2011
MicroRNA 135 Regulates HOXA10 Expression in Endometriosis
Petracco R, Grechukhina O, Popkhadze S, Massasa E, Zhou Y, Taylor HS. MicroRNA 135 Regulates HOXA10 Expression in Endometriosis. The Journal Of Clinical Endocrinology & Metabolism 2011, 96: e1925-e1933. PMID: 21956427, PMCID: PMC3232619, DOI: 10.1210/jc.2011-1231.Peer-Reviewed Original ResearchConceptsEndometrium of womenHOXA10 expressionHOXA10 regulationB expressionProliferative phaseEndometrial stromal cellsUniversity Medical CenterRegulation of HOXA10Time of ovulationMicroRNA-135Endometrial biopsyEndometrial receptivityMCF-7 cellsEndometrial samplesMenstrual cycleLuteal phaseMedical CenterSex steroidsStudy interventionEndometriosisSecretory phaseHOXA10 mRNAMicroRNA-135aStromal cellsEndometrium
2007
Altered expression of HOXA10 in endometriosis: potential role in decidualization
Kim JJ, Taylor HS, Lu Z, Ladhani O, Hastings JM, Jackson KS, Wu Y, Guo SW, Fazleabas AT. Altered expression of HOXA10 in endometriosis: potential role in decidualization. Molecular Human Reproduction 2007, 13: 323-332. PMID: 17350963, DOI: 10.1093/molehr/gam005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBucladesineCells, CulturedDeciduaDNA MethylationEndometriosisEndometriumEpithelial CellsEstradiolFemaleGene Expression RegulationGene SilencingHomeobox A10 ProteinsHomeodomain ProteinsHumansInsulin-Like Growth Factor Binding Protein 1Medroxyprogesterone AcetatePapioPromoter Regions, GeneticRNA, MessengerStromal CellsTranscription FactorsConceptsHuman endometrial stromal cellsStromal cellsEutopic endometriumIGFBP1 mRNAIGFBP1 expressionInsulin-like growth factorMonths of diseaseEndometrial stromal cellsExpression of HOXA10Protein-1 mRNADisease-free animalsGynaecologic disordersHOXA10 levelsOverexpression of HOXA10Induced endometriosisMedroxyprogesterone acetateControl animalsEndometriosisHOXA10 mRNAHOXA10 expressionUterine environmentHOXA10 geneEndometriumGrowth factorAltered expression
2006
Salpingectomy increases peri-implantation endometrial HOXA10 expression in women with hydrosalpinx
Daftary GS, Kayisli U, Seli E, Bukulmez O, Arici A, Taylor HS. Salpingectomy increases peri-implantation endometrial HOXA10 expression in women with hydrosalpinx. Fertility And Sterility 2006, 87: 367-372. PMID: 17173899, DOI: 10.1016/j.fertnstert.2006.06.041.Peer-Reviewed Original ResearchConceptsEndometrial HOXA10 expressionImplantation rateHOXA10 expressionInfertile womenFertile controlsHOXA10 mRNAPolymerase chain reaction findingsProspective clinical trialsReal-time reverse transcription-polymerase chain reactionReverse transcription-polymerase chain reactionHOXA10 protein expressionExpression of HOXA10Academic medical centerHOXA10 mRNA expressionGlandular epithelial cellsHomeobox gene HOXA10Potential molecular mechanismsBilateral hydrosalpinxHydrosalpinx fluidEndometrial stromaMidluteal phasePolymerase chain reactionClinical trialsSalpingectomyMedical CenterRegulation of HOXA10 expression by phytoestrogens
Akbas GE, Fei X, Taylor HS. Regulation of HOXA10 expression by phytoestrogens. AJP Endocrinology And Metabolism 2006, 292: e435-e442. PMID: 16985261, DOI: 10.1152/ajpendo.00167.2006.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedDNA-Binding ProteinsFemaleGene Expression RegulationGenes, ReporterGenisteinHomeobox A10 ProteinsHomeodomain ProteinsHumansIsoflavonesMaternal-Fetal ExchangeMiceMice, Inbred StrainsPhytoestrogensPregnancyPregnancy, AnimalPrenatal Exposure Delayed EffectsReceptors, EstrogenResponse ElementsUterusConceptsHOXA10 estrogen response elementHOXA10 expressionEstrogen response elementAdult mouse uterusUterine HOXA10 expressionEffects of isoflavonesDose-responsive mannerUterine anomaliesUtero exposureMouse uterusResponse elementHOXA10 mRNAAdult exposureDevelopmental anomaliesMüllerian ductsProtein expressionPotential mechanismsReproductive anomaliesUterusAdult expressionGenisteinFemale fertilityEndocrine disruptorsExposureHOXA10Thrombin and Interleukin-1β Regulate HOXA10 Expression in Human Term Decidual Cells: Implications for Preterm Labor
Sarno JL, Schatz F, Lockwood CJ, Huang S, Taylor HS. Thrombin and Interleukin-1β Regulate HOXA10 Expression in Human Term Decidual Cells: Implications for Preterm Labor. The Journal Of Clinical Endocrinology & Metabolism 2006, 91: 2366-2372. PMID: 16551735, DOI: 10.1210/jc.2005-1807.Peer-Reviewed Original ResearchConceptsTerm decidual cellsIL-1betaDecidual cellsProgesterone resistancePreterm laborHOXA10 mRNAHOXA10 expressionMedroxyprogesterone acetate treatmentProtein expressionHOXA10 protein expressionAcademic medical centerIntraamniotic infectionPreterm deliveryQuantitative RT-PCRProgestin resistanceMedroxyprogesterone acetateProgesterone withdrawalProinflammatory cytokinesMAIN OUTCOMEMedical CenterProgesterone responsivenessProstaglandin receptorsHuman parturitionAcetate treatmentAddition of thrombin
2003
Regulation of HOXA-10 Expression by Testosterone in Vitro and in the Endometrium of Patients with Polycystic Ovary Syndrome
Cermik D, Selam B, Taylor HS. Regulation of HOXA-10 Expression by Testosterone in Vitro and in the Endometrium of Patients with Polycystic Ovary Syndrome. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 238-243. PMID: 12519859, DOI: 10.1210/jc.2002-021072.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeOvary syndromeHOXA10 expressionEndometrium of patientsHOXA-10 expressionUterine HOXA10 expressionPregnancy loss rateReproductive-age womenAdverse reproductive outcomesExpression of HOXA10Ovarian androgensOvulatory disordersEndometrial biopsyEndometrial receptivityUterine dysfunctionAndrogen productionPregnancy rateReproductive outcomesTestosterone effectsHOXA10 mRNATestosteroneWomenEndometriumSyndromeHOXA10
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