2025
Revitalizing reproductive health: innovations and future frontiers in restorative medicine
Bulletti F, Giacomucci E, Guido M, Palagiano A, Coccia M, Bulletti C. Revitalizing reproductive health: innovations and future frontiers in restorative medicine. Therapeutic Advances In Reproductive Health 2025, 19: 26334941251345844. PMID: 40546415, PMCID: PMC12182620, DOI: 10.1177/26334941251345844.Peer-Reviewed Original ResearchFertility careThyroid dysfunctionReproductive medicineFactors affecting infertilityLive birth rateMedically Assisted ReproductionNewcastle-Ottawa ScaleCochrane risk of bias toolAssisted Reproductive TechnologyRisk of bias toolMulticenter trialPublic health challengeSurgical correctionReproductive-aged individualsEmbryo transferFertility outcomesART successSystem abnormalitiesBirth ratePregnancy rateAssisted reproductionNewcastle-OttawaWeb of ScienceReproductive technologyInclusion criteriaEstablishment and application of an RNA-seq-based predictive model for the hourly precision window of implantation (WOI) in patients with recurrent implantation failure
He A, Yang T, Lu S, Zou Y, Wan C, Chen Y, Zhao J, Liu N, Liu D, Li Y, Wang Y, Xu B, Hao J, Fu J, Zhang Q, Wang B, Li Y. Establishment and application of an RNA-seq-based predictive model for the hourly precision window of implantation (WOI) in patients with recurrent implantation failure. Journal Of Assisted Reproduction And Genetics 2025, 1-16. PMID: 40304883, DOI: 10.1007/s10815-025-03468-8.Peer-Reviewed Original ResearchRecurrent implantation failureIntrauterine pregnancy ratePersonalized embryo transferLive birth rateImplantation rateB-hCGEndometrial receptivity testPregnancy ratePropensity score matchingImplant failureB-human chorionic gonadotropinEarly spontaneous abortion rateSpontaneous abortion rateControl groupBirth rateIntrauterine pregnancyPregnancy outcomesEndometrial biopsyEmbryo transferChorionic gonadotropinPregnancyPatientsExperimental groupAbortion rateScore matchingA randomized controlled trial comparing embryo vitrification with slush nitrogen to liquid nitrogen in women undergoing frozen embryo transfer: embryology and clinical outcomes
Klimczak A, Osman E, Esbert M, Yildirim R, Whitehead C, Herlihy N, Hanson B, Roberts L, Seli E, Scott R. A randomized controlled trial comparing embryo vitrification with slush nitrogen to liquid nitrogen in women undergoing frozen embryo transfer: embryology and clinical outcomes. Human Reproduction 2025, 40: 426-433. PMID: 39836897, DOI: 10.1093/humrep/deaf003.Peer-Reviewed Original ResearchFrozen embryo transferRandomized Controlled TrialsPregnancy outcomesIVF stimulationPre-clinical trialsEmbryo transferPregnancy rateFutility analysisPost-warming survival rateDATE OF FIRST PATIENT’S ENROLMENT:University-affiliated infertility centerClinical pregnancy rateEmbryo transfer outcomesSustained implantation ratesPreimplantation genetic testingFIRST PATIENT’S ENROLMENTBlastocyst biopsyEmbryological outcomesBlastocyst survivalEmbryo vitrificationHuman oocytesMiscarriage rateImplantation rateNo significant differenceBaseline characteristics
2024
Personalized embryo transfer guided by rsERT with hourly precision improves pregnancy outcomes in patients with a receptive window of implantation: a pilot study
Yang T, Hou Z, Zhang Q, Zhao J, Liu N, Liu D, Li Y, Wang Y, Xu B, Zou Y, Wan C, Li Y. Personalized embryo transfer guided by rsERT with hourly precision improves pregnancy outcomes in patients with a receptive window of implantation: a pilot study. Journal Of Assisted Reproduction And Genetics 2024, 41: 2657-2665. PMID: 39254797, PMCID: PMC11534956, DOI: 10.1007/s10815-024-03246-y.Peer-Reviewed Original ResearchIntrauterine pregnancy ratePersonalized embryo transferWindow of implantationEmbryo transferPropensity score matchingImplantation rateET groupCenter for Reproductive MedicineResultsBefore propensity score matchingImplant failure rateGroup compared to controlsRetrospective pilot studyConventional embryo transferMultiple-pregnancy ratesEndometrial receptivity testCentral South UniversityPregnancy outcomesTransferred embryosPilot studyPregnancy ratePatientsSouth UniversityReproductive medicineScore matchingConfounding factorsThe impact of implementing a non-invasive preimplantation genetic testing for aneuploidies (niPGT-A) embryo culture protocol on embryo viability and clinical outcomes
Sakkas D, Navarro-Sánchez L, Ardestani G, Barroso G, Bisioli C, Boynukalin K, Cimadomo D, Frantz N, Kopcow L, Andrade G, Ozturk B, Rienzi L, Weiser A, Valbuena D, Simón C, Rubio C. The impact of implementing a non-invasive preimplantation genetic testing for aneuploidies (niPGT-A) embryo culture protocol on embryo viability and clinical outcomes. Human Reproduction 2024, 39: 1952-1959. PMID: 39059790, DOI: 10.1093/humrep/deae156.Peer-Reviewed Original ResearchNon-invasive preimplantation genetic testingEmbryo culture protocolsNiPGT-ADay of biopsyPreimplantation genetic testingPGT-APregnancy outcomesPregnancy rateIVF clinicsClinical outcomesControl groupStudy groupGenetic testingReproductive outcomesConcordance rateDay 6Clinical pregnancy rateOverall pregnancy outcomeClinical reproductive outcomesBiopsy stepBlastocyst mediumBlastocyst viabilityBlastocyst developmentCulture protocolMiscarriage rateP-533 Impact on clinical outcomes of day-6 extended culture and reduced culture media volume applied to non-invasive PGT-A
LLuesa C, Navarro-Sánchez L, Ardestani G, Barroso G, Bisioli C, Boynukalin K, Cimadomo D, Andrade G, Valbuena D, Simon-Valles C, Sakkas D. P-533 Impact on clinical outcomes of day-6 extended culture and reduced culture media volume applied to non-invasive PGT-A. Human Reproduction 2024, 39: deae108.873. DOI: 10.1093/humrep/deae108.873.Peer-Reviewed Original ResearchNon-invasive PGT-ACell-free DNAPGT-ASingle embryo transferClinical outcomesDay 5Pregnancy rateStudy groupNiPGT-AConcordance ratePregnancy outcomesDay 6Control groupCell-free DNA resultsDay 5 blastocystsDay 6 blastocystsClinical pregnancy rateDay of biopsyOverall pregnancy outcomeEmbryo culture protocolsBiopsy stepPGT-A.Euploidy rateBlastocyst viabilityBlastocyst qualityP-438 Association of uterine cavity immune cells at the time of frozen embryo transfer with live birth
Rodriguez S, Ibrahim M, Padula L, Fisher E, Rivas K, Paidas M, Strbo N, Attia G. P-438 Association of uterine cavity immune cells at the time of frozen embryo transfer with live birth. Human Reproduction 2024, 39: deae108.787. DOI: 10.1093/humrep/deae108.787.Peer-Reviewed Original ResearchTiming of frozen embryo transferFrozen embryo transferImprove pregnancy ratesT regulatory cellsLive birthsEmbryo transferImmune cellsPregnancy rateUterine segmentInfluence implantationUltrasound guidanceUterine milieuEndometrial receptivityElective single embryo transferFc receptor-positive cellsUpper uterusTotal immune cellsLower uterine segmentInstitutional review board approvalLive-born infantsSingle embryo transferImmune cell profilesLive birth rateGamma delta TCRImmune cell subsetsLeukocytospermia does not negatively impact outcomes in in vitro fertilization cycles with intracytoplasmic sperm injection and preimplantation genetic testing for aneuploidy: findings from 5435 cycles
Gill P, Puchalt N, Molinaro T, Werner M, Seli E, Hotaling J, Cheng P. Leukocytospermia does not negatively impact outcomes in in vitro fertilization cycles with intracytoplasmic sperm injection and preimplantation genetic testing for aneuploidy: findings from 5435 cycles. Journal Of Assisted Reproduction And Genetics 2024, 41: 1213-1219. PMID: 38642270, PMCID: PMC11143111, DOI: 10.1007/s10815-024-03085-x.Peer-Reviewed Original ResearchConceptsLive birth rateIntracytoplasmic sperm injectionClinical pregnancy rateSustained implantation ratesIn vitro fertilizationIn vitro fertilization cyclesPreimplantation genetic testingBlastulation ratePGT-AAneuploidy rateEmbryological outcomesSperm injectionGenetic testingEuploid embryo transferPrevalence of leukocytospermiaRetrospective cohort studyMale partner ageImplantation rateBaseline characteristicsEmbryo transferLeukocytospermiaFertilization cyclesCohort studyPregnancy ratePrimary outcomeEmbryology with precision: effective quality control in the in vitro fertilization laboratory
Basar M, Unsal E, Ergun Y. Embryology with precision: effective quality control in the in vitro fertilization laboratory. Current Opinion In Obstetrics & Gynecology 2024, 36: 200-207. PMID: 38572581, DOI: 10.1097/gco.0000000000000945.Peer-Reviewed Original ResearchConceptsPreimplantation genetic testingIn vitro fertilizationIntracytoplasmic sperm injectionProportion of mature oocytesIn vitro fertilization treatmentClinical pregnancy rateClinical practiceIn vitro fertilization laboratoryEmbryo development ratesImprove IVF outcomesSuccess rateImproving clinical outcomesField of reproductive medicineSperm injectionIVF outcomesClinical outcomesIVF treatmentDiagnostic accuracySuccess rate of IVF treatmentIVF proceduresPregnancy rateGenetic testingMature oocytesReproductive medicineGenetics laboratories
2023
hMG addition affects the change in progesterone level during IVF stimulation and LBR: a retrospective cohort study
Wesevich V, Seckin S, Kelk D, Kallen A, Kodaman P. hMG addition affects the change in progesterone level during IVF stimulation and LBR: a retrospective cohort study. Reproductive Biology And Endocrinology 2023, 21: 117. PMID: 38057813, PMCID: PMC10699021, DOI: 10.1186/s12958-023-01150-1.Peer-Reviewed Original ResearchConceptsClinical pregnancy rateFresh embryo transferPeak P levelsPregnancy outcomesEmbryo transferPregnancy rateIVF stimulationCohort studyHigher clinical pregnancy rateOvarian hyperstimulation IVFSingle fertility centerMethodsRetrospective cohort studyRetrospective cohort studyClinical pregnancy outcomesDay of triggerFrozen embryo transferMultivariable logistic modelLower pregnancy ratesP riseEndometrial receptivityProvider recommendationFertility centerProgesterone levelsConclusionsOur dataHigher LBRPractice and development of male contraception: European Academy of Andrology and American Society of Andrology guidelines
Wang C, Meriggiola M, Amory J, Barratt C, Behre H, Bremner W, Ferlin A, Honig S, Kopa Z, Lo K, Nieschlag E, Page S, Sandlow J, Sitruk‐Ware R, Swerdloff R, Wu F, Goulis D. Practice and development of male contraception: European Academy of Andrology and American Society of Andrology guidelines. Andrology 2023, 12: 1470-1500. PMID: 37727884, DOI: 10.1111/andr.13525.Peer-Reviewed Original ResearchMale contraceptionContraceptive methodsClinical practiceNon-hormonal methodsLack of efficacyUnintended pregnancy ratesEvidence-based recommendationsMale contraceptive methodsAmerican SocietyMale contraceptive developmentAndrology (EAA) guidelinesConsensus guidelinesContraceptive efficacySurgical methodsHormonal methodsPregnancy rateContraceptive useGRADE systemOcclusion methodEuropean AcademySemen analysisReproductive risksContraceptionFamily planningEuropean SocietyWomen with PCOS who undergo IVF: a comprehensive review of therapeutic strategies for successful outcomes
Kotlyar A, Seifer D. Women with PCOS who undergo IVF: a comprehensive review of therapeutic strategies for successful outcomes. Reproductive Biology And Endocrinology 2023, 21: 70. PMID: 37528417, PMCID: PMC10391774, DOI: 10.1186/s12958-023-01120-7.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeOvarian hyperstimulation syndromeOvarian stimulationStimulation protocolFrozen embryo transfer cyclesVitamin D repletionGnRH agonist triggerVitamin D levelsEmbryo transfer cyclesOvarian stimulation protocolsAntagonist cyclesHyperstimulation syndromeHypertensive disordersIVF cyclesPCOS patientsAgonist triggerOvarian syndromeOocyte yieldD levelsImproved outcomesPregnancy rateCommon causeIVF performanceTherapeutic courseInfertile couplesModerate and increased physical activity is not detrimental to live birth rates among women with unexplained infertility and obesity
Vitek W, Sun F, Cardozo E, Hoeger K, Hansen K, Santoro N, Zhang H, Legro R. Moderate and increased physical activity is not detrimental to live birth rates among women with unexplained infertility and obesity. F&S Reports 2023, 4: 308-312. PMID: 37719091, PMCID: PMC10504528, DOI: 10.1016/j.xfre.2023.06.004.Peer-Reviewed Original ResearchLive birth rateSteps/dayPhysical activityInfertility trialsLifestyle modificationUnexplained infertilityObese womenBirth rateClomiphene citrate treatmentUS fertility centersClinical pregnancy rateLifestyle modification programTime of enrollmentModerate physical activityPhysical activity goalsMiscarriage rateFertility centerIntrauterine inseminationFitbit activity trackerPregnancy rateSecondary analysisCitrate treatmentActivity goalsModification programWomenP-238 Non-interventional study comparing the effectiveness and safety of r-hFSH:r-hLH versus r-hFSH in women aged 35-42 years with normal ovarian reserve undergoing GnRH antagonist ART treatment
Arvis P, Lehert P, Chuderland D, Schwarze J, Helwig C, Bidet M, Guivarc'h Leveque A, Lispi M, D'Hooghe T. P-238 Non-interventional study comparing the effectiveness and safety of r-hFSH:r-hLH versus r-hFSH in women aged 35-42 years with normal ovarian reserve undergoing GnRH antagonist ART treatment. Human Reproduction 2023, 38 DOI: 10.1093/humrep/dead093.596.Peer-Reviewed Original ResearchNormal ovarian reserveR-hLHR-hFSHLive birth rateOvarian stimulationOvarian reserveNon-interventional studyART treatmentFrench centersLive birthsPregnancy rateOS cyclesClinical pregnancy rateAdvanced maternal ageOngoing pregnancy rateOvarian reserve biomarkersLow ovarian reserveAnalysis of clinical dataSubgroup of patientsFollow-up periodPregnancy failure rateBirth rateSecondary analysis of clinical dataClinical pregnancyAMH levelsRacial and Ethnic Disparities in Access to and Outcomes of Infertility Treatment and Assisted Reproductive Technology in the United States
Beroukhim G, Seifer D. Racial and Ethnic Disparities in Access to and Outcomes of Infertility Treatment and Assisted Reproductive Technology in the United States. Endocrinology And Metabolism Clinics Of North America 2023, 52: 659-675. PMID: 37865480, DOI: 10.1016/j.ecl.2023.05.005.Peer-Reviewed Original ResearchMeSH KeywordsAmerican Indian or Alaska NativeAsianBlack or African AmericanEthnicityFemaleHealth Services AccessibilityHealthcare DisparitiesHispanic or LatinoHumansInfertilityInfertility, FemalePregnancyPregnancy OutcomeReproductive Techniques, AssistedSocial Determinants of HealthUnited StatesWhiteConceptsEthnic disparitiesInfertility treatmentIntrauterine insemination pregnancy ratesHigh infertility rateAmerican Indian womenAssisted Reproductive TechnologyClinical pregnancyObstetrical complicationsFertility carePregnancy lossFavorable outcomePregnancy rateInfertility rateLive birthsHigher oddsART outcomesHispanic womenWhite womenRobust studiesWomenIndian womenReproductive technologiesBlack womenOutcomesCareVitamin D and infertility
Simpson S, Pal L. Vitamin D and infertility. Current Opinion In Obstetrics & Gynecology 2023, 35: 300-305. PMID: 37266579, DOI: 10.1097/gco.0000000000000887.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeVitamin DGynaecological disordersVitamin D serum levelsOvarian reserve parametersD serum levelsVitamin D deficiencyVitamin D statusDiminished ovarian reserveCommon gynaecological disorderReproductive health burdenHigher pregnancy rateD deficiencyD statusOvarian reserveOvarian syndromeInfertile womenSerum levelsUterine myomaMenstrual regularityEndometriosis patientsInsulin levelsUterine fibroidsHealth burdenPregnancy rateThe impact of air pollution and endocrine disruptors on reproduction and assisted reproduction
Seli D, Taylor H. The impact of air pollution and endocrine disruptors on reproduction and assisted reproduction. Current Opinion In Obstetrics & Gynecology 2023, 35: 210-215. PMID: 36924404, DOI: 10.1097/gco.0000000000000868.Peer-Reviewed Original ResearchConceptsDiminished ovarian reserveOvarian reserveInfertility treatmentAbnormal semen parametersAssisted reproduction outcomesHuman reproductive healthEstrogen-like activityFemale reproductive functionEndocrine disruptorsPregnancy rateUterine leiomyomaReproductive healthReproduction outcomesReproductive functionSemen parametersClinical implicationsLarge-scale studiesAssisted reproductionSperm concentrationPatientsAir pollutionHealth impactsEndocrineTreatmentBisphenol A
2022
Uterine administration of C-X-C motif chemokine ligand 12 increases the pregnancy rates in mice with induced endometriosis
Rosa-E-Silva ACJS, Mamillapalli R, Rosa-E-Silva JC, Ucar A, Schwartz J, Taylor HS. Uterine administration of C-X-C motif chemokine ligand 12 increases the pregnancy rates in mice with induced endometriosis. F&S Science 2022, 4: 65-73. PMID: 36252793, DOI: 10.1016/j.xfss.2022.10.003.Peer-Reviewed Original ResearchConceptsC motif chemokine ligand 12Endometriosis groupPregnancy rateChemokine ligand 12Alpha v beta 3 integrinUterine injectionBeta 3 integrinBMDC recruitmentProgesterone receptorMouse modelBone marrow-derived cell recruitmentHigher cumulative pregnancy rateLigand 12Therapeutic agentsEndometrial receptivity defectsCumulative pregnancy rateEndometrial receptivity markersSham surgery groupBone marrow transplantationLower pregnancy ratesAcademic medical centerPotential therapeutic agentReceptivity markersSurgery groupInduced endometriosisClinical Outcome of Day-3 Cleavage Slow-Growing Embryos at Different Cleavage Rates after Overnight Culture: A Cohort Retrospective Study
Geng L, Lin X, Liu R, Wu J, Luo Y, Sun H, Hou Z, Zhang Q, Xu C, Li X, Cao C, Wang T, Xia X. Clinical Outcome of Day-3 Cleavage Slow-Growing Embryos at Different Cleavage Rates after Overnight Culture: A Cohort Retrospective Study. Journal Of Clinical Medicine 2022, 11: 4417. PMID: 35956032, PMCID: PMC9369477, DOI: 10.3390/jcm11154417.Peer-Reviewed Original ResearchSlow-growing embryosFrozen embryo transferBiochemical pregnancy rateClinical outcomesPregnancy rateOvernight cultureImplantation rateCleavage rateClinical pregnancy rateGroup I. Group IILive birth rateCohort retrospective studyI. Group IIPregnancy outcomesRetrospective studyEmbryo transferGroup IGroup IIIGroup I.Birth ratePregnancyOutcomesEmbryosCellsImplantationPre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial
Taylor H, Li HJ, Carson S, Flores V, Pal L, Robbins J, Santoro NF, Segars JH, Seifer D, Huang H, Young S, Zhang H. Pre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial. BMJ Open 2022, 12: e052043. PMID: 35715184, PMCID: PMC9207753, DOI: 10.1136/bmjopen-2021-052043.Peer-Reviewed Original ResearchConceptsEndometriosis-associated infertilityPlacebo-controlled trialGnRH antagonistFertility treatmentOral GnRH antagonistEndometriosis-related infertilityFertilization-embryo transferLive birth rateUse of gonadotropinsEtiology of infertilityInstitutional review boardAntagonist pretreatmentCommon complicationObstetrical outcomesPeer-reviewed journalsSecondary outcomesIVF treatmentPrimary outcomeHormone agonistImplantation ratePregnancy rateLive birthsEndometriosisLocal protocolsOocyte number
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