2015
High level PHGDH expression in breast is predominantly associated with keratin 5‐positive cell lineage independently of malignancy
Gromova I, Gromov P, Honma N, Kumar S, Rimm D, Talman ML, Wielenga VT, Moreira JM. High level PHGDH expression in breast is predominantly associated with keratin 5‐positive cell lineage independently of malignancy. Molecular Oncology 2015, 9: 1636-1654. PMID: 26026368, PMCID: PMC5528790, DOI: 10.1016/j.molonc.2015.05.003.Peer-Reviewed Original ResearchConceptsOverexpression of PhgdhPHGDH expressionMammary epithelial cellsTriple-negative breast cancer patientsNegative breast cancer patientsEpithelial cellsBreast cancer patientsNormal breast tissueCell lineagesMammary tissue samplesHigh-level expressionExpression of PHGDHProspective cohortCancer patientsCK5-positive cellsBasal phenotypeProteomic profilingTNBC samplesIHC analysisQuantitative IHC analysisCancer typesBreast tissueMalignancyCandidate oncogeneOncogenic function
2010
3-Phosphoglycerate dehydrogenase expression is regulated by HOXA10 in murine endometrium and human endometrial cells
Du H, Vitiello D, Sarno JL, Taylor HS. 3-Phosphoglycerate dehydrogenase expression is regulated by HOXA10 in murine endometrium and human endometrial cells. Reproduction 2010, 139: 237-245. PMID: 19778996, PMCID: PMC3107855, DOI: 10.1530/rep-08-0376.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsCell LineCells, CulturedEndometriumEpithelial CellsFemaleGene Expression Regulation, EnzymologicHomeobox A10 ProteinsHomeodomain ProteinsHumansImmunohistochemistryMenstrual CycleMiceOligonucleotide Array Sequence AnalysisPhosphoglycerate DehydrogenasePregnancyRNA, MessengerRNA, Small InterferingStromal CellsTransfectionConceptsSerine biosynthesisRegulatory relationshipsHOXA10 regulationProtein synthesisPHGDH expressionReal-time PCR resultsStromal cellsCellular differentiationTarget genesHuman endometrial cellsPHGDHMRNA expressionHuman endometrial stromal cellsDe novoWestern blot resultsDehydrogenase expressionBiosynthesisHOXA10Epithelial cellsHOXA10 siRNARegulationExpressionEndometrial stromal cellsHOXA10 expressionBlot results
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply