2025
Extended Treatment Duration of Artemether‐Lumefantrine in Ugandan Children with HIV on Efavirenz‐Based Antiretroviral Therapy: A Randomized Controlled Pharmacokinetic and Pharmacodynamic Trial
Whalen M, Kajubi R, Goodwin J, Orukan F, Colt M, Huang L, Richards K, Hoffmann T, Aweeka F, Parikh S, Mwebaza N. Extended Treatment Duration of Artemether‐Lumefantrine in Ugandan Children with HIV on Efavirenz‐Based Antiretroviral Therapy: A Randomized Controlled Pharmacokinetic and Pharmacodynamic Trial. The Journal Of Clinical Pharmacology 2025, 65: 909-922. PMID: 39853752, DOI: 10.1002/jcph.6193.Peer-Reviewed Original ResearchDesbutyl-lumefantrineAntiretroviral therapyEfavirenz-based antiretroviral therapyEfavirenz-based HIV therapyEFV-based antiretroviral therapyEpisodes of malariaHIV Co-InfectionSignificant reductionExtended treatment durationStatistically significant reductionClinically significant reductionArtemether-lumefantrinePharmacodynamic trialsMalaria episodesPharmacokinetic samplingHIV therapyRandomized studyRecurrence riskDrug interactionsPrimary outcomeRegimensMalariaReinfection riskHIVCo-Infection
2024
Ventricular-subventricular zone stem cell niche adaptations in a mouse model of post-infectious hydrocephalus
Herman J, Rittenhouse N, Mandino F, Majid M, Wang Y, Mezger A, Kump A, Kadian S, Lake E, Verardi P, Conover J. Ventricular-subventricular zone stem cell niche adaptations in a mouse model of post-infectious hydrocephalus. Frontiers In Neuroscience 2024, 18: 1429829. PMID: 39145299, PMCID: PMC11322059, DOI: 10.3389/fnins.2024.1429829.Peer-Reviewed Original ResearchPost-infectious hydrocephalusVentricular-subventricular zoneInfluenza virusMouse modelMouse-adapted influenza virusIntact ependymaStem cellsPostnatal day 4Stem cell numbersStem cell nicheCell-to-cell transmissionOlfactory bulbMultiorgan hemorrhageLateral ventricleIntracerebroventricular injectionVentriculomegalyEmbryonic dayVentricular systemDay 4Cell nicheNo significant reductionHydrocephalusSignificant reductionVentricleCell numberIntegrating mental health into primary care in Nigeria: Implementation outcomes and clinical impact of the HAPPINESS intervention
Iheanacho T, Chu C, Aguocha C, Nwefoh E, Dike C. Integrating mental health into primary care in Nigeria: Implementation outcomes and clinical impact of the HAPPINESS intervention. Cambridge Prisms Global Mental Health 2024, 11: e9. PMID: 38390244, PMCID: PMC10882178, DOI: 10.1017/gmh.2024.4.Peer-Reviewed Original ResearchPost-interventionMental healthScale-up mental health servicesPatient Health Questionnaire scoresPrimary health care centersEffect sizeMental health servicesHealth care centersTechnology-supported interventionsStatistically significant reductionQuasi-experimental designPrimary careIntervention implementationImplementation outcomesHealth servicesHealth actionsCommunity-BasedBrief Psychiatric Rating Scale scoresQuestionnaire scoresSignificant reductionPsychiatric Rating Scale scoresCare centerPsychiatric problemsHappiness interventionsHealth
2023
Changes in Pain Among Housed and Unhoused U.S. Veterans After Receiving Battlefield Acupuncture at One Medical Center
Flike K, St. Pierre C, Howard A, Tsai J. Changes in Pain Among Housed and Unhoused U.S. Veterans After Receiving Battlefield Acupuncture at One Medical Center. Journal Of Alternative And Complementary Medicine 2023, 30: 306-309. PMID: 37878270, DOI: 10.1089/jicm.2023.0131.Peer-Reviewed Original ResearchNaltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial
Grilo C, Lydecker J, Jastreboff A, Pittman B, McKee S. Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial. Obesity 2023, 31: 2762-2773. PMID: 37751990, PMCID: PMC10600891, DOI: 10.1002/oby.23898.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderObesity statusLogistic regressionWeight lossPlacebo-controlled trialWeight loss outcomesPrevalent psychiatric disordersEvidence-based treatmentsPost-treatment assessmentBinge-eating frequencyGreater percentage weight lossMedication outcomesRemission ratePharmacological optionsPlaceboBupropionPsychiatric disordersPercentage weight lossMixed modelsDisordersObesityPatientsSignificant reductionWeight reductionReal-world effectiveness of risankizumab in patients with moderate-to-severe psoriasis using the CorEvitas Psoriasis Registry
Strober B, Ferris L, Callis Duffin K, Janak J, Sima A, Eckmann T, Patel M, Photowala H, Garg V, Armstrong A. Real-world effectiveness of risankizumab in patients with moderate-to-severe psoriasis using the CorEvitas Psoriasis Registry. Journal Of The American Academy Of Dermatology 2023, 90: 82-90. PMID: 37739267, DOI: 10.1016/j.jaad.2023.08.097.Peer-Reviewed Original ResearchDermatology Life Quality Index scoresLife Quality Index scoresPsoriasis RegistryQuality Index scoresSevere psoriasisPsoriasis symptomsClear skinIndex scoreReal-world treatment effectivenessPrior biologic treatmentSevere plaque psoriasisInflammatory skin diseasePatient-reported outcomesEntire study populationReal-world effectivenessSignificant reductionPlaque psoriasisEligible adultsPatient adherenceBiologic treatmentActivity impairmentObservational studyStudy populationRisankizumabPsoriasisGlenohumeral Superior Translation and Subacromial Contract Pressure Are Both Improved With Superior Capsular Reconstruction: A Systematic Review and Meta-analysis of Biomechanical Investigations
Mahatme R, Modrak M, Wilhelm C, Lee M, Owens J, Gillinov S, Fong S, Pettinelli N, Islam W, Jimenez A. Glenohumeral Superior Translation and Subacromial Contract Pressure Are Both Improved With Superior Capsular Reconstruction: A Systematic Review and Meta-analysis of Biomechanical Investigations. Arthroscopy The Journal Of Arthroscopic And Related Surgery 2023, 40: 1279-1287. PMID: 37634706, DOI: 10.1016/j.arthro.2023.08.025.Peer-Reviewed Original ResearchGlenohumeral superior translationSuperior capsular reconstructionStandardized mean differenceSubacromial contact pressureGraft typeFascia lata graftDifferent graft typesCapsular reconstructionRTC tearsBiomechanical outcomesSuperior translationDermal allograftRotator cuffSystematic reviewIrreparable Rotator CuffSuperior capsule reconstructionConfidence intervalsMeta-Analyses (PRISMA) criteriaPreferred Reporting ItemsNumber of shouldersSignificant reductionCapsule reconstructionGraft optionsReconstruction surgeryReporting ItemsA Systematic Review and Meta-Analysis Evaluating the Efficacy of Stand-Alone Digital Interventions to Prevent Substance Use Among Adolescents
Aneni K, Meyer J, Funaro M, Pegram D, Umutoni F, Gomati de la Vega I, Jiao M, Fernandes C, Onyeaka H, Baiden P, Camenga D. A Systematic Review and Meta-Analysis Evaluating the Efficacy of Stand-Alone Digital Interventions to Prevent Substance Use Among Adolescents. Current Addiction Reports 2023, 10: 378-395. DOI: 10.1007/s40429-023-00508-0.Peer-Reviewed Original ResearchSubstance useTobacco useLarge effect sizesSystematic reviewDigital interventionsEffect sizeSystematic literature searchBooster sessionsPrevention servicesPacific Islander groupsTrial studySignificant effect sizePrevent Substance UseMeta-analysisCannabis useLiterature searchAlcohol useEthnic distributionInterventionSignificant reductionAdolescentsMultiple sessionsEfficacyCannabisNative American adolescentsTrastuzumab deruxtecan in recurrent uterine serous carcinoma resistant to trastuzmab based-chemotherapy
McNamara B, Bellone S, Demirkiran C, Hartwich T, Santin A. Trastuzumab deruxtecan in recurrent uterine serous carcinoma resistant to trastuzmab based-chemotherapy. Gynecologic Oncology Reports 2023, 48: 101219. PMID: 37325293, PMCID: PMC10265462, DOI: 10.1016/j.gore.2023.101219.Peer-Reviewed Original ResearchUterine serous carcinomaHER2/neuSerous carcinomaT-DXdTreatment optionsRecurrent uterine serous carcinomaDose-limiting side effectEffective treatment optionNew treatment optionsBone painRecurrent diseaseDurable responsesTrastuzumab deruxtecanCA 125Disease burdenSide effectsCarcinomaAntibody drugsTreatmentSignificant reductionDiseaseNeuExperimental treatmentsMetastaticPainAntiplatelet Strategies Following PCI: A Review of Trials Informing Current and Future Therapies
Thomas A, Gitto M, Shah S, Saito Y, Tirziu D, Chieffo A, Stefanini G, Lansky A. Antiplatelet Strategies Following PCI: A Review of Trials Informing Current and Future Therapies. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100607. PMID: 39130709, PMCID: PMC11307978, DOI: 10.1016/j.jscai.2023.100607.Peer-Reviewed Original ResearchDual antiplatelet therapyAntiplatelet regimensPatient-specific risk profileShorter DAPT durationDuration of therapyPercutaneous coronary interventionDAPT strategyIschemic riskAntiplatelet therapyDAPT durationAntiplatelet strategiesCoronary interventionOngoing trialsMajor trialsRecent trialsPractice guidelinesFuture therapiesRisk profileTherapyStent technologyTrialsRegimensNumber of trialsSignificant reductionSignificant changesA Retrospective Analysis of the American Thrombosis and Hemostasis Network Dataset Describing Outcomes of Dental Extractions in Persons with Hemophilia
Messenger H, Kulkarni R, Recht M, He C. A Retrospective Analysis of the American Thrombosis and Hemostasis Network Dataset Describing Outcomes of Dental Extractions in Persons with Hemophilia. Journal Of Clinical Medicine 2023, 12: 1839. PMID: 36902626, PMCID: PMC10002874, DOI: 10.3390/jcm12051839.Peer-Reviewed Original ResearchDental extractionHemostatic therapyBleeding outcomesStatistically significant increased oddsNon-statistically significant reductionAmerican ThrombosisAssociated with bleedingLikelihood of bleedingHalf-life productsYears of ageDental bleedingImpact of HTBleeding episodesHemophilia AMild haemophiliaSevere haemophiliaMild diseaseRetrospective analysisBleedingFactor concentrationsHemophiliaDentalPWHSignificant reductionYounger ageProspective associations of psychedelic treatment for co-occurring alcohol misuse and posttraumatic stress symptoms among United States Special Operations Forces Veterans
Armstrong S, Xin Y, Sepeda N, Polanco M, Averill L, Davis A. Prospective associations of psychedelic treatment for co-occurring alcohol misuse and posttraumatic stress symptoms among United States Special Operations Forces Veterans. Military Psychology 2023, 36: 184-191. PMID: 38377244, PMCID: PMC10880491, DOI: 10.1080/08995605.2022.2156200.Peer-Reviewed Original ResearchPost-traumatic stress disorderRisky alcohol useAlcohol useRisky drinkersProspective associationsCognitive functioning changesAlcohol misuseCo-occurring alcohol misusePosttraumatic stress symptomsFuture clinical trialsPTSD symptomsComplex traumaPsychedelic-assisted therapyStress disorderStress symptomsClinical characteristicsClinical trialsDMT treatmentPsychedelic treatmentTraditional interventionsTreatment programSignificant reductionSymptomsRespondersTreatment
2022
Computational analysis to define efficacy & molecular mechanisms of 7, 4’- Dihydroxyflavone on eosinophilic esophagitis: Ex-vivo validation in human esophagus biopsies
Maskey A, Wang Z, Chen X, Dunkin D, Yang N, Soffer G, Yuan Q, Li X. Computational analysis to define efficacy & molecular mechanisms of 7, 4’- Dihydroxyflavone on eosinophilic esophagitis: Ex-vivo validation in human esophagus biopsies. Frontiers In Immunology 2022, 13: 1015437. PMID: 36591238, PMCID: PMC9797535, DOI: 10.3389/fimmu.2022.1015437.Peer-Reviewed Original ResearchConceptsLevels of TNFIL-6Abdominal painEosinophilic esophagitisBiopsy samplesAbnormal bowel movementsTreatment of EoEMain treatment optionDihydroxy flavonesSignificant reductionTraditional Chinese medicine practiceDietary eliminationEoE therapyGE refluxSwallowed steroidsBowel movementsEoE patientsEsophageal dysfunctionGI symptomsEosinophilic inflammationImmunological mechanismsSteroid treatmentUpper endoscopyIgE productionChinese medicine practicePrevalence of Plasmodium falciparum haplotypes associated with resistance to sulfadoxine–pyrimethamine and amodiaquine before and after upscaling of seasonal malaria chemoprevention in seven African countries: a genomic surveillance study
Beshir K, Muwanguzi J, Nader J, Mansukhani R, Traore A, Gamougam K, Ceesay S, Bazie T, Kolie F, Lamine M, Cairns M, Snell P, Scott S, Diallo A, Merle C, NDiaye J, Razafindralambo L, Moroso D, Ouedraogo J, Zongo I, Kessely H, Doumagoum D, Bojang K, Ceesay S, Loua K, Maiga H, Dicko A, Sagara I, Laminou I, Ogboi S, Eloike T, Milligan P, Sutherland C. Prevalence of Plasmodium falciparum haplotypes associated with resistance to sulfadoxine–pyrimethamine and amodiaquine before and after upscaling of seasonal malaria chemoprevention in seven African countries: a genomic surveillance study. The Lancet Infectious Diseases 2022, 23: 361-370. PMID: 36328000, DOI: 10.1016/s1473-3099(22)00593-x.Peer-Reviewed Original ResearchConceptsSeasonal malaria chemopreventionMalaria chemopreventionResistance-associated variantsParasite carriageSurvey-weighted prevalenceMalaria transmission seasonQuantitative PCRPrevalence ratiosP falciparumGenomic surveillance studyChemoprevention drugsBlood samplesSurveillance studyTransmission seasonChemopreventionPlasmodium falciparumAmodiaquinePrevalenceMDR1Variant haplotypeSequencing of isolatesSignificant reductionChildrenPyrimethamineCommunity surveyAssociations Between Inpatient Induction on Medications for Opioid Use Disorder and Postdischarge Medications for Opioid Use Disorder Adherence, Overdose, and Service Use
Noam K, Schmutte T, Pirard S, Bourdon C, Langless D, Plant R. Associations Between Inpatient Induction on Medications for Opioid Use Disorder and Postdischarge Medications for Opioid Use Disorder Adherence, Overdose, and Service Use. Journal Of Addiction Medicine 2022, 17: e199-e201. PMID: 37267183, DOI: 10.1097/adm.0000000000001092.Peer-Reviewed Original ResearchConceptsCause hospital readmissionOpioid use disorderHospital readmissionOdds ratioService utilizationMedical adviceOpioid overdoseUse disordersAcute service utilizationRetrospective cohort analysisContinuous Medicaid enrollmentSignificant reductionInpatient inductionPostdischarge medicationsAdherent patientsPostdischarge periodInpatient medicationsEmergency departmentMedicaid adultsInpatient careOpioid overdosesPreadmission periodCohort analysisHigher oddsInpatient daysYoung adult responses to taxes on cigarettes and electronic nicotine delivery systems
Friedman AS, Pesko MF. Young adult responses to taxes on cigarettes and electronic nicotine delivery systems. Addiction 2022, 117: 3121-3128. PMID: 35852452, PMCID: PMC9796020, DOI: 10.1111/add.16002.Peer-Reviewed Original ResearchConceptsElectronic nicotine delivery systemsNicotine delivery systemsDaily vapingYoung adulthoodRegular tobacco useMultivariable linear regressionTobacco Use SupplementOverall health implicationsCigarette smokingDaily smokingRegular smokingObservational studyTobacco useRecent smokingSmokingCigarette tax increaseENDS useYoung adults' responsesDelivery systemHealth costsVapingHealth implicationsRecent evidenceCigarette taxesSignificant reductionA Culturally Grounded Prenatal Coparenting Intervention: Results of a Randomized Controlled Trial With Unmarried Black Parents
McHale JP, Stover CS, Dubé C, Sirotkin YS, Lewis S, McKay K. A Culturally Grounded Prenatal Coparenting Intervention: Results of a Randomized Controlled Trial With Unmarried Black Parents. Journal Of Family Psychology 2022, 36: 479-489. PMID: 35084880, PMCID: PMC9646643, DOI: 10.1037/fam0000965.Peer-Reviewed Original ResearchConceptsControl group mothersIntervention groupMonths postpartumGroup mothersPsychological intimate partner violenceIntimate partner violenceSelf-reported depressionTreat analysisControlled TrialsPrenatal interventionFirst babyDepressive symptomsUsual groupControl groupMother-father dyadsFCC interventionsMothersSignificant reductionInterventionPostpartumUnmarried mothersPartner violenceFather engagementConsultation sessionsGroupA Flavonoid Compound 7, 4 Dihydroxy Flavone as a Potential Therapeutic for the Treatment and Management of EoE
Maskey A, Wang Z, Chen X, Dunkin D, Soffer G, Yuan Q, Li X. A Flavonoid Compound 7, 4 Dihydroxy Flavone as a Potential Therapeutic for the Treatment and Management of EoE. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r4598.Peer-Reviewed Original ResearchLevels of TNFManagement of EoEIL-6Biopsy samplesAbnormal bowel movementsProlonged steroid useDihydroxy flavonesHigh relapse rateRisk of cancerAGE-RAGE pathwayHigh response rateSignificant reductionTraditional Chinese medicine practiceEase of administrationPathway analysisDietary eliminationOral steroidsSystemic steroidsAbdominal painBowel movementsEsophageal dysfunctionGI symptomsMaintenance therapyEosinophilic inflammationGastrointestinal refluxRapid emergence of SARS-CoV-2 Omicron variant is associated with an infection advantage over Delta in vaccinated persons
Chaguza C, Coppi A, Earnest R, Ferguson D, Kerantzas N, Warner F, Young HP, Breban MI, Billig K, Koch RT, Pham K, Kalinich CC, Ott IM, Fauver JR, Hahn AM, Tikhonova IR, Castaldi C, De Kumar B, Pettker CM, Warren JL, Weinberger DM, Landry ML, Peaper DR, Schulz W, Vogels CBF, Grubaugh ND. Rapid emergence of SARS-CoV-2 Omicron variant is associated with an infection advantage over Delta in vaccinated persons. Med 2022, 3: 325-334.e4. PMID: 35399324, PMCID: PMC8983481, DOI: 10.1016/j.medj.2022.03.010.Peer-Reviewed Original ResearchConceptsSpike gene target failureSARS-CoV-2 Omicron variantPositivity rateOmicron variantOmicron infectionVaccine dosesVaccine-induced immunityNumber of dosesTest positivity rateOdds of infectionSARS-CoV-2Significant reductionDominant Delta variantUnvaccinated personsVaccination statusHigher oddsDelta variantInfectionVaccine manufacturersDisease controlVirus copiesDosesPCR testOddsTarget failurePressure‐based estimation of right ventricular ejection fraction
Heerdt PM, Singh I, Elassal A, Kheyfets V, Richter MJ, Tello K. Pressure‐based estimation of right ventricular ejection fraction. ESC Heart Failure 2022, 9: 1436-1443. PMID: 35150211, PMCID: PMC8934966, DOI: 10.1002/ehf2.13839.Peer-Reviewed Original ResearchConceptsRight ventricular ejection fractionCardiac magnetic resonance imagingRight heart catheterizationPulmonary arterial hypertensionMagnetic resonance imagingRV pressure waveformsVentricular ejection fractionRV responseEjection fractionMale PAH patientsCardiac MRI measurementsReceiver operator characteristic curvePressure waveformROC curve analysisClinical reference standardOperator characteristic curveSignificant reductionMeasurements of RVEFPAH patientsArterial hypertensionHeart catheterizationSecondary outcomesStudy cohortLimits of agreementBland-Altman analysis
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