2023
Outcomes of Infliximab-Treated inflammatory bowel disease patients undergoing therapeutic drug monitoring with two different assays
Al-Bawardy B, Jenkins S, Snyder M, Frinack J, Ladwig P, Loftus E, Willrich M. Outcomes of Infliximab-Treated inflammatory bowel disease patients undergoing therapeutic drug monitoring with two different assays. Clinical Biochemistry 2023, 119: 110618. PMID: 37507083, DOI: 10.1016/j.clinbiochem.2023.110618.Peer-Reviewed Original ResearchConceptsInflammatory bowel disease patientsBowel disease patientsEndoscopic healingClinical remissionDisease patientsMcg/Normal serum C-reactive proteinDrug monitoringSerum C-reactive proteinLC-MS/MSInfliximab drug levelsFavorable clinical outcomeC-reactive proteinTherapeutic drug monitoringIBD patientsNormal CRPClinical outcomesDrug levelsPatientsECLIARemissionDifferent assaysOutcomesMcgAssays
2022
Effects of Ketamine Infusion on Breathing and Encephalography in Spontaneously Breathing ICU Patients
Suleiman A, Santer P, Munoz-Acuna R, Hammer M, Schaefer MS, Wachtendorf LJ, Rumyantsev S, Berra L, Chamadia S, Johnson-Akeju O, Baedorf-Kassis EN, Eikermann M. Effects of Ketamine Infusion on Breathing and Encephalography in Spontaneously Breathing ICU Patients. Journal Of Intensive Care Medicine 2022, 38: 299-306. PMID: 35934953, DOI: 10.1177/08850666221119716.Peer-Reviewed Original ResearchConceptsSpontaneous breathing trialKetamine infusionMcg/Inspiratory flowInspiratory workKey secondary endpointProspective interventional studyEnd-expiratory pressurePre-specified time pointsKetamine 10Breathing trialSecondary endpointsPrimary outcomeICU patientsIll patientsMechanical ventilationEsophageal pressureInfusion regimenInterventional studyPropofol sedationRespiratory timingResistive workAirway flowPreclinical studiesElectroencephalographic patterns
2020
Undervirilized male infant with in utero exposure to maternal use of high dose antifungal therapy
Gujral J, Costin G, Khurana D, Yau M, Wallach E, Romero CJ, Wilkes M, Sethuram S, Rapaport R. Undervirilized male infant with in utero exposure to maternal use of high dose antifungal therapy. International Journal Of Pediatric Endocrinology 2020, 2020: 16. PMID: 32944019, PMCID: PMC7488073, DOI: 10.1186/s13633-020-00087-1.Peer-Reviewed Original ResearchDays of lifeHuman chorionic gonadotropinMale infantCortisol responseHigh-dose antifungal therapyPerineo-scrotal hypospadiasSubnormal cortisol responseEndocrine disruptorsAntepartum useWeeks' gestationUtero exposureFirst trimesterMineralocorticoid deficiencyAdrenal corticosteroidsVaginal dischargeMale newbornsAntifungal therapyMaternal useMcg/Androgen receptorCommon pathologyAndrogen synthesisChorionic gonadotropinTesticular responseInfants
1989
Effects of alprazolam and clonidine on carbon dioxide-induced increases in anxiety ratings in healthy human subjects
Woods S, Krystal J, Heninger G, Charney D. Effects of alprazolam and clonidine on carbon dioxide-induced increases in anxiety ratings in healthy human subjects. Life Sciences 1989, 45: 233-242. PMID: 2503670, DOI: 10.1016/0024-3205(89)90255-5.Peer-Reviewed Original ResearchConceptsHealthy human subjectsClonidine 2 mcg/Pulse rateEffects of alprazolamAnxiety-like effectsHuman subjectsRatings of anxietyOral alprazolamHypotensive effectVentilatory responseMcg/Noradrenergic systemBenzodiazepine receptorsAnxiolytic propertiesNeurobiologic mechanismsClonidineNew drugsAlprazolamAnxiety ratingsSubjective anxietyDrugsAnxietyNormal functioningNeural systemsUseful model system
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