2025
Molecular hallmarks of hydrocephalus
Hale A, Zhou B, Rajan A, Duy P, Goolam M, Alper S, Lehtinen M, Lancaster M, Fame R, Kahle K. Molecular hallmarks of hydrocephalus. Science Translational Medicine 2025, 17: eadq1810. PMID: 40465691, DOI: 10.1126/scitranslmed.adq1810.Peer-Reviewed Original ResearchConceptsCerebrospinal fluidBrain-CSF interfacePluripotent stem cell-derived cerebral organoidsStem cell dysfunctionAssociated with dilatationDisrupts synaptogenesisNeural stem cell dysfunctionMolecular classificationPharmacological treatmentCell dysfunctionImpaired neurogenesisBiomechanical instabilityHC subtypesGenome-widePleiotropic mechanismsCSF dynamicsNeural circuitryHydrocephalusEnvironmental insultsCerebral organoidsNeurodevelopmental comorbidities144. Negative Life Events, Neural Circuitry, and Familial Risk for Depression Among Healthy Adolescents Interact to Predict the Onset of Psychopathology One Year Later
Holt-Gosselin B, Vives G, Keding T, Castrillon M, Joormann J, Gee D. 144. Negative Life Events, Neural Circuitry, and Familial Risk for Depression Among Healthy Adolescents Interact to Predict the Onset of Psychopathology One Year Later. Biological Psychiatry 2025, 97: s154. DOI: 10.1016/j.biopsych.2025.02.381.Peer-Reviewed Original ResearchCapoeira and brain function: Hypotheses and perspectives from a systematic review
Monteiro-Junior R, da Rocha Fernandes V, Oliva H, Prudente T, Ribeiro S. Capoeira and brain function: Hypotheses and perspectives from a systematic review. Mental Health And Physical Activity 2025, 28: 100678. DOI: 10.1016/j.mhpa.2025.100678.Peer-Reviewed Original ResearchBrain functionNeurocognitive domainsNetwork of brain regionsRight dorsal premotor cortexModels of brain functionPosterior insular cortexDorsal premotor cortexPost-central gyrusBrains of individualsEmotional processingExecutive controlNeural engagementLeft hemisphereNeurocognitive effectsInsular cortexParietal cortexPrecentral gyrusSubcortical activityBrain regionsCognitive processesPremotor cortexSubcortical regionsBrain activityNeural circuitryMotor areaAttachment as Prediction: Insights From Cognitive and Developmental Neuroscience
Tottenham N, Vannucci A. Attachment as Prediction: Insights From Cognitive and Developmental Neuroscience. Current Directions In Psychological Science 2025, 34: 195-206. DOI: 10.1177/09637214251313714.Peer-Reviewed Original ResearchEarly caregiving experiencesAttachment schemasEmotion regulationMidline cortical regionsCaregiving experienceNeurodevelopmental frameworkDevelopmental neuroscienceEmotional Well-BeingFunctional connectivityNeural circuitryCortical regionsNeural predictionPredictive inferenceWell-beingMemoryEmpirical findingsNeurobiologyCognitionSchemaAttachmentEmotionsNeuroscienceCircuitry
2024
Integrating developmental neuroscience with community-engaged approaches to address mental health outcomes for housing-insecure youth: Implications for research, practice, and policy
Foster J, Hodges H, Beloborodova A, Cohodes E, Phillips M, Anderson E, Fagbenro B, Gee D. Integrating developmental neuroscience with community-engaged approaches to address mental health outcomes for housing-insecure youth: Implications for research, practice, and policy. Developmental Cognitive Neuroscience 2024, 68: 101399. PMID: 38875770, PMCID: PMC11225708, DOI: 10.1016/j.dcn.2024.101399.Peer-Reviewed Original ResearchMental healthHousing insecurityInsecure housingHealth outcomesHousing conditionsExperiences of youthMental health of childrenImprove health outcomesCommunity-engaged approachChild mental healthMental health outcomesYouth mental healthCommunity-engaged researchHealth of childrenDevelopmental neuroscience researchUnsafe housingPolicy recommendationsYouthDevelopmental neurosciencePolicyNeurobehavioral pathwaysNeural circuitryStress literatureHousingInsecurityFamilial risk for depression moderates neural circuitry in healthy preadolescents to predict adolescent depression symptoms in the Adolescent Brain Cognitive Development (ABCD) Study
Holt-Gosselin B, Keding T, Rodrigues K, Rueter A, Hendrickson T, Perrone A, Byington N, Houghton A, Miranda-Dominguez O, Feczko E, Fair D, Joormann J, Gee D. Familial risk for depression moderates neural circuitry in healthy preadolescents to predict adolescent depression symptoms in the Adolescent Brain Cognitive Development (ABCD) Study. Developmental Cognitive Neuroscience 2024, 68: 101400. PMID: 38870601, PMCID: PMC11225685, DOI: 10.1016/j.dcn.2024.101400.Peer-Reviewed Original ResearchAdolescent Brain Cognitive DevelopmentAdolescent depressive symptomsDepressive symptomsFamilial riskFunctional connectivityResting-state FC patternsCognitive developmentFamily history of depressionAdolescent-onset depressionLow familial riskHistory of depressionElevated familial riskMixed-effects regression analysisNucleus accumbensStriatal FCLR youthHR youthSensory/somatomotor networkFC patternsNeural circuitryNeural markersDepression riskDepressionPreadolescentsLongitudinal study
2023
Brn3b regulates the formation of fear-related midbrain circuits and defensive responses to visual threat
Lee H, Weinberg-Wolf H, Lee H, Lee T, Conte J, Godoy-Parejo C, Demb J, Rudenko A, Kim IJ. Brn3b regulates the formation of fear-related midbrain circuits and defensive responses to visual threat. PLOS Biology 2023, 21: e3002386. PMID: 37983249, PMCID: PMC10695396, DOI: 10.1371/journal.pbio.3002386.Peer-Reviewed Original ResearchConceptsTranscription factor Brn3bLoss of neuronsVisual threatLateral posterior nucleusMutant mice displayDefensive responsesDefensive freezing responsesPosterior nucleusTachykinin 2Mice displayMidbrain circuitVisual circuitsNeural circuitryBrn3bSpecific genetic componentsFreezing responseFear-associated behaviorsSocial isolationTac2Behavioral phenotypesMolecular mechanismsFunctional organizationGenetic componentResponseSimilar mechanismDevelopmental changes in endogenous testosterone have sexually‐dimorphic effects on spontaneous cortical dynamics
Picci G, Ott L, Penhale S, Taylor B, Johnson H, Willett M, Okelberry H, Wang Y, Calhoun V, Stephen J, Wilson T. Developmental changes in endogenous testosterone have sexually‐dimorphic effects on spontaneous cortical dynamics. Human Brain Mapping 2023, 44: 6043-6054. PMID: 37811842, PMCID: PMC10619376, DOI: 10.1002/hbm.26496.Peer-Reviewed Original ResearchConceptsCortical activityRobust sex differencesFunctional brain developmentTypically-developing youthSpontaneous cortical activityLowest relative powerCortical dynamicsEndogenous testosteronePrefrontal cortexExecutive functionFrontal cortexPubertal hormonesNeural circuitryResting-stateStructural MRIEffects of testosteroneSex differencesEffects of endogenous testosteroneDevelopmental changesBrain developmentReverse patternBehavioral changesGamma activityDevelopmental windowDevelopmental patternsChronic pain, chronic stress and substance use: overlapping mechanisms and implications
Schaffer J, Fogelman N, Seo D, Sinha R. Chronic pain, chronic stress and substance use: overlapping mechanisms and implications. Frontiers In Pain Research 2023, 4: 1145934. PMID: 37415830, PMCID: PMC10320206, DOI: 10.3389/fpain.2023.1145934.Peer-Reviewed Original ResearchChronic painChronic stressSubstance useSubstance misuseCommon reasons adultsCommon pathophysiologic processChronic pain pathologiesMedial prefrontal circuitsPrefrontal cortex dysfunctionPrescription opioidsPain pathologiesPathophysiologic processesPainBrain areasBiologic underpinningsMedical careReasons adultsEnormous burdenNeural circuitryPrefrontal circuitsVentromedial prefrontal cortex dysfunctionPsychobiological processesIndividual wellnessWellnessRiskHeading Direction Tracks Internally Directed Selective Attention in Visual Working Memory
Thom J, Nobre A, van Ede F, Draschkow D. Heading Direction Tracks Internally Directed Selective Attention in Visual Working Memory. Journal Of Cognitive Neuroscience 2023, 35: 856-868. PMID: 36802368, DOI: 10.1162/jocn_a_01976.Peer-Reviewed Original ResearchConceptsVisual working memoryWorking memorySelective attentionOrienting of attentionWorking memory delaysVirtual reality experienceCentral coloured cueGaze biasMemory delayVisual itemsNeural circuitryMemorized locationReality experienceColor cuesOrienting responseVisual representationMemorySensory informationSpatial layoutHead movementsCuesHead orientation responsesExternal environmentItemsPrior Sexual Trauma Exposure Impacts Posttraumatic Dysfunction and Neural Circuitry Following a Recent Traumatic Event in the AURORA Study
Rowland G, Roeckner A, Ely T, Lebois L, van Rooij S, Bruce S, Jovanovic T, House S, Beaudoin F, An X, Neylan T, Clifford G, Linnstaedt S, Germine L, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Gentile N, Hudak L, Pascual J, Seamon M, Harris E, Pearson C, Merchant R, Domeier R, Rathlev N, Sergot P, Sanchez L, Miller M, Pietrzak R, Joormann J, Pizzagalli D, Sheridan J, Smoller J, Harte S, Elliott J, Kessler R, Koenen K, McLean S, Ressler K, Stevens J, Harnett N. Prior Sexual Trauma Exposure Impacts Posttraumatic Dysfunction and Neural Circuitry Following a Recent Traumatic Event in the AURORA Study. Biological Psychiatry Global Open Science 2023, 3: 705-715. PMID: 37881578, PMCID: PMC10593890, DOI: 10.1016/j.bpsgos.2023.02.004.Peer-Reviewed Original ResearchPrior sexual traumaPosttraumatic dysfunctionAcute trauma exposureLifetime trauma loadTrauma exposureSexual traumaTrauma loadNeural circuitryVisual cortex connectivitySexual trauma exposureTraumatic eventsMagnetic resonance imagingUnderlying neurobiological mechanismsPosttraumatic stress disorderPrevious sexual traumaRecent traumatic eventsEmergency departmentCortex connectivityAcute aftermathVisual processing regionsLeft amygdalaPosttraumatic depressionSubsequent traumatic eventsResonance imagingConnectivity differences
2022
Hypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates
Scheinost D, Chang J, Lacadie C, Brennan-Wydra E, Foster R, Boxberger A, Macari S, Vernetti A, Constable RT, Ment LR, Chawarska K. Hypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates. Scientific Reports 2022, 12: 16230. PMID: 36171268, PMCID: PMC9517994, DOI: 10.1038/s41598-022-20617-6.Peer-Reviewed Original ResearchConceptsFirst Year InventoryAnterior insulaFunctional connectivityMaternal mental health factorsLeft anterior insulaState functional connectivityMental health factorsSubsample of participantsPostmenstrual ageSalience networkFamily historySocial domainsNeural circuitryAutismSocial behaviorBrain imagingHigher likelihoodInsulaSocial developmentHypoconnectivityExploratory analysisThird trimesterFuture onsetHealth factorsRisk scorePersonalized medicine and disorders of consciousness
Fins J. Personalized medicine and disorders of consciousness. 2022, 131-140. DOI: 10.1093/oso/9780198863465.003.0010.Peer-Reviewed Original ResearchPersonalized medicineNext-generation personalized medicineDisorders of consciousnessDevelopment of therapeuticsDomain of personalized medicineAccurate diagnostic classificationPathological phenotypesUnique biologyTherapeutic responseMolecular levelIndividual diseasesGuiding treatmentCare of patientsPersonalized therapySide effectsTherapeutic effectMinimally conscious stateBiological characteristicsMolecular biomarkersBiologyDiseaseCharacterize diseaseNeural circuitryPatientsDiagnostic classification
2021
Maternal perinatal anxiety and neural responding to infant affective signals: Insights, challenges, and a road map for neuroimaging research
Yatziv T, Vancor EA, Bunderson M, Rutherford HJV. Maternal perinatal anxiety and neural responding to infant affective signals: Insights, challenges, and a road map for neuroimaging research. Neuroscience & Biobehavioral Reviews 2021, 131: 387-399. PMID: 34563563, PMCID: PMC8642296, DOI: 10.1016/j.neubiorev.2021.09.043.Peer-Reviewed Original ResearchConceptsInfant cuesSensitive responsivenessMothers' sensitive responsivenessFunctional neuroimaging studiesMaternal perinatal anxietyPerinatal maternal anxietyPerinatal anxietyCue valenceNeural correlatesAffective signalsSensitive caregivingNeuroimaging studiesCore facetsAnxiety symptomsLongitudinal investigationNeural circuitryMixed findingsDepression symptomsMaternal anxietyAnxietyCuesFuture researchTemporal dynamicsCaregivingCurrent researchRecent advances in understanding neural correlates of anxiety disorders in children and adolescents
Zugman A, Winkler A, Pine D. Recent advances in understanding neural correlates of anxiety disorders in children and adolescents. Current Opinion In Psychiatry 2021, 34: 617-623. PMID: 34475352, PMCID: PMC8490291, DOI: 10.1097/yco.0000000000000743.Peer-Reviewed Original ResearchConceptsAnxiety disordersBrain regionsMedial prefrontal cortexNeural indicesLow-level threatNeural correlatesSmall effect sizesPrefrontal cortexNeural circuitryBrain circuitryCircuitry dysfunctionBrain connectivityCommon psychiatric diagnosesFearEffect sizeMost mental illnessesStria terminalisBed nucleusAnxietyAdolescentsPsychiatric diagnosisMental illnessRecent workDisordersChildrenLooking Back at the Next 40 Years of ASD Neuroscience Research
McPartland JC, Lerner MD, Bhat A, Clarkson T, Jack A, Koohsari S, Matuskey D, McQuaid GA, Su WC, Trevisan DA. Looking Back at the Next 40 Years of ASD Neuroscience Research. Journal Of Autism And Developmental Disorders 2021, 51: 4333-4353. PMID: 34043128, PMCID: PMC8542594, DOI: 10.1007/s10803-021-05095-5.Commentaries, Editorials and Letters
2020
Learning About Safety: Conditioned Inhibition as a Novel Approach to Fear Reduction Targeting the Developing Brain
Odriozola P, Gee DG. Learning About Safety: Conditioned Inhibition as a Novel Approach to Fear Reduction Targeting the Developing Brain. American Journal Of Psychiatry 2020, 178: 136-155. PMID: 33167673, PMCID: PMC7951569, DOI: 10.1176/appi.ajp.2020.20020232.Peer-Reviewed Original ResearchConceptsSafety signal learningExtinction learningSignal learningAnxiety disordersAnxious youthSafety cuesDorsal anterior cingulate cortexInhibition of fearFronto-amygdala circuitryCross-species evidenceAnterior cingulate cortexFear responsesAnxiety-like behaviorFrontolimbic circuitryCingulate cortexNeural circuitryCore featuresPrelimbic cortexBasic neuroscienceTranslational frameworkCuesYouthFearLearningAnimal modelsEarly Intervention for Schizophrenia: Building Systems of Care for Knowledge Translation
Srihari V, Cahill J. Early Intervention for Schizophrenia: Building Systems of Care for Knowledge Translation. 2020, 191-210. DOI: 10.7551/mitpress/13412.003.0018.Peer-Reviewed Original ResearchEarly interventionMental disordersMental healthLarge disease burdenQuality of lifeKnowledge translationClinical stagingDisease burdenEarly treatmentMental illnessIntervention modalitiesNeural circuitryDiagnostic issuesDisordersInterventionCurrent nosologyBiological mechanismsSchizophreniaOutcomesTreatmentHealthIllnessStagingEpidemiologyH. ChenDeveloping and Implementing Tools for Prevention and Early Intervention
Torous J, Chanen A, Chen E, Do K, Heinssen R, McGorry P, Nordentoft M, Schoenbaum M, Srihari V, Verma S. Developing and Implementing Tools for Prevention and Early Intervention. 2020, 211-234. DOI: 10.7551/mitpress/13412.003.0019.Peer-Reviewed Original ResearchEarly interventionMental disordersMental healthLarge disease burdenQuality of lifeClinical stagingDisease burdenEarly treatmentMental illnessIntervention modalitiesNeural circuitryDiagnostic issuesDisordersInterventionCurrent nosologyKnowledge translationBiological mechanismsPreventionOutcomesTreatmentHealthIllnessStagingEpidemiologyH. ChenSubstance use and mothers’ neural responses to infant cues
Lowell AF, Maupin AN, Landi N, Potenza MN, Mayes LC, Rutherford HJV. Substance use and mothers’ neural responses to infant cues. Infant Mental Health Journal Infancy And Early Childhood 2020, 41: 264-277. PMID: 32057121, PMCID: PMC7160016, DOI: 10.1002/imhj.21835.Peer-Reviewed Original ResearchConceptsEvent-related potentialsInfant cuesInfant facesNeural responsesSubstance useMaternal neural responseMothers' neural responsesSpecific ERP componentsMother-child attachmentParent-infant relationshipSense of rewardSubstance-using mothersAttentional allocationNeutral facesFacial affectERP componentsMothers' responsivenessInfant vocalizationsMaternal substance useNeural circuitryInfant cryingCuesInitial processingFaceProcessing
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