2024
Ultrasonography for Procedural Guidance
Munoz-Acuna R, Leibowitz A, Bose S. Ultrasonography for Procedural Guidance. 2024, 493-507. DOI: 10.1007/978-3-031-45731-9_21.Peer-Reviewed Original ResearchIntensive care unitCare unitEvaluate cardiac functionCritically ill patientsStandard of careSonographic evaluationPelvic contentsCardiac functionExtracorporeal supportAbnormal anatomyVenous structuresLung parenchymaVascular accessIll patientsCritical care unitsClinical practiceUltrasound machineDiagnostic toolUltrasoundUltrasonographyProcedural guidance
2023
Chest Wall Anomaly Presenting as Pulmonary Nodule
Ely S, Van Udelsman B, Bader A, Woodard G. Chest Wall Anomaly Presenting as Pulmonary Nodule. Annals Of Thoracic Surgery Short Reports 2023, 2: 88-90. PMID: 39790260, PMCID: PMC11708574, DOI: 10.1016/j.atssr.2023.11.021.Peer-Reviewed Original ResearchHeterogenous lung inflammation CT patterns distinguish pneumonia and immune checkpoint inhibitor pneumonitis and complement blood biomarkers in acute myeloid leukemia: proof of concept
Aminu M, Daver N, Godoy M, Shroff G, Wu C, Torre-Sada L, Goizueta A, Shannon V, Faiz S, Altan M, Garcia-Manero G, Kantarjian H, Ravandi-Kashani F, Kadia T, Konopleva M, DiNardo C, Pierce S, Naing A, Kim S, Kontoyiannis D, Khawaja F, Chung C, Wu J, Sheshadri A. Heterogenous lung inflammation CT patterns distinguish pneumonia and immune checkpoint inhibitor pneumonitis and complement blood biomarkers in acute myeloid leukemia: proof of concept. Frontiers In Immunology 2023, 14: 1249511. PMID: 37841255, PMCID: PMC10570510, DOI: 10.3389/fimmu.2023.1249511.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsGround-glass opacitiesBlood biomarkersImmune checkpoint inhibitor pneumonitisCheckpoint inhibitor pneumonitisAcute myeloid leukemiaPost-test probabilityCheckpoint inhibitorsMyeloid leukemiaCT patternsLung inflammationPneumonitisInfected lungsRelevant blood biomarkersDiagnostic valueLung parenchymaPneumoniaCT imagesBloodBiomarkersPatientsHabitat imagesBlood modelDetection of pneumoniaLeukemiaPCSK6 and Survival in Idiopathic Pulmonary Fibrosis
Oldham J, Allen R, Lorenzo-Salazar J, Molyneaux P, Ma S, Joseph C, Kim J, Guillen-Guio B, Hernández-Beeftink T, Kropski J, Huang Y, Lee C, Adegunsoye A, Pugashetti J, Linderholm A, Vo V, Strek M, Jou J, Muñoz-Barrera A, Rubio-Rodriguez L, Hubbard R, Hirani N, Whyte M, Hart S, Nicholson A, Lancaster L, Parfrey H, Rassl D, Wallace W, Valenzi E, Zhang Y, Mychaleckyj J, Stockwell A, Kaminski N, Wolters P, Molina-Molina M, Banovich N, Fahy W, Martinez F, Hall I, Tobin M, Maher T, Blackwell T, Yaspan B, Jenkins R, Flores C, Wain L, Noth I. PCSK6 and Survival in Idiopathic Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2023, 207: 1515-1524. PMID: 36780644, PMCID: PMC10263132, DOI: 10.1164/rccm.202205-0845oc.Peer-Reviewed Original ResearchConceptsGenome-wide significanceTransplantation-free survivalIdiopathic pulmonary fibrosisStage IIPF survivalDownstream analysisPulmonary fibrosisIPF progressionWide association studyPeripheral blood gene expressionProportional hazards regressionStage II casesLimited treatment optionsStage I casesBlood gene expressionGene expressionAssociation studiesMolecular determinantsHazards regressionTreatment optionsPlasma concentrationsLung parenchymaConsistent effect directionMolecular driversProtein
2022
Pleomorphic Carcinoma Versus Sarcomatoid Malignant Mesothelioma
Baine M, Cai G, Zhang X. Pleomorphic Carcinoma Versus Sarcomatoid Malignant Mesothelioma. Practical Anatomic Pathology 2022, 137-145. DOI: 10.1007/978-3-031-14402-8_23.Peer-Reviewed Original ResearchSarcomatoid malignant mesotheliomaPleomorphic carcinomaMalignant mesotheliomaGiant cell carcinomaCell lung carcinomaSmall biopsy specimensPleural involvementPeripheral tumorsClinicopathologic featuresUpper lobeSarcomatoid morphologyCell carcinomaBiopsy specimensLung carcinomaLung parenchymaMalignant tumorsSpindle cellsAnatomic localizationChest wallCarcinomaGiant cellsMesotheliomaLungTumorsCellsCD38 Mediates Lung Fibrosis by Promoting Alveolar Epithelial Cell Aging.
Cui H, Xie N, Banerjee S, Dey T, Liu RM, Antony VB, Sanders YY, Adams TS, Gomez JL, Thannickal VJ, Kaminski N, Liu G. CD38 Mediates Lung Fibrosis by Promoting Alveolar Epithelial Cell Aging. American Journal Of Respiratory And Critical Care Medicine 2022, 206: 459-475. PMID: 35687485, PMCID: PMC12039157, DOI: 10.1164/rccm.202109-2151oc.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisLung fibrosisCD38 expressionAlveolar epithelial cell injuryEpithelial cell injuryEffective therapeutic strategyHuman lung parenchymaIPF lungsLung functionPulmonary fibrosisDisease progressionFibrotic lungsReal-time PCRYoung miceLung parenchymaOld miceCell injuryTherapeutic strategiesFibrosisPharmacological inactivationCD38Single-cell RNA sequencingFlow cytometryWestern blottingOld animalsLung Spatial Profiling Reveals a T Cell Signature in COPD Patients with Fatal SARS-CoV-2 Infection
Yang CX, Tomchaney M, Landecho MF, Zamacona BR, Oto M, Zulueta J, Malo J, Knoper S, Contoli M, Papi A, Vasilescu DM, Sauler M, Straub C, Tan C, Martinez FD, Bhattacharya D, Rosas IO, Kheradmand F, Hackett TL, Polverino F. Lung Spatial Profiling Reveals a T Cell Signature in COPD Patients with Fatal SARS-CoV-2 Infection. Cells 2022, 11: 1864. PMID: 35740993, PMCID: PMC9220844, DOI: 10.3390/cells11121864.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseCOPD patientsLung parenchymaFatal SARS-CoV-2 infectionsMemory CD4 T cell responsesPre-existing lung diseaseCD4 T cell responsesSARS-CoV-2 infectionSARS-CoV-2 entryMemory T cell differentiationSARS-CoV-2 disease 2019Obstructive pulmonary diseaseT cell responsesT-cell signatureCOVID-19 infectionCOVID-19T cell differentiationAntigen primingMemory CD4Pulmonary diseaseControl lungsImmune microenvironmentLung diseaseT cellsT lymphocytesCompromised Cardiopulmonary Function in Fibulin-5 Deficient Mice.
Ramachandra AB, Mikush N, Sauler M, Humphrey JD, Manning EP. Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice. Journal Of Biomechanical Engineering 2022, 144 PMID: 35171214, PMCID: PMC8990734, DOI: 10.1115/1.4053873.Peer-Reviewed Original ResearchConceptsRight heart functionDeficient micePulmonary arteryHeart functionCompromised right ventricular functionFibulin-5 deficient micePulmonary arterial structureRight ventricular functionVentilation-perfusion relationshipsElastic fiber contentElastic fibersFiber dysfunctionLung compliancePulmonary healthVentricular functionCardiopulmonary functionAlveolar disruptionPulmonary pathologyLung parenchymaMurine modelMouse modelArterial structureHistological quantificationElastic laminaRight circulation
2021
Adult with mass burnt lime aspiration: A case report and literature review
Li X, Hou H, Dai B, Tan W, Zhao H. Adult with mass burnt lime aspiration: A case report and literature review. World Journal Of Clinical Cases 2021, 9: 9935-9941. PMID: 34877333, PMCID: PMC8610930, DOI: 10.12998/wjcc.v9.i32.9935.Peer-Reviewed Original ResearchFlexible fiberoptic bronchoscopyForeign body forcepsForeign body aspirationRare foreign bodyFiberoptic bronchoscopySevere complicationsCase reportBiopsy forcepsFollow-upLung parenchymaSecondary infectionBronchoscopyPuncture needlePatient's conditionTimely treatmentExperience of treatmentForeign bodyLocal hospitalAspirationTreatmentForcepsBronchusAerodermectasiaBiopsyCryotherapyInhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis
Kumar A, Elko E, Bruno SR, Mark ZF, Chamberlain N, Mihavics BK, Chandrasekaran R, Walzer J, Ruban M, Gold C, Lam YW, Ghandikota S, Jegga AG, Gomez JL, Janssen-Heininger YM, Anathy V. Inhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis. Thorax 2021, 77: 669-678. PMID: 34400514, PMCID: PMC8847543, DOI: 10.1136/thoraxjnl-2021-216882.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisProtein disulfide isomerase A3Lung fibrosisPulmonary fibrosisClub cellsFibrosis-related proteinsMechanism of actionControl patientsLung functionBleomycin modelLung parenchymaFibrosisTherapeutic potentialMiceOsteopontin productionSpecific deletionPatientsProtein signaturesInhibitionResearch ConsortiumPathologyCellsSPP1Human transcriptome datasetsMajor interactorsThe Survival Advantage of Lobectomy over Wedge Resection Lessens as Health-Related Life Expectancy Decreases
Salazar MC, Canavan ME, Walters SL, Chilakamarry S, Ermer T, Blasberg JD, Yu JB, Gross CP, Boffa DJ. The Survival Advantage of Lobectomy over Wedge Resection Lessens as Health-Related Life Expectancy Decreases. JTO Clinical And Research Reports 2021, 2: 100143. PMID: 34590002, PMCID: PMC8474228, DOI: 10.1016/j.jtocrr.2021.100143.Peer-Reviewed Original ResearchStage I NSCLCWedge resectionSurveillance EpidemiologyMortality riskHigh riskSurvival advantageLife expectancyNational Cancer Institute's Surveillance EpidemiologyEnd Results-MedicareTreatment-naive patientsEarly-stage NSCLCRetrospective cohort studySuperior local controlShort life expectancyLife expectancy decreasesPerioperative complicationsCohort studyComorbid conditionsLung parenchymaLobectomyCox modelReasonable optionPatientsNSCLCLocal control
2020
Chaotic activation of developmental signalling pathways drives idiopathic pulmonary fibrosis
Froidure A, Marchal-Duval E, Homps-Legrand M, Ghanem M, Justet A, Crestani B, Mailleux A. Chaotic activation of developmental signalling pathways drives idiopathic pulmonary fibrosis. European Respiratory Review 2020, 29: 190140. PMID: 33208483, PMCID: PMC9488512, DOI: 10.1183/16000617.0140-2019.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisPulmonary fibrosisActivation of developmental pathwaysChronically injured lungTransforming growth factor-bChronic lung injuryStem cell therapyType 2 cell hyperplasiaSonic hedgehog pathwayRemodelling of lung parenchymaGrowth factor BIdiopathic pulmonary fibrosis fibroblastsRegulation of cell transformationLung repairLung injuryCell therapyExpression of pathwaysActivation of developmental signaling pathwaysLung architectureLung parenchymaDevelopmental signaling pathwaysTranscriptional integrityHedgehog pathwayFibrosisLung
2018
Human airway trypsin‐like protease exerts potent, antifibrotic action in pulmonary fibrosis
Menou A, Flajolet P, Duitman J, Justet A, Moog S, Jaillet M, Tabèze L, Solhonne B, Garnier M, Mal H, Mordant P, Castier Y, Cazes A, Sallenave J, Mailleux A, Crestani B. Human airway trypsin‐like protease exerts potent, antifibrotic action in pulmonary fibrosis. The FASEB Journal 2018, 32: 1250-1264. PMID: 29122847, DOI: 10.1096/fj.201700583r.Peer-Reviewed Original ResearchConceptsHuman airway trypsin-like proteaseIdiopathic pulmonary fibrosisPulmonary fibrosisAntifibrotic actionHAT expressionBleomycin-induced pulmonary fibrosis modelPrimary human pulmonary fibroblastsAberrant wound healing responseFibrotic lung disordersDestruction of lung parenchymaAttenuate lung injuryPulmonary fibrosis modelProstaglandin E2 pathwayHuman pulmonary fibroblastsWound healing responseBleomycin challengeLung injuryTrypsin-like proteaseExtracellular matrix depositionExcessive extracellular matrixLung disordersPulmonary fibroblastsFibrosis modelLung parenchymaDeposition of excessive extracellular matrix
2017
Annexin A2 supports pulmonary microvascular integrity by linking vascular endothelial cadherin and protein tyrosine phosphatases
Luo M, Flood EC, Almeida D, Yan L, Berlin DA, Heerdt PM, Hajjar KA. Annexin A2 supports pulmonary microvascular integrity by linking vascular endothelial cadherin and protein tyrosine phosphatases. Journal Of Experimental Medicine 2017, 214: 2535-2545. PMID: 28694388, PMCID: PMC5584111, DOI: 10.1084/jem.20160652.Peer-Reviewed Original ResearchConceptsAlveolar hypoxiaVascular endothelial cadherinMicrovascular integrityPulmonary edemaSrc homology phosphatase 2Vascular integrityEndothelial cellsVascular endothelial growth factorMicrovascular endothelial cellsEndothelial growth factorAdherens junction protein vascular endothelial cadherinEndothelial cadherinAirway obstructionNeutrophil infiltrationPulmonary microvasculatureAnnexin A2 functionsVascular leakLung parenchymaMice displayAltitude sicknessBarrier functionGrowth factorHypoxiaPhospholipid-binding proteinsProtein tyrosine phosphatasePrognostic value of NK and T-lymphocytes markers in operable non-small cell lung cancer (NSCLC).
Skrzypski M, Szymanowska-Narloch A, Jassem E, Marczyk M, Polanska J, Biernat W, Rzyman W, Maciejewska A, Pawlowski R, Jassem J. Prognostic value of NK and T-lymphocytes markers in operable non-small cell lung cancer (NSCLC). Journal Of Clinical Oncology 2017, 35: 11556-11556. DOI: 10.1200/jco.2017.35.15_suppl.11556.Peer-Reviewed Original ResearchNon-small cell lung cancerRelapsed non-small cell lung cancerDistant metastasis-free survivalNormal lung parenchymaPrognostic valueLung parenchymaOperable non-small cell lung cancerEarly-stage non-small cell lung cancerShorter distant metastasis-free survivalStage non-small cell lung cancerNK activation markersNSCLC histological typesExpression of CXCR3Immune-targeted therapiesEndothelin receptor type BIIIA NSCLC patientsMetastasis-free survivalNK cell markersCell lung cancerT lymphocyte markersNormal lung tissuesPrimary resectionFree survivalNK cellsNSCLC patients
2016
Irreversible Electroporation in Interventional Oncology: Where We Stand and Where We Go
Savic LJ, Chapiro J, Hamm B, Gebauer B, Collettini F. Irreversible Electroporation in Interventional Oncology: Where We Stand and Where We Go. RöFo 2016, 188: 735-745. PMID: 27074423, DOI: 10.1055/s-0042-104203.Peer-Reviewed Original ResearchConceptsClinical evidenceIrreversible electroporationInterventional oncologyPancreatic irreversible electroporationSite-specific complicationsAvailable clinical evidenceUse of IRELimited clinical evidenceFavorable safety profileTolerable morbidityOncologic efficacyPreclinical findingsBile ductSafety profileNeurovascular bundleInvasive treatmentLung parenchymaAblation therapySolid tumorsClinical settingTumor ablation therapyHeat sink effectNon-thermal fashionLiverTumor ablation
2014
Cathepsin E Promotes Pulmonary Emphysema via Mitochondrial Fission
Zhang X, Shan P, Homer R, Zhang Y, Petrache I, Mannam P, Lee PJ. Cathepsin E Promotes Pulmonary Emphysema via Mitochondrial Fission. American Journal Of Pathology 2014, 184: 2730-2741. PMID: 25239563, PMCID: PMC4188869, DOI: 10.1016/j.ajpath.2014.06.017.Peer-Reviewed Original ResearchConceptsActivation/apoptosisPulmonary emphysemaChronic obstructive pulmonary disease (COPD) lungsCigarette smoke-induced lung diseaseSmoke-induced lung diseaseChronic obstructive pulmonary diseaseDynamin-related protein 1Obstructive pulmonary diseaseProtein 1Mitochondrial fission protein dynamin-related protein 1Lung tissue sectionsCathepsin ENew therapeutic targetsAir space enlargementFission protein dynamin-related protein 1Pulmonary diseaseEmphysematous changesClinical entityLung diseaseMolecular mechanismsEmphysema developmentMitochondrial fissionLung parenchymaE miceLung elasticityCD4+CD25+FoxP3+ Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-β1 exposed murine lung
Peng X, Moore MW, Peng H, Sun H, Gan Y, Homer RJ, Herzog EL. CD4+CD25+FoxP3+ Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-β1 exposed murine lung. Frontiers In Pharmacology 2014, 5: 80. PMID: 24904415, PMCID: PMC4032896, DOI: 10.3389/fphar.2014.00080.Peer-Reviewed Original ResearchTGF-β1Lung fibrosisDepletion of TregsRole of TregsRegulatory T cellsMurine lung fibrosisHuman TGF-β1 geneFibroblast growth factor 9TGF-β1 signalingTGF-β1 geneGrowth factor 9Model of fibrosisRegulatory TregTreg quantityCD25 antibodyDoxycycline-inducible overexpressionPulmonary fibrosisNaïve CD4Fibrocyte recruitmentIL-1αFGF-9 expressionLung parenchymaT cellsTregsFibrocyte accumulationPulmonary Fibrosis
Murray L, Homer R, Gulati M, Herzog E. Pulmonary Fibrosis. 2014, 2636-2653. DOI: 10.1016/b978-0-12-386456-7.05307-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsInterstitial lung diseasePulmonary fibrosisLung fibrosisConnective tissue disease-related interstitial lung diseaseIdiopathic pulmonary fibrosisSalient clinical featuresDistinctive pathological featuresWound healing responseClinical featuresChronic injuryLung diseasePathological featuresCirculating BiomarkersInflammatory responseLung parenchymaCertain therapiesPathogenic mechanismsScar tissueClinical monitoringFibrosisHealing responseFatal natureGenetic formsDiseasePotential role
2011
Evolving Genomic Approaches to Idiopathic Pulmonary Fibrosis: Moving Beyond Genes
Kass DJ, Kaminski N. Evolving Genomic Approaches to Idiopathic Pulmonary Fibrosis: Moving Beyond Genes. Clinical And Translational Science 2011, 4: 372-379. PMID: 22029812, PMCID: PMC3229869, DOI: 10.1111/j.1752-8062.2011.00287.x.Peer-Reviewed Original ResearchConceptsGenomic technologiesIdiopathic pulmonary fibrosisPathogenesis of diseaseGenomic discoveriesSystems biology approachGene expression profilingContribution of microRNAsMost human diseasesGenomic approachesGene networksBiology approachHuman genomeEpigenetic researchGenomic dataExpression profilingHuman diseasesPulmonary fibrosisDiagnosis of IPFGenesLarge collaborative studiesProgressive scarringPeripheral bloodClinical severityLung parenchymaTherapeutic goals
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