthInappropriate practicesGuidelinesMyoclonicManagementProfessionalsEtiologyMedical dramasMouthThe Default Mode Network and Altered Consciousness in Epilepsy
Danielson N, Guo J, Blumenfeld H. The Default Mode Network and Altered Consciousness in Epilepsy. Behavioural Neurology 2011, 24: 55-65. DOI: 10.1155/2011/912720.Peer-Reviewed Original ResearchLoss of consciousnessDefault mode networkDefault mode network activitySeizure typesMode networkArousal systemNetwork inhibition hypothesisTypes of seizuresSubcortical arousal systemsCertain cortical regionsPrecuneus/posterior cingulateLateral parietal cortexNetwork activityActive inhibitionAltered consciousnessAbsence seizuresCortical deactivationCortical areasEpileptic seizuresAwake statePosterior cingulateParietal cortexSeizuresCortical regionsElectrophysiological modalities
2010
A prospective study of loss of consciousness in epilepsy using virtual reality driving simulation and other video games
Yang L, Morland TB, Schmits K, Rawson E, Narasimhan P, Motelow JE, Purcaro MJ, Peng K, Raouf S, DeSalvo MN, Oh T, Wilkerson J, Bod J, Srinivasan A, Kurashvili P, Anaya J, Manza P, Danielson N, Ransom CB, Huh L, Elrich S, Padin-Rosado J, Naidu Y, Detyniecki K, Hamid H, Farooque P, Astur R, Xiao B, Duckrow RB, Blumenfeld H. A prospective study of loss of consciousness in epilepsy using virtual reality driving simulation and other video games. Epilepsy & Behavior 2010, 18: 238-246. PMID: 20537593, PMCID: PMC2914099, DOI: 10.1016/j.yebeh.2010.04.011.Peer-Reviewed Original ResearchConceptsVideo gamesVirtual realityComputer-based tasksDaily lifePerformance dataProspective studyEssential partGameContinuous video/EEG monitoringVideo/EEG monitoringTraffic accidentsSimulatorNetworkTaskNormal daily lifeSeizure typesDrivingEEG monitoringSeizuresDriving impairmentPatientsImpair consciousnessSpecific typesAnatomical networksReality
2008
Efficacy of Clobazam as Add-on Therapy for Refractory Epilepsy
Montenegro MA, Arif H, Nahm EA, Resor SR, Hirsch LJ. Efficacy of Clobazam as Add-on Therapy for Refractory Epilepsy. Clinical Neuropharmacology 2008, 31: 333-338. PMID: 19050410, DOI: 10.1097/wnf.0b013e31815cd960.Peer-Reviewed Original ResearchConceptsRefractory epilepsyEpilepsy centersColumbia Comprehensive Epilepsy CenterAntiepileptic drug regimenEfficacy of clobazamIntroduction of clobazamUS epilepsy centersUse of clobazamMultiple seizure typesComprehensive Epilepsy CenterAntiepileptic drug trialsPopulation of patientsAddition of clobazamMeasures of efficacyBinary logistic regressionDrug regimenSeizure freedomSeizure typesKaplan-MeierUS CentersDrug trialsPatientsUS FoodClobazamDrug Administration
2003
Hypothalamic hamartomas: seven cases and review of the literature
Nguyen D, Singh S, Zaatreh M, Novotny E, Levy S, Testa F, Spencer SS. Hypothalamic hamartomas: seven cases and review of the literature. Epilepsy & Behavior 2003, 4: 246-258. PMID: 12791326, DOI: 10.1016/s1525-5050(03)00086-6.Peer-Reviewed Original ResearchConceptsSessile lesionsPrecocious pubertyDifferent surgical optionsGamma Knife surgeryRare developmental lesionIntrinsic epileptogenicityGelastic seizuresGelastic epilepsySeizure typesPartial resectionSurgical optionsHypothalamic hamartomaOpen surgeryTranscallosal approachClinical aspectsSubtemporal approachIntraventricular componentDevelopmental lesionsCognitive declineLesionsAvailable evidenceResectionSurgerySeizuresSubsequent developmentTonic–Absence Seizures: An Underrecognized Seizure Type
Shih TT, Hirsch LJ. Tonic–Absence Seizures: An Underrecognized Seizure Type. Epilepsia 2003, 44: 461-465. PMID: 12614405, DOI: 10.1046/j.1528-1157.2003.39602.x.Peer-Reviewed Original ResearchConceptsSymptomatic generalized epilepsySeizure typesTonic seizuresGeneralized epilepsyAbsence seizuresMultiple seizure typesParoxysmal fast activityEpilepsy monitoring unitSlow spikeElectroclinical patternClinical patternStatic encephalopathyClinical correlatesClinical correlationTonic activityInternational LeagueFast activitySeizuresNormal cognitionPatientsEpilepsy diagnosisEpilepsyGPFAMonitoring unitEncephalopathy
2002
Levetiracetam May Be More Effective for Late-Onset Partial Epilepsy
Bazil CW, Rose A, Resor S, Yapicular B, Hirsch LJ. Levetiracetam May Be More Effective for Late-Onset Partial Epilepsy. JAMA Neurology 2002, 59: 1905-1908. PMID: 12470178, DOI: 10.1001/archneur.59.12.1905.Peer-Reviewed Original ResearchConceptsLevetiracetam therapySeizure typesRetrospective medical record reviewFrontal lobe onsetSame seizure typesTemporal lobe onsetLarge prospective trialsMedical record reviewSubset of patientsPopulation of patientsLocalization-related epilepsyNew antiepileptic drugsProspective trialRefractory epilepsyRecord reviewAntiepileptic drugsPartial epilepsySignificant worseningDrug choiceClinical experiencePatientsEpileptic seizuresEpilepsyCertain drugsCertain subpopulations
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply