2015
The Role of Hox Genes in Female Reproductive Tract Development, Adult Function, and Fertility
Du H, Taylor HS. The Role of Hox Genes in Female Reproductive Tract Development, Adult Function, and Fertility. Cold Spring Harbor Perspectives In Medicine 2015, 6: a023002. PMID: 26552702, PMCID: PMC4691806, DOI: 10.1101/cshperspect.a023002.Peer-Reviewed Original ResearchConceptsReproductive tract developmentEndometrial developmentTract developmentPolycystic ovarian syndromeFemale reproductive tract developmentFemale reproductive trackOvarian syndromeEndometrial receptivityImplantation rateFemale infertilityGene expressionMüllerian defectsHOXA11 expressionGene mutationsReproductive trackAdult functionDevelopmental abnormalitiesHOXA10AbnormalitiesEndocrine disruptorsDiethylstilbestrolImplantationEssential regulatorExpressionThe Relationship Among HOXA10, Estrogen Receptor α, Progesterone Receptor, and Progesterone Receptor B Proteins in Rectosigmoid Endometriosis: A Tissue Microarray Study
Zanatta A, Pereira RM, da Rocha A, Cogliati B, Baracat EC, Taylor HS, da Motta E, Serafini PC. The Relationship Among HOXA10, Estrogen Receptor α, Progesterone Receptor, and Progesterone Receptor B Proteins in Rectosigmoid Endometriosis: A Tissue Microarray Study. Reproductive Sciences 2015, 22: 31-37. PMID: 25217304, PMCID: PMC4527422, DOI: 10.1177/1933719114549846.Peer-Reviewed Original ResearchConceptsProgesterone receptorRectosigmoid endometriosisEstrogen receptor αSecretory phaseReceptor αType of endometriosisExpression of ERExpression of HOXA10Tissue microarray blocksConsecutive patientsOvarian endometriosisOvarian lesionsEndometriotic lesionsDeep endometriosisMenstrual cycleAllred scoreExpression of proteinsHomeobox A10Deep diseaseEndometriosisMicroarray blocksSteroid receptorsPatientsReceptorsHOXA10
2011
HOX Genes and Endometriosis
Kulp J, Cakmak H, Taylor H. HOX Genes and Endometriosis. 2011, 184-189. DOI: 10.1002/9781444398519.ch18.Peer-Reviewed Original ResearchEndometrial polyps affect uterine receptivity
Rackow BW, Jorgensen E, Taylor HS. Endometrial polyps affect uterine receptivity. Fertility And Sterility 2011, 95: 2690-2692. PMID: 21269620, PMCID: PMC3096716, DOI: 10.1016/j.fertnstert.2010.12.034.Peer-Reviewed Original Research
2010
Regulation of tryptophan 2,3-dioxygenase by HOXA10 enhances embryo viability through serotonin signaling
Doherty LF, Kwon HE, Taylor HS. Regulation of tryptophan 2,3-dioxygenase by HOXA10 enhances embryo viability through serotonin signaling. AJP Endocrinology And Metabolism 2010, 300: e86-e93. PMID: 20959529, PMCID: PMC3023205, DOI: 10.1152/ajpendo.00439.2010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineDNA, AntisenseEmbryo ImplantationEmbryo, MammalianEmbryonic DevelopmentEndometriumFemaleHomeobox A10 ProteinsHomeodomain ProteinsHumansImmune ToleranceMiceOrgan SpecificityRandom AllocationReceptor, Serotonin, 5-HT1DReceptors, SerotoninRNA, MessengerSerotonin 5-HT1 Receptor AntagonistsSerotonin AntagonistsSignal TransductionT-LymphocytesTryptophan OxygenaseUterusConceptsTDO expressionSerotonin productionEndometrial stromaTDO mRNASerotonin receptor subtypesHOXA10 antisenseImmune toleranceImpaired embryo developmentEndometrial glandsSerotonin levelsMurine uterusReceptor subtypesT cellsSerotonin receptorsTryptophan catabolismEmbryo developmentEmbryo implantationTryptophan metabolismBiosynthesis of serotoninTryptophan availabilityHOXA10 expressionEmbryo qualitySerotoninHOXA10Regulation of tryptophanThe role of the Hoxa10/HOXA10 gene in the etiology of endometriosis and its related infertility: a review
Zanatta A, Rocha AM, Carvalho FM, Pereira RM, Taylor HS, Motta EL, Baracat EC, Serafini PC. The role of the Hoxa10/HOXA10 gene in the etiology of endometriosis and its related infertility: a review. Journal Of Assisted Reproduction And Genetics 2010, 27: 701-710. PMID: 20821045, PMCID: PMC2997955, DOI: 10.1007/s10815-010-9471-y.Peer-Reviewed Original ResearchConceptsHOXA10 expressionAspects of endometriosisHomeobox A10 (HOXA10) geneWindow of implantationEtiology of endometriosisRetrograde menstruation theoryMüllerian tractSurgical treatmentRelated infertilityEndometrial expressionEndometriotic fociLaboratory findingsEmbryo implantationEndometriosisInfertilityHOXA10 geneMethodsThis reviewEtiologyHOXA10DiseasePeak of expressionMolecular mechanismsRecent studiesImplantationHOXA10 Inhibits Kruppel-Like Factor 9 Expression in the Human Endometrial Epithelium1
Du H, Sarno J, Taylor HS. HOXA10 Inhibits Kruppel-Like Factor 9 Expression in the Human Endometrial Epithelium1. Biology Of Reproduction 2010, 83: 205-211. PMID: 20463357, PMCID: PMC2907284, DOI: 10.1095/biolreprod.110.083980.Peer-Reviewed Original ResearchConceptsKruppel-like factor 9Endometrial epithelial cellsProgesterone receptorEndometrial epitheliumKLF9 expressionEpithelial cellsStromal cellsHuman endometrial epithelial cellsReproductive-age womenKLF9 mRNASteroid responsivenessEndometrial tissuePgR expressionSecretory phase endometrial epitheliumMenstrual cycleProgesterone actionProgesterone responsivenessSex steroidsSecretory phaseProliferative phaseProtein expressionFactor 9Reporter assaysHOXA10EpitheliumBisphenol‐A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response
Bromer JG, Zhou Y, Taylor MB, Doherty L, Taylor HS. Bisphenol‐A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response. The FASEB Journal 2010, 24: 2273-2280. PMID: 20181937, PMCID: PMC3230522, DOI: 10.1096/fj.09-140533.Peer-Reviewed Original ResearchConceptsEpigenetic alterationsCytosine-guanine dinucleotides (CpGs) methylationUtero BPA exposureHomeobox gene HOXA10Developmental programmingDiminished methylationChromatin immunoprecipitationBisulfite sequencingEpigenetic mechanismsDNA methylationPromoter sequencesBPA exposureMethylation profilesExpression patternsGene expressionUterine organogenesisUterine estrogen responsesMethylationNovel mechanismGeneral mechanismPregnant CD-1 miceProtein expressionCD-1 miceHOXA10ExpressionMolecular Mechanisms of Treatment Resistance in Endometriosis: The Role of Progesterone–Hox Gene Interactions
Cakmak H, Taylor H. Molecular Mechanisms of Treatment Resistance in Endometriosis: The Role of Progesterone–Hox Gene Interactions. Seminars In Reproductive Medicine 2010, 28: 069-074. PMID: 20104430, PMCID: PMC3107856, DOI: 10.1055/s-0029-1242996.Peer-Reviewed Original ResearchConceptsProgesterone receptor expressionEndometriosis-related infertilityEndometrium of womenExpression of HOXA10Progesterone-responsive genesTime of implantationProgesterone target genesHOXA10 gene expressionEndometrial growthIGFBP-1Progesterone resistanceEndometrial receptivityProgesterone responseEutopic endometriumHuman endometriumProgesterone levelsReceptor expressionTreatment resistanceSex steroidsEndometriosisEndometriumDiminished activityAlphavbeta3 integrinHOXA10Women3-Phosphoglycerate dehydrogenase expression is regulated by HOXA10 in murine endometrium and human endometrial cells
Du H, Vitiello D, Sarno JL, Taylor HS. 3-Phosphoglycerate dehydrogenase expression is regulated by HOXA10 in murine endometrium and human endometrial cells. Reproduction 2010, 139: 237-245. PMID: 19778996, PMCID: PMC3107855, DOI: 10.1530/rep-08-0376.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsCell LineCells, CulturedEndometriumEpithelial CellsFemaleGene Expression Regulation, EnzymologicHomeobox A10 ProteinsHomeodomain ProteinsHumansImmunohistochemistryMenstrual CycleMiceOligonucleotide Array Sequence AnalysisPhosphoglycerate DehydrogenasePregnancyRNA, MessengerRNA, Small InterferingStromal CellsTransfectionConceptsSerine biosynthesisRegulatory relationshipsHOXA10 regulationProtein synthesisPHGDH expressionReal-time PCR resultsStromal cellsCellular differentiationTarget genesHuman endometrial cellsPHGDHMRNA expressionHuman endometrial stromal cellsDe novoWestern blot resultsDehydrogenase expressionBiosynthesisHOXA10Epithelial cellsHOXA10 siRNARegulationExpressionEndometrial stromal cellsHOXA10 expressionBlot results
2009
Hypermethylation of HOXA10 by in utero Diethylstilbestrol Exposure: An Epigenetic Mechanism for Altered Developmental Programming
Bromer J, Wu J, Zhou Y, Taylor H. Hypermethylation of HOXA10 by in utero Diethylstilbestrol Exposure: An Epigenetic Mechanism for Altered Developmental Programming. Endocrine Reviews 2009, 30: 286-286. DOI: 10.1210/edrv.30.3.9997.Peer-Reviewed Original ResearchDES exposureHOXA10 expressionDevelopmental programmingUtero DES exposureUtero diethylstilbestrol exposureHuman endometrial cellsExpression of HOXA10Homeobox gene HOXA10Female reproductive tractDiethylstilbestrol exposureNon-steroidal estrogensClassic estrogensEndometrial cellsShort-term exposureDNA methyltransferases 1Uterine organogenesisDevelopmental anomaliesCaudal portionIncreased expressionHOXA10 geneReproductive tractEpigenetic mechanismsExposure resultsDiethylstilbestrolHOXA10
2008
Calpain5 expression is decreased in endometriosis and regulated by HOXA10 in human endometrial cells
Penna I, Du H, Ferriani R, Taylor HS. Calpain5 expression is decreased in endometriosis and regulated by HOXA10 in human endometrial cells. Molecular Human Reproduction 2008, 14: 613-618. PMID: 18829447, PMCID: PMC2734161, DOI: 10.1093/molehr/gan055.Peer-Reviewed Original ResearchConceptsEndometrial cellsGlandular cellsDevelopment of endometriosisHuman endometrial cellsExpression of HOXA10Real-time RT-PCRQuantitative real-time RT-PCRHOXA10 siRNAEndometrial biopsyEpithelial cell lineDecidual samplesEutopic endometriumMenstrual cyclePregnancy terminationEndometriosisFertile controlsHOXA10 expressionDecreased expressionRT-PCRProtein expressionRespective controlsHOXA10BiopsyCell linesAberrant regulation
2006
Regulation of HOXA10 expression by phytoestrogens
Akbas GE, Fei X, Taylor HS. Regulation of HOXA10 expression by phytoestrogens. AJP Endocrinology And Metabolism 2006, 292: e435-e442. PMID: 16985261, DOI: 10.1152/ajpendo.00167.2006.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedDNA-Binding ProteinsFemaleGene Expression RegulationGenes, ReporterGenisteinHomeobox A10 ProteinsHomeodomain ProteinsHumansIsoflavonesMaternal-Fetal ExchangeMiceMice, Inbred StrainsPhytoestrogensPregnancyPregnancy, AnimalPrenatal Exposure Delayed EffectsReceptors, EstrogenResponse ElementsUterusConceptsHOXA10 estrogen response elementHOXA10 expressionEstrogen response elementAdult mouse uterusUterine HOXA10 expressionEffects of isoflavonesDose-responsive mannerUterine anomaliesUtero exposureMouse uterusResponse elementHOXA10 mRNAAdult exposureDevelopmental anomaliesMüllerian ductsProtein expressionPotential mechanismsReproductive anomaliesUterusAdult expressionGenisteinFemale fertilityEndocrine disruptorsExposureHOXA10HOXA10 expression in ectopic endometrial tissue
Browne H, Taylor H. HOXA10 expression in ectopic endometrial tissue. Fertility And Sterility 2006, 85: 1386-1390. PMID: 16647375, DOI: 10.1016/j.fertnstert.2005.10.072.Peer-Reviewed Original ResearchConceptsEctopic endometrial tissueEndometrial tissueHOXA10 expressionEndometrial developmentEctopic endometriumEutopic endometriumLung parenchymaH-scoreNormal endometrial developmentEutopic endometrial tissuesPathogenesis of endometriosisHOXA10 protein expressionMean H-scoreOvarian endometriomaFertile womenPelvic peritoneumStromal expressionMAIN OUTCOMEEndometriosisGlandular epitheliumEndometriumDiminished expressionProtein expressionHOXA10P resistanceAn autoregulatory element maintains HOXA10 expression in endometrial epithelial cells
Kelly M, Daftary G, Taylor HS. An autoregulatory element maintains HOXA10 expression in endometrial epithelial cells. American Journal Of Obstetrics And Gynecology 2006, 194: 1100-1107. PMID: 16580301, DOI: 10.1016/j.ajog.2005.12.025.Peer-Reviewed Original ResearchConceptsEndometrial epithelial cellsHOXA10 expressionProgesterone receptorAutoregulatory elementRegulatory regionsEpithelial cellsGene expressionBT-20 cellsSteroid-induced gene expressionReporter gene expressionEndometrial receptivityIshikawa cellsSex steroidsBase pair elementSteroid receptorsAlternative molecular mechanismsStromal cellsHOXA10 proteinReporter constructsExpression increasesMolecular mechanismsReceptorsReporter activityDirect bindingHOXA10
2004
HOXA10 Expression in Endometrial Adenocarcinoma
Lane DB, Rutherford TJ, Taylor HS. HOXA10 Expression in Endometrial Adenocarcinoma. Tumor Biology 2004, 25: 264-269. PMID: 15627890, DOI: 10.1159/000081390.Peer-Reviewed Original ResearchConceptsEndometrial adenocarcinomaExpression of HOXA10Endometrial tissueHOXA10 expressionHOXA10 gene expressionNormal endometriumProgesterone receptorEstrogen receptorStage IEndometrial hyperplasiaNeoplastic endometriumGene expressionAdenocarcinomaAbnormal differentiationEndometriumReceptorsSignificant differencesNorthern blot analysisAdult reproductive tissuesBlot analysisHOXA10Aberrant regulationTissueP53Reproductive tissuesHOXA10, Pbx2, and Meis1 Protein Expression in the Human Endometrium: Formation of Multimeric Complexes on HOXA10 Target Genes
Sarno JL, Kliman HJ, Taylor HS. HOXA10, Pbx2, and Meis1 Protein Expression in the Human Endometrium: Formation of Multimeric Complexes on HOXA10 Target Genes. The Journal Of Clinical Endocrinology & Metabolism 2004, 90: 522-528. PMID: 15494461, DOI: 10.1210/jc.2004-0817.Peer-Reviewed Original ResearchConceptsTarget gene specificityGene specificityHoxA10 target geneMultimeric complexesTranscription factorsTarget genesTrimeric complexHOXA10 regulationEMX2 geneMeis1Myeloid differentiationPBX2 expressionDimer bindingProtein expressionBinding sitesHOXA10Cycle stagesGenesObserved expressionPBX2ExpressionCofactorBindingEmbryonic uterine developmentHuman endometrium
2003
HOXC and HOXD Gene Expression in Human Endometrium: Lack of Redundancy with HOXA Paralogs1
Akbas GE, Taylor HS. HOXC and HOXD Gene Expression in Human Endometrium: Lack of Redundancy with HOXA Paralogs1. Biology Of Reproduction 2003, 70: 39-45. PMID: 12954737, DOI: 10.1095/biolreprod.102.014969.Peer-Reviewed Original ResearchConceptsEndometrial developmentExpression of HOXC10Secretory phasePrimary endometrial stromal cellsSemiquantitative reverse transcription-polymerase chain reactionEndometrial stromal cellsReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionEndometrial proliferationEndometrial receptivityEndometrial differentiationMenstrual cycleHuman endometriumIshikawa cellsSex steroidsDecreased expressionStromal cellsChain reactionEndometriumHOXA genesHOXA10HOXD10Distinct expression patternsSitu hybridizationHOXC10Regulation of HOXA-10 Expression by Testosterone in Vitro and in the Endometrium of Patients with Polycystic Ovary Syndrome
Cermik D, Selam B, Taylor HS. Regulation of HOXA-10 Expression by Testosterone in Vitro and in the Endometrium of Patients with Polycystic Ovary Syndrome. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 238-243. PMID: 12519859, DOI: 10.1210/jc.2002-021072.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeOvary syndromeHOXA10 expressionEndometrium of patientsHOXA-10 expressionUterine HOXA10 expressionPregnancy loss rateReproductive-age womenAdverse reproductive outcomesExpression of HOXA10Ovarian androgensOvulatory disordersEndometrial biopsyEndometrial receptivityUterine dysfunctionAndrogen productionPregnancy rateReproductive outcomesTestosterone effectsHOXA10 mRNATestosteroneWomenEndometriumSyndromeHOXA10Regulation of Insulin-Like Growth Factor Binding Protein-1 Promoter Activity by FKHR and HOXA10 in Primate Endometrial Cells1
Kim JJ, Taylor HS, Akbas GE, Foucher I, Trembleau A, Jaffe RC, Fazleabas AT, Unterman TG. Regulation of Insulin-Like Growth Factor Binding Protein-1 Promoter Activity by FKHR and HOXA10 in Primate Endometrial Cells1. Biology Of Reproduction 2003, 68: 24-30. PMID: 12493691, DOI: 10.1095/biolreprod.102.009316.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBinding SitesCells, CulturedCloning, MolecularDNADNA-Binding ProteinsEndometriumFemaleForkhead Box Protein O1Forkhead Transcription FactorsGene Expression RegulationHomeobox A10 ProteinsHomeodomain ProteinsHumansInsulin-Like Growth Factor Binding Protein 1Molecular Sequence DataMutationPapioPregnancyPromoter Regions, GeneticRecombinant Fusion ProteinsRNA, MessengerSequence DeletionSequence Homology, Nucleic AcidSpecies SpecificityTranscription FactorsConceptsIGFBP-1 promoter activityProtein-1 promoter activityInsulin-like growth factorInsulin response sequencePromoter activityBaboon endometriumFollicular phaseMenstrual cycleEndometrial cellsDecidualization processLiver cellsGrowth factorProtein 1HOXA10PregnancyEndometriumTranscription factorsReporter gene studiesForkhead transcription factorHomeobox transcription factorGene studiesFKHRCellsActivityFactors
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