2025
First-in-Human Implantable Inferior Vena Cava Sensor for Remote Care in Heart Failure FUTURE-HF
Kalra P, Gogorishvili I, Khabeishvili G, Málek F, Toman O, Critoph C, Flett A, Cowburn P, Mehra M, Sheridan W, Britton J, Buxo T, Kealy R, Kent A, Greene B, Guha K, Gardner R, Loke I, Vazir A, Brugts J, Gray A, Testani J, Damman K. First-in-Human Implantable Inferior Vena Cava Sensor for Remote Care in Heart Failure FUTURE-HF. JACC Heart Failure 2025, 13: 1000-1010. PMID: 40208140, DOI: 10.1016/j.jchf.2025.01.019.Peer-Reviewed Original ResearchConceptsInferior vena cavaHeart failureIVC areaTechnical endpointsElevated natriuretic peptide levelsN-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptideAnalysis of clinical outcomesFirst-in-human experienceFirst-in-human studyMarkers of congestionOptimal HF treatmentReduce HF eventsNYHA functional classProcedure-related complicationsNatriuretic peptide levelsNatriuretic peptideVena cavaSafety endpointsHF hospitalizationClinical findingsClinical outcomesProcedural successFollow-upPrimary safety
2024
Scanning the aged to minimize missed injury: An Eastern Association for the Surgery of Trauma multicenter study
Ho V, Kishawi S, Hill H, O'Brien J, Ratnasekera A, Seng S, Ton T, Butts C, Muller A, Diaz B, Baltazar G, Petrone P, Pacheco T, Morrissey S, Chung T, Biller J, Jacobson L, Williams J, Nebughr C, Udekwu P, Tann K, Piehl C, Veatch J, Capasso T, Kuncir E, Kodadek L, Miller S, Altan D, Mentzer C, Damiano N, Burke R, Earley A, Doris S, Villa E, Wilkinson M, Dixon J, Wu E, Moncrief M, Palmer B, Herzing K, Egodage T, Williams J, Haan J, Lightwine K, Colling K, Harry M, Nahmias J, Tay-Lasso E, Cuschieri J, Hinojosa C, Claridge J. Scanning the aged to minimize missed injury: An Eastern Association for the Surgery of Trauma multicenter study. Journal Of Trauma And Acute Care Surgery 2024, 98: 101-110. PMID: 38797882, PMCID: PMC11599468, DOI: 10.1097/ta.0000000000004390.Peer-Reviewed Original ResearchNegative predictive valueHigh-risk criteriaBlunt trauma patientsPan-scanTorso CTMissed injuriesComputed tomographyTrauma patientsClinical algorithmInjury diagnosisIncidence of blunt traumaPositive clinical findingsPhysical exam findingsLack of evidence-based guidanceMulticenter studyClinical findingsProspective validationExam findingsEvidence-based guidanceBlunt traumaClinical useGeriatric patientsPatientsPredictive valueTrauma populationGenetic and molecular drivers of scleroderma pathogenesis
Odell I. Genetic and molecular drivers of scleroderma pathogenesis. Clinics In Dermatology 2024, 43: 153-159. PMID: 39675445, PMCID: PMC12009687, DOI: 10.1016/j.clindermatol.2024.12.007.Peer-Reviewed Original ResearchGrowth factor signalingFactor signalingScleroderma pathogenesisActivated growth factor receptorsGenetic association studiesTherapeutic approachesMolecular driversHereditary hemorrhagic telangiectasiaAssociation studiesRegulatory genesGrowth factor receptorImmune regulatory genesGenetic studiesBiological insightsVascular endothelial cellsMolecular mechanismsHemorrhagic telangiectasiaImmune dysregulationClinical findingsVascular abnormalitiesHeterogeneous diseaseClinical phenotypeFactor receptorPatient phenotypesMultiple malignanciesImmunogenicity of cell death and cancer immunotherapy with immune checkpoint inhibitors
Catanzaro E, Beltrán-Visiedo M, Galluzzi L, Krysko D. Immunogenicity of cell death and cancer immunotherapy with immune checkpoint inhibitors. Cellular & Molecular Immunology 2024, 22: 24-39. PMID: 39653769, PMCID: PMC11685666, DOI: 10.1038/s41423-024-01245-8.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsImmunogenic cell deathImmunogenic cell death inducerCheckpoint inhibitorsRefractory to immune checkpoint inhibitorsImmunogenicity of cell deathFraction of patientsCombinatorial treatment strategiesAdaptive immune responsesCell deathCombinatorial partnersCancer immunotherapyCombinatorial regimensClinical findingsClinical managementTreatment strategiesClinical activityImmune responseImmunotherapyPatientsCancerOncology settingInhibitorsDeathInducerCheckpoint Inhibitor-Induced Autoimmune Diabetes: An Autoinflammatory Disease.
Quandt Z, Perdigoto A, Anderson M, Herold K. Checkpoint Inhibitor-Induced Autoimmune Diabetes: An Autoinflammatory Disease. Cold Spring Harbor Perspectives In Medicine 2024, 15: a041603. PMID: 39038853, PMCID: PMC11917379, DOI: 10.1101/cshperspect.a041603.Peer-Reviewed Original ResearchAutoimmune diabetesBlockade of programmed cell death protein 1Agents targeting immune checkpointsCell death protein 1Autoimmune side effectsPD-L1Immune checkpointsAutoimmune disease riskClinical findingsAdverse eventsLevels of lipaseSide effectsInflammatory processIslets of LangerhansProtein 1DiabetesDisease riskIncreased levelsCheckpointAutoantibodiesBlockadeCancerPancreasDiagnosisLangerhansTesting in functional constipation—What's new and what works
Rodriguez L. Testing in functional constipation—What's new and what works. Alimentary Pharmacology & Therapeutics 2024, 60: s30-s41. PMID: 38940015, DOI: 10.1111/apt.17857.Peer-Reviewed Original ResearchColonic manometryFecal incontinenceConventional therapyRadiopaque markersFunctional constipationNon-retentive fecal incontinenceDiagnostic studiesFailed medical therapyLumbar spine MRIRecto-anal inhibitory reflexAnal resting pressureAbdominal X-raySpine MRIAnorectal manometryMedical therapyPaediatric constipationSurgical interventionClinical findingsInhibitory reflexEvaluate anatomySpinal abnormalitiesColonic transitMedical historyPaediatric gastroenterologistsConstipationRenal Cell Carcinoma of Variant Histology: New Biologic Understanding Leads to Therapeutic Advances.
Salgia N, Zengin Z, Pal S, Dizman N. Renal Cell Carcinoma of Variant Histology: New Biologic Understanding Leads to Therapeutic Advances. American Society Of Clinical Oncology Educational Book 2024, 44: e438642. PMID: 38776514, PMCID: PMC11235416, DOI: 10.1200/edbk_438642.Peer-Reviewed Original ResearchConceptsRenal cell carcinomaPapillary renal cell carcinomaBiology of renal cell carcinomaHistology renal cell carcinomaPatient populationRenal cell carcinoma histologyMetastatic renal cell carcinomaRenal cell carcinoma casesOptimization of treatment regimensNon-clear cellPrecision oncology approachesDiagnosed solid tumorsSarcomatoid dedifferentiationVariant histologyRare subtypeHistopathological subtypesCell carcinomaSolid tumorsClinical featuresTreatment regimensClinical findingsOncology approachesTherapeutic advancesTherapeutic approachesUnique pathogenesesGenetic Databases and Online Ring Chromosome Registry
Hu Q, Ma D, Li P, Liehr T. Genetic Databases and Online Ring Chromosome Registry. 2024, 31-42. DOI: 10.1007/978-3-031-47530-6_3.Peer-Reviewed Original ResearchDatabase of Genomic VariantsRing chromosomesClinical Genome Resource (ClinGenDatabase of Chromosomal ImbalanceAtlas of GeneticsOnline Mendelian InheritanceGenome browserPatient advocate organizationsGenomic variantsEnsembl ResourcesClinical cytogeneticsGenomic technologiesSupernumerary markerChromosomal imbalancesMendelian inheritanceDiagnostic geneticsGenetic databasesChromosome databaseChromosomeGenetic testingGeneticsCytogeneticsDisease RegistryClinical findingsWeb resourcesDiagnosis and treatment of Wernicke's encephalopathy: A systematic literature review
Cantu-Weinstein A, Branning R, Alamir M, Weleff J, Do M, Nero N, Anand A. Diagnosis and treatment of Wernicke's encephalopathy: A systematic literature review. General Hospital Psychiatry 2024, 87: 48-59. PMID: 38306946, DOI: 10.1016/j.genhosppsych.2024.01.005.Peer-Reviewed Original ResearchConceptsWernicke's encephalopathyCase reportIV thiamineRandomized Controlled TrialsComplete resolution of symptomsTreatment of Wernicke's encephalopathyControlled TrialsAverage ageResolution of symptomsDiagnosing WEWE patientsCross-sectional studyComplete resolutionRetrospective studyClinical findingsProspective studyNeurological symptomsTreatment guidelinesDiagnostic standardHuman studiesThiamine treatmentInclusion criteriaClinical guidelinesCognitive dysfunctionSystematic reviewReal-World Tralokinumab Use in Dupilumab-Experienced Patients: A Eetrospective Multi-Center Case Series
Herman E, Burgy J, Shahriari M. Real-World Tralokinumab Use in Dupilumab-Experienced Patients: A Eetrospective Multi-Center Case Series. SKIN The Journal Of Cutaneous Medicine 2024, 8: s321. DOI: 10.25251/skin.8.supp.321.Peer-Reviewed Original ResearchTreated with dupilumabAtopic dermatitisDupilumab treatmentTralokinumab treatmentCase seriesSafety profileLong-term disease controlHead-to-head studiesDiscontinued dupilumab treatmentTreated with topicalMulti-center case seriesDuration of treatmentLack of efficacyEvaluate clinical findingsBiologic dupilumabHerpes labialisNRS scoresAdult patientsClinical findingsDupilumabTreatment optionsEffective therapyTralokinumabDisease durationJoint pain
2023
The Clinical Utility of Antroduodenal Manometry in the Evaluation of Children with Upper Gastrointestinal Symptoms
Arbizu R, Trauernicht S, Pinillos S, Nurko S, Rodriguez L. The Clinical Utility of Antroduodenal Manometry in the Evaluation of Children with Upper Gastrointestinal Symptoms. Journal Of Pediatric Gastroenterology And Nutrition 2023, 77: 734-740. PMID: 37756372, DOI: 10.1097/mpg.0000000000003956.Peer-Reviewed Original ResearchConceptsGroup B symptomsUpper gastrointestinal symptomsIdiopathic etiologyB symptomsGastrointestinal symptomsPhase IIITreatment responseInitial successful responseIntestinal phase IIIOverall treatment responseSuccessful treatment responseSmall bowel motilityEvaluation of childrenSuccessful responseManometry measuresUGI symptomsAbdominal distentionAntroduodenal manometryPredominant symptomBowel motilityRetrospective reviewClinical findingsClinical utilitySymptomsEtiologyThe ASSESS-AKI Study found urinary epidermal growth factor is associated with reduced risk of major adverse kidney events
Menez S, Wen Y, Xu L, Moledina D, Thiessen-Philbrook H, Hu D, Obeid W, Bhatraju P, Ikizler T, Siew E, Chinchilli V, Garg A, Go A, Liu K, Kaufman J, Kimmel P, Himmelfarb J, Coca S, Cantley L, Parikh C. The ASSESS-AKI Study found urinary epidermal growth factor is associated with reduced risk of major adverse kidney events. Kidney International 2023, 104: 1194-1205. PMID: 37652206, PMCID: PMC10840723, DOI: 10.1016/j.kint.2023.08.007.Peer-Reviewed Original ResearchConceptsMajor adverse kidney eventsUEGF/CrUrinary epidermal growth factorAdverse kidney eventsChronic kidney diseaseEpidermal growth factorKidney eventsKidney failureEGF expressionUrinary EGF/CrAcute Kidney Injury studyGrowth factorIschemia-reperfusion injuryProportional hazards regressionTubular healthKidney atrophyObservational cohortHospitalized participantsTubular functionClinical findingsHazards regressionKidney diseaseClinical variablesProgressive atrophyUrinary EGFMonitoring Treatment Response, Early Recurrence, and Survival in Uterine Serous Carcinoma and Carcinosarcoma Patients Using Personalized Circulating Tumor DNA Biomarkers
Bellone S, McNamara B, Mutlu L, Demirkiran C, Hartwich T, Harold J, Yang-Hartwich Y, Siegel E, Santin A. Monitoring Treatment Response, Early Recurrence, and Survival in Uterine Serous Carcinoma and Carcinosarcoma Patients Using Personalized Circulating Tumor DNA Biomarkers. International Journal Of Molecular Sciences 2023, 24: 8873. PMID: 37240216, PMCID: PMC10219151, DOI: 10.3390/ijms24108873.Peer-Reviewed Original ResearchConceptsUterine serous carcinomaCS patientsEarly recurrenceDroplet digital polymerase chain reactionCA 125Serous carcinomaCtDNA testingTime of surgeryTime of recurrenceReliable tumor biomarkersTumour DNA biomarkersCarcinosarcoma patientsUSC patientsRecurrent diseaseOccult diseaseOverall survivalEndometrial cancerAggressive variantInitial treatmentRecurrent tumorsResidual tumorClinical findingsTreatment courseTreatment trialsPIK3CA mutationsThe effects of flow settings during high-flow nasal cannula support for adult subjects: a systematic review
Li J, Albuainain F, Tan W, Scott J, Roca O, Mauri T. The effects of flow settings during high-flow nasal cannula support for adult subjects: a systematic review. Critical Care 2023, 27: 78. PMID: 36855198, PMCID: PMC9974062, DOI: 10.1186/s13054-023-04361-5.Peer-Reviewed Original ResearchConceptsHigh-flow nasal cannulaHigh-flow nasal cannula treatmentIn vivo studiesPatient's peak inspiratory flowHigh-flow nasal cannula supportFraction of inspired oxygenPositive end-expiratory pressurePeak inspiratory flowSystematic reviewEnd-expiratory pressureDead space washoutNon-dependent lung regionsIn vitro studiesRisk of biasROX indexNasal cannulaClinical findingsImprove oxygenationPediatric populationPatient discomfortAlveolar overdistentionInspiratory flowWeb of SciencePatient comfortPatientsA 1-Tesla MRI system for dedicated brain imaging in the neonatal intensive care unit
Berson E, Mozayan A, Peterec S, Taylor S, Bamford N, Ment L, Rowe E, Lisse S, Ehrlich L, Silva C, Goodman T, Payabvash S. A 1-Tesla MRI system for dedicated brain imaging in the neonatal intensive care unit. Frontiers In Neuroscience 2023, 17: 1132173. PMID: 36845429, PMCID: PMC9951115, DOI: 10.3389/fnins.2023.1132173.Peer-Reviewed Original ResearchNeonatal intensive care unitIntensive care unitIntraventricular hemorrhageCare unitHypoxic injuryIntracranial pathologyAverage gestational ageParenchymal injuryPreterm neonatesCommon indicationIschemic lesionsNICU patientsGestational ageClinical findingsPatient weightInfantsTranscranial ultrasoundMRIInjuryCareMicrohemorrhagesScansLesionsFollowPathologyChapter 29 The aging eye and age-related ocular pathologies
Arat Y. Chapter 29 The aging eye and age-related ocular pathologies. 2023, 319-338. DOI: 10.1016/b978-0-323-98804-9.00001-3.Peer-Reviewed Original ResearchEye diseaseAge-related ocular pathologiesAge-related macular degenerationSight-threatening eye diseaseDry eye diseaseAge-related pathogenesisOcular surfaceMacular degenerationOcular pathologyAging eyeClinical findingsOphthalmic diseasesAge-relatedAge-related diseasesFunctional changesDiseaseEyesPathologyAgeGlaucomaIncreased vulnerabilityCataractPathogenesisRetinaLate lifeExamining mGlu5 Receptor Availability as a Predictor of Vulnerability to PTSD: An [18F]FPEB and PET Study in Male and Female Rats
Asch R, Fowles K, Pietrzak R, Taylor J, Esterlis I. Examining mGlu5 Receptor Availability as a Predictor of Vulnerability to PTSD: An [18F]FPEB and PET Study in Male and Female Rats. Chronic Stress 2023, 7: 24705470231215001. PMID: 38024327, PMCID: PMC10666551, DOI: 10.1177/24705470231215001.Peer-Reviewed Original ResearchPost-traumatic stress disorderReceptor availabilityFemale ratsPathophysiology of PTSDFootshock exposureMetabotropic glutamate receptor 5Recent preclinical findingsGlutamate receptor 5Positron emission tomographyPreclinical findingsClinical findingsFe ratsReceptor 5Lower baselineEmission tomographyGreater riskPET studiesRatsStress disorderDifferential involvementPassive copingSex differencesMalesPTSD susceptibilityBaselineCurrent diagnosis and management of cardiac melanoma: a case series and review
Long A, Chang J, Glahn J, Olino K, Tran T, Clune J. Current diagnosis and management of cardiac melanoma: a case series and review. Journal Of Cancer Metastasis And Treatment 2023, 9: null-null. DOI: 10.20517/2394-4722.2022.113.Peer-Reviewed Original ResearchUse of immunotherapyCardiac melanomaCardiac tumorsSurveillance imagingMalignant melanomaRoutine surveillance imagingCardiac metastasisCase seriesCDKN2A variantsClinical findingsAutopsy studyBRAF mutationsNRAS mutationsPatientsCurrent diagnosisImmunotherapyMelanomaGenetic profilingHigh rateTumorsDiagnosisImagingMetastasisTherapySymptoms
2022
Inguinal patch in mpox (monkeypox) virus infection and eccrine syringometaplasia: report of two cases with in situ hybridization and electron microscopy findings
Roy S, Sarhan J, Liu X, Murphy M, Bunick C, Choate K, Damsky W, McNiff J. Inguinal patch in mpox (monkeypox) virus infection and eccrine syringometaplasia: report of two cases with in situ hybridization and electron microscopy findings. British Journal Of Dermatology 2022, 188: 574-576. PMID: 36763786, DOI: 10.1093/bjd/ljac146.Peer-Reviewed Original ResearchConceptsVirus infectionUnusual clinical findingsElectron microscopy findingsEccrine epitheliumSquamous syringometaplasiaClinical findingsSitu hybridizationEccrine ductsMicroscopy findingsSyringometaplasiaUltrastructural characteristicsInfectionViral mRNAsFindingsPatientsHistopathologicalDiseaseEpitheliumA Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer.
Nardone A, Qiu X, Spisak S, Nagy Z, Feiglin A, Feit A, Cohen Feit G, Xie Y, Font-Tello A, Guarducci C, Hermida-Prado F, Syamala S, Lim K, Munoz Gomez M, Pun M, Cornwell M, Liu W, Ors A, Mohammed H, Cejas P, Brock JB, Freedman ML, Winer EP, Fu X, Schiff R, Long HW, Metzger Filho O, Jeselsohn R. A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer. Cancer Research 2022, 82: 3673-3686. PMID: 35950920, PMCID: PMC9588703, DOI: 10.1158/0008-5472.can-21-3186.Peer-Reviewed Original ResearchConceptsInvasive lobular breast cancerInvasive ductal cancerLobular breast cancerTamoxifen resistanceBreast cancerInferior long-term outcomesTumor progressionLong-term outcomesBreast cancer subtypesPotential therapeutic avenuesDuctal cancerClinical findingsPoor outcomeReceptor axisClinical trialsDisease progressionPatient outcomesPreclinical modelsClinical investigationRelated commentaryTherapeutic avenuesCancer subtypesTherapeutic resistanceCancerClinical samples
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