2024
Ligand‐gated ion channels as potential biomarkers for ADT‐mediated cognitive decline in prostate cancer patients
Verma S, Singh V, Nagampalli V, Ponsky L, Li C, Chao H, Gupta S. Ligand‐gated ion channels as potential biomarkers for ADT‐mediated cognitive decline in prostate cancer patients. Molecular Carcinogenesis 2024, 63: 1051-1063. PMID: 38482990, PMCID: PMC11096008, DOI: 10.1002/mc.23708.Peer-Reviewed Original ResearchConceptsAndrogen deprivation therapyN-methyl-D-aspartate receptorsGamma-aminobutyric acidLigand-gated ion channelsType 1 angiotensin II receptorGlial cellsAndrogen signaling inhibitorsProstate cancer cell culture modelHigher risk of cognitive dysfunctionProstate cancer patientsPotential biomarkersBrain-derived neurotrophic factorCognitive dysfunctionIon channelsProtein-protein interaction network analysisAngiotensin II receptorsNuclear receptor subfamily 3 group C member 1Real-time polymerase chain reaction assayBrain glial cellsCytokine-cytokine receptor interactionCancer cell culture modelsAnalysis of genesGene-disease associationsInteraction network analysisPolymerase chain reaction assay
2022
Association of Alzheimer’s Disease with COVID-19 Susceptibility and Severe Complications: A Nationwide Cohort Study
Chung S, Chang Y, Jeon J, Shin J, Song T, Kim J. Association of Alzheimer’s Disease with COVID-19 Susceptibility and Severe Complications: A Nationwide Cohort Study. Journal Of Alzheimer’s Disease 2022, 87: 701-710. PMID: 35275548, DOI: 10.3233/jad-220031.Peer-Reviewed Original ResearchConceptsSevere COVID-19 complicationsCOVID-19 infectionCOVID-19 complicationsSusceptibility to COVID-19 infectionSevere complicationsIncreased riskRatio propensity score matchingAssociation of Alzheimer's diseasePrevalence of participantsRisk of severe COVID-19 complicationsReal-time reverse transcription polymerase chain reaction assayIdentification of patientsNationwide cohort studyBinary logistic regression analysisLogistic regression analysisReverse transcription polymerase chain reaction assaySecondary outcome analysisPolymerase chain reaction assayAlzheimer's diseaseActivity interventionsPropensity score matchingMechanical ventilationCohort studyStudy participantsComplications
2020
Impact of CMV Reactivation, Treatment Approaches, and Immune Reconstitution in a Nonmyeloablative Tolerance Induction Protocol in Cynomolgus Macaques.
Alonso-Guallart P, Duran-Struuck R, Zitsman J, Sameroff S, Pereira M, Stern J, Berglund E, Llore N, Pierre G, Lopes E, Kofman S, Danton M, Sondermeijer H, Woodland D, Kato Y, Ekanayake-Alper D, Iuga A, Wuu C, Wu A, Lipkin W, Tokarz R, Sykes M, Griesemer A. Impact of CMV Reactivation, Treatment Approaches, and Immune Reconstitution in a Nonmyeloablative Tolerance Induction Protocol in Cynomolgus Macaques. Transplantation 2020, 104: 270-279. PMID: 31385931, PMCID: PMC6994365, DOI: 10.1097/tp.0000000000002893.Peer-Reviewed Original ResearchConceptsBone marrow transplantationImmune reconstitutionCytomegalovirus viremiaCytomegalovirus reactivationPost-BMTCMV reactivationT cellsHigh dosesHigher doses of ganciclovirImpact of CMV reactivationTreatment of CMV viremiaCynomolgus macaquesCourse of viremiaManagement of cytomegalovirusCyclosporin A-treated animalsDose of ganciclovirNonmyeloablative conditioning regimenT-cell countsCD8 T cellsCynomolgus macaque modelTolerance induction protocolsMonths post-BMTPolymerase chain reaction assayCMV viremiaMonitoring cytomegalovirus
1998
Detection of the SYT-SSX chimeric RNA of synovial sarcoma in paraffin-embedded tissue and its application in problematic cases.
Argani P, Zakowski M, Klimstra D, Rosai J, Ladanyi M. Detection of the SYT-SSX chimeric RNA of synovial sarcoma in paraffin-embedded tissue and its application in problematic cases. Modern Pathology 1998, 11: 65-71. PMID: 9556426.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedChromosomes, Human, Pair 18Diagnosis, DifferentialFemaleHead and Neck NeoplasmsHumansImmunohistochemistryKeratinsMaleMolecular Probe TechniquesNeoplasm ProteinsParaffin EmbeddingPolymerase Chain ReactionProteinsProto-Oncogene ProteinsRecombinant Fusion ProteinsRepressor ProteinsRNA, NeoplasmSarcoma, SynovialSkin NeoplasmsThoracic NeoplasmsTranscription, GeneticTranslocation, GeneticX ChromosomeConceptsSynovial sarcomaMalignant solitary fibrous tumorSkin adnexal tumorsThymus-like differentiationSpindle epithelial tumorSolitary fibrous tumorSpindle cell tumorsSYT-SSXReverse-transcriptase polymerase chain reaction assayParaffin-embedded tissuesPolymerase chain reaction assayAdnexal tumorsFibrous tumorEpithelial tumorsCell tumorsChimeric RNAsRNA transcriptsTarget sequenceTumorThoracic regionSarcomaSubcutaneous tissue
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply