2025
1170-P: Gender Identity, Racial/Ethnic Identity, and Health Behaviors—Which High Schoolers Are at Highest Risk for Type 2 Diabetes?
SHARER A, BRIMACOMBE M, OYOLA-CARTAGENA K, DOYLE R, FINCK C, OLEZESKI C, SANTOS M. 1170-P: Gender Identity, Racial/Ethnic Identity, and Health Behaviors—Which High Schoolers Are at Highest Risk for Type 2 Diabetes? Diabetes 2025, 74 DOI: 10.2337/db25-1170-p.Peer-Reviewed Original ResearchHealth behaviorsYouth Risk Behavior SurveyType 2 diabetesRisk of obesityRegression modelsBinary logistic regression modelTransgender youthLogistic regression modelsPhysical activityRacial/ethnic groupsDevelopment of type 2 diabetesRisk Behavior SurveyUnique stressorsHealthBehavior SurveyObesityMinority stress theoryHigh riskMinority stressNon-significant relationshipT2DYouthTreatment outcomesRiskGender identity
2024
Associations between fasting glucose rate-of-change and the missense variant, rs373863828, in an adult Samoan cohort
Rivara A, Russell E, Carlson J, Pomer A, Naseri T, Reupena M, Manna S, Viali S, Minster R, Weeks D, DeLany J, Kershaw E, McGarvey S, Hawley N. Associations between fasting glucose rate-of-change and the missense variant, rs373863828, in an adult Samoan cohort. PLOS ONE 2024, 19: e0302643. PMID: 38829901, PMCID: PMC11146712, DOI: 10.1371/journal.pone.0302643.Peer-Reviewed Original ResearchConceptsType 2 diabetesAllele of rs373863828Body mass indexFasting GlucoseAdult SamoansDevelopment of type 2 diabetesOdds of type 2 diabetesReduction of modifiable risk factorsRs373863828 genotypeAssociated with higher body mass indexType 2 diabetes developmentGlucose rate of changeMass indexHousehold asset scoreUrbanization of residenceHigher Body Mass IndexRisk factorsModifiable risk factorsRate of changeBaseline variablesMultivariate linear regressionPhysical activityDiabetes preventionType 2 diabetes mellitusSmoking status
2021
Longitudinal associations between ambient air pollution and insulin sensitivity: results from the KORA cohort study
Zhang S, Mwiberi S, Pickford R, Breitner S, Huth C, Koenig W, Rathmann W, Herder C, Roden M, Cyrys J, Peters A, Wolf K, Schneider A. Longitudinal associations between ambient air pollution and insulin sensitivity: results from the KORA cohort study. The Lancet Planetary Health 2021, 5: e39-e49. PMID: 33421408, DOI: 10.1016/s2542-5196(20)30275-8.Peer-Reviewed Original ResearchConceptsLong-term air pollution exposureAir pollution exposureAnnual average air pollutant concentrationsAssociation of air pollutionAverage air pollutant concentrationsPollution exposureLongitudinal associationsType 2 diabetesAir pollutant concentrationsLand-use regression modelsAssociated with air pollution exposureExposure to air pollutionCooperative Health ResearchAmbient air pollutionRegression modelsConcentrations of fasting insulinKORA F4German Federal Ministry of EducationHealth researchIQR incrementAir pollutionAnnual rateKORA cohortDevelopment of type 2 diabetesKORA S4
2011
Role of inhibitory κB kinase and c-Jun NH2-terminal kinase in the development of hepatic insulin resistance in critical illness diabetes
Jiang S, Messina J. Role of inhibitory κB kinase and c-Jun NH2-terminal kinase in the development of hepatic insulin resistance in critical illness diabetes. AJP Gastrointestinal And Liver Physiology 2011, 301: g454-g463. PMID: 21680774, PMCID: PMC3174535, DOI: 10.1152/ajpgi.00148.2011.Peer-Reviewed Original ResearchConceptsHepatic Insulin SignalingInsulin signalingHepatic insulin resistanceJNK1 kinasesImpairment of hepatic insulin signalingExpression of dominant-negative JNK1Phosphorylation of insulin receptor substrate 1Serine phosphorylation of insulin receptor substrate 1C-JunInsulin receptor substrate 1Dominant-negative JNK1C-Jun NH(2)-terminal kinaseC-Jun NH2-terminal kinaseDevelopment of hepatic insulin resistanceIncreased serine phosphorylationSerine kinaseInsulin resistanceSubstrate 1Molecular mechanismsKinaseCritical illnessIKKAssociated with increased mortalityDevelopment of type 2 diabetesJNK1
2010
Adaptations in Mitochondrial Function Parallel, but Fail to Rescue, the Transition to Severe Hyperglycemia and Hyperinsulinemia: A Study in Zucker Diabetic Fatty Rats
Lenaers E, De Feyter H, Hoeks J, Schrauwen P, Schaart G, Nabben M, Nicolay K, Prompers J, Hesselink M. Adaptations in Mitochondrial Function Parallel, but Fail to Rescue, the Transition to Severe Hyperglycemia and Hyperinsulinemia: A Study in Zucker Diabetic Fatty Rats. Obesity 2010, 18: 1100-1107. PMID: 19875988, DOI: 10.1038/oby.2009.372.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAdenine Nucleotide Translocator 1AnimalsDiabetes Mellitus, ExperimentalHyperglycemiaHyperinsulinismIon ChannelsMaleMitochondria, MuscleMitochondrial ProteinsMuscle Fibers, SkeletalObesityOxidation-ReductionOxygen ConsumptionProtein CarbonylationRatsRats, ZuckerSeverity of Illness IndexUncoupling Protein 3ConceptsUncoupling protein 3Palmitoyl-CoAMitochondrial functionZucker diabetic fattyFat oxidative capacityReduced fat oxidative capacityProgressive development of insulin resistanceMitochondrial defectsDevelopment of insulin resistanceCarbonyl cyanide p-trifluoromethoxyphenylhydrazoneIntrinsic mitochondrial defectIntrinsic mitochondrial functionInsulin resistanceMitochondrial dysfunctionMuscle mitochondrial functionPyruvate oxidationMitochondrial adaptationsType 2 diabetesState 3Development of type 2 diabetesMitochondrial capacityProtein 3Fa/fa ratsP-trifluoromethoxyphenylhydrazonePyruvate
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