2025
Risk stratifying acute total occlusions in non-ST-segment elevation myocardial infarction: time for a modified GRACE score?
Altin S, Miao J. Risk stratifying acute total occlusions in non-ST-segment elevation myocardial infarction: time for a modified GRACE score? The American Journal Of Cardiology 2025 PMID: 40921236, DOI: 10.1016/j.amjcard.2025.08.053.Peer-Reviewed Original ResearchShort-term exposure to ambient temperature variability and myocardial infarction hospital admissions: A nationwide case-crossover study in Sweden
Ni W, Stafoggia M, Zhang S, Ljungman P, Breitner S, de Bont J, Jernberg T, Atar D, Schneider A, Agewall S. Short-term exposure to ambient temperature variability and myocardial infarction hospital admissions: A nationwide case-crossover study in Sweden. PLOS Medicine 2025, 22: e1004607. PMID: 40392899, PMCID: PMC12091774, DOI: 10.1371/journal.pmed.1004607.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionNon-ST-segment elevation myocardial infarctionAssociated with increased riskHospital admissionAssociated with increased risk of hospital admissionElevation myocardial infarctionHospitalization riskRisk of hospital admissionConditional logistic regression modelsPopulation-based nationwide studyMyocardial infarctionShift exposureCase-crossover designPotential effect modifiersCase-crossover studyAssociated with decreased riskPatient's residential areaTemperature variabilityLogistic regression modelsNo significant associationHistory of diseaseTime-stratifiedMI hospitalizationSWEDEHEART registryClimate changeMoving towards precision medicine for older adults with non-ST-segment elevation myocardial infarction
Nouri A, Nanna M. Moving towards precision medicine for older adults with non-ST-segment elevation myocardial infarction. Heart 2025, 111: 541-543. PMID: 40037762, DOI: 10.1136/heartjnl-2025-325817.Commentaries, Editorials and LettersNon-ST-segment elevation myocardial infarctionOlder adultsElevation myocardial infarctionMyocardial infarction
2024
Short-term effects of ambient temperature variability on myocardial infarction hospitalizations in Sweden: A nationwide case-crossover study
Ni W, Stafoggia M, Zhang S, Ljungman P, Breitner S, Bont J, Jernberg T, Atar D, Schneider A, Agewall S. Short-term effects of ambient temperature variability on myocardial infarction hospitalizations in Sweden: A nationwide case-crossover study. European Heart Journal 2024, 45: ehae666.3605. DOI: 10.1093/eurheartj/ehae666.3605.Peer-Reviewed Original ResearchNon-ST-segment elevation myocardial infarctionCase-crossover studyST-segment elevation myocardial infarctionMI hospitalizationHome addressSWEDEHEART registryShort-term effectsElevation myocardial infarctionTemperature variabilityConditional logistic regression modelsPopulation-based nationwide studyAssessed potential effect modificationPatient's home addressMyocardial infarction hospitalizationsPotential effect modificationMyocardial infarctionEffects of temperature variabilityCase-crossover designAssociated with decreased riskSeven-day averageAssociated with increased riskNationwide SWEDEHEART registryLogistic regression modelsClimate changeEffect modificationShort-Term Effects of Lower Air Temperature and Cold Spells on Myocardial Infarction Hospitalizations in Sweden
Ni W, Stafoggia M, Zhang S, Ljungman P, Breitner S, Bont J, Jernberg T, Atar D, Agewall S, Schneider A. Short-Term Effects of Lower Air Temperature and Cold Spells on Myocardial Infarction Hospitalizations in Sweden. Journal Of The American College Of Cardiology 2024, 84: 1149-1159. PMID: 39230547, DOI: 10.1016/j.jacc.2024.07.006.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionAssociated with increased riskRisk of hospitalizationShort-term effectsConditional logistic regression modelsPopulation-based nationwide studyMyocardial infarctionMyocardial infarction hospitalizationsCase-crossover designCase-crossover studyIncreased riskAssociated with decreased riskIncreased risk of hospitalizationCases admitted to hospitalLogistic regression modelsElevation myocardial infarctionNationwide studyRegression modelsHospitalExposure indicatorsPercentile temperatureNSTEMIORRiskLow air temperatureThe impact of ticagrelor therapy on CABG-related bleeding in patients with STEMI managed with pPCI and following on-pump CABG
Durmaz E, Ikitimur B, Arapi B, Tel Ustunisik C, Soysal A, İncesu G, Gulfidan A, Yalman H, Cidem S, Tokdil H, Raimoglu U, Raimoglou D, Akman Z, Atici A, Karadag B. The impact of ticagrelor therapy on CABG-related bleeding in patients with STEMI managed with pPCI and following on-pump CABG. Heart And Vessels 2024, 40: 1-7. PMID: 39030310, DOI: 10.1007/s00380-024-02434-1.Peer-Reviewed Original ResearchConceptsCABG-related bleedingST-segment elevation myocardial infarctionCoronary Artery Bypass GraftingLong-term cardiovascular eventsCABG surgeryRisk of long-term cardiovascular eventsCardiovascular eventsMechanical cardiac support devicesIn-hospital coronary artery bypass graftingOn-pump coronary artery bypass graftingAssociated with long-term cardiovascular eventsOn-pump CABG surgeryDiagnosis of ST-segment elevation myocardial infarctionDay of surgeryShort-term cardiovascular outcomesArtery Bypass GraftingElevation myocardial infarctionCardiac support devicePercutaneous coronary interventionTicagrelor doseTicagrelor therapyNo significant differenceStudy patientsAntiplatelet treatmentRetrospective studyPercutaneous Coronary Revascularization Strategies After Myocardial Infarction A Systematic Review and Network Meta-Analysis
Reddy R, Howard J, Jamil Y, Madhavan M, Nanna M, Lansky A, Leon M, Ahmad Y. Percutaneous Coronary Revascularization Strategies After Myocardial Infarction A Systematic Review and Network Meta-Analysis. Journal Of The American College Of Cardiology 2024, 84: 276-294. PMID: 38986670, DOI: 10.1016/j.jacc.2024.04.051.Peer-Reviewed Original ResearchConceptsRelative riskCardiovascular mortalityMyocardial infarctionMultivessel coronary artery diseaseAll-Cause MortalityAdverse cardiac eventsST-segment elevation myocardial infarctionComplete revascularizationCoronary artery diseaseBayesian network meta-analysesMortality reductionA Systematic ReviewNetwork meta-analysesElevation myocardial infarctionSystematic reviewMeta-analysesCardiac eventsArtery diseasePrimary outcomeNetwork Meta-AnalysisRevascularization strategyMeta-analysisHead-to-head trialsCoronary revascularization strategyAcute kidney injuryCase Volumes and Outcomes Among Early-Career Interventional Cardiologists in the United States
Rymer J, Narcisse D, Chen A, Wojdyla D, Ashley S, Damluji A, Shah B, Nanna M, Swaminathan R, Gutierrez J, Uzendu A, Nelson A, Bethel G, Kearney K, Jones W, Rao S, Doll J. Case Volumes and Outcomes Among Early-Career Interventional Cardiologists in the United States. Journal Of The American College Of Cardiology 2024, 83: 1990-1998. PMID: 38749617, PMCID: PMC11173360, DOI: 10.1016/j.jacc.2024.03.395.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAnnual case volumeNational Cardiovascular Data Registry CathPCI RegistryCase volumeIncreased risk of mortalityBleeding riskRisk of mortalityST-segment elevation myocardial infarctionMedian annual case volumeEarly-careerCertificate databaseCathPCI RegistryInterventional cardiologistsMortality riskElevation myocardial infarctionAmerican BoardIncreased riskSystem databasePredicted riskBleeding outcomesAcute presentationTreated patientsMortality rateProcedural characteristicsCareer statusFibrinolytic Agents in Thromboembolic Diseases: Historical Perspectives and Approved Indications
Rashedi S, Greason C, Sadeghipour P, Talasaz A, O'Donoghue M, Jimenez D, Monreal M, Anderson C, Elkind M, Kreuziger L, Lang I, Goldhaber S, Konstantinides S, Piazza G, Krumholz H, Braunwald E, Bikdeli B. Fibrinolytic Agents in Thromboembolic Diseases: Historical Perspectives and Approved Indications. Seminars In Thrombosis And Hemostasis 2024, 50: 773-789. PMID: 38428841, DOI: 10.1055/s-0044-1781451.Peer-Reviewed Original ResearchST-segment elevation myocardial infarctionTissue plasminogen activatorFood and Drug AdministrationFibrinolytic agentsThromboembolic diseasePlasminogen activatorFood and Drug Administration approvalArterial thromboembolic eventsElevation myocardial infarctionCentral venous access device occlusionPlasma half-lifeU.S. Food and Drug AdministrationAcute ischemic strokePulmonary embolismThromboembolic eventsHemodynamic compromiseDevice occlusionTreated patientsRecanalize occluded vesselsActive protease plasminDrug AdministrationMyocardial infarctionApproved indicationsOccluded vesselIschemic stroke
2023
The association of timing of coronary artery bypass grafting for non-ST-elevation myocardial infarction and clinical outcomes in the contemporary United States
Park D, Singireddy S, Mangalesh S, Fishman E, Ambrosini A, Jamil Y, Vij A, Sikand N, Ahmad Y, Frampton J, Nanna M. The association of timing of coronary artery bypass grafting for non-ST-elevation myocardial infarction and clinical outcomes in the contemporary United States. Coronary Artery Disease 2023, 35: 261-269. PMID: 38164979, PMCID: PMC11042982, DOI: 10.1097/mca.0000000000001314.Peer-Reviewed Original ResearchLength of stayCoronary artery bypassElevation myocardial infarctionNSTEMI hospitalizationsHospital mortalityArtery bypassCABG surgeryMyocardial infarctionHigher oddsLonger LOSBurden of complicationsHospital-associated costsNon-home dischargeAcute kidney injuryHigh-risk featuresPercutaneous coronary interventionAssociation of timingOutcomes of interestNSTEMI populationGastrointestinal hemorrhageHospital outcomesKidney injuryPerioperative complicationsCoronary interventionBlood transfusionStress Ulcer Prophylaxis in Mechanically Ventilated Patients With Acute Myocardial Infarction
Banna S, Schenck C, Shahu A, Thomas A, Heck C, Tangredi R, Ali T, Miller P. Stress Ulcer Prophylaxis in Mechanically Ventilated Patients With Acute Myocardial Infarction. JACC Advances 2023, 3: 100750. PMID: 38939822, PMCID: PMC11198220, DOI: 10.1016/j.jacadv.2023.100750.Peer-Reviewed Original ResearchInvasive mechanical ventilationProton pump inhibitorsStress ulcer prophylaxisAcute myocardial infarctionUlcer prophylaxisVentilator-associated pneumoniaMyocardial infarctionVentilator daysST-segment elevation myocardial infarctionBackground Proton pump inhibitorsLess ventilator-associated pneumoniaVizient Clinical Data BaseObservation cohort studyProportion of patientsElevation myocardial infarctionMultivariable logistic regressionClostridium difficile infectionLower hospitalization costsClinical data baseCardiogenic shockHospital mortalityCohort studyMultivariate adjustmentHospitalization costsMechanical ventilationArrhythmias After Acute Myocardial Infarction
Frampton J, Ortengren A, Zeitler E. Arrhythmias After Acute Myocardial Infarction. The Yale Journal Of Biology And Medicine 2023, 96: 83-94. PMID: 37009192, PMCID: PMC10052595, DOI: 10.59249/lswk8578.Peer-Reviewed Original ResearchConceptsNon-ST-segment elevation myocardial infarctionST-segment elevation myocardial infarctionElevation myocardial infarctionMyocardial infarctionAcute myocardial infarctionHospital admissionAssociated with increased morbidityInfarctionIncidence of arrhythmiasBrady-arrhythmiasHospitalEpidemiologyReperfusion techniquesAdmissionIschemic arrhythmiasLong-Term Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention Among Medicare Beneficiaries
Almarzooq Z, Tamez H, Wang Y, Curtis J, Kirtane A, Secemsky E, Valsdottir L, Yeh R. Long-Term Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention Among Medicare Beneficiaries. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100584. PMID: 39129810, PMCID: PMC11307545, DOI: 10.1016/j.jscai.2023.100584.Peer-Reviewed Original ResearchNon-CTO percutaneous coronary interventionCTO percutaneous coronary interventionPercutaneous coronary interventionLong-term major adverse cardiovascular eventsChronic total occlusion (CTO) percutaneous coronary interventionMajor adverse cardiovascular eventsAdverse cardiovascular eventsHospital eventsHigh riskCardiovascular eventsCoronary interventionMyocardial infarctionLower riskNational Cardiovascular Data Registry CathPCI RegistryST-elevation myocardial infarctionHospital event ratesElevation myocardial infarctionLong-term outcomesRepeat revascularizationStable anginaCathPCI RegistryResults PatientsTerm outcomesPCI proceduresMedicare beneficiaries
2022
Sex Differences in Characteristics, Treatments, and Outcomes Among Patients Hospitalized for Non–ST-Segment–Elevation Myocardial Infarction in China: 2006 to 2015
Guo W, Du X, Gao Y, Hu S, Lu Y, Dreyer RP, Li X, Spatz ES, Masoudi FA, Krumholz HM, Zheng X. Sex Differences in Characteristics, Treatments, and Outcomes Among Patients Hospitalized for Non–ST-Segment–Elevation Myocardial Infarction in China: 2006 to 2015. Circulation Cardiovascular Quality And Outcomes 2022, 15: e008535-e008535. PMID: 35607994, PMCID: PMC9208815, DOI: 10.1161/circoutcomes.121.008535.Peer-Reviewed Original ResearchConceptsSegment elevation myocardial infarctionInvasive strategyMyocardial infarctionHospital mortalityHospital outcomesMultivariable logistic regression modelCardiovascular risk factorsElevation myocardial infarctionSex-related disparitiesQuality of careProportion of womenLogistic regression modelsSex differencesClinical characteristicsClinical profileRisk factorsClinical covariatesSex-specific differencesPatientsInfarctionST segmentSex gapChinese hospitalsMortalityWomen
2021
The influence of biological age and sex on long-term outcome after percutaneous coronary intervention for ST-elevation myocardial infarction.
Rathod KS, Jones DA, Jain AK, Lim P, MacCarthy PA, Rakhit R, Lockie T, Kalra S, Dalby MC, Malik IS, Whitbread M, Firoozi S, Bogle R, Redwood S, Cooper J, Gupta A, Lansky A, Wragg A, Mathur A, Ahluwalia A. The influence of biological age and sex on long-term outcome after percutaneous coronary intervention for ST-elevation myocardial infarction. Am J Cardiovasc Dis 2021, 11: 659-678. PMID: 34849299, PMCID: PMC8611266.Peer-Reviewed Original ResearchST-segment elevation myocardial infarctionCause mortalityFemale sexCox analysisMyocardial infarctionST-elevation myocardial infarctionAge-matched menObservational cohort studyElevation myocardial infarctionPercutaneous coronary interventionKaplan-Meier analysisLong-term outcomesProportional hazards modelSub-group analysisHigh mortality rateYears of agePost-PCIPrimary PCICoronary interventionSTEMI patientsCohort studyMultivariate adjustmentPrimary outcomeUnivariate predictorsMenopausal yearsChanges in ST segment elevation myocardial infarction hospitalisations in China from 2011 to 2015
Zhou T, Li X, Lu Y, Murugiah K, Bai X, Hu S, Gao Y, Masoudi FA, Krumholz HM, Li J. Changes in ST segment elevation myocardial infarction hospitalisations in China from 2011 to 2015. Open Heart 2021, 8: e001666. PMID: 34599073, PMCID: PMC8488733, DOI: 10.1136/openhrt-2021-001666.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPrehospital delayMyocardial infarctionSegment elevation myocardial infarctionProportion of patientsElevation myocardial infarctionAcute cardiovascular careAcute myocardial infarctionWeighted national estimateHealth service capacityRisk-adjusted ratesAcute reperfusionEligible patientsHospital deathReperfusion therapyMedical chartsPatient characteristicsHospital treatmentPatient outcomesRandom cohortCardiovascular diseaseCardiovascular carePatientsNational estimatesStandardised definitionsComparative Outcomes of Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction Among Medicare Beneficiaries With Multivessel Coronary Artery Disease
Secemsky EA, Butala N, Raja A, Khera R, Wang Y, Curtis JP, Maddox TM, Virani SS, Armstrong EJ, Shunk KA, Brindis RG, Bhatt D, Yeh RW. Comparative Outcomes of Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction Among Medicare Beneficiaries With Multivessel Coronary Artery Disease. Circulation Cardiovascular Interventions 2021, 14: e010323. PMID: 34372676, PMCID: PMC8485756, DOI: 10.1161/circinterventions.120.010323.Peer-Reviewed Original ResearchAssociation of STEMI regionalization of care with de facto NSTEMI regionalization
Montoy JCC, Shen YC, Krumholz HM, Hsia RY. Association of STEMI regionalization of care with de facto NSTEMI regionalization. American Heart Journal 2021, 242: 1-5. PMID: 34274313, PMCID: PMC8568654, DOI: 10.1016/j.ahj.2021.07.002.Peer-Reviewed Original ResearchConceptsNon-ST elevation myocardial infarctionST-elevation myocardial infarctionElevation myocardial infarctionMyocardial infarctionPercutaneous coronary intervention-capable hospitalsPCI-capable hospitalsRegionalization of careCapable hospitalsSTEMI regionalizationPatient volumeHospitalInfarctionPatientsCareRegionalization programOne-Year Outcome After Percutaneous Coronary Intervention for Acute Coronary Syndrome ― An Analysis of 20,042 Patients From a Japanese Nationwide Registry ―
Sawano M, Kohsaka S, Ishii H, Numasawa Y, Yamaji K, Inohara T, Amano T, Ikari Y, Nakamura M. One-Year Outcome After Percutaneous Coronary Intervention for Acute Coronary Syndrome ― An Analysis of 20,042 Patients From a Japanese Nationwide Registry ―. Circulation Journal 2021, 85: 1756-1767. PMID: 34162778, DOI: 10.1253/circj.cj-21-0098.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionST-elevation myocardial infarctionHeart failureHospital survivorsCoronary interventionIschemic strokeUnstable anginaMyocardial infarctionHigh riskAcute myocardial infarction populationNon-fatal ischemic strokeLate adverse cardiac eventsJapanese nationwide cohortJapanese nationwide registryNon-cardiac deathAcute heart failureAdverse cardiac eventsAcute coronary syndromeHeart failure eventsOne-year outcomesElevation myocardial infarctionSudden cardiac deathMyocardial infarction populationQuality of careACS patientsAssociation of Cardiac Care Regionalization With Access, Treatment, and Mortality Among Patients With ST-Segment Elevation Myocardial Infarction
Shen YC, Krumholz H, Hsia RY. Association of Cardiac Care Regionalization With Access, Treatment, and Mortality Among Patients With ST-Segment Elevation Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2021, 14: e007195. PMID: 33641339, PMCID: PMC7969448, DOI: 10.1161/circoutcomes.120.007195.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionST-segment elevation myocardial infarction (STEMI) systemsSame-day percutaneous coronary interventionST-segment elevation myocardial infarctionSTEMI regionalizationLong-term mortalityOutcomes of patientsElevation myocardial infarctionPCI-capable hospitalsEmergency medical services agenciesMyocardial infarction systemLocal emergency medical services agenciesPoints greater reductionPercentage point decreasePCI capabilityCoronary interventionMyocardial infarctionAdministrative databasesPatientsSTEMIPoint decreaseMortalityTimely accessReadmissionGreater reduction
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