2025
Imaging of the Uterus after Endometrial Ablation.
Revzin M, Nezami N, Osman M, Jha P, Butler K, Pellerito J. Imaging of the Uterus after Endometrial Ablation. RadioGraphics 2025, 45: e240040. PMID: 40705686, DOI: 10.1148/rg.240040.Peer-Reviewed Original ResearchConceptsEndometrial ablationUterine bleedingImaging findingsPathophysiology of abnormal uterine bleedingAbnormal uterine bleedingCross-sectional imaging modalitiesAlternative to hysterectomyExcessive uterine bleedingTreatment of excessive uterine bleedingMinimally invasive surgerySurgical historyEndometrial cancerImaging reviewUterusAssociated with EARadiology literatureInvasive surgeryRadiological interpretationImaging modalitiesPostablationMedical conditionsBleedingPathological conditionsOptimal assessmentPathological processesEfficacy of balloon stent or oral estrogen for adhesion prevention in septate uterus: A randomized clinical trial
Deng S, Zhao Z, Feng L, Huang X, Wang S, Xue X, Yan L, Ma B, Hao L, Li X, Yang L, Si M, Zhang H, Chen Z, Zhu L. Efficacy of balloon stent or oral estrogen for adhesion prevention in septate uterus: A randomized clinical trial. Chinese Medical Journal 2025, 138: 985-987. PMID: 40143426, PMCID: PMC12037080, DOI: 10.1097/cm9.0000000000003473.Peer-Reviewed Original Research
2024
Patient Views and Values Placed on the Uterus
Chang O, Huynh A, Ringel N, Hudson P, Halder G, Winkleman W, Ton J, Davidson E, Meriwether K. Patient Views and Values Placed on the Uterus. O&G Open 2024, 1: 48-48. PMID: 41001598, PMCID: PMC12456592, DOI: 10.1097/og9.0000000000000048.Peer-Reviewed Original ResearchGynecologic conditionsHysterectomy proceduresBenign gynecologic conditionsPelvic organ prolapseProspective cohort studyTreatment of gynecological disordersUterine preservationPelvic painOrgan prolapseMedian agePatient ageUrinary incontinenceChart reviewGynecological disordersCohort studyUterusPatient questionnaireWhite racePatientsMedical CenterHysterectomyPerson-centered careMulticenterGrounded theory approachPhysiological rolePO0222 Feasibility of 3-D Printed Prototypes of Indwelling Intrauterine Tube for Tandem-Based Cervical Brachytherapy
Tien C, Damast S, Glennon A. PO0222 Feasibility of 3-D Printed Prototypes of Indwelling Intrauterine Tube for Tandem-Based Cervical Brachytherapy. Brachytherapy 2024, 23: s105. DOI: 10.1016/j.brachy.2024.08.156.Peer-Reviewed Original ResearchSmit sleeveIntrauterine tubeCervical brachytherapyAnimal modelsClinical useUtero timeCT imagesBeam radiationPrevent perforationBrachytherapyClinical prototypeIn-house methodologyClinicMinutesImplantationSTL fileSleeveCervixIntrauterineDaysUterusUteroLong-termCoefficient of thermal expansionISO testsPilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluation
Grun M, Honhar P, Wang Y, Rossano S, Khang M, Suh H, Fowles K, Kliman H, Cavaliere A, Carson R, Marquez‐Nostra B, Saltzman W. Pilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluation. Bioengineering & Translational Medicine 2024, 9: e10661. PMID: 39553429, PMCID: PMC11561825, DOI: 10.1002/btm2.10661.Peer-Reviewed Original ResearchVaginal dosage formsBioadhesive nanoparticlesCynomolgus monkeysAnalysis of inflammatory biomarkersVaginal microbicidesVaginal canalMultiple dosesInflammatory biomarkersTherapeutic efficacyVaginal fluidSystemic circulationLong-term deliveryNoninvasive imagingClinical translationDosage formsNon-human primatesDelivery vehiclesMonkeysDeliveryVaginitisUterusMicrobicidesSafety evaluationBiodistributionDose
2023
Progress on the Endometrium
Frankfurter D, Kliman H. Progress on the Endometrium. Obstetrics And Gynecology Clinics Of North America 2023, 50: 677-694. PMID: 37914487, DOI: 10.1016/j.ogc.2023.09.002.Peer-Reviewed Original ResearchConceptsAbsence of pregnancyEvidence-based approachEndometrial assessmentStromal maturationEndometrial proliferationEndometrial pathologyInflammatory mediatorsOvarian steroidsImplantation failureBlastocyst implantationEndometrial sloughingDiagnostic measuresEndometriumOffer hopeDynamic tissueDevelopmental markersSingle testTissueInternal reproductionMaturationEndometriosisPregnancyDecidualizationInfertilityUterus
2021
Reports From Four International Clinical Trials for Cancers of the Cervix, Uterus and Vulva, and a New Guideline for Cervical Cancer
Damast S, Fields E, Kidd E, Harkenrider M, Chopra S, Chino J. Reports From Four International Clinical Trials for Cancers of the Cervix, Uterus and Vulva, and a New Guideline for Cervical Cancer. International Journal Of Radiation Oncology • Biology • Physics 2021, 111: 299-306. PMID: 34473967, DOI: 10.1016/j.ijrobp.2021.05.002.Peer-Reviewed Original ResearchAmenorrhea and Abnormal Uterine Bleeding
Collins S, Martin J, Pal L. Amenorrhea and Abnormal Uterine Bleeding. 2021, 525-541. DOI: 10.1007/978-3-030-75385-6_49.Peer-Reviewed Original ResearchMenstrual cycleWorsening of anemiaAbnormal uterine bleedingImpaired nutritional statusManagement of patientsGeneral health issuesUterine bleedingMenstrual flowCommon causeLoss of fertilityNutritional statusInfectious diseasesAmenorrheaSuch disordersHealth issuesAbnormal durationSocial isolationBleedingPatientsAnemiaDysfunctionHypothalamusUterusWorseningAbnormalitiesVascular biology of uterine fibroids: connecting fibroids and vascular disorders.
Kirschen GW, AlAshqar A, Miyashita-Ishiwata M, Reschke L, El Sabeh M, Borahay MA. Vascular biology of uterine fibroids: connecting fibroids and vascular disorders. Reproduction 2021, 162: r1-r18. PMID: 34034234, PMCID: PMC8320308, DOI: 10.1530/rep-21-0087.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsVascular disordersMyometrial smooth muscle cellsSystemic vascular disorderSmooth muscle cellsAbdominal painAldosterone systemUrinary retentionEndothelial dysfunctionEssential hypertensionUterine fibroidsBenign tumorsFibroid growthDisease processFibroidsNovel treatmentsFibroid pathogenesisMuscle cellsCell-intrinsic factorsVascular biologyPharmaceutical agentsUterusVasculature systemDisordersConstipationHypertensionGenetics of agenesis/hypoplasia of the uterus and vagina: narrowing down the number of candidate genes for Mayer–Rokitansky–Küster–Hauser Syndrome
Mikhael S, Dugar S, Morton M, Chorich LP, Tam KB, Lossie AC, Kim HG, Knight J, Taylor HS, Mukherjee S, Capra JA, Phillips JA, Friez M, Layman LC. Genetics of agenesis/hypoplasia of the uterus and vagina: narrowing down the number of candidate genes for Mayer–Rokitansky–Küster–Hauser Syndrome. Human Genetics 2021, 140: 667-680. PMID: 33469725, PMCID: PMC9211441, DOI: 10.1007/s00439-020-02239-y.Peer-Reviewed Original ResearchConceptsKüster-Hauser syndromeMouse modelHuman studiesCandidate variantsAgenesis/hypoplasiaMethodsWhole-exome sequencingMayer-RokitanskyCandidate genesCongenital absenceExome sequencingAuditory defectsSanger sequencingPatientsRare variantsSyndromeUterusMRKHVaginaFurther investigationDigenic combinationsPhysiological candidatesGenetic basisSame geneVariant analysisGenes
2020
Effects of combined 17β-estradiol and progesterone on weight and blood pressure in postmenopausal women of the REPLENISH trial
Black D, Minkin M, Graham S, Bernick B, Mirkin S. Effects of combined 17β-estradiol and progesterone on weight and blood pressure in postmenopausal women of the REPLENISH trial. Menopause The Journal Of The North American Menopause Society 2020, 28: 32-39. PMID: 32932401, PMCID: PMC7769186, DOI: 10.1097/gme.0000000000001659.Peer-Reviewed Original ResearchConceptsE2/P4Diastolic blood pressureSystolic blood pressureBlood pressurePostmenopausal womenREPLENISH trialMonth 12Treatment-emergent adverse eventsWeight gainTwelve-month useHealthy postmenopausal womenSevere vasomotor symptomsBody mass indexAdverse eventsVasomotor symptomsMass indexEfficacy profileWomenBaselineHypertensionPlaceboUterusTrialsImportant changesPrevious findings
2018
American Society for Reproductive Medicine position statement on uterus transplantation: a committee opinion
Allyse M, Amer H, Coutifaris C, Falcone T, Famuyide A, Flyckt R, Gargiulo A, Heimbach J, Johannesson L, Jowsey-Gregoire S, Khan Z, Langstraat C, Levin S, McDiarmid S, Miller C, Mulligan D, O'Neill K, Penzias A, Pfeifer S, Porrett P, Quintini C, Reindollar R, Rosen C, Silasi D, Stewart E, Testa G, Tzakis A, Tullius S, Penzias A, Bendikson K, Falcone T, Gitlin S, Gracia C, Hansen K, Jindal S, Kalra S, Mersereau J, Odem R, Rebar R, Reindollar R, Rosen M, Sandlow J, Schlegel P, Stovall D. American Society for Reproductive Medicine position statement on uterus transplantation: a committee opinion. Fertility And Sterility 2018, 110: 605-610. PMID: 30196945, DOI: 10.1016/j.fertnstert.2018.06.017.Peer-Reviewed Original ResearchConceptsUterus transplantationAbsolute uterus factor infertilitySuccessful uterus transplantationSuccessful medical treatmentAmerican SocietyPatient advocacy groupsTransplanted uterusFactor infertilityMedical treatmentHealth professionalsSuccessful birthTransplantationCommittee OpinionReproductive medicinePosition statementFirst childRecent media reportsBirthAdvocacy groupsReportScientific reportsInfertilityUterusInnovations in reconstructive microsurgery: Reconstructive transplantation
Kollar B, Tasigiorgos S, Dorante M, Carty M, Talbot S, Pomahac B. Innovations in reconstructive microsurgery: Reconstructive transplantation. Journal Of Surgical Oncology 2018, 118: 800-806. PMID: 30098294, DOI: 10.1002/jso.25147.Peer-Reviewed Original ResearchConceptsReconstructive transplantationViable reconstructive optionPediatric transplantsUpper extremityLower extremitiesAbdominal wallReconstructive optionsAdditional proceduresReconstructive microsurgeryTransplantationFace transplantTransplantPresent review articleExtremitiesReview articlePatientsUterusNeckUterine Incarceration: A Case Study
Lawrence A, Morelli E, Simoni M, Illuzzi J. Uterine Incarceration: A Case Study. Journal Of Midwifery & Women's Health 2018, 63: 352-356. PMID: 29870155, DOI: 10.1111/jmwh.12866.Peer-Reviewed Original ResearchUterine Neoplasms, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology.
Koh WJ, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR, Chon HS, Chu C, Cohn D, Crispens MA, Damast S, Dorigo O, Eifel PJ, Fisher CM, Frederick P, Gaffney DK, George S, Han E, Higgins S, Huh WK, Lurain JR, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Fader AN, Remmenga SW, Reynolds RK, Tillmanns T, Ueda S, Wyse E, Yashar CM, McMillian NR, Scavone JL. Uterine Neoplasms, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network 2018, 16: 170-199. PMID: 29439178, DOI: 10.6004/jnccn.2018.0006.Peer-Reviewed Original ResearchConceptsEndometrial carcinomaUterine neoplasmsNCCN Clinical Practice GuidelinesEarly-stage endometrial carcinomaCommon gynecologic malignancyClinical practice guidelinesEndometrial carcinoma casesMalignant epithelial tumorsNCCN guidelinesGynecologic malignanciesEndometrial cancerUterine sarcomaCarcinoma casesPractice guidelinesEpithelial tumorsCarcinomaNeoplasmsUterusTwo-thirdsDiagnosisInner liningTreatmentGuidelinesEndometriumSarcoma
2017
Embryo implantation evolved from an ancestral inflammatory attachment reaction
Griffith OW, Chavan AR, Protopapas S, Maziarz J, Romero R, Wagner GP. Embryo implantation evolved from an ancestral inflammatory attachment reaction. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: e6566-e6575. PMID: 28747528, PMCID: PMC5559003, DOI: 10.1073/pnas.1701129114.Peer-Reviewed Original ResearchConceptsTerm pregnancyMaterno-fetal interfaceEGF-like growth factorInflammatory responseImmune responseEmbryo implantationPregnancyGrowth factorMucin 1Molecular changesImplantationKey markersMiceParturitionExhibit expressionMorphological changesHumansOpossumEutherian mammalsUterusImmunohistochemistryTranscriptomic analysisPlacentaImplantation reactionLocalization profilesCatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility
Chung JJ, Miki K, Kim D, Shim SH, Shi HF, Hwang JY, Cai X, Iseri Y, Zhuang X, Clapham DE. CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility. ELife 2017, 6: e23082. PMID: 28226241, PMCID: PMC5362262, DOI: 10.7554/elife.23082.Peer-Reviewed Original ResearchConceptsMammalian female reproductive tractSevere male subfertilityFemale reproductive tractIon channel complexNovel subunitCatSper complexEvolutionary adaptationMale subfertilityReproductive tractMouse spermSperm Ca2Normal fertilityTargeted disruptionSperm cellsFlagellaChannel complexFemale uterusSubunitsEpididymal spermatozoaSpermComplexesFertilizationSubfertilityUterusMice
2016
Endometriosis and Stem Cell Trafficking
Pluchino N, Taylor HS. Endometriosis and Stem Cell Trafficking. Reproductive Sciences 2016, 23: 1616-1619. PMID: 27821558, DOI: 10.1177/1933719116671219.Peer-Reviewed Original ResearchConceptsEndometriotic lesionsStem cellsCell traffickingPresence of endometriosisProgression of endometriosisAdult stem cellsEpithelial fateEndometrial physiologyEutopic endometriumStem cell traffickingDysfunctional endometriumEndometriosisMolecular mechanismsCell mobilityBlood circulationNew targetsEndometriumUterusLesionsTraffickingCritical roleCellsMajor roleEngraftmentBMDSCA Murine 5-Fluorouracil-Based Submyeloablation Model for the Study of Bone Marrow-Derived Cell Trafficking in Reproduction
Tal R, Liu Y, Pluchino N, Shaikh S, Mamillapalli R, Taylor H. A Murine 5-Fluorouracil-Based Submyeloablation Model for the Study of Bone Marrow-Derived Cell Trafficking in Reproduction. Endocrinology 2016, 157: 3749-3759. PMID: 27427897, PMCID: PMC6285241, DOI: 10.1210/en.2016-1418.Peer-Reviewed Original ResearchConceptsStem cell factorDonor chimerismOvarian functionBone marrowIntact ovarian functionGreen fluorescent protein miceTransgenic green fluorescent protein (GFP) miceEndometrial regenerationRegimen resultsEndometrial stromaControl miceTransplant modelBM cellsBMDCsCTX-1CD31 stainingImmunohistochemical analysisDay 28Cell traffickingUterine cellsUterusBMTCD45 markersMiceCytometry analysisCase Report: Spontaneous Vaginal Delivery in the Setting of a Bicornuate Uterus With Longitudinal Septum
Deshmukh U, Yu L, Heim K, Cron J, Campbell K. Case Report: Spontaneous Vaginal Delivery in the Setting of a Bicornuate Uterus With Longitudinal Septum. Journal Of Pediatric And Adolescent Gynecology 2016, 29: 199-200. DOI: 10.1016/j.jpag.2016.01.096.Peer-Reviewed Original Research
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