2018
Diethylstilbestrol (DES)
Bjorkman S, Taylor H. Diethylstilbestrol (DES). 2018, 760-766. DOI: 10.1016/b978-0-12-801238-3.64417-3.Peer-Reviewed Original Research
2016
Diethylstilbestrol activates CatSper and disturbs progesterone actions in human spermatozoa
Zou Q, Peng Z, Zhao Q, Chen H, Cheng Y, Liu Q, He Y, Weng S, Wang H, Wang T, Zheng L, Luo T. Diethylstilbestrol activates CatSper and disturbs progesterone actions in human spermatozoa. Human Reproduction 2016, 32: 290-298. PMID: 28031325, DOI: 10.1093/humrep/dew332.Peer-Reviewed Original ResearchConceptsNon-genomic mannerProgesterone actionHuman sperm functionEndocrine-disrupting chemicalsSperm intracellular calcium concentrationsWhole-cell patch-clamp techniqueSperm functionHuman spermatozoaPARTICIPANTS/MATERIALSHuman sperm penetrationIndicator Fluo-4 AMIntracellular calcium concentrationROLE OF CHANCEAcrosome reactionEffects of diethylstilbestrolPatch-clamp techniqueFluo-4 AMFemale reproductive tract fluidsMale reproductive systemTyrosine phosphorylationReproductive tract fluidsDES exposurePostnatal exposureEstrogenic endocrine disruptorsAbility of sperm
2010
Lesions of the Vulva and Vagina
Chhieng D, Hui P. Lesions of the Vulva and Vagina. Current Clinical Pathology 2010, 15-34. DOI: 10.1007/978-1-60761-164-6_2.Peer-Reviewed Original ResearchSquamous cell carcinomaCell carcinomaPrimary clear cell carcinomaVulvar squamous cell carcinomaLow-risk HPV subtypesIntrauterine DES exposureHigh-risk HPVExtramammary Paget's diseaseMalignant mesenchymal tumorSquamous intraepithelial neoplasiaCommon primary malignancyClear cell carcinomaPreinvasive conditionsVulvar cancerHPV subtypesPrimary malignancyDES exposureLichen sclerosusIntraepithelial neoplasiaPaget's diseaseSquamous carcinomaWidespread metastasesAggressive angiomyxomaCondyloma acuminatumMesenchymal tumorsIn Utero Exposure to Diethylstilbestrol (DES) or Bisphenol-A (BPA) Increases EZH2 Expression in the Mammary Gland: An Epigenetic Mechanism Linking Endocrine Disruptors to Breast Cancer
Doherty LF, Bromer JG, Zhou Y, Aldad TS, Taylor HS. In Utero Exposure to Diethylstilbestrol (DES) or Bisphenol-A (BPA) Increases EZH2 Expression in the Mammary Gland: An Epigenetic Mechanism Linking Endocrine Disruptors to Breast Cancer. Discover Oncology 2010, 1: 146-155. PMID: 21761357, PMCID: PMC3140020, DOI: 10.1007/s12672-010-0015-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzhydryl CompoundsBlotting, WesternCarcinogensCell Line, TumorDiethylstilbestrolEndocrine DisruptorsEnhancer of Zeste Homolog 2 ProteinEpigenesis, GeneticFemaleGene ExpressionHistone-Lysine N-MethyltransferaseHumansMammary Neoplasms, ExperimentalMicePhenolsPolycomb Repressive Complex 2PregnancyPrenatal Exposure Delayed EffectsReverse Transcriptase Polymerase Chain ReactionConceptsUtero exposureMCF-7 cellsEZH2 expressionMammary tissueMammary glandBreast cancerBreast cancer riskEffects of BPAAdult mammary tissueEZH2 protein expressionPersistent epigenetic changesZeste homolog 2DES exposureFetal exposureEZH2 mRNA expressionBreast neoplasiaNeoplastic changesCancer riskBPA treatmentEndocrine-disrupting chemicalsAdult womenDevelopmental programmingMRNA expressionUteroMice
2009
Hypermethylation of HOXA10 by in utero Diethylstilbestrol Exposure: An Epigenetic Mechanism for Altered Developmental Programming
Bromer J, Wu J, Zhou Y, Taylor H. Hypermethylation of HOXA10 by in utero Diethylstilbestrol Exposure: An Epigenetic Mechanism for Altered Developmental Programming. Endocrine Reviews 2009, 30: 286-286. DOI: 10.1210/edrv.30.3.9997.Peer-Reviewed Original ResearchDES exposureHOXA10 expressionDevelopmental programmingUtero DES exposureUtero diethylstilbestrol exposureHuman endometrial cellsExpression of HOXA10Homeobox gene HOXA10Female reproductive tractDiethylstilbestrol exposureNon-steroidal estrogensClassic estrogensEndometrial cellsShort-term exposureDNA methyltransferases 1Uterine organogenesisDevelopmental anomaliesCaudal portionIncreased expressionHOXA10 geneReproductive tractEpigenetic mechanismsExposure resultsDiethylstilbestrolHOXA10Hypermethylation of Homeobox A10 by in Utero Diethylstilbestrol Exposure: An Epigenetic Mechanism for Altered Developmental Programming
Bromer JG, Wu J, Zhou Y, Taylor HS. Hypermethylation of Homeobox A10 by in Utero Diethylstilbestrol Exposure: An Epigenetic Mechanism for Altered Developmental Programming. Endocrinology 2009, 150: 3376-3382. PMID: 19299448, PMCID: PMC2703508, DOI: 10.1210/en.2009-0071.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceDiethylstilbestrolDNA (Cytosine-5-)-MethyltransferasesDNA MethylationEpigenesis, GeneticFemaleGene Expression Regulation, DevelopmentalGenes, HomeoboxHomeobox A10 ProteinsHomeodomain ProteinsHumansMiceMolecular Sequence DataPregnancyPrenatal Exposure Delayed EffectsUterusConceptsDES exposureHOXA10 expressionDevelopmental programmingUtero DES exposureUtero diethylstilbestrol exposureHuman endometrial cellsExpression of HOXA10Homeobox gene HOXA10Female reproductive tractDiethylstilbestrol exposureEndometrial cellsClassical estrogenHomeobox A10Short-term exposureDNA methyltransferases 1Uterine organogenesisDevelopmental anomaliesCaudal portionIncreased expressionHOXA10 geneReproductive tractNonsteroidal estrogensEpigenetic mechanismsExposure resultsDiethylstilbestrol
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