2015
Uterine glucocorticoid receptors are critical for fertility in mice through control of embryo implantation and decidualization
Whirledge SD, Oakley RH, Myers PH, Lydon JP, DeMayo F, Cidlowski JA. Uterine glucocorticoid receptors are critical for fertility in mice through control of embryo implantation and decidualization. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 15166-15171. PMID: 26598666, PMCID: PMC4679013, DOI: 10.1073/pnas.1508056112.Peer-Reviewed Original ResearchConceptsGlucocorticoid receptorPresence of GRExaggerated inflammatory responseSex steroid receptorsImmune cell recruitmentStromal cell decidualizationFemale reproductive tractAdrenal axisKO miceInflammatory responseUterine physiologyUterine biologyEndocrine organMouse uterusBlastocyst implantationGlucocorticoid signalingMouse modelCell recruitmentEmbryo implantationImmunomodulatory functionsKnockout miceGR signalingSteroid receptorsReproductive tractDecidualizationThe Relationship Among HOXA10, Estrogen Receptor α, Progesterone Receptor, and Progesterone Receptor B Proteins in Rectosigmoid Endometriosis: A Tissue Microarray Study
Zanatta A, Pereira RM, da Rocha A, Cogliati B, Baracat EC, Taylor HS, da Motta E, Serafini PC. The Relationship Among HOXA10, Estrogen Receptor α, Progesterone Receptor, and Progesterone Receptor B Proteins in Rectosigmoid Endometriosis: A Tissue Microarray Study. Reproductive Sciences 2015, 22: 31-37. PMID: 25217304, PMCID: PMC4527422, DOI: 10.1177/1933719114549846.Peer-Reviewed Original ResearchConceptsProgesterone receptorRectosigmoid endometriosisEstrogen receptor αSecretory phaseReceptor αType of endometriosisExpression of ERExpression of HOXA10Tissue microarray blocksConsecutive patientsOvarian endometriosisOvarian lesionsEndometriotic lesionsDeep endometriosisMenstrual cycleAllred scoreExpression of proteinsHomeobox A10Deep diseaseEndometriosisMicroarray blocksSteroid receptorsPatientsReceptorsHOXA10
2013
A Role for Glucocorticoids in Stress-Impaired Reproduction: Beyond the Hypothalamus and Pituitary
Whirledge S, Cidlowski JA. A Role for Glucocorticoids in Stress-Impaired Reproduction: Beyond the Hypothalamus and Pituitary. Endocrinology 2013, 154: 4450-4468. PMID: 24064362, PMCID: PMC3836069, DOI: 10.1210/en.2013-1652.Peer-Reviewed Original ResearchConceptsGlucocorticoid signalingAbsence of stressOffspring fitnessReproductive investmentReproductive successGonadal axisCentral regulatorEvolutionary advantageStress responseReproductive eventsSex steroid receptorsAction of glucocorticoidsReproductive statusReproductionReproductive systemCentral actionAdrenal axisSignalingGlucocorticoid secretionImmune responseGlucocorticoid receptorStress contributesSteroid receptorsGlucocorticoidsMetabolic status
2006
Induction of Neuron-derived Orphan Receptor-1 in the Dentate Gyrus of the Hippocampal Formation Following Transient Global Ischemia in the Rat
Kim Y, Hong S, Noh M, Kim S, Huh P, Park S, Sun W, Kim H. Induction of Neuron-derived Orphan Receptor-1 in the Dentate Gyrus of the Hippocampal Formation Following Transient Global Ischemia in the Rat. Molecules And Cells 2006, 22: 8-12. PMID: 16951544, DOI: 10.1016/s1016-8478(23)17384-5.Peer-Reviewed Original ResearchConceptsTransient global ischemiaDentate gyrusGlobal ischemiaCultured cerebral cortical neuronsNOR-1Induction of neuronsCerebral cortical neuronsOxygen-glucose deprivationTransient ischemic injuryAdult rat brainForebrain neuronal cellsOrphan receptor 1Different brain regionsBrain ischemiaIschemic injuryCortical neuronsNeuronal depolarizationRat brainHippocampal formationReceptor 1Brain regionsSteroid receptorsIschemiaNeuronal cellsBasal levelsAn autoregulatory element maintains HOXA10 expression in endometrial epithelial cells
Kelly M, Daftary G, Taylor HS. An autoregulatory element maintains HOXA10 expression in endometrial epithelial cells. American Journal Of Obstetrics And Gynecology 2006, 194: 1100-1107. PMID: 16580301, DOI: 10.1016/j.ajog.2005.12.025.Peer-Reviewed Original ResearchConceptsEndometrial epithelial cellsHOXA10 expressionProgesterone receptorAutoregulatory elementRegulatory regionsEpithelial cellsGene expressionBT-20 cellsSteroid-induced gene expressionReporter gene expressionEndometrial receptivityIshikawa cellsSex steroidsBase pair elementSteroid receptorsAlternative molecular mechanismsStromal cellsHOXA10 proteinReporter constructsExpression increasesMolecular mechanismsReceptorsReporter activityDirect bindingHOXA10
2001
[7α-18F]fluoro-17α-methyl-5α-dihydrotestosterone: a ligand for androgen receptor-mediated imaging of prostate cancer
Garg P, Labaree D, Hoyte R, Hochberg R. [7α-18F]fluoro-17α-methyl-5α-dihydrotestosterone: a ligand for androgen receptor-mediated imaging of prostate cancer. Nuclear Medicine And Biology 2001, 28: 85-90. PMID: 11182568, DOI: 10.1016/s0969-8051(00)00172-4.Peer-Reviewed Original ResearchConceptsProstate cancerAndrogen receptor-dependent mechanismReceptor-mediated imagingReceptor-dependent mechanismProstate of ratsPositron emission tomographySex hormonesAndrogen receptorSteroid receptorsEmission tomographyCancerCarrier-added radiosynthesisReceptorsSteroids bindHigh affinityAndrogensProstateRatsHormoneGlobulin
2000
Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases
Stern D. Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases. Breast Cancer Research 2000, 2: 176. PMID: 11250707, PMCID: PMC138772, DOI: 10.1186/bcr51.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedBiomarkersBreast NeoplasmsEpidermal Growth FactorErbB ReceptorsFemaleGene AmplificationGene Expression Regulation, DevelopmentalGene Expression Regulation, NeoplasticGenes, erbBHumansProtein-Tyrosine KinasesReceptor, ErbB-2Signal TransductionTranscriptional ActivationTransforming Growth FactorsTrastuzumabConceptsBreast cancerErbB family receptor tyrosine kinasesReceptor tyrosine kinasesHER2/neuTyrosine kinaseEpidermal growth factor receptorGrowth factor receptorClinical trialsSteroid receptorsTherapeutic antibodiesErbB-2Factor receptorReceptorsCancerPhysiological regulatorSignificant subsetFamily membersKinaseOptimal useNeuHormoneTrialsAntibodiesHerceptin
1998
Kainate Glutamate Receptors (GluR5–7) in the Rat Arcuate Nucleus: Relationship to Tanycytes, Astrocytes, Neurons and Gonadal Steroid Receptors
Diano S, Naftolin F, Horvath T. Kainate Glutamate Receptors (GluR5–7) in the Rat Arcuate Nucleus: Relationship to Tanycytes, Astrocytes, Neurons and Gonadal Steroid Receptors. Journal Of Neuroendocrinology 1998, 10: 239-247. PMID: 9630393, DOI: 10.1046/j.1365-2826.1998.00195.x.Peer-Reviewed Original ResearchConceptsGonadal steroid receptorsKainate glutamate receptorsArcuate nucleusGlutamate receptorsKainate receptorsSteroid receptorsGlutamate actionAndrogen receptorGlial elementsMorphological synaptic plasticityNeuro-glial interactionsRat arcuate nucleusIonotropic glutamate receptorsElectron microscopic immunocytochemistrySame perikaryaGonadal steroidsExcitatory neurotransmissionSynaptic plasticityMicroscopic immunocytochemistryReceptorsNeuronsCell populationsDouble labelHormone regulationAstrocytesRegulation of Glucocorticoid and Estrogen Receptor Activity by Phosphorylation
Garabedian M, Rogatsky I, Hittelman A, Knoblauch R, Trowbridge J, Krstic M. Regulation of Glucocorticoid and Estrogen Receptor Activity by Phosphorylation. Progress In Gene Expression 1998, 237-260. DOI: 10.1007/978-1-4612-1764-0_9.Peer-Reviewed Original ResearchVersatile posttranslational modificationSignal transduction pathwaysSteroid receptor functionSteroid receptorsTreatment of cellsDNA replicationProtein phosphorylationPosttranslational modificationsTranscription factorsProtein kinaseTransduction pathwaysRegulation of glucocorticoidTranscriptional activityAbsence of hormoneGene expressionIntracellular kinasesPhosphatase activityPhosphorylationEnzymatic activityCell proliferationKinaseReceptor functionEstrogen receptor activityReceptor activityReceptors
1996
Type 1 receptor tyrosine kinases are differentially phosphorylated in mammary carcinoma and differentially associated with steroid receptors.
Bacus SS, Chin D, Yarden Y, Zelnick CR, Stern DF. Type 1 receptor tyrosine kinases are differentially phosphorylated in mammary carcinoma and differentially associated with steroid receptors. American Journal Of Pathology 1996, 148: 549-58. PMID: 8579117, PMCID: PMC1861670.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorBreast NeoplasmsErbB ReceptorsFemaleFrozen SectionsGenes, erbB-2HumansImmunohistochemistryPhosphorylationPhosphotyrosinePrognosisProto-Oncogene MasReceptor Protein-Tyrosine KinasesReceptor, ErbB-2Receptor, ErbB-4Receptors, EstrogenReceptors, ProgesteroneReceptors, SteroidRetrospective StudiesConceptsMammary carcinomaReceptor tyrosine kinasesType 1 receptor tyrosine kinasesMammary carcinoma patientsType 1 receptorExpression of neuAnti-neu antibodyEpidermal growth factor receptorGrowth factor receptorTyrosine kinaseCarcinoma patientsPrognostic factorsPoor prognosisClinical evaluationTherapeutic strategiesCarcinomaHER-4Frozen sectionsSteroid receptorsNeu/ErbBNeuFactor receptorReceptorsDifferent biological activitiesTyrosine phosphorylation
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