2025
Trajectories of Major Depression and Generalized Anxiety Symptoms Among People With Disabilities During the COVID-19 Pandemic
Lowe S, Fan J, Michel C, Manning R, Adler J, Bogart K, Nario-Redmond M, Ostrove J, Wang K. Trajectories of Major Depression and Generalized Anxiety Symptoms Among People With Disabilities During the COVID-19 Pandemic. American Journal Of Orthopsychiatry 2025 PMID: 40338598, DOI: 10.1037/ort0000855.Peer-Reviewed Original ResearchGeneralized anxiety disorderGeneralized anxiety disorder symptomsSymptom trajectoriesSocial isolationDisability stigmaGeneralized anxiety symptomsPredictors of trajectory membershipLatent class growth analysisPandemic-related stressorsAnxiety disordersMajor depressionAnxiety symptomsOdds of membershipTraumatic eventsPersistent MDHigher social isolationTrajectory membershipLongitudinal studyDisability characteristicsDisabilityDepressionSymptomsGeneral populationGrowth analysisPredictorsExploring the Relationship Between Lifestyle and Post-COVID Psychiatric Symptoms: Findings from a Brazilian Cohort.
Borges S, Roncete G, Amendola F, Zanetti M, Miguel E, Filho G, Forlenza O, Damiano R. Exploring the Relationship Between Lifestyle and Post-COVID Psychiatric Symptoms: Findings from a Brazilian Cohort. American Journal Of Lifestyle Medicine 2025, 15598276251328022. PMID: 40161283, PMCID: PMC11948251, DOI: 10.1177/15598276251328022.Peer-Reviewed Original ResearchPost-traumatic stress disorderGeneralized anxiety disorderCommon mental disordersSuicidal ideationPsychiatric symptomsSeverity of alcohol useAssociated with suicidal ideationContext of depressionPsychiatric well-beingMonths post-hospitalizationAnxiety disordersStress disorderCOVID-19 survivorsMental disordersExtended recovery periodIncreased depressionSubstance useAlcohol useConsumption of sedativesDepressionLifestyle factorsIncreased intake of fruitsIdeationDisordersIntake of fruits
2024
Improvements in Sleep Quality in Patients With Major Depressive and Generalized Anxiety Disorders Treated With Individualized, Parcel‐Guided Transcranial Magnetic Stimulation
Tang S, Holle J, Mor S, Dadario N, Ryan M, Teo C, Sughrue M, Yeung J. Improvements in Sleep Quality in Patients With Major Depressive and Generalized Anxiety Disorders Treated With Individualized, Parcel‐Guided Transcranial Magnetic Stimulation. Brain And Behavior 2024, 14: e70088. PMID: 39415644, PMCID: PMC11483549, DOI: 10.1002/brb3.70088.Peer-Reviewed Original ResearchConceptsGeneralized anxiety disorderRepetitive transcranial magnetic stimulationCentral executive networkGeneralized Anxiety Disorder-7Affective disordersBeck Depression InventoryAnxiety disordersTheta burst stimulationTranscranial magnetic stimulationPittsburgh Sleep Quality IndexDorsolateral prefrontal cortexIndividualized repetitive transcranial magnetic stimulationRTMS targetsMagnetic stimulationIntermittent theta burst stimulationFunctional connectivity networksPrefrontal cortexDepressive disorderMajor depressionAffective symptomsQuality of lifeAnxiety symptomsExecutive networkDepression InventorySleep Quality IndexMechanisms Underlying the Use of Abusive and Neglectful Behaviors in Dementia Caregiving: The Role of Caregiver Mental Health.
Browning W, Yildiz M, Hernandez Chilatra J, Yefimova M, Maxwell C, Sullivan T, Winstead V, Pickering C. Mechanisms Underlying the Use of Abusive and Neglectful Behaviors in Dementia Caregiving: The Role of Caregiver Mental Health. Research In Gerontological Nursing 2024, 17: 227-236. PMID: 39347758, DOI: 10.3928/19404921-20240808-01.Peer-Reviewed Original ResearchConceptsCaregiver mental healthFamily caregiversAssociated with increased oddsAnxiety disordersCare recipientsMental healthNeglectful behaviorsAnxiety symptomsFamily caregiver populationDementia family caregiversImpact of caregivingAnxiety symptom severityClinically significant depressionGeneralized anxiety disorderMental health symptomologyWorsening anxiety symptomsWorsening depressive symptomsIntensive longitudinal designPhysically aggressive behaviorDementia caregiversCaregiver populationCaregiver psychopathologyLinear mixed modelsSignificant interaction effectCaregiversMild Traumatic Brain Injury in U.S. Military Veterans: Results from the National Health and Resilience in Veterans Study
Meshberg-Cohen S, Cook J, Fischer I, Pietrzak R. Mild Traumatic Brain Injury in U.S. Military Veterans: Results from the National Health and Resilience in Veterans Study. Psychiatry 2024, 87: 314-328. PMID: 39186319, DOI: 10.1080/00332747.2024.2392226.Peer-Reviewed Original ResearchMild traumatic brain injuryNational Health and ResilienceU.S. military veteransPsychosocial functioningTraumatic brain injuryVeterans StudyMilitary veteransCurrent posttraumatic stress disorderOutcomes of mild traumatic brain injuryLifetime psychiatric conditionsGeneralized anxiety disorderComorbid psychiatric diagnosesPosttraumatic stress disorderPoor psychosocial functioningMild traumatic brain injury eventDrug use disordersBrain injuryPrevention of disabilityAssociated with increased oddsAnxiety disordersDepressive disorderStress disorderPsychiatric diagnosisMTBI symptomsPsychiatric characteristicsSuccessful Aging in US Veterans with Mental Disorders: Results From the National Health and Resilience in Veterans Study
Shin J, Fischer I, Na P, Jeste D, Pietrzak R. Successful Aging in US Veterans with Mental Disorders: Results From the National Health and Resilience in Veterans Study. American Journal Of Geriatric Psychiatry 2024, 33: 85-91. PMID: 39214753, DOI: 10.1016/j.jagp.2024.07.018.Peer-Reviewed Original ResearchGeneralized anxiety disorderPosttraumatic stress disorderMental disordersSomatic symptomsNational Health and ResilienceUS military veteransSuccessful agingAnxiety disordersDepressive disorderUS veteransStress disorderPromote successful agingHigher gratitudeVeterans StudyMilitary veteransInterventions targeting psychosocial factorsOne-in-fiveVeteransMDDDisordersPsychosocial factorsGratitudeNegative associationSymptomsMultivariate logistic regressionApplication of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and somatic traits
Hartwell E, Jinwala Z, Milone J, Ramirez S, Gelernter J, Kranzler H, Kember R. Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and somatic traits. Neuropsychopharmacology 2024, 49: 1958-1967. PMID: 39043921, PMCID: PMC11480112, DOI: 10.1038/s41386-024-01922-2.Peer-Reviewed Original ResearchSubstance use disordersPost-traumatic stress disorderGeneralized anxiety disorderGenetic liabilityPolygenic scoresBipolar disorderSubstance use phenotypesSomatic traitsBody mass indexSubstance use categoriesEffect of genetic liabilityAnxiety disordersDepression-relatedDepressive disorderApplication of polygenic scoresStress disorderPsychiatric disordersPsychiatric phenotypesUse disorderPhenome-wide association studyGenetic influencesCross-sectional sampleMedical illnessPrecision medicine effortsPhenotyped sampleDifferences in Mental Illness Stigma by Disorder and Gender: Population-Based Vignette Randomized Experiment in Rural Uganda.
Lee Y, Christ R, Mbabazi R, Dabagia J, Prendergast A, Wykoff J, Dasari S, Safai D, Nakaweesi S, Aturinde S, Galvin M, Akena D, Ashaba S, Waiswa P, Rosenheck R, Tsai A. Differences in Mental Illness Stigma by Disorder and Gender: Population-Based Vignette Randomized Experiment in Rural Uganda. PLOS Mental Health 2024, 1: e0000069. PMID: 39188639, PMCID: PMC11345708, DOI: 10.1371/journal.pmen.0000069.Peer-Reviewed Original ResearchMental illness stigmaIllness stigmaAnxiety disordersMental disordersLevels of mental illness stigmaRural UgandaImprove population mental healthAnti-stigma initiativesLevel of stigmaPopulation mental healthGeneralized anxiety disorderDSM-5 criteriaAlcohol use disorderEmpirical p-valuesVignette studyMental illnessPairwise mean comparisonsDistricts of UgandaPopulation-basedMental healthDepressive disorderGender combinationsUse disorderSecondary analysisStudy participantsPosttraumatic stress disorder and insomnia in US military veterans: Prevalence, correlates, and psychiatric and functional burden
Georgescu M, Fischer I, Beydoun M, McCarthy E, DeViva J, Pietrzak R. Posttraumatic stress disorder and insomnia in US military veterans: Prevalence, correlates, and psychiatric and functional burden. Journal Of Sleep Research 2024, 34: e14269. PMID: 38845413, PMCID: PMC11624313, DOI: 10.1111/jsr.14269.Peer-Reviewed Original ResearchPosttraumatic stress disorderStress disorderMilitary veteransInsomnia groupCo-occurring posttraumatic stress disorderBurden of PTSDTreating posttraumatic stress disorderClinical management of insomniaRates of psychiatric conditionsGeneralized anxiety disorderCurrent suicidal ideationMitigate suicide riskUS veteransManagement of insomniaUS military veteransMental health burdenFunctional burdenAnxiety disordersDepressive disorderSuicidal ideationSuicide riskPsychiatric conditionsPsychosocial functioningSocial functioningInsomniaObstructive respiratory disease in U.S. veterans: Prevalence, characteristics, and health burden
Bamonti P, Fischer I, Moye J, Poghosyan H, Pietrzak R. Obstructive respiratory disease in U.S. veterans: Prevalence, characteristics, and health burden. Journal Of Psychiatric Research 2024, 176: 140-147. PMID: 38857555, DOI: 10.1016/j.jpsychires.2024.05.053.Peer-Reviewed Original ResearchPhysical health burdenNationally Representative SampleU.S. veteransObstructive respiratory diseaseHealth burdenRepresentative sampleNational Health and ResiliencePhysical health characteristicsRespiratory diseaseSecondary data analysisSevere somatic symptomsHealth characteristicsVA healthcareVeterans StudyTrauma burdenLow-incomeSomatic symptomsPosttraumatic stressMultivariate regression analysisVeteransMedical conditionsCurrent suicidal ideationGeneralized anxiety disorderMedical comorbiditiesNicotine use disorderLifetime prevalence, comorbidities, and Sociodemographic predictors of post-traumatic stress disorder (PTSD): the National Epidemiology of Iranian Children and adolescents Psychiatric disorders (IRCAP)
Hooshyari Z, Mohammadi M, Salmanian M, Ahmadi N, Khaleghi A, Garakani A. Lifetime prevalence, comorbidities, and Sociodemographic predictors of post-traumatic stress disorder (PTSD): the National Epidemiology of Iranian Children and adolescents Psychiatric disorders (IRCAP). European Child & Adolescent Psychiatry 2024, 33: 3965-3978. PMID: 38656607, DOI: 10.1007/s00787-024-02441-7.Peer-Reviewed Original ResearchPrevalence of post-traumatic stress disorderPost-traumatic stress disorderTraumatic eventsAnxiety disordersStress disorderPsychiatric disordersSchool-Age Children-Present and Lifetime VersionKiddie Schedule for Affective DisordersSchedule for Affective DisordersLifetime prevalenceLifetime prevalence of post-traumatic stress disorderType of traumatic eventPredictors of post-traumatic stress disorderRates of PTSDSeparation anxiety disorderGeneralized anxiety disorderK-SADS-PLOppositional defiant disorderPrevalence of PTSDRates of comorbidityAdolescent psychiatric disordersLifetime prevalence ratesPrevalence rates of comorbiditiesDepressive disorderLifetime VersionAntipsychotic agents in anxiety disorders: An umbrella review
Garakani A, Buono F, Salehi M, Funaro M, Klimowicz A, Sharma H, Faria C, Larkin K, Freire R. Antipsychotic agents in anxiety disorders: An umbrella review. Acta Psychiatrica Scandinavica 2024, 149: 295-312. PMID: 38382649, DOI: 10.1111/acps.13669.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSecond-generation antipsychoticsFirst-generation antipsychoticsGeneralized anxiety disorderStudies of antipsychoticsAnxiety disordersAntipsychotic agentsEfficacy of first-generation antipsychoticsTreatment of anxiety disordersEfficacy of antipsychotic agentsMeta-analysesAntidepressant treatmentNonantipsychotic medicationsAntipsychoticsFirst-line treatmentAnxietyComparing monotherapyUmbrella reviewDisordersQuetiapineSystematic reviewSide effectsAMSTAR-2Off-labelAPA PsycInfoCINAHL CompleteGeneralized anxiety and mild anxiety symptoms in U.S. military veterans: Prevalence, characteristics, and functioning
Macdonald-Gagnon G, Stefanovics E, Potenza M, Pietrzak R. Generalized anxiety and mild anxiety symptoms in U.S. military veterans: Prevalence, characteristics, and functioning. Journal Of Psychiatric Research 2024, 171: 263-270. PMID: 38325107, DOI: 10.1016/j.jpsychires.2024.02.013.Peer-Reviewed Original ResearchConceptsGeneralized anxiety disorderMild anxiety symptomsAnxiety symptomsMilitary veteransU.S. veteransCorrelates of generalized anxiety disorderCorrelates of anxiety symptomsAnxiety symptom severityU.S. military veteransAnxiety disordersGeneralized anxietyPoor mental healthSuicidal thoughtsSymptom severityMental disordersExcessive anxietyAnxietyMagnitude associationsMental healthFunctional impairmentVeteransFunctional correlatesClinical samplesNationally Representative SampleSymptoms
2023
W70. ASSOCIATION BETWEEN MBD5 GENE AND DEPRESSIVE SYMPTOMATOLOGY IN MEXICAN POPULATION: RESULTS FROM MXGDAR/ENCODAT COHORT
Camarena B, Sanabrais-Jiménez M, García A, Genis A, Villatoro-Velazquez J, Fleiz-Bautista C, Bustos-Gamiño M, Martínez-Magaña J, Nicolini H, Medina-Mora M. W70. ASSOCIATION BETWEEN MBD5 GENE AND DEPRESSIVE SYMPTOMATOLOGY IN MEXICAN POPULATION: RESULTS FROM MXGDAR/ENCODAT COHORT. European Neuropsychopharmacology 2023, 75: s141. DOI: 10.1016/j.euroneuro.2023.08.257.Peer-Reviewed Original ResearchDepressive symptomsAnxiety symptomsAnxiety disordersSubstantial disease burdenMexican populationGenetic principal componentsYears of lifeGeneralized anxiety disorderFindings of associationsDisease burdenHealthy controlsMexican cohortMajor depressiveGeneral populationDiagnostic criteriaLifetime symptomatologyGenetic overlapSymptomsMBD5 geneDepressiveBackground AnxietyCohortProtein 5DepressionGreater mortalityPrescribing of Z-Drugs With and Without Opioid Coprescribing to Primary Care Patients in a Large Health Care System From 2019-2020.
Anand A, Weleff J, Thompson N, Barnett B. Prescribing of Z-Drugs With and Without Opioid Coprescribing to Primary Care Patients in a Large Health Care System From 2019-2020. The Journal Of Clinical Psychiatry 2023, 84 PMID: 37707315, DOI: 10.4088/jcp.22m14753.Peer-Reviewed Original ResearchConceptsZ-drug prescribingDiagnosis of opioid use disorderZ-drug prescriptionsOpioid use disorderZ-drugsHealth care systemPrimary care clinicsWhite raceUse disorderCare systemAssociated with increasing ageCare clinicsOlder ageStudy periodDiagnosis of bipolar disorderCross-sectional studyPrimary care patientsLarger health care systemAdult patientsPatient populationOpioidGeneralized anxiety disorderPatientsBipolar disorderPost-lockdownPotentially Traumatic Events of Women of Color in an Urban Adult Basic Education Program
Crouch M, Miller-Roenigk B, Schrader S, Griffith F, Simmons S, Gordon D. Potentially Traumatic Events of Women of Color in an Urban Adult Basic Education Program. Journal Of Aggression Maltreatment & Trauma 2023, 33: 432-450. PMID: 38798799, PMCID: PMC11114608, DOI: 10.1080/10926771.2023.2231384.Peer-Reviewed Original ResearchAdult Basic EducationTraumatic eventsLife Events ChecklistAdult basic education programsGeneralized anxiety disorderPaucity of researchEvents ChecklistTrauma typesABE studentsAnxiety disordersHigh school graduationMillions of studentsAnxiety scoresWomen of colorBasic education programsPresent researchHigher ratingsSchool graduationHealth QuestionnaireEducational needsPatient Health QuestionnaireStudentsDiverse peopleMore researchDepressionCandidate biomarkers in psychiatric disorders: state of the field
Abi-Dargham A, Moeller S, Ali F, DeLorenzo C, Domschke K, Horga G, Jutla A, Kotov R, Paulus M, Rubio J, Sanacora G, Veenstra-VanderWeele J, Krystal J. Candidate biomarkers in psychiatric disorders: state of the field. World Psychiatry 2023, 22: 236-262. PMID: 37159365, PMCID: PMC10168176, DOI: 10.1002/wps.21078.Peer-Reviewed Original ResearchError-related negativityAutism spectrum disorderAnxiety disordersSpectrum disorderFunctional magnetic resonance imaging (fMRI) measuresEvent-related brain potentialsPost-traumatic stress disorderSocial anxiety disorderTreatment responseCandidate biomarkersGeneralized anxiety disorderResting-state functional magnetic resonance imaging (rsfMRI) measuresDefinitive testingBrain potentialsNeuroscience literatureElectrophysiological indicesStress disorderMagnetic resonance imaging (MRI) measuresNaturalistic settingConnectomic measuresNumerous candidate biomarkersPresence of illnessMobile health toolsIndividual levelBiomarker validation processThe current state-of-the-art in pharmacotherapy for pediatric generalized anxiety disorder
Castagna P, Farahdel E, Potenza M, Crowley M. The current state-of-the-art in pharmacotherapy for pediatric generalized anxiety disorder. Expert Opinion On Pharmacotherapy 2023, 24: 835-847. PMID: 37074259, PMCID: PMC10197951, DOI: 10.1080/14656566.2023.2199921.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSelective serotonin reuptake inhibitorsSelective norepinephrine reuptake inhibitorGeneralized anxiety disorderAnxiety disordersReuptake inhibitorsPediatric generalized anxiety disorderBetter long-term outcomesSecond-line treatmentNorepinephrine reuptake inhibitorsSerotonin reuptake inhibitorsFirst-line interventionLong-term outcomesCombination of psychotherapyPrevalent psychiatric disordersEvidence-based statePediatric anxiety disordersArt pharmacotherapyModerate effect sizeFunctional outcomeEarly recognitionMood disordersElevated riskPsychiatric disordersBetter outcomesElectronic databasesMultimorbidity and Correlates of Comorbid Depression and Generalized Anxiety Disorder in a Nationally Representative US Sample
Jegede O, Stefanovics E, Rhee T, Rosenheck R. Multimorbidity and Correlates of Comorbid Depression and Generalized Anxiety Disorder in a Nationally Representative US Sample. The Journal Of Nervous And Mental Disease 2023, 211: 355-361. PMID: 36807207, DOI: 10.1097/nmd.0000000000001625.Peer-Reviewed Original ResearchConceptsMajor depressive disorderAdditional psychiatric diagnosesRepresentative US sampleComorbid groupPsychiatric disordersPsychiatric diagnosisPoor mental health qualityMental health-related qualityPoorer mental health-related qualityAnxiety disordersHealth-related qualityAdditional psychiatric disordersNationally Representative US SampleMental health qualityLogistic regression analysisSubstance use disordersNational Epidemiologic SurveyMDD-only groupRelated Conditions-IIISingle disorder groupsGeneralized anxiety disorderSingle diagnosis groupsPsychiatric comorbidityComorbid depressionDepressive disorderThe DIAMOND-KID: Psychometric Properties of a Structured Diagnostic Interview for DSM-5 Anxiety, Mood, and Obsessive-Compulsive and Related Disorders in Children and Adolescents
Tolin D, Sain K, Davis E, Gilliam C, Hannan S, Springer K, Stubbing J, George J, Jean A, Goldblum R, Katz B, Everhardt K, Darrow S, Ohr E, Young M, Serchuk M. The DIAMOND-KID: Psychometric Properties of a Structured Diagnostic Interview for DSM-5 Anxiety, Mood, and Obsessive-Compulsive and Related Disorders in Children and Adolescents. Assessment 2023, 30: 2351-2363. PMID: 36632642, DOI: 10.1177/10731911221143994.Peer-Reviewed Original ResearchConceptsSelf-report measuresDiagnostic InterviewSemi-structured diagnostic interviewObsessive-compulsive disorderGeneralized anxiety disorderSymptoms of anxietyDSM-5 AnxietyPediatric psychiatric disordersTest-retest reliability dataDisorder childrenAdolescent versionTest-retest reliabilityObsessive-CompulsiveAnxiety disordersConvergent validitySemi-structured interviewsQuestionable rangePsychometric propertiesAnxietyMoodRelated disordersInterrater reliability dataInitial interviewParents/guardiansGroup comparisons
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