2025
Identifying subgroups of adverse childhood experiences (ACEs) in adult general hospital attendees: associations with mental and physical health measures
Saunders R, Nolte T, Osborn T, Delamain H, Riedl D, Fonagy P, Lampe A. Identifying subgroups of adverse childhood experiences (ACEs) in adult general hospital attendees: associations with mental and physical health measures. Journal Of Psychiatric Research 2025, 187: 291-298. PMID: 40408977, DOI: 10.1016/j.jpsychires.2025.05.024.Peer-Reviewed Original ResearchConceptsAdverse childhood experiencesACE clustersHealth outcomesHealth conditionsAssessment of adverse childhood experiencesCombinations of adverse childhood experiencesIncreased ACE exposurePhysical health measuresChildhood experiencesPhysical health conditionsMental health conditionsPhysical health outcomesAdult health outcomesHigh adverse childhood experiencesAustrian university hospitalLogistic regression modelsACE exposureMental healthHealth measuresSubgroups of individualsOdds ratioLatent class analysisPrevention strategiesOutpatient departmentHospital attendees
2024
Identifying subgroups of individuals based on their epistemic stance, attachment dimensions and childhood trauma: A latent profile analysis
Delamain H, Saunders R, Tanzer M, Luyten P, Fonagy P, Campbell C. Identifying subgroups of individuals based on their epistemic stance, attachment dimensions and childhood trauma: A latent profile analysis. Journal Of Psychiatric Research 2024, 181: 701-708. PMID: 39753089, DOI: 10.1016/j.jpsychires.2024.12.033.Peer-Reviewed Original ResearchConceptsLatent profile analysisAttachment dimensionsChildhood traumaSubgroups of individualsMental health symptom severityWellbeing measuresRisk of mental health concernsMental health outcomesMental health concernsMental health symptomsRisk of negative outcomesHealth outcomesFour-profile solutionMental healthHealth symptomsSociodemographic variablesGroup comparison testsEducation levelHigher risk of negative outcomesLinear regression analysisGeneral populationRelationship statusDemographic factorsHealth concernEpistemic stanceBayesian subtyping for multi-state brain functional connectome with application on preadolescent brain cognition
Chen T, Zhao H, Tan C, Constable T, Yip S, Zhao Y. Bayesian subtyping for multi-state brain functional connectome with application on preadolescent brain cognition. Biostatistics 2024, 26: kxae045. PMID: 39656842, PMCID: PMC11823269, DOI: 10.1093/biostatistics/kxae045.Peer-Reviewed Original ResearchAdolescent Brain Cognitive DevelopmentVariational inference algorithmApproximate posterior inferenceFunctional connectivityMultiple cognitive statesInference algorithmExtensive simulationsNetwork topologyNetwork featuresFunctional network patternsBrain functional connectomeBrain functional connectivityEstimation accuracySubgroups of individualsNeurobiological heterogeneityCognitive profileCognitive statesConverging evidencePosterior inferenceDetection alternativesNeuroscience literatureBrain cognitionFunctional connectomeNetworkCognitive developmentThe associations between synaptic density and “A/T/N” biomarkers in Alzheimer’s disease: An 18F-SynVesT-1 PET/MR study
Li J, Huang Q, Qi N, He K, Li S, Huang L, Pan F, Ren S, Hua F, Huang Y, Guan Y, Guo Q, Zhao J, Xie F. The associations between synaptic density and “A/T/N” biomarkers in Alzheimer’s disease: An 18F-SynVesT-1 PET/MR study. Cerebrovascular And Brain Metabolism Reviews 2024, 44: 1199-1207. PMID: 38295871, PMCID: PMC11179616, DOI: 10.1177/0271678x241230733.Peer-Reviewed Original ResearchSynaptic densityF-FDG PET/CTInvestigate synaptic densityFDG uptakeF-FDGCognitive impairmentClinical syndromeCI groupPlasma testingPET/MR studiesPathological changesSubgroups of individualsSynaptic density lossDensity lossBiomarkersAlzheimer's clinical syndromePatientsPET/MRHippocampusAlzheimer's diseaseHippocampal volumeParahippocampal gyrusCI+ groupDiseaseSynapse loss
2020
Comparison of latent typologies of posttraumatic stress disorder and depression symptoms across military personnel from India and the US
Contractor A, Weiss N, Schick M, Natesan Batley P, Forkus S, Sharma R. Comparison of latent typologies of posttraumatic stress disorder and depression symptoms across military personnel from India and the US. Journal Of Anxiety Disorders 2020, 70: 102195. PMID: 32035292, PMCID: PMC7074844, DOI: 10.1016/j.janxdis.2020.102195.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLow-severity classHighest severity classStress disorderDepressive symptomsPTSD classU.S. sampleOptimal class solutionMulti-group invarianceClass solutionSubgroups of individualsLatent class solutionAnxiety severityMilitary personnelAlcohol useDepressionCulturally-sensitive interventionsHigher severityDisordersSeveral classesHeterogeneous subgroupsModeratelyIndia samplesSymptomsSeverity
2016
Arbaclofen in Children and Adolescents with Autism Spectrum Disorder: A Randomized, Controlled, Phase 2 Trial
Veenstra-VanderWeele J, Cook E, King B, Zarevics P, Cherubini M, Walton-Bowen K, Bear M, Wang P, Carpenter R. Arbaclofen in Children and Adolescents with Autism Spectrum Disorder: A Randomized, Controlled, Phase 2 Trial. Neuropsychopharmacology 2016, 42: 1390-1398. PMID: 27748740, PMCID: PMC5436109, DOI: 10.1038/npp.2016.237.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderFragile X syndromeSpectrum disorderClinician-rated Clinical Global ImpressionAnimal models of fragile X syndromeGABA-BModel of fragile X syndromeSocial avoidance symptomsClinical Global ImpressionPlacebo-ControlledGABA-B agonistSubgroups of individualsPilot open-label trialExploratory post hoc analysisAffective labilityAvoidance symptomsPost hoc analysis of participantsOpen-label trialBehavioral phenotypesGlobal ImpressionArbaclofenSecondary analysisX syndromeSocial behaviorSocial domains
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