2025
A computable electronic health record ARDS classifier recapitulates an association between the MUC5B promoter polymorphism and ARDS in critically ill adults.
Kerchberger V, McNeil J, Zheng N, Chang D, Rosenberger C, Rogers A, Bastarache J, Feng Q, Wei W, Ware L. A computable electronic health record ARDS classifier recapitulates an association between the MUC5B promoter polymorphism and ARDS in critically ill adults. CHEST Critical Care 2025, 100150. DOI: 10.1016/j.chstcc.2025.100150.Peer-Reviewed Original ResearchElectronic health recordsCritically Ill AdultsElectronic health record dataMUC5B Promoter PolymorphismIll adultsAt-risk adultsNegative predictive valuePositive predictive valueDiagnostic billing codesHealth recordsHospital participationGenetic risk factorsDNA biobanksBilling codesBioVUStudy designPromoter polymorphismCohort of critically ill adultsAt-riskCohen's kappaModerate agreementRisk factorsGenotyped cohortPredictive valueBiobank
2024
Early goal enteral nutrition associated with decreased in-hospital death in mechanically ventilated critically ill adults: a retrospective cohort study
Powierza C, Doyle M, Wasden K, Intihar T, Korwin A, Honiden S, Knauert M. Early goal enteral nutrition associated with decreased in-hospital death in mechanically ventilated critically ill adults: a retrospective cohort study. BMJ Open Respiratory Research 2024, 11: e001962. PMID: 38749534, PMCID: PMC11097881, DOI: 10.1136/bmjresp-2023-001962.Peer-Reviewed Original ResearchConceptsEarly enteral nutritionIn-Hospital DeathCritically Ill AdultsRetrospective cohort studyDays of intubationEnteral nutritionIll adultsAdult patientsCohort studyAssociated with decreased in-hospital deathsMechanically ventilated critically ill adultsGoal enteral nutritionIncreased hospital dischargeInitiation of ENCritically ill adult patientsMechanically ventilated adult patientsIncidence of in-hospital deathMedical intensive care unitAssociated with significant improvementsIll adult patientsDose of ENIntensive care unitClinical outcomesImprove mortalityPrimary outcomeGuidelines for Neuroprognostication in Critically Ill Adults with Moderate–Severe Traumatic Brain Injury
Muehlschlegel S, Rajajee V, Wartenberg K, Alexander S, Busl K, Creutzfeldt C, Fontaine G, Hocker S, Hwang D, Kim K, Madzar D, Mahanes D, Mainali S, Meixensberger J, Sakowitz O, Varelas P, Weimar C, Westermaier T. Guidelines for Neuroprognostication in Critically Ill Adults with Moderate–Severe Traumatic Brain Injury. Neurocritical Care 2024, 40: 448-476. PMID: 38366277, PMCID: PMC10959796, DOI: 10.1007/s12028-023-01902-2.Peer-Reviewed Original ResearchTraumatic brain injuryBrain injuryFunctional outcomesSurrogate decision-makersSurrogates of patientsSystematic narrative reviewIMPACT lab modelQuality of evidenceClinical variablesDesirability of outcomesClinically relevant predictorsCritically Ill AdultsRecommendations AssessmentComfort measuresIn-Hospital MortalityConclusionsThese guidelinesMsTBIEligibility criteriaPoor outcomeIll adultsPatient triagePractice recommendationsIndividual predictorsInternational Mission for PrognosisNarrative review
2023
Guidelines for Neuroprognostication in Critically Ill Adults with Intracerebral Hemorrhage
Hwang D, Kim K, Muehlschlegel S, Wartenberg K, Rajajee V, Alexander S, Busl K, Creutzfeldt C, Fontaine G, Hocker S, Madzar D, Mahanes D, Mainali S, Sakowitz O, Varelas P, Weimar C, Westermaier T, Meixensberger J. Guidelines for Neuroprognostication in Critically Ill Adults with Intracerebral Hemorrhage. Neurocritical Care 2023, 40: 395-414. PMID: 37923968, PMCID: PMC10959839, DOI: 10.1007/s12028-023-01854-7.Peer-Reviewed Original ResearchClinical grading scaleClinical variablesGrading scaleRecommendations AssessmentPoor outcomeIntensive care unit admissionCandidate clinical variablesCritically Ill AdultsIndividual clinical variablesMajor clinical predictorsCare unit admissionCounseling of patientsBest practice statementsJudgment of prognosisNarrative systematic reviewConclusionsThese guidelinesUnit admissionNeurological recoveryClinical predictorsIll adultsCounseling patientsIntracerebral hemorrhageFunctional outcomeConsensus statementNeuroprognosticationCost-Effectiveness of Rapid Hemosil Versus in-House and Send-out ADAMTS13 Activity Testing in the Care of Patients with Immune Thrombotic Thrombocytopenic Purpura
Allen C, Ito S, Butt A, Purcell A, Richmond R, Cuker A, Goshua G. Cost-Effectiveness of Rapid Hemosil Versus in-House and Send-out ADAMTS13 Activity Testing in the Care of Patients with Immune Thrombotic Thrombocytopenic Purpura. Blood 2023, 142: 368. DOI: 10.1182/blood-2023-184927.Peer-Reviewed Original ResearchImmune thrombotic thrombocytopenic purpuraTherapeutic plasma exchangeIncremental cost-effectiveness ratioThrombotic thrombocytopenic purpuraPLASMIC scoreIncremental net monetary benefitProbabilistic sensitivity analysesPlasma exchangeThrombocytopenic purpuraMedical intensive care unitADAMTS13 activity testingIntensive care unitCare of patientsActivity levelsHigh pretest probabilityClinical trial dataCost-effectiveness ratioCost-effectiveness evaluationDeterministic sensitivity analysesNet monetary benefitEmpiric treatmentAdverse eventsPrimary outcomeIll adultsCare unit
2022
Modulation of the Association Between Age and Death by Risk Factor Burden in Critically Ill Patients With COVID-19
Sunderraj A, Cho C, Cai X, Gupta S, Mehta R, Isakova T, Leaf D, Srivastava A, Walther C, Anumudu S, Arunthamakun J, Kopecky K, Milligan G, McCullough P, Nguyen T, Shaefi S, Krajewski M, Shankar S, Pannu A, Valencia J, Waikar S, Kibbelaar Z, Athavale A, Hart P, Upadhyay S, Vohra I, Oyintayo A, Green A, Rachoin J, Schorr C, Shea L, Edmonston D, Mosher C, Shehata A, Cohen Z, Allusson V, Bambrick-Santoyo G, Bhatti N, Mehta B, Williams A, Brenner S, Walters P, Go R, Rose K, Hernán M, Zhou A, Kim E, Lisk R, Chan L, Mathews K, Coca S, Altman D, Saha A, Soh H, Wen H, Bose S, Leven E, Wang J, Mosoyan G, Nadkarni G, Pattharanitima P, Gallagher E, Friedman A, Guirguis J, Kapoor R, Meshberger C, Kelly K, Parikh C, Garibaldi B, Corona-Villalobos C, Wen Y, Menez S, Malik R, Cervantes C, Gautam S, Mallappallil M, Ouyang J, John S, Yap E, Melaku Y, Mohamed I, Bajracharya S, Puri I, Thaxton M, Bhattacharya J, Wagner J, Boudourakis L, Nguyen H, Ahoubim A, Thomas L, Sirganagari D, Guru P, Kashani K, Tehranian S, Zhou Y, Bergl P, Rodriguez J, Shah J, Gupta M, Kumar P, Lazarous D, Kassaye S, Melamed M, Johns T, Mocerino R, Prudhvi K, Zhu D, Levy R, Azzi Y, Fisher M, Yunes M, Sedaliu K, Golestaneh L, Brogan M, Kumar N, Chang M, Thakkar J, Raichoudhury R, Athreya A, Farag M, Schenck E, Cho S, Plataki M, Alvarez-Mulett S, Gomez-Escobar L, Pan D, Lee S, Krishnan J, Whalen W, Charytan D, Macina A, Chaudhry S, Wu B, Modersitzki F, Srivastava A, Leidner A, Martinez C, Kruser J, Wunderink R, Hodakowski A, Velez J, Price-Haywood E, Matute-Trochez L, Hasty A, Mohamed M, Avasare R, Zonies D, Leaf D, Gupta S, Sise M, Newman E, Abu Omar S, Pokharel K, Sharma S, Singh H, Correa S, Shaukat T, Kamal O, Wang W, Yang H, Boateng J, Lee M, Strohbehn I, Li J, Mueller A, Redfern R, Cairl N, Naimy G, Abu-Saif A, Hall D, Bickley L, Rowan C, Madhani-Lovely F, Cruz V, Hess K, Jacobs A, Peev V, Reiser J, Byun J, Vissing A, Kapania E, Post Z, Patel N, Hermes J, Sutherland A, Patrawalla A, Finkel D, Danek B, Arikapudi S, Paer J, Cangialosi P, Liotta M, Radbel J, Puri S, Sunderram J, Scharf M, Ahmed A, Berim I, Vatson J, Anand S, Levitt J, Garcia P, Boyle S, Song R, Zhang J, Woo S, Deng X, Katz-Greenberg G, Senter K, Sharshir M, Rusnak V, Ali M, Bansal A, Podoll A, Chonchol M, Sharma S, Burnham E, Douin D, Rashidi A, Hejal R, Judd E, Latta L, Tolwani A, Albertson T, Adams J, Chang S, Beutler R, Schulze C, Macedo E, Rhee H, Liu K, Jotwani V, Koyner J, Shah C, Jaikaransingh V, Toth-Manikowski S, Joo M, Lash J, Neyra J, Chaaban N, Elias M, Ahmad Y, Iardino A, Au E, Sharma J, Sosa M, Taldone S, Contreras G, De La Zerda D, Gershengorn H, Shukla B, Fornoni A, Ferreira T, Hayek S, Blakely P, Berlin H, Azam T, Shadid H, Pan M, Hayer P, Meloche C, Feroze R, Kaakati R, Perry D, Bitar A, Anderson E, Padalia K, Donnelly J, Admon A, Flythe J, Tugman M, Chang E, Brown B, Leonberg-Yoo A, Spiardi R, Miano T, Roche M, Vasquez C, Bansal A, Ernecoff N, Kapoor S, Verma S, Chen H, Kovesdy C, Molnar M, Azhar A, Hedayati S, Nadamuni M, Shastri S, Willett D, Short S, Renaghan A, Enfield K, Bhatraju P, Malik A, Semler M, Vijayan A, Joy C, Li T, Goldberg S, Kao P, Schumaker G, Goyal N, Faugno A, Schumaker G, Hsu C, Tariq A, Meyer L, Kshirsagar R, Weiner D, Jose A, Christov M, Griffiths J, Gupta S, Kapoor A, Wilson P, Arora T, Ugwuowo U. Modulation of the Association Between Age and Death by Risk Factor Burden in Critically Ill Patients With COVID-19. Critical Care Explorations 2022, 4: e0755. PMID: 36050992, PMCID: PMC9426819, DOI: 10.1097/cce.0000000000000755.Peer-Reviewed Original ResearchICU factorsIll patientsRisk factorsEffect modificationCOVID-19Older ageRisk factor burdenCritically ill patientsMulticenter cohort studyMultivariable logistic regressionRisk of deathLogistic regression modelsKey risk factorsInhospital mortalityCohort studyMultiplicative interaction termIll adultsPrimary outcomeAdverse outcomesPrimary exposureICU bedsComorbiditiesPatientsLogistic regressionAdditional studiesBest Practice for Improving Sleep in the ICU. Part I: Non-pharmacologic
Korwin A, Knauert M. Best Practice for Improving Sleep in the ICU. Part I: Non-pharmacologic. 2022, 231-248. DOI: 10.1007/978-3-031-06447-0_14.ChaptersIntensive care unitICU patientsNormal sleepCritical care treatmentNon-pharmacologic therapiesNon-pharmacologic interventionsMost ICU patientsAbnormal circadian rhythmPoor quality sleepCircadian functionAcute illnessCritical illnessPatient characteristicsIll adultsCare unitChronotherapeutic interventionsCare treatmentSleep preferenceCurrent evidencePatient careCircadian disruptionSleepPatientsFuture interventionsPractice changeAssociation of vancomycin plus piperacillin–tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study
Miano TA, Hennessy S, Yang W, Dunn TG, Weisman AR, Oniyide O, Agyekum RS, Turner AP, Ittner CAG, Anderson BJ, Wilson FP, Townsend R, Reilly JP, Giannini HM, Cosgriff CV, Jones TK, Meyer NJ, Shashaty MGS. Association of vancomycin plus piperacillin–tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study. Intensive Care Medicine 2022, 48: 1144-1155. PMID: 35833959, PMCID: PMC9463324, DOI: 10.1007/s00134-022-06811-0.Peer-Reviewed Original ResearchConceptsPiperacillin-tazobactamKidney biomarkersCystatin CAcute kidney injury riskProspective cohort studyCystatin C concentrationCystatin C measurementKidney function biomarkersCreatinine secretionAntibiotic initiationCohort studyProspective cohortIll adultsClinical outcomesAssociation of vancomycinAntibiotic treatmentTubular secretionCreatinine concentrationTreatment weightingResultsThe studyTrue injuryHigh incidenceCreatinineDay 14Early changes
2021
VTE Prophylaxis in Critically Ill Adults A Systematic Review and Network Meta-analysis
Fernando SM, Tran A, Cheng W, Sadeghirad B, Arabi YM, Cook DJ, Møller MH, Mehta S, Fowler RA, Burns KEA, Wells PS, Carrier M, Crowther MA, Scales DC, English SW, Kyeremanteng K, Kanji S, Kho ME, Rochwerg B. VTE Prophylaxis in Critically Ill Adults A Systematic Review and Network Meta-analysis. CHEST Journal 2021, 161: 418-428. PMID: 34419428, DOI: 10.1016/j.chest.2021.08.050.Peer-Reviewed Original ResearchConceptsIncidence of DVTRandomized clinical trialsMechanical compressive deviceRisk of DVTIll adultsCombination therapyRCTs of patientsSystematic reviewAdults A Systematic ReviewCombination pharmacologic therapyCompressive devicePrimary pharmacologic agentsRisk of VTELow-certainty evidencePrevention of VTEA Systematic ReviewNetwork Meta-AnalysisFull-text reviewThromboprophylaxis agentsVenous thromboprophylaxisVTE prophylaxisRecommendations AssessmentPharmacologic therapyPulmonary embolismIll patientsPharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis
Burry LD, Cheng W, Williamson DR, Adhikari NK, Egerod I, Kanji S, Martin CM, Hutton B, Rose L. Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis. Intensive Care Medicine 2021, 47: 943-960. PMID: 34379152, PMCID: PMC8356549, DOI: 10.1007/s00134-021-06490-3.Peer-Reviewed Original ResearchConceptsNon-pharmacological interventionsDelirium occurrenceIll adultsIll patientsInternational Clinical Trials RegistryDuration of deliriumOccurrence of deliriumMechanical ventilation durationMulti-component non-pharmacological interventionsClinical Trials RegistryLength of stayMulti-component interventionRandom-effects modelingEvidence networksWeb of ScienceEvidence certaintySedation interruptionSedative interruptionHospital lengthICU lengthCochrane riskSecondary outcomesStandard careBias toolControlled TrialsHospital-Level Variation in Death for Critically Ill Patients with COVID-19
Churpek M, Gupta S, Spicer A, Parker W, Fahrenbach J, Brenner S, Leaf D, Walther C, Anumudu S, Arunthamakun J, Kopecky K, Milligan G, McCullough P, Nguyen T, Shaefi S, Krajewski M, Shankar S, Pannu A, Valencia J, Waikar S, Kibbelaar Z, Athavale A, Hart P, Upadhyay S, Vohra I, Green A, Rachoin J, Schorr C, Shea L, Edmonston D, Mosher C, Shehata A, Cohen Z, Allusson V, Bambrick-Santoyo G, Bhatti N, Mehta B, Williams A, Brenner S, Walters P, Go R, Rose K, Hernán M, Chan L, Mathews K, Coca S, Altman D, Saha A, Soh H, Wen H, Bose S, Leven E, Wang J, Mosoyan G, Nadkarni G, Pattharanitima P, Gallagher E, Friedman A, Guirguis J, Kapoor R, Meshberger C, Kelly K, Parikh C, Garibaldi B, Corona-Villalobos C, Wen Y, Menez S, Malik R, Cervantes E, Gautam S, Mallappallil M, Ouyang J, John S, Yap E, Melaku Y, Mohamed I, Bajracharya S, Puri I, Thaxton M, Bhattacharya J, Wagner J, Boudourakis L, Nguyen H, Ahoubim A, Thomas L, Sirganagari D, Guru P, Kashani K, Tehranian S, Zhou Y, Bergl P, Rodriguez J, Shah J, Gupta M, Kumar P, Lazarous D, Kassaye S, Melamed M, Johns T, Mocerino R, Prudhvi K, Zhu D, Levy R, Azzi Y, Fisher M, Yunes M, Sedaliu K, Golestaneh L, Brogan M, Kumar N, Chang M, Thakkar J, Raichoudhury R, Athreya A, Farag M, Schenck E, Cho S, Plataki M, Alvarez-Mulett S, Gomez-Escobar L, Pan D, Lee S, Krishnan J, Whalen W, Charytan D, Macina A, Chaudhry S, Wu B, Modersitzki F, Srivastava A, Leidner A, Martinez C, Kruser J, Wunderink R, Hodakowski A, Velez J, Price-Haywood E, Matute-Trochez L, Hasty A, Mohamed M, Avasare R, Zonies D, Sise M, Newman E, Abu Omar S, Pokharel K, Sharma S, Singh H, Correa S, Shaukat T, Kamal O, Wang W, Yang H, Boateng J, Lee M, Strohbehn I, Li J, Mueller A, Redfern R, Cairl N, Naimy G, Abu-Saif A, Hall D, Bickley L, Rowan C, Madhai-Lovely F, Peev V, Reiser J, Byun J, Vissing A, Kapania E, Post Z, Patel N, Hermes J, Sutherland A, Patrawalla A, Finkel D, Danek B, Arikapudi S, Paer J, Cangialosi P, Liotta M, Radbel J, Sunderram J, Puri S, Vatson J, Scharf M, Ahmed A, Berim I, Anand S, Levitt J, Garcia P, Boyle S, Song R, Arif A, Zhang J, Woo S, Deng X, Katz-Greenberg G, Senter K, Sharshir M, Rusnak V, Ali M, Peters T, Hughes K, Bansal A, Podoll A, Chonchol M, Sharma S, Burnham E, Rashidi A, Hejal R, Judd E, Latta L, Tolwani A, Albertson T, Adams J, Chang S, Beutler R, Monica S, Schulze C, Macedo E, Rhee H, Liu K, Jotwani V, Koyner J, Shah C, Jaikaransingh V, Toth-Manikowski S, Joo M, Lash J, Neyra J, Chaaban N, Iardino A, Au E, Sharma J, Sosa M, Taldone S, Contreras G, De La Zerda D, Fornoni A, Gershengorn H, Hayek S, Blakely P, Berlin H, Azam T, Shadid H, Pan M, O’Hayer P, Meloche C, Feroze R, Kaakati R, Perry D, Bitar A, Anderson E, Padalia K, Launius C, Donnelly J, Admon A, Flythe J, Tugman M, Chang E, Brown B, Leonberg-Yoo A, Spiardi R, Miano T, Roche M, Vasquez C, Bansal A, Ernecoff N, Kapoor S, Verma S, Chen H, Kovesdy C, Molnar M, Azhar A, Hedayati S, Nadamuni M, Shastri S, Willett D, Short S, Renaghan A, Enfield K, Bhatraju P, Malik A, Semler M, Vijayan A, Joy C, Li T, Goldberg S, Kao P, Schumaker G, Goyal N, Faugno A, Hsu C, Tariq A, Meyer L, Kshirsagar R, Weiner D, Christov M, Griffiths J, Gupta S, Kapoor A, Wilson P, Arora T, Ugwuowo U. Hospital-Level Variation in Death for Critically Ill Patients with COVID-19. American Journal Of Respiratory And Critical Care Medicine 2021, 204: 403-411. PMID: 33891529, PMCID: PMC8480242, DOI: 10.1164/rccm.202012-4547oc.Peer-Reviewed Original ResearchConceptsInterhospital variationAcute PhysiologyIll patientsOdds ratioSocioeconomic statusCreative Commons Attribution Non-Commercial No Derivatives License 4.0COVID-19Considerable interhospital variationMulticenter cohort studyPatient-level factorsHospital-level variablesHospital-level variationIntensive care unitCoronavirus disease 2019Mixed-effects logistic regressionUnited States hospitalsDerivatives License 4.0Median odds ratioHospital mortalityCohort studyIll adultsPrimary outcomeCare unitDisease 2019Individual patientsThrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19
Al-Samkari H, Gupta S, Leaf R, Wang W, Rosovsky R, Brenner S, Hayek S, Berlin H, Kapoor R, Shaefi S, Melamed M, Sutherland A, Radbel J, Green A, Garibaldi B, Srivastava A, Leonberg-Yoo A, Shehata A, Flythe J, Rashidi A, Goyal N, Chan L, Mathews K, Hedayati S, Dy R, Toth-Manikowski S, Zhang J, Mallappallil M, Redfern R, Bansal A, Short S, Vangel M, Admon A, Semler M, Bauer K, Hernán M, Leaf D, Walther C, Anumudu S, Arunthamakun J, Kopecky K, Milligan G, McCullough P, Nguyen T, Shaefi S, Krajewski M, Shankar S, Pannu A, Valencia J, Bauer K, Waikar S, Kibbelaar Z, Athavale A, Hart P, Upadhyay S, Vohra I, Oyintayo A, Green A, Rachoin J, Schorr C, Shea L, Edmonston D, Mosher C, Shehata A, Cohen Z, Allusson V, Bambrick-Santoyo G, aain Bhatti N, Mehta B, Williams A, Brenner S, Walters P, Go R, Rose K, Hernán M, Zhou A, Kim E, Lisk R, Chan L, Mathews K, Coca S, Altman D, Saha A, Soh H, Wen H, Bose S, Leven E, Wang J, Mosoyan G, Pattharanitima P, Gallagher E, Friedman A, Guirguis J, Kapoor R, Meshberger C, Kelly K, Parikh C, Garibaldi B, Corona-Villalobos C, Wen Y, Menez S, Malik R, Cervantes C, Gautam S, Mallappallil M, Ouyang J, John S, Yap E, Melaku Y, Mohamed I, Bajracharya S, Puri I, Thaxton M, Bhattacharya J, Wagner J, Boudourakis L, Nguyen H, Ahoubim A, Thomas L, Sirganagari D, Guru P, Zhou Y, Bergl P, Rodriguez J, Shah J, Gupta M, Kumar P, Lazarous D, Kassaye S, Melamed M, Johns T, Mocerino R, Prudhvi K, Zhu D, Levy R, Azzi Y, Fisher M, Yunes M, Sedaliu K, Golestaneh L, Brogan M, Thakkar J, Kumar N, Ross M, Chang M, Raichoudhury R, Athreya A, Farag M, Schenck E, Cho S, Plataki M, Alvarez-Mulett S, Gomez-Escobar L, Pan D, Lee S, Krishnan J, Whalen W, Charytan D, Macina A, Srivastava A, Leidner A, Martinez C, Kruser J, Wunderink R, Hodakowski A, Q. Velez J, Price-Haywood E, Matute-Trochez L, Hasty A, Mohamed M, Avasare R, Zonies D, Leaf D, Gupta S, Al-Samkari H, Leaf R, Rosovsky R, Sise M, Newman E, Omar S, Pokharel K, Sharma S, Singh H, Correa S, Shaukat T, Kamal O, Wang W, Lee M, Strohbehn I, Li J, Mueller A, Redfern R, Cairl N, Naimy G, Abu-Saif A, Hall D, Bickley L, Rowan C, Madhani-Lovely F, Peev V, Reiser J, Byun J, Vissing A, Kapania E, Post Z, Patel N, Hermes J, Sutherland A, Patrawalla A, Finkel D, Danek B, Arikapudi S, Paer J, Cangialosi P, Liotta M, Radbel J, Puri S, Sunderram J, Scharf M, Ahmed A, Berim I, Vatson J, Karp G, Anand S, Levitt J, Garcia P, Boyle S, Song R, Zhang J, Woo S, Deng X, Katz-Greenberg G, Sharshir M, Rusnak V, Ali M, Bansal A, Podoll A, Chonchol M, Sharma S, Burnham E, Rashidi A, Hejal R, Judd E, Latta L, Tolwani A, Albertson T, Adams J, Chang S, Beutler R, Schulze C, Macedo E, Rhee H, Liu K, Jotwani V, Koyner J, Shah C, Jaikaransingh V, Toth-Manikowski S, Joo M, Lash J, Neyra J, Chaaban N, Elias M, Ahmad Y, Dy R, Iardino A, Au E, Sharma J, Sosa M, Taldone S, Contreras G, De La Zerda D, Gershengorn H, Fornoni A, Hayek S, Blakely P, Berlin H, Azam T, Shadid H, Pan M, O’Hayer P, Meloche C, Feroze R, Padalia K, Leya J, Donnelly J, Admon A, Flythe J, Tugman M, Chang E, Brown B, Leonberg-Yoo A, Spiardi R, Miano T, Roche M, Vasquez C, Bansal A, Ernecoff N, Kapoor S, Verma S, Chen H, Kovesdy C, Molnar M, Azhar A, Hedayati S, Nadamuni M, Shastri S, Willett D, Short S, Renaghan A, Enfield K, Bhatraju P, Malik A, Semler M, Vijayan A, Joy C, Li T, Goldberg S, Kao P, Schumaker G, Goyal N, Faugno A, Schumaker G, Hsu C, Tariq A, Meyer L, Kshirsagar R, Weiner D, Christov M, Griffiths J, Gupta S, Kapoor A, Chugh S, Wilson P, Arora T, Ugwuowo U. Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19. Annals Of Internal Medicine 2021, 174: m20-6739. PMID: 33493012, PMCID: PMC7863679, DOI: 10.7326/m20-6739.Peer-Reviewed Original ResearchConceptsEarly therapeutic anticoagulationTarget trial emulationTherapeutic anticoagulationVenous thromboembolismTrial emulationICU admissionMajor bleedingIll adultsIll patientsCOVID-19Incidence of VTEIntensive care unit admissionHigher D-dimer levelsCare unit admissionCritically ill patientsMajor bleeding eventsMulticenter cohort studyD-dimer levelsCoronavirus disease 2019Bleeding eventsUnit admissionCohort studyHospital dischargeIndependent predictorsMedian ageAssociation Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19
Gupta S, Wang W, Hayek SS, Chan L, Mathews KS, Melamed ML, Brenner SK, Leonberg-Yoo A, Schenck EJ, Radbel J, Reiser J, Bansal A, Srivastava A, Zhou Y, Finkel D, Green A, Mallappallil M, Faugno AJ, Zhang J, Velez JCQ, Shaefi S, Parikh CR, Charytan DM, Athavale AM, Friedman AN, Redfern RE, Short SAP, Correa S, Pokharel KK, Admon AJ, Donnelly JP, Gershengorn HB, Douin DJ, Semler MW, Hernán MA, Leaf DE, Walther C, Anumudu S, Arunthamakun J, Kopecky K, Milligan G, McCullough P, Nguyen T, Shaefi S, Krajewski M, Shankar S, Pannu A, Valencia J, Waikar S, Kibbelaar Z, Athavale A, Hart P, Upadhyay S, Vohra I, Oyintayo A, Green A, Rachoin J, Schorr C, Shea L, Edmonston D, Mosher C, Shehata A, Cohen Z, Allusson V, Bambrick-Santoyo G, Bhatti N, Mehta B, Williams A, Brenner S, Walters P, Go R, Rose K, Hernán M, Lisk R, Zhou A, Kim E, Chan L, Mathews K, Coca S, Altman D, Saha A, Soh H, Wen H, Bose S, Leven E, Wang J, Mosoyan G, Nadkarni G, Pattharanitima P, Gallagher E, Friedman A, Guirguis J, Kapoor R, Meshberger C, Kelly K, Parikh C, Garibaldi B, Corona-Villalobos C, Wen Y, Menez S, Malik R, Cervantes C, Gautam S, Mallappallil M, Ouyang J, John S, Yap E, Melaku Y, Mohamed I, Bajracharya S, Puri I, Thaxton M, Bhattacharya J, Wagner J, Boudourakis L, Nguyen H, Ahoubim A, Kashani K, Tehranian S, Thomas L, Sirganagari D, Guru P, Zhou Y, Bergl P, Rodriguez J, Shah J, Gupta M, Kumar P, Lazarous D, Kassaye S, Melamed M, Johns T, Mocerino R, Prudhvi K, Zhu D, Levy R, Azzi Y, Fisher M, Yunes M, Sedaliu K, Golestaneh L, Brogan M, Kumar N, Chang M, Thakkar J, Raichoudhury R, Athreya A, Farag M, Schenck E, Cho S, Plataki M, Alvarez-Mulett S, Gomez-Escobar L, Pan D, Lee S, Krishnan J, Whalen W, Charytan D, Macina A, Chaudhry S, Wu B, Modersitzki F, Srivastava A, Leidner A, Martinez C, Kruser J, Wunderink R, Hodakowski A, Velez J, Price-Haywood E, Matute-Trochez L, Hasty A, Mohamed M, Avasare R, Zonies D, Leaf D, Gupta S, Sise M, Newman E, Omar S, Pokharel K, Sharma S, Singh H, Correa S, Shaukat T, Kamal O, Wang W, Yang H, Boateng J, Lee M, Strohbehn I, Li J, Mueller A, Redfern R, Cairl N, Naimy G, Abu-Saif A, Hall D, Bickley L, Rowan C, Madhani-Lovely F, Peev V, Reiser J, Byun J, Vissing A, Kapania E, Post Z, Patel N, Hermes J, Sutherland A, Patrawalla A, Finkel D, Danek B, Arikapudi S, Paer J, Cangialosi P, Liotta M, Radbel J, Puri S, Sunderram J, Scharf M, Ahmed A, Berim I, Vatson J, Anand S, Levitt J, Garcia P, Boyle S, Song R, Arif A, Zhang J, Woo S, Deng X, Katz-Greenberg G, Senter K, Sharshir M, Rusnak V, Ali M, Peters T, Hughes K, Bansal A, Podoll A, Chonchol M, Sharma S, Burnham E, Douin D, Rashidi A, Hejal R, Judd E, Latta L, Tolwani A, Albertson T, Adams J, Chang S, Beutler R, Schulze C, Macedo E, Rhee H, Liu K, Jotwani V, Koyner J, Shah C, Jaikaransingh V, Toth-Manikowski S, Joo M, Lash J, Neyra J, Chaaban N, Elias M, Ahmad Y, Iardino A, Au E, Sharma J, Sosa M, Taldone S, Contreras G, Zerda D, Fornoni A, Gershengorn H, Hayek S, Blakely P, Berlin H, Azam T, Shadid H, Pan M, O’ Hayer P, Meloche C, Feroze R, Padalia K, Bitar A, Leya J, Donnelly J, Admon A, Flythe J, Tugman M, Chang E, Brown B, Leonberg-Yoo A, Spiardi R, Miano T, Roche M, Vasquez C, Bansal A, Ernecoff N, Kapoor S, Verma S, Chen H, Kovesdy C, Molnar M, Azhar A, Hedayati S, Nadamuni M, Shastri S, Willett D, Short S, Renaghan A, Enfield K, Bhatraju P, Malik A, Semler M, Vijayan A, Joy C, Li T, Goldberg S, Kao P, Schumaker G, Goyal N, Faugno A, Hsu C, Tariq A, Meyer L, Kshirsagar R, Jose A, Weiner D, Christov M, Griffiths J, Gupta S, Kapoor A, Wilson P, Arora T, Ugwuowo U. Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19. JAMA Internal Medicine 2021, 181: 41-51. PMID: 33080002, PMCID: PMC7577201, DOI: 10.1001/jamainternmed.2020.6252.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenal Cortex HormonesAdultAgedAntibodies, Monoclonal, HumanizedAnticoagulantsCohort StudiesCOVID-19COVID-19 Drug TreatmentCritical IllnessEarly Medical InterventionFemaleHospital MortalityHospitalizationHumansIntensive Care UnitsMaleMiddle AgedMortalityOrgan Dysfunction ScoresPatient PositioningProne PositionProportional Hazards ModelsReceptors, Interleukin-6Respiration, ArtificialRespiratory InsufficiencySARS-CoV-2Young AdultConceptsIntensive care unitICU admissionIll patientsCohort studyHazard ratioInverse probability weightingCOVID-19Severe COVID-19 illnessTocilizumab-treated patientsCytokine release syndromeMulticenter cohort studyDay of admissionCox regression modelRandomized clinical trialsCOVID-19 illnessCoronavirus disease 2019Interleukin-6 receptorHospital mortalityRelease syndromeIll adultsCare unitIllness characteristicsClinical trialsTocilizumabEarly treatment
2020
In-hospital cardiac arrest in critically ill patients with covid-19: multicenter cohort study
Hayek S, Brenner S, Azam T, Shadid H, Anderson E, Berlin H, Pan M, Meloche C, Feroz R, O’Hayer P, Kaakati R, Bitar A, Padalia K, Perry D, Blakely P, Gupta S, Shaefi S, Srivastava A, Charytan D, Bansal A, Mallappallil M, Melamed M, Shehata A, Sunderram J, Mathews K, Sutherland A, Nallamothu B, Leaf D, Investigators S, Malik A, Bitar A, Abu-Saif A, Green A, Ahoubim A, Oyintayo A, Jose A, Athreya A, Jacobs A, Fornoni A, Hodakowski A, Leidner A, Shehata A, Iardino A, Friedman A, Renaghan A, Leonberg-Yoo A, Bansal A, Athavale A, Podoll A, Azhar A, Patrawalla A, Pannu A, Zhou A, Srivastava A, Admon A, Vissing A, Bansal A, Vijayan A, Hasty A, Sutherland A, Faugno A, Saha A, Williams A, Rashidi A, Mueller A, Kapoor A, Tolwani A, Macina A, Tariq A, Ahmed A, Danek B, Wu B, Shukla B, Mehta B, Brown B, Garibaldi B, Schulze C, Walther C, Martinez C, Hsu C, Corona-Villalobos C, Vasquez C, Meloche C, Shah C, Parikh C, Rowan C, Schorr C, Joy C, Mosher C, Meshberger C, Kovesdy C, Weiner D, Edmonston D, Perry D, Hall D, Charytan D, De La Zerda D, Leaf D, Zonies D, Altman D, Lazarous D, Zhu D, Sirganagari D, Pan D, Finkel D, Willett D, Price-Haywood E, Schenck E, Cervantes C, Anderson E, Au E, Burnham E, Leven E, Chang E, Gallagher E, Judd E, Newman E, Yap E, Kapania E, Kim E, Macedo E, Madhani-Lovely F, Modersitzki F, Contreras G, Naimy G, Bambrick-Santoyo G, Nadkarni G, Mosoyan G, Katz-Greenberg G, Schumaker G, Milligan G, Nguyen H, Berlin H, Rhee H, Singh H, Gershengorn H, Yang H, Soh H, Wen H, Chen H, Shadid H, Strohbehn I, Mohamed I, Berim I, Puri I, Vohra I, Kruser J, Sunderram J, Lash J, Krishnan J, Radbel J, Adams J, Shah J, Neyra J, Koyner J, Vatson J, Rachoin J, Boateng J, Paer J, Flythe J, Griffiths J, Rodriguez J, Li J, Ouyang J, Sharma J, Wang J, Zhang J, Reiser J, Guirguis J, Byun J, Donnelly J, Wagner J, Levitt J, Hermes J, Velez J, Valencia J, Arunthamakun J, Thakkar J, Bhattacharya J, Sedaliu K, Prudhvi K, Pokharel K, Senter K, Kelly K, Liu K, Kopecky K, Rose K, Kashani K, Padalia K, Hess K, Mathews K, Enfield K, Golestaneh L, Bickley L, Latta L, Meyer L, Boudourakis L, Thomas L, Chan L, Shea L, Matute-Trochez L, Gomez-Escobar L, Elias M, Plataki M, Thaxton M, Sosa M, Liotta M, Christov M, Mallappallil M, Tugman M, Scharf M, Semler M, Brogan M, Roche M, Krajewski M, Sise M, Lee M, Chang M, Pan M, Melamed M, Chonchol M, Hernán M, Molnar M, Yunes M, Joo M, Sharshir M, Farag M, Fisher M, Nadamuni M, Gupta M, Ali M, Mohamed M, Ernecoff N, Kumar N, Cairl N, Patel N, Goyal N, Bhatti N, Chaaban N, Kamal O, Garcia P, Kao P, Walters P, Hayer P, Pattharanitima P, Bergl P, Bhatraju P, Blakely P, Wilson P, McCullough P, Cangialosi P, Hart P, Guru P, Kumar P, Feroze R, Kapoor R, Hejal R, Kshirsagar R, Kaakati R, Lisk R, Beutler R, Levy R, Wunderink R, Raichoudhury R, Redfern R, Go R, Malik R, Song R, Avasare R, Mocerino R, Spiardi R, Hedayati S, Taldone S, John S, Hayek S, Abu Omar S, Brenner S, Anumudu S, Gautam S, Short S, Woo S, Kapoor S, Gupta S, Kassaye S, Alvarez-Mulett S, Goldberg S, Tehranian S, Shaefi S, Shastri S, Sharma S, Upadhyay S, Gupta S, Anand S, Bajracharya S, Verma S, Shankar S, Correa S, Chaudhry S, Bose S, Puri S, Cho S, Arikapudi S, Lee S, Toth-Manikowski S, Coca S, Menez S, Chang S, Sharma S, Waikar S, Boyle S, Arora T, Ferreira T, Shaukat T, Johns T, Azam T, Nguyen T, Albertson T, Li T, Miano T, Ugwuowo U, Rusnak V, Allusson V, Jotwani V, Peev V, Jaikaransingh V, Cruz V, Wang W, Whalen W, Deng X, Ahmad Y, Zhou Y, Melaku Y, Azzi Y, Wen Y, Cohen Z, Kibbelaar Z, Post Z. In-hospital cardiac arrest in critically ill patients with covid-19: multicenter cohort study. The BMJ 2020, 371: m3513. PMID: 32998872, PMCID: PMC7525342, DOI: 10.1136/bmj.m3513.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestMulticenter cohort studyIntensive care unitCardiac arrestCardiopulmonary resuscitationHospital dischargeIll patientsCohort studyIll adultsCare unitCOVID-19Intensive care unit bedsDay of admissionPulseless electrical activityCoronavirus disease 2019Hospital mortalityMore comorbiditiesNeurological statusOlder patientsRisk factorsPoor survivalDisease 2019PatientsDiverse hospitalsUnit beds
2019
Pharmacological interventions for the treatment of delirium in critically ill adults
Burry L, Hutton B, Williamson DR, Mehta S, Adhikari NK, Cheng W, Ely EW, Egerod I, Fergusson DA, Rose L. Pharmacological interventions for the treatment of delirium in critically ill adults. Cochrane Database Of Systematic Reviews 2019, 2019: cd011749. PMID: 31479532, PMCID: PMC6719921, DOI: 10.1002/14651858.cd011749.pub2.Peer-Reviewed Original ResearchConceptsTreatment of deliriumIntensive care unitComa-free daysDuration of deliriumNon-pharmacological interventionsLong-term outcomesIll adultsPharmacological interventionsMechanical ventilationAgonist dexmedetomidineDrug classesICU stayIll patientsReview authorsPatient outcomesOvid MEDLINELonger intensive care unitLong-term cognitive outcomesActive drug treatmentAvailable pharmacological interventionsMultiple pharmacological interventionsLonger ICU stayIll adult patientsResolution of symptomsHigh dependency unitDiagnosis of elevated intracranial pressure in critically ill adults: systematic review and meta-analysis
Fernando SM, Tran A, Cheng W, Rochwerg B, Taljaard M, Kyeremanteng K, English SW, Sekhon MS, Griesdale DEG, Dowlatshahi D, McCredie VA, Wijdicks EFM, Almenawer SA, Inaba K, Rajajee V, Perry JJ. Diagnosis of elevated intracranial pressure in critically ill adults: systematic review and meta-analysis. The BMJ 2019, 366: l4225. PMID: 31340932, PMCID: PMC6651068, DOI: 10.1136/bmj.l4225.Peer-Reviewed Original ResearchConceptsElevated intracranial pressureOptic nerve sheath diameterIntracranial pressureNon-invasive testsMidline shiftIll patientsPhysical examinationSystematic reviewPhysical examination signsDoppler pulsatility indexGlasgow Coma ScaleNerve sheath diameterInvasive ICP monitoringPhysical examination featuresPatient-level dataDiagnostic Accuracy Studies toolTranscranial Doppler pulsatility indexEnglish-language studiesHierarchical summary receiverExamination signsComa ScaleCT findingsIll adultsPulsatility indexBasal cisternsAntimotility agents for the treatment of acute noninfectious diarrhea in critically ill patients: A practice management guideline from the Eastern Association for the Surgery of Trauma.
Bugaev N, Bhattacharya B, Chiu WC, Como JJ, Cripps MW, Ferrada P, Gelbard RB, Gondek S, Kasotakis G, Kim D, Mentzer C, Robinson BRH, Salcedo ES, Yeh DD. Antimotility agents for the treatment of acute noninfectious diarrhea in critically ill patients: A practice management guideline from the Eastern Association for the Surgery of Trauma. Journal Of Trauma And Acute Care Surgery 2019, 87: 915-921. PMID: 31574060, DOI: 10.1097/ta.0000000000002449.Peer-Reviewed Original ResearchConceptsDiphenoxylate/atropineNoninfectious diarrheaSurgery of TraumaElemental dietIll adultsIll patientsEastern AssociationIntensive care unit patientsResolution of diarrheaPractice management guidelinesCare unit patientsDaily clinical practiceLevel of evidenceDiarrhea resolutionFecal frequencyAntimotility agentsHospital lengthRecommendations AssessmentUnit patientsClinical diarrheaDiarrheaClinical practiceAtropineLevel IIIPatientsCriteria for Clinically Relevant Bleeding in Critically Ill Children
Karam O, Nellis ME, Zantek ND, Lacroix J, Faustino EVS. Criteria for Clinically Relevant Bleeding in Critically Ill Children. Pediatric Critical Care Medicine 2019, Publish Ahead of Print: &na;. PMID: 30575698, DOI: 10.1097/pcc.0000000000001828.Peer-Reviewed Original ResearchConceptsRelevant bleedingStreaks of bloodIll childrenEndotracheal tubeClinical relevancePediatric critical care physiciansClinically Relevant BleedingML/Critical care physiciansCritical illnessIll adultsOrgan failureCare physiciansGastric tubeClinical significanceNurse practitionersBleedingDiagnostic criteriaClinical practiceResponse rateIntensivists' perceptionWeb-based surveyDiagnostic definitionRespondents' geographical locationBlood
2018
Does improvement in symptoms and quality of life in chronic schizophrenia reduce family caregiver burden?
Rhee TG, Rosenheck RA. Does improvement in symptoms and quality of life in chronic schizophrenia reduce family caregiver burden? Psychiatry Research 2018, 271: 402-404. PMID: 30530058, PMCID: PMC6382537, DOI: 10.1016/j.psychres.2018.12.005.Peer-Reviewed Original ResearchConceptsFamily caregiver burdenQuality of lifeCaregiver burdenPatient's symptomsClinical changesExperience of burdenCATIE schizophrenia trialAssociation of changesSmall clinical changesIll adultsClinical statusSchizophrenia trialsChronic schizophreniaLongitudinal associationsSymptomsWeak associationBurdenSchizophreniaAssociationAdultsTrialsClinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU
Devlin JW, Skrobik Y, Gélinas C, Needham DM, Slooter AJC, Pandharipande PP, Watson PL, Weinhouse GL, Nunnally ME, Rochwerg B, Balas MC, van den Boogaard M, Bosma KJ, Brummel NE, Chanques G, Denehy L, Drouot X, Fraser GL, Harris JE, Joffe AM, Kho ME, Kress JP, Lanphere JA, McKinley S, Neufeld KJ, Pisani MA, Payen JF, Pun BT, Puntillo KA, Riker RR, Robinson BRH, Shehabi Y, Szumita PM, Winkelman C, Centofanti JE, Price C, Nikayin S, Misak CJ, Flood PD, Kiedrowski K, Alhazzani W. Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU. Critical Care Medicine 2018, 46: e825-e873. PMID: 30113379, DOI: 10.1097/ccm.0000000000003299.Peer-Reviewed Original ResearchConceptsAgitation/sedationManagement of painClinical practice guidelinesAdult patientsPractice guidelinesPractice statementsCritical illness survivorsTreatment of painBest practice statementsCritical care medicineInternational expertsICU survivorsRecommendations AssessmentIll adultsClinical caveatsGuideline groupSection groupImproved outcomesSleep disruptionCare medicineDeliriumPainClinical relevanceSedationGuideline development
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