2023
A structural blueprint for interleukin-21 signal modulation
Abhiraman G, Bruun T, Caveney N, Su L, Saxton R, Yin Q, Tang S, Davis M, Jude K, Garcia K. A structural blueprint for interleukin-21 signal modulation. Cell Reports 2023, 42: 112657. PMID: 37339051, PMCID: PMC10320830, DOI: 10.1016/j.celrep.2023.112657.Peer-Reviewed Original Research
2019
A single phosphoacceptor residue in BGLF3 is essential for transcription of Epstein-Barr virus late genes
Li J, Walsh A, Lam TT, Delecluse HJ, El-Guindy A. A single phosphoacceptor residue in BGLF3 is essential for transcription of Epstein-Barr virus late genes. PLOS Pathogens 2019, 15: e1007980. PMID: 31461506, PMCID: PMC6713331, DOI: 10.1371/journal.ppat.1007980.Peer-Reviewed Original ResearchConceptsPost-translational modificationsLate gene expressionLate genesGene expressionPhosphoacceptor residuesPre-initiation complexPotential phosphorylation sitesViral DNA replicationNew virus particlesEarly gene expressionPhosphorylation sitesVirus particlesDNA replicationTATA boxHerpesvirus proteinsEctopic expressionTrimeric complexLate proteinsLate transcriptsHost cellsEarly proteinsGenesTranscriptionLate kineticsProtein
2014
Cerebral cavernous malformation proteins at a glance
Draheim KM, Fisher OS, Boggon TJ, Calderwood DA. Cerebral cavernous malformation proteins at a glance. Journal Of Cell Science 2014, 127: 701-707. PMID: 24481819, PMCID: PMC3924200, DOI: 10.1242/jcs.138388.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosis Regulatory ProteinsCapillary PermeabilityCarrier ProteinsCentral Nervous System NeoplasmsHemangioma, Cavernous, Central Nervous SystemHumansKRIT1 ProteinMembrane ProteinsMicrotubule-Associated ProteinsNeoplasm ProteinsProto-Oncogene Proteinsrho GTP-Binding ProteinsSignal TransductionConceptsAdaptor proteinCerebral Cavernous Malformation ProteinsMulti-domain adaptor proteinBasic cellular processesProtein-protein interactionsCerebral cavernous malformationsAccompanying posterGlance articleCCM proteinsCellular processesProtein functionCellular phenotypesTrimeric complexFunction mutationsCell adhesionCell scienceProteinLeaky blood vesselsFocal neurological defectsCurrent understandingNeurological defectsCytoskeletalGenesPDCD10KRIT1
2004
HOXA10, Pbx2, and Meis1 Protein Expression in the Human Endometrium: Formation of Multimeric Complexes on HOXA10 Target Genes
Sarno JL, Kliman HJ, Taylor HS. HOXA10, Pbx2, and Meis1 Protein Expression in the Human Endometrium: Formation of Multimeric Complexes on HOXA10 Target Genes. The Journal Of Clinical Endocrinology & Metabolism 2004, 90: 522-528. PMID: 15494461, DOI: 10.1210/jc.2004-0817.Peer-Reviewed Original ResearchConceptsTarget gene specificityGene specificityHoxA10 target geneMultimeric complexesTranscription factorsTarget genesTrimeric complexHOXA10 regulationEMX2 geneMeis1Myeloid differentiationPBX2 expressionDimer bindingProtein expressionBinding sitesHOXA10Cycle stagesGenesObserved expressionPBX2ExpressionCofactorBindingEmbryonic uterine developmentHuman endometrium
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