2025
Shared subcortical arousal systems across sensory modalities during transient modulation of attention
Khalaf A, Lopez E, Li J, Horn A, Edlow B, Blumenfeld H. Shared subcortical arousal systems across sensory modalities during transient modulation of attention. NeuroImage 2025, 312: 121224. PMID: 40250641, DOI: 10.1016/j.neuroimage.2025.121224.Peer-Reviewed Original ResearchConceptsSubcortical arousal systemsArousal systemSensory modalitiesEvent-related fMRI paradigmModulation of visual attentionModulation of attentionFMRI paradigmConscious awarenessPerception taskPerceptual modalitiesCentral thalamusMidbrain reticular formationBasal forebrainBasal gangliaVisual attentionSubcortical targetsFMRI datasetsTherapeutic neuromodulationTransient modulationReticular formationSustained changesAttentionForebrainThalamusHypothalamus
2019
Up and Down States of Cortical Neurons in Focal Limbic Seizures
Yue Z, Freedman IG, Vincent P, Andrews JP, Micek C, Aksen M, Martin R, Zuckerman D, Perrenoud Q, Neske GT, Sieu LA, Bo X, Cardin JA, Blumenfeld H. Up and Down States of Cortical Neurons in Focal Limbic Seizures. Cerebral Cortex 2019, 30: 3074-3086. PMID: 31800015, PMCID: PMC7197089, DOI: 10.1093/cercor/bhz295.Peer-Reviewed Original ResearchConceptsFocal limbic seizuresDeep anesthesiaLimbic seizuresCortical neuronsVivo whole-cell recordingsDepressed cortical functionInput resistanceNeocortical slow wavesSubcortical arousal systemsLoss of consciousnessWhole-cell recordingsCortical-subcortical networksSeizure propagationMembrane potentialRat modelCortical functionTemporal lobeSeizuresCortical arousalExtracellular recordingsElectrophysiological propertiesCortical electrophysiologyFiring rateAnesthesiaArousal system
2017
Seizures and Sleep in the Thalamus: Focal Limbic Seizures Show Divergent Activity Patterns in Different Thalamic Nuclei
Feng L, Motelow JE, Ma C, Biche W, McCafferty C, Smith N, Liu M, Zhan Q, Jia R, Xiao B, Duque A, Blumenfeld H. Seizures and Sleep in the Thalamus: Focal Limbic Seizures Show Divergent Activity Patterns in Different Thalamic Nuclei. Journal Of Neuroscience 2017, 37: 11441-11454. PMID: 29066556, PMCID: PMC5700426, DOI: 10.1523/jneurosci.1011-17.2017.Peer-Reviewed Original ResearchConceptsFocal limbic seizuresLimbic seizuresCentral lateralDifferent thalamic nucleiSeizure propagationThalamic nucleiNeuronal activityDivergent activity patternsFocal temporal lobe seizuresDepressed cortical functionDifferent thalamic regionsLimbic seizure propagationTemporal lobe seizuresFemale rat modelTemporal lobe epilepsySleep spindlesImpairment of consciousnessSubcortical arousal systemsVentral posteromedial nucleusSlow-wave sleepOverall firing rateQuality of lifeThalamocortical network activityThalamocortical information flowActivity patterns
2016
Chapter 1 Neuroanatomical Basis of Consciousness
Blumenfeld H. Chapter 1 Neuroanatomical Basis of Consciousness. 2016, 3-29. DOI: 10.1016/b978-0-12-800948-2.00001-7.Peer-Reviewed Original ResearchSubcortical componentsAssociation cortexArousal systemGamma-amino butyric acidSubcortical arousal systemsHeteromodal association cortexFrontoparietal association cortexLevel of consciousnessAmino butyric acidUpper brainstemBasal forebrainWidespread projectionsLevel of alertnessCortical componentsSpecialized brain networksClinical disordersNeuroanatomical basisFunctional neuroanatomyCortical anatomyBrain networksCortexHemispheric specializationConsciousness systemMemory encodingVisual processing
2011
The Default Mode Network and Altered Consciousness in Epilepsy
Danielson N, Guo J, Blumenfeld H. The Default Mode Network and Altered Consciousness in Epilepsy. Behavioural Neurology 2011, 24: 55-65. DOI: 10.1155/2011/912720.Peer-Reviewed Original ResearchLoss of consciousnessDefault mode networkDefault mode network activitySeizure typesMode networkArousal systemNetwork inhibition hypothesisTypes of seizuresSubcortical arousal systemsCertain cortical regionsPrecuneus/posterior cingulateLateral parietal cortexNetwork activityActive inhibitionAltered consciousnessAbsence seizuresCortical deactivationCortical areasEpileptic seizuresAwake statePosterior cingulateParietal cortexSeizuresCortical regionsElectrophysiological modalities
2010
Impaired consciousness in temporal lobe seizures: role of cortical slow activity
Englot DJ, Yang L, Hamid H, Danielson N, Bai X, Marfeo A, Yu L, Gordon A, Purcaro MJ, Motelow JE, Agarwal R, Ellens DJ, Golomb JD, Shamy MC, Zhang H, Carlson C, Doyle W, Devinsky O, Vives K, Spencer DD, Spencer SS, Schevon C, Zaveri HP, Blumenfeld H. Impaired consciousness in temporal lobe seizures: role of cortical slow activity. Brain 2010, 133: 3764-3777. PMID: 21081551, PMCID: PMC2995886, DOI: 10.1093/brain/awq316.Peer-Reviewed Original ResearchConceptsTemporal lobe seizuresSlow wave activityTemporal lobe epilepsySimple partial seizuresSubcortical arousal systemsImpaired consciousnessSeizure activityTemporal lobeLobe epilepsyArousal systemCortical functionFocal temporal lobe seizuresHz slow wave activityMesial temporal lobe epilepsyCortical slow activityDepressed cortical functionNetwork inhibition hypothesisTemporal lobe disordersComplex partial seizuresBilateral temporal lobesLanguage-dominant temporal lobeSlow wavesCortical-subcortical networksPowerful inhibitory effectIntracranial electroencephalography recordings
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