2025
Sleep and Circadian-Related Outcomes after Critical Illness
Pisani M. Sleep and Circadian-Related Outcomes after Critical Illness. Seminars In Respiratory And Critical Care Medicine 2025 PMID: 40164118, DOI: 10.1055/a-2531-1137.Peer-Reviewed Original ResearchPost-intensive care syndromeCircadian disruptionExamined symptomsConstellation of symptomsSleep complaintsInfluence long-term outcomesSurvivors of critical illnessIntensive care unitIntensive care unit environmentSleepCritical illnessQuality of lifeCritically ill patientsIll patientsIllnessPost-ICUSymptomsStudy of critically ill patients
2024
Sleep Deficiency and Opioid Use Disorder Trajectory, Mechanisms, and Interventions
Langstengel J, Yaggi H. Sleep Deficiency and Opioid Use Disorder Trajectory, Mechanisms, and Interventions. Sleep Medicine Clinics 2024, 19: 625-638. PMID: 39455182, DOI: 10.1016/j.jsmc.2024.07.009.Peer-Reviewed Original ResearchConceptsOpioid use disorderRelapsing brain diseaseSleep deficiencyLoss of controlOpioid usePain perceptionUse disorderMultiple potential causesCognitive functionPoor sleep qualitySleep disordersAutonomic activityTherapeutic targetDisrupted sleepCircadian disruptionOpioidSleep qualityBrain diseasesPotential causesDisordersSleepDeficiencyBidirectional mechanismPainPatients
2023
0841 Feasibility of Actigraphy during a Daytime Bright Pilot Study in the Medical ICU
Lukas M, Doyle M, Intihar T, Wright K, Redeker N, Pisani M, Yaggi H, Knauert M. 0841 Feasibility of Actigraphy during a Daytime Bright Pilot Study in the Medical ICU. Sleep 2023, 46: a370-a371. DOI: 10.1093/sleep/zsad077.0841.Peer-Reviewed Original ResearchRest-activity patternsCircadian quotientMICU patientsPilot studyCosinor analysisStudy days 1Illness severity scoresCritical illnessMedical ICUMethods PatientsOngoing RCTsMean ageSeverity scorePatient outcomesActigraphy recordingsPatientsDay 1Patient careCircadian disruptionResults ThirteenActigraphyTotal recordingCircadian alignmentCircadian misalignmentMesor
2022
Best Practice for Improving Sleep in the ICU. Part I: Non-pharmacologic
Korwin A, Knauert M. Best Practice for Improving Sleep in the ICU. Part I: Non-pharmacologic. 2022, 231-248. DOI: 10.1007/978-3-031-06447-0_14.ChaptersIntensive care unitICU patientsNormal sleepCritical care treatmentNon-pharmacologic therapiesNon-pharmacologic interventionsMost ICU patientsAbnormal circadian rhythmPoor quality sleepCircadian functionAcute illnessCritical illnessPatient characteristicsIll adultsCare unitChronotherapeutic interventionsCare treatmentSleep preferenceCurrent evidencePatient careCircadian disruptionSleepPatientsFuture interventionsPractice changeSleep in Critical Illness: Future Directions
Knauert M, Parthasarathy S. Sleep in Critical Illness: Future Directions. 2022, 291-309. DOI: 10.1007/978-3-031-06447-0_17.ChaptersIntensive care unitCritical illnessSleep disruptionSleep promotionCircadian disruptionAcute illness factorsCritical care outcomesCritical illness outcomesAspects of sleepICU sleepCare unitICU cliniciansIllness factorsPatient outcomesMethodologic limitationsIllness outcomesSleep interventionsCare outcomesClinical practiceSleep measuresSleep deficiencyNatural historyLimited evidenceSleepIllness
2020
Pilot Observational Study to Detect Diurnal Variation and Misalignment in Heart Rate Among Critically Ill Patients
Knauert MP, Murphy TE, Doyle MM, Pisani MA, Redeker NS, Yaggi HK. Pilot Observational Study to Detect Diurnal Variation and Misalignment in Heart Rate Among Critically Ill Patients. Frontiers In Neurology 2020, 11: 637. PMID: 32760341, PMCID: PMC7373742, DOI: 10.3389/fneur.2020.00637.Peer-Reviewed Original ResearchMedical ICU admissionIntensive care unitHeart rateIll patientsICU admissionCircadian alignmentMedical record chart abstractionsProspective observational cohort studyCircadian disruptionMedical ICU patientsObservational cohort studyCritical illness outcomesPilot observational studyContinuous telemetric monitoringChart abstractionExploratory analysisCohort studyCritical illnessHospital admissionICU patientsCare unitPatient interviewsFrequent bloodOdds ratioObservational study
2016
Fus1 KO Mouse As a Model of Oxidative Stress-Mediated Sporadic Alzheimer's Disease: Circadian Disruption and Long-Term Spatial and Olfactory Memory Impairments
Coronas-Samano G, Baker KL, Tan WJ, Ivanova AV, Verhagen JV. Fus1 KO Mouse As a Model of Oxidative Stress-Mediated Sporadic Alzheimer's Disease: Circadian Disruption and Long-Term Spatial and Olfactory Memory Impairments. Frontiers In Aging Neuroscience 2016, 8: 268. PMID: 27895577, PMCID: PMC5108791, DOI: 10.3389/fnagi.2016.00268.Peer-Reviewed Original ResearchSporadic Alzheimer's diseaseKO miceOxidative stressAlzheimer's diseaseYounger ageWT adult miceOlfactory memory impairmentsEffective therapeutic treatmentMore sleep timeClear deficitNeurobehavioral deficitsRisk factorsAD hallmarksMetabolic dysregulationOlfactory bulbAdult miceAnimal modelsSleep timeEarly interventionMemory impairmentAD etiologyPharmacological targetsTherapeutic treatmentCircadian disruptionMiceComparing average levels and peak occurrence of overnight sound in the medical intensive care unit on A-weighted and C-weighted decibel scales
Knauert M, Jeon S, Murphy TE, Yaggi HK, Pisani MA, Redeker NS. Comparing average levels and peak occurrence of overnight sound in the medical intensive care unit on A-weighted and C-weighted decibel scales. Journal Of Critical Care 2016, 36: 1-7. PMID: 27546739, PMCID: PMC5097003, DOI: 10.1016/j.jcrc.2016.06.005.Peer-Reviewed Original ResearchConceptsIntensive care unitMedical intensive care unitCare unitWorld Health Organization recommendationsProspective observational studyICU patient roomsIllness severityPatient factorsMechanical ventilationObservational studyPeak occurrenceICU environmentSignificant discordanceCircadian disruptionPatient roomsDecibel scaleSound levelsEquivalent sound levelPeak measuresDeliriumLevelsMeaningful factorsSleepLow-frequency soundAverage level
2005
Period3 Structural Variation: A Circadian Biomarker Associated with Breast Cancer in Young Women
Zhu Y, Brown HN, Zhang Y, Stevens RG, Zheng T. Period3 Structural Variation: A Circadian Biomarker Associated with Breast Cancer in Young Women. Cancer Epidemiology Biomarkers & Prevention 2005, 14: 268-270. PMID: 15668506, DOI: 10.1158/1055-9965.268.14.1.Peer-Reviewed Original ResearchConceptsCircadian genesCell cycle regulationCycle regulationCircadian biologyBiological pathwaysGenesHuman cancersCell proliferationLength variationTumor developmentStructural variationsCircadian rhythmNovel panelNovel findingsBreast cancerCircadian disruptionPotential biomarkersBiologyMutationsCaucasian controlsApoptosisBiomarkers AssociatedPathwayRegulationDeregulation
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